Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8153676 | Use of compounds of formula A-R-Xo pharmaceutically acceptable salts thereof for producing a pharmaceutically preparations The invention relates to a compound of formula A-R—X or pharmaceutically acceptable salts thereof which can be used for producing a pharmaceutical preparation suitable for preventing or treating cancerous diseases, pathological consequences of alcohol abuse, viral... | 04/10/2012 |
| 8119680 | α-Haloketone derivatives of imidazolyl-substituted aromatic compounds and compounds prepared therefrom Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. ... | 02/21/2012 |
| 8071636 | Methods of treating alpha adrenergic mediated conditions Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for al... | 12/06/2011 |
| 8039501 | Synephrine derivatives useful as anti-inflammatory agents This invention provides compounds having the structural formula: wherein: R1 is an acyl or sulfonyl group, R2 is an acyl group selected from the grou... | 10/18/2011 |
| 7977367 | Substituted imidazole propanamide glucokinase activators The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R | 07/12/2011 |
| 7943650 | Methods of treating cancer with imidazolyl compounds Disclosed in certain embodiments is a method of treating and/or mitigating prostate cancer, ovarian cancer, melanoma, colorectal cancer, breast cancer or lung cancer, comprising administering to an individual in need thereof a pharmaceutical composition comprising a... | 05/17/2011 |
| 7897633 | Inhibitors of glutaminyl cyclase The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophre... | 03/01/2011 |
| 7884121 | Process for the preparation of phenylcarbamates This invention relates to a process for the preparation of an aminoalkyl phenyl carbamate compound of formula 1, wherein R1 and R2 independently are hydrogen or C1-6 alkyl; R3 and... | 02/08/2011 |
| 7858654 | Imidazole-substituted arylamides as P2Xand P2Xantagonists Compounds of the formula I: wherein R1 is optionally substituted imidazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. A... | 12/28/2010 |
| 7812047 | 4-imidazolines The present invention relates to compounds of formula wherein R1, R2, X, Y and Ar are as defined herein and to their pharmaceutically active salts, with the exclusion of the r... | 10/12/2010 |
| 7687530 | Inhibition of chronic tissue transplant rejection Disclosed is a method of inhibiting acute and chronic tissue transplant rejection in a subject with a tissue transplant. The method comprises the step of administering to the subject an effective amount of a compound represented by Formula (I): | 03/30/2010 |
| 7678822 | Induction of immune tolerance Methods of inducing immune tolerance by administering an immunosuppressive agent and a compound represented by Formula (I) are disclosed: Additionally methods of suppressing an immune response by administering an immunosuppre... | 03/16/2010 |
| 7625935 | High purity butoconazole nitrate with specified particle size and a process for the preparation thereof One object of the invention is high purity butoconazole nitrate of the formula (I) (I) containing maximum 0.1 wt % of chemical impurities, wherein at least 95% of the particles of the substance are below 75 μm by diameter, whereas at least 99% of the particles are ... | 12/01/2009 |
| 7566734 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors. ... | 07/28/2009 |
| 7550497 | Phosphoramide derivatives New phosphoramide derivatives of formula (I) and the salts and solvates thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful as antiinflammatory and analgesic agents. | 06/23/2009 |
| 7507757 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH | 03/24/2009 |
| 7456208 | CCK-1 receptor modulators Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases. ... | 11/25/2008 |
| 7429575 | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or i... | 09/30/2008 |
| 7365070 | Modulators of melanocortin receptor This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by formula I: ... | 04/29/2008 |
| 7361678 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 04/22/2008 |
| 7358342 | Preparation derived from shark cartilage for treatment of diseased related to excessive PHF or excessive intracellular calcium A preparation derived from shark cartilage for the treatment of diseases related to excessive PHF or Excessive intracellular calcium. ... | 04/15/2008 |
| 7358369 | Radiolabelled phenylethyl imidazole carboxylic acid ester derivatives Halogenated carboxylic ester derivatives of phenylethyl imidazole, and their method of preparation are disclosed. Radio-halogenated forms of these compounds are ideally suited for positron-imaging of the adrenal glands, as it is known that these compounds demonstrat... | 04/15/2008 |
| 7351825 | Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04/01/2008 |
| 7351429 | Oral solid preparation The invention is to provide an oral solid pharmaceutical that is uniform in the content of KRP-197, having bladder-selective anticholinergic activity, being a therapeutic drug for pollakiuria and urinary incontinence, and being active with a very low dosage, that ca... | 04/01/2008 |
| 7345077 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4- (substituted cycloalkylmethyl) imidazol-2-ones and 4- (substituted cycloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in ... | 03/18/2008 |
| 7336989 | System and method for quantitative or qualitative measurement of exogenous substances in tissue and other materials using laser-induced fluorescence spectroscopy Methods and systems for determination of one or more substances within a material are described. A flow of fluorescence-exciting/ablative energy (e.g., laser pulse(s), preferably in the ultraviolet region (e.g. 193-nm)), is directed onto the material to ablate a thi... | 02/26/2008 |
| 7326705 | Heterocyclic sodium/proton exchange inhibitors and method Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C—R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, al... | 02/05/2008 |
| 7319149 | Chelants and macrocyclic metal complex radiopharmaceuticals thereof Chelants and macrocyclic metal complexes thereof, methods of preparing the chelants and macrocyclic metal complexes, and radiopharmaceutical compositions comprising the macrocyclic metal complexes are disclosed. Methods of using the macrocyclic metal complexes as ra... | 01/15/2008 |
| 7319104 | hPPARs activators Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseases or conditions associated w... | 01/15/2008 |
| 7317104 | Chelants and macrocyclic metal complex radiopharmaceuticals thereof Chelants and macrocyclic metal complexes thereof, methods of preparing the chelants and macrocyclic metal complexes, and radiopharmaceutical compositions comprising the macrocyclic metal complexes are disclosed. Methods of using the macrocyclic metal complexes as ra... | 01/08/2008 |
| 7312199 | Process for the production of (−)-epigallocatechin gallate A process is provided for making (−)-epigallocatechin gallate (EGCG) by subjecting a green tea extract to chromatography on a macroporous polar resin, eluting EGCG from the resin with a polar elution solvent, optionally concentrating the eluate, optionally regener... | 12/25/2007 |
| 7304049 | Succinoylaminobenzodiazepines as inhibitors of Aβ protein production This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, mor... | 12/04/2007 |
| 7300929 | Mediators of hedgehog signaling pathways, compositions and uses related thereto The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small ... | 11/27/2007 |
| 7297794 | Phenoxy amine compounds and compositions for delivering active agents Phenoxy amine compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 11/20/2007 |
| 7294644 | CB 1 receptor inverse agonists The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, m and X are as defined in the description and claims, an... | 11/13/2007 |
| 7282503 | Fungicidal mixtures based on imidazole derivatives Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X1 and X2 represent halogen and phenyl which can be substituted by halo... | 10/16/2007 |
| 7279478 | Cathepsin cysteine protease inhibitors This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as o... | 10/09/2007 |
| 7271271 | Imidazolo-related compounds, compositions and methods for their use Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are usef... | 09/18/2007 |
| 7250434 | CCK-1 receptor modulators Certain imidazole compounds are CCK1 modulators useful in the treatment of CCK1 mediated diseases. ... | 07/31/2007 |
| 7250412 | PH sensitive prodrugs of 2,6-Diisopropylphenol The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylpheno... | 07/31/2007 |
