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| Number | Title | Issue Date |
| 8124640 | Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof Pharmaceutical composition comprising 5 to 20% of an idazoxan salt or of idazoxan hydrate, 10 to 40% of microcrystalline cellulose, 1 to 5% of lubricant, 0.1 to 0.5% of colloidal silica and from 29.5% to 84.8% of lactose, with respect to the total mass. ... | 02/28/2012 |
| 7595335 | Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof A pharmaceutical composition comprising idazoxan or derivatives and their therapeutically acceptable salts, racemates, optically active isomers and polymorphs. ... | 09/29/2009 |
| 7410999 | Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.... | 08/12/2008 |
| 7375125 | Melanocortin-4 receptor binding compounds and methods of use thereof Provided are MC4-R binding compounds of the formula XVII: wherein L2 is a linker group, and P1, P2, P3, P4, Z1, Z2, Z3, Z4, ... | 05/20/2008 |
| 7371773 | Breast cancer resistance protein () inhibitor The invention provides a drug which inhibits BCRP. A breast cancer resistance protein inhibitor containing, as an active ingredient, a diphenylacrylonitrile derivative represented by the following formula (1): [where... | 05/13/2008 |
| 7368608 | 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivatives and a process for preparing 2-amidomethyl-1,4-benzodioxane derivatives An 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivative represented by the following formula (1), wherein cycle A may have further 1 to 4 substituents, and said substituent means a substituent selected from the group consisti... | 05/06/2008 |
| 7345078 | NF-κB inhibitors and uses thereof A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The ... | 03/18/2008 |
| 7338970 | Pharmaceutical composition based on a polymorphic form I of idazoxan Pharmaceutical composition comprising 5 to 20% of an idazoxan salt or of idazoxan hydrate, 10 to 40% of microcrystalline cellulose, 1 to 5% of lubricant, 0.1 to 0.5% of colloidal silica and from 29.5% to 84.8% of lactose, with respect to the total mass. ... | 03/04/2008 |
| 7029706 | Composition for the treatment of cutaneous mycosis The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and silica. ... | 04/18/2006 |
| 6956051 | Enkephalin conjugates The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeutic compound conjugated to ... | 10/18/2005 |
| 6947365 | Method for protecting phase lock loop in optical system A method for protecting a phase lock loop (PLL) in an optical system is disclosed. The disclosed method will determine whether the currently reading data is erroneous and then maintain the frequency currently locked by the PLL circuit when the waveform lengths of th... | 09/20/2005 |
| 6911478 | Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing amidine- a... | 06/28/2005 |
| 6878735 | Multi-substituted imidazolines and method of use thereof A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The ... | 04/12/2005 |
| 6852726 | Substituted indoles as alpha-1 agonists This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: wherein X is —S(O)n— or —C(O)—, A is C1-... | 02/08/2005 |
| 6835743 | Pesticidal pyrazoles and derivatives Process for the protection of a building that has already been built or is going to be built, whereby an effective amount of an insecticidally active compound is spread around or under the said building at discrete locations. The insecticide may be an arylpyrazole. | 12/28/2004 |
| 6762190 | Thienylalanine derivatives as inhibitors of cell adhesion The present invention relates to compounds of formula (I), in which A, B, X, Y, R1, R2, R3 and n have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmacologically active compounds. They are vitron... | 07/13/2004 |
| 6756395 | Imidazolinyimethyl aralklsulfonamides Compounds of the Formula: where R1-R6 are those defined herein and methods for producing the same. Also provided are pharmaceutical compositions comprising a Compound of Formula I and methods for th... | 06/29/2004 |
| 6743817 | Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists... | 06/01/2004 |
| 6720317 | Inhibitors of factor Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 04/13/2004 |
| 6699862 | Indolyl-2-phenyl bisamidines useful as antiproliferative agents Novel indolyl-2-phenyl bisamidines are described which are DNA methyltransferase inhibiting agents, and pharmaceutical compositions containing them are used as antiproliferative agents for treating a disease, especially a neoplastic disease, characterized... | 03/02/2004 |
| 6680312 | Sulfonamide derivatives, their production and use The present invention is to provide a compound or a salt thereof represented by the formula: ##STR1## wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, the ring A is an optionally su... | 01/20/2004 |
| 6677341 | (R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and m... | 01/13/2004 |
| 6632815 | Inhibitors of factor Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 10/14/2003 |
| 6610725 | Fluorinated imidazoline benzodioxane, preparation and therapeutic uses thereof The present invention relates to novel fluorinated benzodioxane imidazoline derivatives, to their preparation and to their therapeutic applications. The invention is directed more particularly toward the compounds corresponding to the structure of general form... | 08/26/2003 |
| 6596745 | Method for treating fibrotic diseases with azolium chroman compounds Provided is a method of treating or ameliorating hypertension in an animal comprising administering an effective amount of a compound of formula I: ##STR1##... | 07/22/2003 |
| 6528535 | Bicyclic inhibitors of protein farnesyl transferase The present invention provide compounds of Formula I ##STR1## The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable... | 03/04/2003 |
| 6525086 | Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X, T, Q, Z, U, Y, Ar, p and n are as defined in the speci... | 02/25/2003 |
| 6410539 | Imidazole derivatives and their use as farnesyl protein transferase inhibitors The present invention relates to a compound of Formula (1) wherein Ar1 represent (A) or (B) or (C); R1 is hydrogen, C1-4 alkyl or C1-4 alkanoyl; R12 and R13 are independently hydrogen or C | 06/25/2002 |
| 6348464 | Pyrrolecarbonylimino derivatives as naaladase inhibitors The present invention relates to pharmaceutical compositions and methods of using pyrrolecarbonylimino derivatives to inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, thereby effecting neuronal activities, inhibiting ang... | 02/19/2002 |
| 6331552 | Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations including them Substituted imidazolidine derivatives of the formula I, ##STR1## in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active com... | 12/18/2001 |
| 6319935 | Conformationally rigid bicyclic and adamantane derivatives useful as 댒-adrenergic blocking agents A compound of formula I ##STR1## in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; X is nitrogen, oxygen or ... | 11/20/2001 |
| 6232336 | Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine- and enamide-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, a method for the preparation of nitric oxide-releasing amidin... | 05/15/2001 |
| 6191159 | Disubstituted pyrazolines and triazolines as factor Xa inhibitors The present application describes disubstituted pyrazolines and triazolines of formulae I and II: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of M1 and M2 maybe N and D may be a variety of N-containing gro... | 02/20/2001 |
| 6162818 | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists This invention involves compounds having the following structure: ##STR1## wherein: a) R1 is hydrogen; or alkyl; bond (a) is a single or a double bond; b) R2 and R3 are each independently selected from hydrogen; unsub... | 12/19/2000 |
| 6159998 | Substituted indoles and uses thereof This invention is directed to novel indole and benzothiazole compounds which are selective for cloned human alpha 2 receptors. This invention is also related to uses of these compounds for any indication where use of an alpha 2 agonist may be appropriate.... | 12/12/2000 |
| 6153638 | Use of efaroxan for producing medicine for treating huntington 's disease The invention concerns the use of efaroxan or therapeutically-acceptable salts, in its racemic form or in the form of an optically-active isomer, for treating Huntington's disease.... | 11/28/2000 |
| 6103744 | 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one dopamine autoreceptor agonists Disclosed are compounds of the formula ##STR1## wherein: R1 is hydrogen or C1 -C6 alkyl; R2 is selected from hydrogen, straight-chain and branched C1 -C10 alkyl, cyclohexylmethyl or --(CH | 08/15/2000 |
| 6093727 | Imidazole and imidazoline derivatives and uses thereof This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human a, adrenergic receptors. This invention is also related to the use of these compounds for the treatment of any disease where modulation... | 07/25/2000 |
| 6090811 | Anti-neurogenic inflammatory compounds and compositions and methods of use thereof A novel use for the class of biologically active bis-heterocyclic, e.g., bis-indole alkaloid compounds, which have been named topsentins, bromotopsentins, homocarbonyltopsentins, nortopsentins, hamacanthins, bis-indole ethylamines, or dragmacidins, pharma... | 07/18/2000 |
| 6080769 | Imidazolidin-4-one derivatives useful as anticancer agents The present invention relates to compounds of formula 1 ##STR1## and to pharmaceutically acceptable salts and solvates thereof, wherein Z, R, R3 and R4 are as defined herein. The invention also relates to pharmaceutical composit... | 06/27/2000 |
