Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 8188136 | Crystalline modification of fipronil The present invention relates to a crystalline modification of fipronil, to process for the preparation of the same, to pesticidal and parasiticidal mixtures and compositions comprising said crystalline modification and to their use for combating pests and parasites... | 05/29/2012 |
| 8183206 | Drugs comprising combination of antithrombotic agent with pyrazolone derivative It is intended to provide drugs for treating ischemic diseases which are safe and have little side effects. Namely, drugs having a combination of an antithrombotic agent and a pyrazolone derivative defined in the description or its pharmaceutically acceptable salt. | 05/22/2012 |
| 8153677 | Substituted pyrazolylamide compounds useful as glucokinase activators Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroary... | 04/10/2012 |
| 8124642 | Pesticidal N-phenylpyrazole derivatives The invention relates to 5-(substituted dithio- or dioxy-alkylamino)pyrazole derivatives of formula (I) or salts thereof: wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for... | 02/28/2012 |
| 8106086 | Indoledione derivative A compound represented by the general formula (I-a): [wherein R1a and R2a each means hydrogen, lower cycloalkyl, lower alkyl, etc.; R3a means hydrogen, lower cycloalkyl, lower alkyl, etc.; R4a an... | 01/31/2012 |
| 8063092 | Crystalline modification of fipronil The present invention relates to a crystalline modification of fipronil, to a process for the preparation of the same, to pesticidal and parasiticidal mixtures and compositions comprising said crystalline modification and to their use for combating pests and parasit... | 11/22/2011 |
| 8044084 | Mixture comprising strobilurins and ethylene modulators The present invention relates to mixtures comprising a) a compound of the formula I in which X, m, Q and a are as defined in the de... | 10/25/2011 |
| 8017643 | Condensed heterocyclic pyrazole derivatives as kinase inhibitors Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith dis... | 09/13/2011 |
| 7994208 | Crystalline chemotherapeutic N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea·¼ Ethanolate Crystalline Form 1, ways to make it, formulations comprising it and made with it and methods of treating patients having disease using it is disclosed. ... | 08/09/2011 |
| 7943654 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors There are provided thieno[2,3-c]pyrazole derivatives of formula (I), wherein A is an aryl or heteroaryl ring, on which the substituent-NHZR5 is at the ortho position to the CONH linker; R1 and R2 are the same or different and, indepe... | 05/17/2011 |
| 7902248 | Oxime glucokinase activators Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders. ... | 03/08/2011 |
| 7884123 | Substituted thieno[2,3-c]pyrazoles, process for preparing them, compositions containing them, and use thereof Compounds of formula (I), wherein R1 and R3 have the meanings given in the description, said compounds being in all isomeric forms; and salts thereof; processes for the preparation of the compounds and intermediates; compos... | 02/08/2011 |
| 7872038 | 1-phenyl and 1-pyridylpyrazole derivatives and their use as pesticides The invention relates to 1-(2,4,6-trisubstituted-phenyl)-5-amino-4-substituted-pyrazole derivatives of formula (I) or salts thereof wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to the... | 01/18/2011 |
| 7872039 | 3-aminoindazoles Novel 3-aminoindazoles of the formula (I) are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal... | 01/18/2011 |
| 7863314 | 5-membered heterocycle-based p38 kinase inhibitors Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the... | 01/04/2011 |
| 7851499 | Insecticidal fertilizer mixtures This invention relates to insecticidal fertilizer mixtures containing (a) an agonist or antagonist of ion channels in the insect nervous system; (b) a fertilizer; (c) optionally, an adherent; and (d) optionally, on... | 12/14/2010 |
| 7851500 | Aminopyrazole kinase inhibitors The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents. ... | 12/14/2010 |
| 7820709 | N-phenylpyrazole derivatives as pesticides The invention relates to polar 5-aminopyrazole carbamate derivatives of formula (I) or salts thereof: (I), wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of... | 10/26/2010 |
| 7816392 | Crystalline modifications to pyraclostrobin The present invention relates to novel crystalline modifications of pyraclostrobin, to processes for their preparation and to the use of the novel modifications for preparing crop protection compositions. ... | 10/19/2010 |
| 7803832 | N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides The invention relates to a sulfonamide compound of formula (I) or a pharmaceutically, veterinarily or agriculturally acceptable salt or solvate thereof, where the groups R1-R5 are described in the description, to compositions comprising such co... | 09/28/2010 |
| 7759382 | Acylated amino acid amidyl pyrazoles and related compounds This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula I. The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is furth... | 07/20/2010 |
| 7700640 | Process for making phenoxy benzamide compounds A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula... | 04/20/2010 |
| 7687533 | N-(1-arylpyrazol-4l) sulfonamides and their use as parasiticides The invention relates to a sulfonamide compound of formula (I) or a pharmaceutically, veterinarily or agriculturally acceptable salt or solvate thereof, where the groups R1-R5 are described in the description, to compositions comprising such co... | 03/30/2010 |
| 7645787 | Pyrazole derivatives and diabetic medicine containing them The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicine. ... | 01/12/2010 |
| 7629375 | Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarc... | 12/08/2009 |
| 7608635 | Pyrazole compounds that modulate HSP90 activity Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of fo... | 10/27/2009 |
| 7541378 | Condensed heterocyclic pyrazole derivatives as kinase inhibitors Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith dis... | 06/02/2009 |
| 7538135 | Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds Compounds of the formula provide pharmacological agents which bind to Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the treatment of conditions media... | 05/26/2009 |
| 7501449 | 2-or 3-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof Compounds corresponding to the formula (I) as defined in the disclosure as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the inven... | 03/10/2009 |
| 7482375 | Compounds useful in therapy Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents H, C1-6-alkyl, C1-6alkyloxy, C3-8cycloalkyl... | 01/27/2009 |
| 7468386 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula wherein R1, R3, R4, R5, R6, R7 and R8 are as defined. Compounds... | 12/23/2008 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7435728 | Pyrazole derivatives This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation ther... | 10/14/2008 |
| 7432287 | Heteroarylcarbamoylbenzene derivative Compounds represented by formula (I): as well as their pharmaceutically acceptable salts are disclosed. The compounds are useful as glucokinase activating agents for the treatment of diabetes and related conditions. Composi... | 10/07/2008 |
| 7425640 | Substituted 5-carboxyamide pyrazoles and [1,2,4]triazoles as antiviral agents The present invention provides compounds of formula I wherein X, Y, R1-R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders... | 09/16/2008 |
| 7407971 | Substituted pyrrolo-pyrazole derivatives as kinase inhibitors A new class of pyrazolo derivative compounds having the formula where R and R1 have the meanings given herein. The pyrazolo derivative compounds are useful in treating cell proliferative disorders caused by and/o... | 08/05/2008 |
| 7399766 | Soluble amide & ester pyrazinoylguanidine sodium channel blockers The present invention provides a pyrazinoylguanidine compound represented by formula (I): where the structural variables are as defined herein. The compounds are useful for promoting hydration of mucosal surfaces. ... | 07/15/2008 |
| 7354944 | Thiadiazole compounds and methods of use The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnorm... | 04/08/2008 |
| 7335649 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 02/26/2008 |
| 7335374 | Multi-layer barrier preventing wood pest access to wooden structures A method and device are disclosed which prevent the intrusion of insects onto wood structures by using a barrier capable of retaining pesticide. In the disclosed method, the barrier maintains a minimal effective level of insecticide for a predetermined period of tim... | 02/26/2008 |
