Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8163790 | Metronidazole cocrystals and imipramine cocrystals Cocrystals of metronidazole are described herein. Such cocrystals are a cocrystal of metronidazole with gentisic acid and a cocrystal of metronidazole with gallic acid. Cocrystals of imipramine hydrochloride are also described. Such cocrystals are a cocrystal of imi... | 04/24/2012 |
| 8153675 | Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid The invention provides a crystalline freebase form of 4′-{2-ethoxy-4-ethyl-5-[((S) -2-mercapto-4-methylpentanoylamino)methyl]imidazol-1-ylmethyl}-3′-fluorobiphenyl-2 -carboxylic acid. This invention also provides pharmaceutical compositions comprising the crysta... | 04/10/2012 |
| 8119679 | Method for preparation of 2,4-dinitroimidazole which is an intermediate for insensitive meltcastable molecular explosive The present invention provides a method for preparing 2,4-dinitroimidazole, wherein separation of 1,4-donitroimidazole in powder form is avoided so that it is possible to eliminate allergy problems in workers and simplify the process, thereby improving process econo... | 02/21/2012 |
| 8030338 | Method for producing 2-nitroimidazole derivative It is an object to provide a method for producing a 2-nitroimidazole derivative having an acyclic sugar chain in a side chain, which is suitable for production of a derivative having a radioisotope. A method for producing 1-(1-benzoyloxymethyl-2-hydroxyethyl)... | 10/04/2011 |
| 7994205 | Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors The present invention provides an aryl- or heteroaryl compound represented by the formula (Ia) or (Ib) wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition comprising th... | 08/09/2011 |
| 7981916 | Solubilizing of metronidazole Metronidazole is solubilized in an aqueous phase, by mixing same with niacinamide and at least two glycolic cosolvents; the resulting solutions and pharmaceutical compositions comprised thereof are useful for the treatment of dermatological conditions/afflictions, n... | 07/19/2011 |
| 7906544 | Inhibition of bacterial biofilms with imidazole derivatives Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same. ... | 03/15/2011 |
| 7858653 | 2-imidazoles The present invention relates to compounds of formula I, wherein X is —CH2— or —NH—; Y is —CH(lower alkoxy)-, —CH(lower alkyl)-, —O—, —S—, —S(O)—, —S(O)2 | 12/28/2010 |
| 7855221 | Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid The invention provides a crystalline freebase form of 4′-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]imidazol-1-ylmethyl}-3′-fluorobiphenyl-2-carboxylic acid. This invention also provides pharmaceutical compositions comprising the crystall... | 12/21/2010 |
| 7851497 | Bactericidal composition for agricultural or horticultural use and method of controlling plant disease To provide an improved fungicidal composition for agricultural or horticultural use, and a method for controlling plant diseases by applying the composition to plants. A fungicidal composition for agricultural or horticultural use, which comprises at least on... | 12/14/2010 |
| 7816389 | Organic compounds 14-O—[(((C1-6)Alkoxy-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O—[(((C1-6)Mono- or dialkylamino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Hydroxy-(C1-6)-alkyl)-phenylsulfanyl)-acetyl]-mu... | 10/19/2010 |
| 7759379 | Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4′, R4″, R4″′, R5, Y and L2 are as herein defined, salts and prodrugs the... | 07/20/2010 |
| 7718686 | Imidazole variants as modulators of GABA receptor for the treatment of GI disorders The present invention relates to novel compounds having a positive allosteric GÀBAB receptor (GDR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lowe... | 05/18/2010 |
| 7652055 | 2-imidazolines The present invention relates to compounds of formula I wherein X—Y, R1, and n are as defined herein and to their pharmaceutically active salts. Compounds of formula I have a good affinity to the t... | 01/26/2010 |
| 7642280 | Inhibitors of acyl glucosaminyl inositol amidase and methods of use The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring... | 01/05/2010 |
| 7442717 | Substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic aid Novel substituted 2-aminoimidazoles of formula I, process for their preparation, their use as medicament or diagnostic aid, and medicament containing them. The compounds of this type are useful in the prevention or treatment of various disorders and can be employed ... | 10/28/2008 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7405229 | Cathepsin cysteine protease inhibitors This invention relates to a class of compounds having the general formula (I) which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone r... | 07/29/2008 |
| 7368437 | Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents Methods and compounds for inhibiting the enzymes adenosine monophosphate deaminase or adenoside deaminase are provided. Such methods and compounds are useful in agriculture, horticulture and/or pharmacology as, for example, active compounds for crop protection or ph... | 05/06/2008 |
| 7361654 | Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associated disea... | 04/22/2008 |
| 7348317 | Aqueous compositions containing metronidazole An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a cyclodextrin such as beta-cyclodextrin and the second is niacin or niacinamid... | 03/25/2008 |
| 7348333 | Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists There are described cycloalkyl derivatives of the formula (I) R1—Y-A-B-D-E-F-G (I) in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds a... | 03/25/2008 |
| 7345076 | Inhibitors of cellular necrosis The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly u... | 03/18/2008 |
| 7345077 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4- (substituted cycloalkylmethyl) imidazol-2-ones and 4- (substituted cycloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in ... | 03/18/2008 |
| 7342118 | Imidazole compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inh... | 03/11/2008 |
| 7342038 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 3,3-diphenyl indole compounds, as well as analogues thereof, which are specific potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a ther... | 03/11/2008 |
| 7326728 | Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula ... | 02/05/2008 |
| 7323188 | Composition for controlling harmful bio-organisms and method for controlling harmful bio-organisms using the same A composition for controlling harmful bio-organisms comprising (a) at least one imidazole compound represented by formula (I): wherein R represents a lower alkyl group or a lower alkoxy group; and n represents an... | 01/29/2008 |
| 7309721 | Aminoalkylphosphonates and related compounds as Edg receptor agonists The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejecti... | 12/18/2007 |
| 7294641 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or salt thereof: in... | 11/13/2007 |
| 7285565 | Benzamides and related inhibitors of factor Xa Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 10/23/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7282503 | Fungicidal mixtures based on imidazole derivatives Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X1 and X2 represent halogen and phenyl which can be substituted by halo... | 10/16/2007 |
| 7265135 | 2-oxy, 2-amino, and 2-thio-imidazole compounds The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compo... | 09/04/2007 |
| 7256208 | Monocyclic -Aryl hydantoin modulators of androgen receptor function The present invention relates to novel compounds useful in the treatment of androgen receptor associated conditions, such as age-related diseases, pharmaceutical compositions containing at least one of the compounds of the present invention and methods of treating a... | 08/14/2007 |
| 7253191 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3 and R4 are as defined in the description. The compou... | 08/07/2007 |
| 7244441 | Stents and intra-luminal prostheses containing map kinase inhibitors A coated stent or intra-luminal prosthesis containing a MAP kinase inhibitor controls, reduces, or prevents restenosis, inflammation, and complications associated with stent or intra-luminal prosthesis implantation and/or cardiovascular disease. ... | 07/17/2007 |
| 7238212 | Imidazole compounds and use of these compounds for dyeing keratinous fibers The disclosure relates to novel imidazole compounds which can be useful as couplers for the oxidation dyeing of keratinous fibers. The present disclosure also relates to a dyeing composition for dyeing keratinous fibers comprising at least one oxidation base and at ... | 07/03/2007 |
| 7223781 | 2-mercapto-4,5-diarylimidazole derivatives and the use thereof as cyclooxygenase inhibitors The invention relates to the 2-mercapto-4,5-diarylimidazole derivatives of formula (I), wherein R1, R2, R3 and R4 are defined as in the description. The inventive compounds have an immunomodulatory and cyclooxygenase-inhib... | 05/29/2007 |
| 7186742 | Benzamide inhibitors of the P2Xreceptor The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1–R3 are as defined herein. The compounds of the invention are useful in the tr... | 03/06/2007 |
