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| Number | Title | Issue Date |
| 7816319 | Methods and products for manipulating uncoupling protein expression The invention is based in part on the discovery that uncoupling proteins (UCPs) are expressed in the plasma membrane of rapidly dividing cells but not of growth arrested, chemotherapy resistant cells. It has also been found according to the invention that UCP is exp... | 10/19/2010 |
| 7786077 | Insulins combinations A pharmaceutical association or combination comprising a therapeutic effective amount of insulin or insulin analogue, and a therapeutic effective amount of a pharmaceutically acceptable betaine, in which the insulin and the betaine possibly form a chemical entity or... | 08/31/2010 |
| 7732402 | Mammalian telomerase Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents. ... | 06/08/2010 |
| 7635674 | Synergistic pharmaceutical combination for the prevention or treatment of diabetes The invention refers to a synergistic pharmaceutical combination which comprises (a) a first pharmaceutical composition containing an antidiabetic or anti-hyperlipidemic active agent and one or more conventional carrier(s), and (b) a second pharmaceutical compositio... | 12/22/2009 |
| 7435380 | Pseudo-plastic or thixotropic liquid deodorant product for ostomy pouches A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties of the carrier allow the composition to be conveniently dispensed from... | 10/14/2008 |
| 7429564 | Oral insulin therapy Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and that result in a lower incidence o... | 09/30/2008 |
| 7419952 | Use of exendins and agonists thereof to treat diabetes Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that aff... | 09/02/2008 |
| 7417028 | Human glucagon-like-peptide-1 modulators and their use in treatment of diabetes and related conditions The present invention provides novel human glucagon-like peptide-1 (GLP-1)-receptor modulators that have biological activity similar or superior to native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP ... | 08/26/2008 |
| 7414021 | Method and composition for restoration of age related tissue loss in the face or selected areas of the body A treatment method for restoring of age related tissue loss in the face or selected areas of the body is disclosed which includes injecting an injectable composition containing a growth factor and hyaluronic acid as a carrier into the dermis, the hypodermis, or both... | 08/19/2008 |
| 7411042 | Tumor associated nucleic acids and uses therefor The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acid molecules, and antibodies relating ... | 08/12/2008 |
| 7387996 | Formulations of insulin Stable insulin formulations can be prepared by mixing a monomeric insulin and a soluble acylated insulin analog. ... | 06/17/2008 |
| 7378390 | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin ana... | 05/27/2008 |
| 7364161 | Card game This invention is mainly a 7-card stud poker game, played with at least one standard poker deck of 52 cards, plus at least one Joker. After a player places a Poker wager and/or a Pair Of Aces Or Better wager, the player then has the option to place a Bonus wager, ag... | 04/29/2008 |
| 7358222 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks th... | 04/15/2008 |
| 7357936 | Adjuvant systems and vaccines The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting particle is essentially devoid of antigen. ... | 04/15/2008 |
| 7351798 | Stabilized protein crystals, formulations comprising them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and composition... | 04/01/2008 |
| 7338465 | Infusion device and method thereof The disclosures made herein relate to an infusion device specifically adapted for syringe injections. In one embodiment of the disclosures made herein, an infusion device comprises a body including an accessible surface having a single inlet port therein, an engagem... | 03/04/2008 |
| 7335750 | Hybrid compositions for intracellular targeting Hybrid compounds comprising a first domain and a second domain are provided. The first domain and the second domain are preferably covalently linked, and the first domain comprises a domain which is capable of specific binding to Gb3; and the second domai... | 02/26/2008 |
| 7326680 | Uterine contraction inhibitors A composition for inhibiting spontaneous myometrial contraction or bradykinin-induced contraction, comprising adrenomedullin. The composition of the present invention may be used to selectively inhibit spontaneous myometrial contraction or bradykinin-induced contrac... | 02/05/2008 |
| 7312196 | Formulations for amylin agonist peptides The present invention is concerned with a pharmaceutical formulation comprising an amylin agonist and optionally a buffer, a tonicifier or stabilizer, and a preservative in a container, for example, a vial, prefilled cartridge, prefilled syringe or disposable pen. T... | 12/25/2007 |
| 7304029 | Neuroprotective effect of growth hormone The invention relates to neuroprotection and to medicaments for use therein. Neuroprotection is induced by activation of neural growth hormone receptors, primarily using medicaments comprising growth hormone, growth hormone analogs or ligands which are functionally ... | 12/04/2007 |
| 7291591 | Alcohol-free transdermal insulin composition The instant invention is directed toward a dermal delivery system composition comprising an aqueous base vehicle including Emu oil, at least one fatty acid alkyl ester, polyethylene glycol, and a gelling agent, in combination with a therapeutically effective amount ... | 11/06/2007 |
| 7278419 | Method for treating diabetes mellitus in a patient The need for the delivery of insulin by injection can be reduced or eliminated by delivering aerosolized insulin. Repeatability of dosing is obtainable by using either regular insulin or monomeric insulin. When delivering insulin (not monomeric) by inhalation, the t... | 10/09/2007 |
| 7279457 | Rapid acting drug delivery compositions Drug formulations for systemic drug delivery with improved stability and rapid onset of action are described herein. The formulations may be administered via buccal administration, sublingual administration, pulmonary delivery, nasal administration, subcutaneous adm... | 10/09/2007 |
| 7276581 | Mutated Src oncogene composition and methods The present invention provides a mutant oligonucleotide composition encoding a cellular c-Src tyrosine kinase oncogene. Methods for isolating, expressing and characterizing recombinant Src mutant polypeptide are also provided. The invention further relates to method... | 10/02/2007 |
| 7276236 | Methods of preparing immune globin and uses thereof The present invention provides for methods of preparing purified immune globulins, immune globulin compositions, and methods of treating allergies and conditions by administering immune globulin compositions. For example, the present invention provides for purified ... | 10/02/2007 |
| 7271278 | Application of chromium-amino acid complexes in the treatment of diabetes and other diseases Compositions comprising chromium (III) 1:3 complexes comprising amino acids and methods of use thereof are provided. ... | 09/18/2007 |
| 7271238 | Amylin agonist peptides and uses therefor Agonist analogues of amylin and related pharmaceutical compositions, and methods of treatment of diabetes and other insulin-requiring states, as well as methods of treatment of hypoglycemia, are provided. ... | 09/18/2007 |
| 7268112 | Use of insulin for the treatment of cartilaginous disorders The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or cartilaginous disorders, including arthritis, comprising the administration of insulin and/or insulin variants. Optionally, the administratio... | 09/11/2007 |
| RE39789 | Tumor therapy Neoplasia is treated by administering to a mammalian host a composition comprising ligands for the NKG2D receptor. In addition, other NKG2D ligands, proteins specific for the neoplastic cells and cytokines may be included to enhance the immune response. The composit... | 08/21/2007 |
| 7259139 | Means for maintenance and/or correction of glucose concentration in blood The invention relates to preparations that are useful in maintaining mammalian blood glucose concentrations. These preparations contain insulin, and a polymeric matrix. The polymeric matrix has a core of biodegradable, hydrophobic polymer, and an outer shell of a bi... | 08/21/2007 |
| 7253169 | Aza compounds, pharmaceutical compositions and methods of use The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities. ... | 08/07/2007 |
| 7244703 | Pharmaceutical compositions and methods for peptide treatment Compositions and methods for treating a patient with a pharmaceutically active peptide that combines a pharmaceutically active peptide, a permeation enhancer, and a carrier, are disclosed. ... | 07/17/2007 |
| 7244709 | Compositions and methods for enhanced mucosal delivery of parathyroid hormone Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteo... | 07/17/2007 |
| 7244438 | Uses for polycationic compounds The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release. ... | 07/17/2007 |
| 7223561 | Process of high purity albumin production A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-g... | 05/29/2007 |
| 7217694 | Inhibitors of IAPP fibril formation and uses thereof New antifibrillogenic agents and compositions containing same, methods of using the antifibrillogenic agents and compositions for inhibiting amyloid fibril formation, and effective therapeutics for preventing or delaying the progression of, e g., Alzheimer's disease... | 05/15/2007 |
| 7205277 | Zinc-free and low-zinc insulin preparations having improved stability The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of ... | 04/17/2007 |
| 7205276 | Zinc-free and low-zinc insulin preparations having improved stability The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of ... | 04/17/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
