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| Number | Title | Issue Date |
| 8188134 | Thiophene-carboxamides useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds and methods of using the compositions in the treatment of various disease, conditions, or... | 05/29/2012 |
| 8183276 | Therapeutic agents The invention encompasses 2-[4-(imidazolyl)-phenyl]vinyl-heterocycle derivatives which selectively attenuate production of Abeta(1-42) and are useful in the treatment of Alzheimer's disease. Pharmaceutical compositions and methods of use are also encompassed. ... | 05/22/2012 |
| 8163789 | Selective and dual-action p53/MDM2/MDM4 antagonists A fragment-based strategy, involving “multicomponent reaction chemistry” (MCR), can identify novel chemotypes that disrupt the p53/MDM2 or p53/MDM4 complex employs. This approach uses high resolution structural information to delineate the region of a first prot... | 04/24/2012 |
| 8158668 | Methods for treating CNS disorders with 4-imidazole derivatives The present invention relates to methods for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, n... | 04/17/2012 |
| 8153674 | Organic compounds The present invention provides a compound of formula (I): said compound is inhibitor of aldosterone synthase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase. Accordingly... | 04/10/2012 |
| 8143301 | Hepatitis C virus inhibitors The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infec... | 03/27/2012 |
| 8143300 | Inhibitors of cellular necrosis The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly u... | 03/27/2012 |
| 8138215 | Hepatitis C virus inhibitors The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infec... | 03/20/2012 |
| 8124639 | Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors The present invention relates to a series of substituted bicyclic[3.1.0]heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R1-R5 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their... | 02/28/2012 |
| 8119678 | Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 02/21/2012 |
| 8119677 | Polyamides containing amino butyric acid-based building blocks The present invention relates to polyamide compositions and therapies for treating cells infected with papilloma virus. ... | 02/21/2012 |
| 8067455 | Amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol... | 11/29/2011 |
| 8063090 | Mineralocorticoid receptor modulators The present invention relates to diphenylmethyl imidazole mineralocorticoid receptor modulators compounds having the structure and their use in treating cardiovascular events. ... | 11/22/2011 |
| 8058303 | Pharmaceutical composition for external use Provided is a pharmaceutical composition for external use which includes the following components: 1) luliconazole and/or a salt thereof; 2) N-methyl-2-pyrollidone; and 3) benzyl alcohol and/or diester of a dibasic acid. The diester of the dibasic acid is a diethyl ... | 11/15/2011 |
| 8053457 | 3-imidazolyl-indoles for the treatment of proliferative diseases The invention relates to 3-heterocyclyl indolyl compounds of formula I capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively: wherein R1... | 11/08/2011 |
| 7998995 | LXR and FXR modulators Compounds of the invention are disclosed, such as compounds of formulae LX-LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R | 08/16/2011 |
| 7964626 | Process for producing N,N′-carbonyldiimidazole The present invention provides a process for producing N,N′-carbonyldiimidazole, comprising: reacting phosgene, diphosgene, or triphosgene with imidazole in an inert solvent to produce N,N′-carbonyldiimidazole; to imidazole hydrochloride yielded as a by-product ... | 06/21/2011 |
| 7960424 | Liquid pharmaceutical formulations of palonosetron The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.... | 06/14/2011 |
| 7947725 | Liquid pharmaceutical formulations of palonosetron The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.... | 05/24/2011 |
| 7947724 | Liquid pharmaceutical formulations of palonosetron The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.... | 05/24/2011 |
| 7919516 | Deuterium-enriched ondansetron The present application describes deuterium-enriched ondansetron, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. ... | 04/05/2011 |
| 7897632 | Multi-cyclic cinnamide derivatives The present invention provides a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group that may be substituted with a C1-6 alkyl group, or the li... | 03/01/2011 |
| 7858652 | Substituted 4-imidazoles The present invention relates to a compound of formula I, wherein R1 is selected from the group consisting of hydrogen and lower alkyl; each R2 is independently selected from ... | 12/28/2010 |
| 7851496 | Ionic liquid type crown ether derivatives, method for preparing the same and method for isolating metal ions using the same Disclosed relates to an ionic liquid type crown ether derivative, expressed by Chemical Formula 1 below, for isolating metal ions, a method for preparing the same and a method for isolating selectively the metal ions using the cycle size of the same. The present inv... | 12/14/2010 |
| 7842708 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIa inhibitors The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L1, M and R11 are as defined her... | 11/30/2010 |
| 7834044 | Substituted-2-imidazoles The present invention relates to compounds of formula I wherein R1 is selected from the group consisting of hydrogen and lower alkyl; each R2 is independently selected from th... | 11/16/2010 |
| 7829590 | Thiophene-carboxamides useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinase, represented by structural formula I: or pharmaceutically acceptable salts thereof, wherein values of the variables of structural formula are... | 11/09/2010 |
| 7803828 | Functionally selective alpha2C adrenoreceptor agonists In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharma... | 09/28/2010 |
| 7781472 | Therapy for the treatment of disease Disclosed herein are pharmaceutical compositions comprising oxybutynin, or a free base thereof or a pharmaceutically acceptable salt thereof, and pilocarpine, or a free base thereof or a pharmaceutically acceptable salt thereof. Also disclosed are methods of treatin... | 08/24/2010 |
| 7745474 | Imidazole derivatives for the treatment of gastrointestinal disorders The present invention relates to novel imidazole derivatives having a positive allosteric GABAB receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of tra... | 06/29/2010 |
| 7745473 | Indole derivative for alkylating specific base sequence of DNA and alkylating agent and drug containing the derivative There is provided a novel pyrrole-imidazole polyamide compound for alkylating the specific base sequence of DNA, the polyamide compound being capable of being synthesized through fewer reaction steps than known hybrid molecules and having a combination of a high rea... | 06/29/2010 |
| 7728027 | Process for synthesizing compounds useful for treating hepatitis C The present disclosure generally relates to a process for synthesizing methyl ((1S)-1-(((2S)-2-(5-(4′-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylp... | 06/01/2010 |
| 7723369 | Substituted imidazole derivatives, compositions, and methods of use as PTPase inhibitors The present invention provides imidazole derivatives of Formula (I-IV), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I-IV), and their use in treating human or animal disorders. The compounds of the invention inhibit ... | 05/25/2010 |
| 7714013 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 05/11/2010 |
| 7678821 | Compositions for the treatment of overactive bladder Disclosed herein are pharmaceutical compositions comprising combinations of tolterodine, an antimuscarinic agent, and pilocarpine, a compound that causes stimulation of salivary glands. Also disclosed are methods of treating a patient suffering from overactive bladd... | 03/16/2010 |
| 7666894 | Therapy for the treatment of disease Disclosed herein are pharmaceutical compositions comprising oxybutynin, or a free base thereof or a pharmaceutically acceptable salt thereof, and pilocarpine, or a free base thereof or a pharmaceutically acceptable salt thereof. Also disclosed are methods of treatin... | 02/23/2010 |
| 7582668 | Imidazoyl-benzamide anti-cancer agents Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders. ... | 09/01/2009 |
| 7553862 | 4-amino-1,5-substituted-1,5-dihydro-imidazol-2-ones The present invention relates to compounds of formula I wherein R1, R2, R3, and R4 are as defined herein and to pharmaceutically a... | 06/30/2009 |
| 7491742 | Imidazole derivatives as phosphodiesterase VII inhibitors Imidazole derivatives of the formula I in which R1 is H, A, benzyl, indan-5-yl, 1,2,3,4-tetrahydronaphthalen-5-yl, dibenzothien-2-yl, or phenyl which is unsubstituted or mono-, di- or trisubstituted ... | 02/17/2009 |
| 7491743 | Inhibitors of cellular necrosis The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly u... | 02/17/2009 |
