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Class 514/451 - The hetero ring is six-membered


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the hetero ring is six-membered.
No. of patents: 338
Last issue date: 12/22/2009


1                  
NumberTitleIssue Date
7635715Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
12/22/2009
7622498Sugar derivatives comprising oxiranes or α, β-unsaturated δ-lactones, process for their preparation and their utilisation as pesticides
Pesticidal compounds of general formula (I) Wherein  represents a double bond; A— represents ═C(R5)—C(═O)—, wherein R represents hydrogen or halogen, R1 and R2 represent, indepen...
11/24/2009
7618996Diaryl ether derivatives and uses thereof
Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such antagonism in animals are described herein.
11/17/2009
7417039Use of substituted azetidinone compounds for the treatment of sitosterolemia
The present invention is directed to the use of sterol absorption inhibiting compounds, pharmaceutical compositions thereof, therapeutic combinations and their use in combination with other lipid lowering agents to treat or prevent sitosterolemia and/or to lower the...
08/26/2008
7410998Inhibitors of NADH:ubiquinone oxidoreductase
Benzopyran-based inhibitors of NADH:ubiquinone oxidoreductase for inhibiting the growth of cancer cells. ...
08/12/2008
7399783Methods for the treatment of scar tissue
A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids formulated in a pharmaceutically acceptable topical carrier. The method incl...
07/15/2008
7381731Pharmaceutical composition comprising citrulline
Embodiments of the present invention include compositions and pharmaceutical compositions comprising citrulline and Hmg-CoA reductase inhibitors. Further embodiments relate to the use of such composition treat subjects and stimulating nitric oxide synthase. ...
06/03/2008
7368469Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
Use of an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with another antihypertensive, a cholesterol lowering agent, a diuretic or aspirin, in the manufacture of a medicament for the prevention of ...
05/06/2008
73549452-oxadiazolechromone derivatives
Novel compounds of the formula I in which R, X and n are as defined herein, are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for protection o...
04/08/2008
73296343-Phenyl substituted 3-substituted-4ketolactams and ketolactones
The invention relates to novel 3-phenyl-substituted, 3-substituted 4-ketolactams and -lactones of the formula (I) in which Q, W, X, Y, A, B and G are as defined in the disclosure, to proc...
02/12/2008
7323456Carboxylic acid derivatives compounds and agents comprising the compounds as active ingredient
A compound of formula (I) (wherein all symbols are as defined in the specification) and a salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active ingredient. Because a ...
01/29/2008
7323452Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives...
01/29/2008
7317125Diacylglycerol acyltransferase inhibitors
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutica...
01/08/2008
7300953Process for preparing nitrile compound, carboxylic acid compound or carboxylic acid ester compound
The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R repres...
11/27/2007
7297714Inhibitors of cathepsin S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides m...
11/20/2007
7282562Compositions and methods for the treatment of immune related diseases
The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases. ...
10/16/2007
7280894Communication system for communication between in-vehicle terminals and center, and in-vehicle terminal employed in communication system
In a communication system for downloading programs from a center to in-vehicle terminals, a center can check whether downloading has been completed normally or a program is operating normally in an in-vehicle terminal. According to the timing of activating a downloa...
10/09/2007
7261769Stabilized anthocyanin extract from
A method of making a red pigmented composition is disclosed which includes (a) preparing an aqueous extract of Garcinia indica fruit comprising at least one red colorant; (b) treating the extract with a cation exchange resin so that one or more red colorant a...
08/28/2007
72561582,4,5,-trisubstituted phenylketo-enols for use as pesticides and herbicides
The invention relates to new phenyl-substituted cyclic ketoenols of the formula (I) in which Het represents one of the groups  w...
08/14/2007
7244853Dioxanes and uses thereof
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable...
07/17/2007
7229988Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen spe...
06/12/2007
7214701Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ...
05/08/2007
7211680Vitamin D derivatives with carbo-or heterocyclic substituents at C-25, a process for their production, intermediate products and their use for producing medicaments
Compounds of Formula I, wherein Y1, Y2, R1–R6, Q and Z are as defined herein, are vitamin D derivatives. These compounds are useful for, e.g., the treatment hyperprol...
05/01/2007
7205333Multivalent neuraminidase inhibitor conjugates
The invention relates to a multimeric compound or a pharmaceutically acceptable salt or derivative thereof which comprises three or more neuraminidase-binding groups attached to a spacer or linking group, in which the neuraminidase-binding group is a compound which ...
04/17/2007
7192982Modulators of peroxisome proliferator activated receptors
Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or uns...
03/20/2007
7192940Ether compounds
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo...
03/20/2007
7183314Compound for treatment of anxiety and methods of preparation and use thereof
A method for preventing or for treating anxiety in a patient in need thereof comprising administering wogonin to the patient in an effective dose that does not cause sedative or myorelaxant side effects. Methods for extracting wogonin from the roots of Scutelleri...
02/27/2007
7183238[1,2]-oxazine-3,5-diones
The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I) in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a pl...
02/27/2007
7157421Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders
A compound of the formula where R1 is H, C1–C4 alkyl and OH; R2 in is H, C1–C4 alkyl and OH; R3 is H and C1–C4
01/02/2007
7145015Benzocycloheptenes, process for their production, pharmaceutical preparations that contain that latter as well as their use for the production of pharmaceutical agents
Benzocycloheptenes of formula (I), in which R1, R2 and Y have the meanings that indicated herein, exhibit selective estrogenic activity on bones and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therap...
12/05/2006
7141602Process for obtaining HMG-CoA reductase inhibitors of high purity
Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of d...
11/28/2006
7141605Method of controlling animal pests and disinfecting inanimate surfaces
A method of treating plant and animal systems and inanimate surfaces for the purposes of controlling plant pests, introducing pesticides and nutrients into plants, mitigating frost damage to plants, increasing crop yields, controlling certain plant diseases, control...
11/28/2006
7138429Flavonoid compound and process for producing the same
A preparation process is provided for preparing a novel flavonoid compound having a high level of antioxidative action. The flavonoid compound is obtained by subjecting hesperidin to microbial fermentation treatment with Aspergillus saitoi. ...
11/21/2006
7125853Bicyclic carbohydrate compounds useful in the treatment of infections caused by sp., such as hepatitis C and bovine viral diarrhea viruses
We describe the use of bicyclic carbohydrates for the treatment of hepatitis C virus infections. Different bicyclic carbohydrates were tested in vitro against DNA-viruses, retro-viruses and Flaviviridae sp., an important family of human and animal RNA pathoge...
10/24/2006
7119085Methods to treat alzheimer's disease
The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases. ...
10/10/2006
7115632Sulfonyl aryl or heteroaryl hydroxamic acid compounds
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid ...
10/03/2006
7101907Topical administration of statins for treatment of bone disorders
The topical administration of statins for the treatment of bone disorders is disclosed. ...
09/05/2006
7074432Method of modifying the release profile of sustained release compositions
The present invention relates to a method for the sustained release in vivo of a biologically active agent comprising administering to a subject in need of treatment an effective amount of a sustained release composition comprising a biocompatible polymer having the...
07/11/2006
7067127GIcNAc phosphotransferase of the lysosomal targeting pathway
The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ...
06/27/2006
7053109Aminediols for the treatment of Alzheimer's disease
The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the...
05/30/2006
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