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| Number | Title | Issue Date |
| 8168670 | Pyrazolone derivative emulsion formulations Pyrazolone derivative emulsion formulations are provided. The emulsion formulations include a pyrazolone derivative active agent, e.g., Edaravone, oil, water and an emulsifier. Also provided are methods of making and using the subject emulsion formulations. ... | 05/01/2012 |
| 8093282 | Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein J1, U1, U2, B, Y, and A are as described. Methods, compositions, and... | 01/10/2012 |
| 8088812 | Sigma receptor inhibitors The invention relates to compounds of formula I having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising t... | 01/03/2012 |
| 8088813 | 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) An improved thrombopoietin mimetic, the bis-(monoethanolamine) salt of 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid. ... | 01/03/2012 |
| 8076368 | Percutaneous absorption type cerebral protective agent A percutaneous absorption type cerebral protective agent containing as an active ingredient, 0.1 to 30 percent by mass of 3-methyl-1-phenyl-2-pyrazolin-5-one represented by the following formula: or a medically acceptable s... | 12/13/2011 |
| 8053458 | Dipyrazole compounds and their use as central nervous system agents The present invention is directed to dipyrazole compounds of formula I and their pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I. The compounds of t... | 11/08/2011 |
| 8022093 | Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia. ... | 09/20/2011 |
| 7989485 | Imidazole compounds having pharmaceutical activity towards the sigma receptor The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals. ... | 08/02/2011 |
| 7863312 | Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or prevent... | 01/04/2011 |
| 7795293 | 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) An improved thrombopoietin mimetic, the bis-(monoethanolamine) salt of 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid. ... | 09/14/2010 |
| 7786159 | Thrombopoietin mimetics The invention relates to compounds and their use in the treatment of thrombocytopenia resulting from diseases or conditions such as immune thrombocytopenic purpura, cancer chemotherapy, surgery, bone marrow or stem cell transplantation, radiation injury or treatment... | 08/31/2010 |
| 7700639 | Chemical compounds, process for their preparation and use thereof Disclosed are compounds of formula (I) or pesticidally acceptable salts thereof wherein, for example, W is ═CR8— or ═C(NR9R10)—, R8 is halogen, R9 and R10 are independently of one another hydr... | 04/20/2010 |
| 7652057 | Pyrazolones as 11b-HSD1 inhibitors for diabetes Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4 have the significance given in claim 1 can be used in the form of pharmaceutical compositio... | 01/26/2010 |
| 7547719 | 3′-[(2z)-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hy-drazino]-2′-hydroxy-[1,1′-piphenyl]-acid bis-(monoethanolamine) An improved thrombopoietin mimetic, the bis-(monoethanolamine) salt of 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid. ... | 06/16/2009 |
| 7517900 | Pyrazole derivatives as cannabinoid receptor modulators The present application describes compounds according to Formula I, wherein A, B, E, R1, R2, R3, R4, Y and Z are described herein. Additionally, the present application describes pharmaceutical compositions comprising at l... | 04/14/2009 |
| 7410991 | Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or prevent... | 08/12/2008 |
| 7335779 | Modulation of pathogenicity The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R1 is H... | 02/26/2008 |
| 7335649 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 02/26/2008 |
| 7332481 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 02/19/2008 |
| 7312239 | Medicament for prevention and/or therapy of arterial wall disorder An object of the present invention is to provide a medicament and method which is useful for prevention and/or therapy of arterial wall injury. According to the present invention, there is provided a method for prevention and/or therapy of arterial wall injury which... | 12/25/2007 |
| 7312204 | Insecticides The present invention relates to insecticidal mixtures of chloronicotinyl insecticides of the formula (I) in which R1 represents C1-C5-alkyl, R2 | 12/25/2007 |
| 7312199 | Process for the production of (−)-epigallocatechin gallate A process is provided for making (−)-epigallocatechin gallate (EGCG) by subjecting a green tea extract to chromatography on a macroporous polar resin, eluting EGCG from the resin with a polar elution solvent, optionally concentrating the eluate, optionally regener... | 12/25/2007 |
| 7309711 | Fungicidal agent combinations The invention relates to novel fungicidallly active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and the active compounds listed in the disclosure. ... | 12/18/2007 |
| 7288572 | Active substance combinations having insecticidal and acaricidal properties The present invention relates to novel insecticidally and acaricidally active compound combinations of N2-[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide of the form... | 10/30/2007 |
| 7276516 | CB1 antagonist compounds Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention ... | 10/02/2007 |
| 7253290 | Pyrazole derivatives as GnRH inhibitors The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R1, R2, R5, R6, R6a, R7, R8, A, B and M are... | 08/07/2007 |
| 7241783 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted thiosemicarbazone derivative. | 07/10/2007 |
| 7223760 | Substituted triazole compounds Novel substituted triazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ... | 05/29/2007 |
| 7217729 | Substituted indoles, process for the production thereof and use thereof for combatting pain Substituted indoles of the formula I, a process for the production of such compounds, pharmaceutical preparations containing these compounds and the use of these compounds for alleviating pain. ... | 05/15/2007 |
| 7211596 | Stable high-concentration injection containing pyrazolone derivative An injection which contains as the active ingredient a pyrazolone derivative which typically is Edaravone, a physiologically acceptable salt thereof, or a hydrate or solvate of either in an amount of 3 to 60 mg/mL. It is excellent in long-term stability, product sto... | 05/01/2007 |
| 7211600 | Methods of modulating tyrosine protein kinase function with indolinone compounds The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers characterized by over-activity or inappropriate activity c-kit kinase... | 05/01/2007 |
| 7208514 | Tumorigenesis inhibitor A compound having a xanthine oxidase inhibitory activity, such as 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid and the like, can be a drug for preventing cancer including colon cancer and the like, as an agent for suppressing tumorigenesis. ... | 04/24/2007 |
| 7160870 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 01/09/2007 |
| 7135499 | Active substance combinations having insecticidal and acaricidal properties The present invention relates to novel insecticidally and acaricidally active compound combinations of N2-[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide of the form... | 11/14/2006 |
| 7125880 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 an... | 10/24/2006 |
| 7112594 | Fused bicyclic amide compounds and medicinal use thereof Compounds represented by the following general formula (I) wherein ring A is benzene, cyclohexane, pyridine, piperidine, a derivative thereof, imidazole, a derivative thereof, etc.; the ring B represents benzene, cyclohexane, pyrrole or a derivative thereof, furan, ... | 09/26/2006 |
| 7067664 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 an... | 06/27/2006 |
| 7034049 | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3–C6 cycloalkyl group optionally substituted by a straight or branched C1–C6 alkyl or arylalkyl group; R1 is a straig... | 04/25/2006 |
| 6992188 | Substituted heterocyclic derivatives Corticotropin-releasing factor (CRF) antagonists having the formula wherein the dashed lines, A, B, D E, F, Z, G, R3, and R5 having the definitions set forth in the specification pharmaceutical com... | 01/31/2006 |
| 6979693 | Pyrazole derivatives-p38 MAP kinase inhibitors The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these com... | 12/27/2005 |
