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| Number | Title | Issue Date |
| 8309598 | Cooling compounds A method of providing a cooling sensation to the skin or the mucous membranes of the body, comprising the application thereto of at least one compound of the Formula I in which X is selected from S and O, R1 is s... | 11/13/2012 |
| 7812050 | Polymorphic form of fluoro-7-(2,2,2-trifluoroethoxy) phenoxathiin-10,10-dioxide Provided herein is a new form of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathin 10,10-dioxide, which demonstrates higher stability relative to other forms of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin-10,10-dioxide. In particular, this new form affords less dosag... | 10/12/2010 |
| 7432296 | Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds corresponding to formula I, as well as to their use in the production of drugs and in related methods of treating or inhib... | 10/07/2008 |
| 7291732 | Isomeric fused pyrrolocarbazoles and isoindolones The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directe... | 11/06/2007 |
| 7238362 | Dithianon-based fungicidal mixtures Fungicidal mixtures, comprising A) the compound of the formula I B) a biphenylamide of the formula II, in which Z is a... | 07/03/2007 |
| 7196081 | Compounds with hydroxycarbonyl-halogenoalkyl side chains The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the following general f... | 03/27/2007 |
| 7138426 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 11/21/2006 |
| 7115651 | Macrocycles and uses thereof The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) wherein R0–R4, Z, X, A—B, D—E, G—J, and... | 10/03/2006 |
| 7105566 | Methods of treatment during vascular procedures The invention provides in one embodiment a method for treating vascular trauma. The method can include administering to an individual undergoing vascular trauma an effective amount of a retinoic acid receptor (RAR) antagonist or an RAR inhibitor. The methods can be ... | 09/12/2006 |
| 7087626 | Pyrrole derivatives as pharmaceutical agents Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ... | 08/08/2006 |
| 7074819 | Benzopyran or thiobenzopyran derivatives The present invention relates to a novel benzopyran or thiobenzopyran derivative represented by formula (1): pharmaceutically acceptable salt or stereoisomer thereof, in which X, R1, R2, R3, R4 and A are defined as describ... | 07/11/2006 |
| 7053210 | Efficient synthesis of pyropheophorbide a and its derivatives A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1′-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves treating chlorin e6, in the form of its trimethyl ester, wit... | 05/30/2006 |
| 7030250 | Process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides and intermediates The process for obtaining 4-(N-alkylamino)-5,6-dihydro-4H-thien-(2,3-b)-thiopyran-2-sulfonamide-7,7-dioxides (I) wherein R1 is H or C1-5 alkyl, and R2 is C1-5 alkyl, starts from the corresponding 4-(N-alkylamino)-5,6-dihyd... | 04/18/2006 |
| 6963002 | Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman An improved process for the preparation of key intermediates for tazarotene, 4,4-dimethyl-6-ethynylthiochroman, is provided comprising (a) reacting 4,4-dimethyl-6-acetylthiochroman of the formula with an acid chloride ... | 11/08/2005 |
| 6919090 | Active substance combinations with insecticidal and acaricidal properties The invention relates to novel active combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/19/2005 |
| 6908934 | Therapeutic compounds for treating dyslipidemic conditions Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia | 06/21/2005 |
| 6872746 | Isomeric fused pyrrolocarbazoles and isoindolones The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directe... | 03/29/2005 |
| 6806288 | Substituted benzopyran derivatives for the treatment A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3 | 10/19/2004 |
| 6680332 | Substituted 5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyrans and benzothiopyrans and the use thereof as potentiators of AMPA Disclosed is a method for treating a disorder responsive to the positive modulation of AMPA receptors in animals suffering therefrom, comprising administering to an animal in need thereof a compound of Formula I: ##STR1## or a pharmaceutically acceptable ... | 01/20/2004 |
| 6635650 | Substituted dimeric compounds The invention relates to compounds of formula (I): wherein: A represents NR1 C(Q)R2, C(Q)NR2 R3 or NR1 C(Q)NR2 R3, B represents NR1 C(Q)R2, C(Q)NR2... | 10/21/2003 |
| 6610733 | Optically active chroman and thiochroman derivatives The present invention includes a compound having the following general formula (1): ##STR1## in which x represents an oxygen atom or a sulfur atom, m represents an integer of 2 to 14, and n represents an integer of 2 to 7, or hydrates or pharmaceut... | 08/26/2003 |
| 6498194 | Fungicidal mixtures The invention relates to a novel fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent together with, and synergistically effective amounts of (a) at least one benzophenone of formula I ##STR1## wherein R1 | 12/24/2002 |
| 6492389 | Small molecule inhibitors of BCL-2 proteins Small molecule inhibitors of Bcl-2 function are used to induce apoptosis of cells which are subject to Bcl-2, which cells are otherwise subject to Bcl-2 mediated blockage of apoptosis. The compounds are useful for treating cancer, autoimmune disorders and... | 12/10/2002 |
| 6413998 | Compositions and methods for treating bone deficit conditions Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating condi... | 07/02/2002 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6369071 | Nitric oxide donors and pharmaceutical compositions containing them An organic compound is provided which contains at least one nitric oxide donor group and at least one group being, or being adapted to be converted in vivo to a free sulfhydryl group. A preferred compound contains at least one sulfhydryl group, either in ... | 04/09/2002 |
| 6271264 | Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polyme... | 08/07/2001 |
| 6162815 | RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds having the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## which are useful for the treatment of a wide variety of dis... | 12/19/2000 |
| 6133288 | Pentacyclic compounds, intermediates, processes, compositions, and methods The present invention provides compounds of formula I and II: ##STR1## wherein X is --O--, --S--, or --NR5 --; Y is --O--, --S--, --CH2 --, --CH2 CH2 --, --CH.dbd.CH--, or --NR5 --; B is --CH2 | 10/17/2000 |
| 6117869 | Compounds for and methods of inhibiting matrix metalloproteinases The present invention relates to compounds of Formula I that inhibit matrix metalloproteinases and to a method of inhibiting matrix metalloproteinases using the compounds ##STR1## More particularly, the present invention relates to a method of treati... | 09/12/2000 |
| 6110961 | Phenoxathin derivatives as inhibitors of monoamine oxidase The present invention provide phenoxathiin compounds useful in the prophylaxis and treatment of mental disorders, such as depression. The present invention also provides a method for treating a mammal having depression, anxiety or other conditions respons... | 08/29/2000 |
| 6028099 | Use of an inhibitor of the protein tyrosine kinase pathway in the treatment of choroidal neovascularization The present invention is directed to a method for the prophylactic and therapeutic treatment of choroidal neovascularization. The method involves the administration of an inhibitor of the protein tyrosine kinase pathway to an animal, such as a mammal, in ... | 02/22/2000 |
| 6028069 | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter Cyclic sulphones of formula (I) are disclosed, in which: R1 and R2 each independently of one another stand for H, A, CF3, CH2 F, CHF2, C2 F5, Hal, OH, OA, NH2, NHA, NA... | 02/22/2000 |
| 6005007 | Retinoids, methods for their production and use Dienoic retinoids having activity for retinoid X receptors or are panagonists on retinoic acid receptors and retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such compounds and methods for their therapeutic us... | 12/21/1999 |
| 5994270 | Fungicides for the control of take-all disease of plants Plant disease caused by soil-borne fungus Gaeumannonyces graminis (Gg) is controlled by applying to the seed or the soil a fungicide which has the following general formula: ##STR1##... | 11/30/1999 |
| 5965529 | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclo... | 10/12/1999 |
| 5962413 | Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in comb... | 10/05/1999 |
| 5958970 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple cond... | 09/28/1999 |
| 5919814 | Heterocyclic compounds The invention relates to compound of general formula (I): ##STR1## wherein: Z represents O or CH2 n is from 0 to 4 R, X and Y are as defined in the description, and A represents ##STR2## wherein R1, R2, R6,... | 07/06/1999 |
| 5910509 | Antimicrobial agent for agriculture The invention provides a method of treating or preventing a fungal infection comprising administering to a plant having a fungal infection a composition comprising an effective amount of a compound of formula I, wherein said compound is the following or a... | 06/08/1999 |
