Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 6103749 | Aryl imidazole compounds having phosphodiesterase IV inhibitory activity Novel compounds which are effective PDE IV inhibitors are disclosed. These compounds have the general structure of: ##STR1## where R1, R2, R3, R4, X1, X2 and Z are described herein. Th... | 08/15/2000 |
| 6090801 | Pharmaceutical compositions containing ceftriaxone and penems Pharmaceutical formulations comprising ceftriaxone in combination with a penem of formula (I) in which R1 is hydrogen or an organic group; R2 is a ring system of formula (II), wherein R4 and R5 are hydrogen or o... | 07/18/2000 |
| 6080744 | Topical antifungal treatment A topical mycological treatment composition for medical, veterinarian, or dental use contains as active ingredients clotrimazole, ketoconazole, micanazole, nystatin, tolnaftate, propionic acid, sodium propionate, undecelynic acid, and zinc undecelynate. T... | 06/27/2000 |
| 6080768 | Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system Compounds of the formula: ##STR1## wherein the variables are as defined in the specification. These compounds are useful in the treatment of arterial hypertension and heart failure, of renal insufficiency, of peripheral arteriopathies and of cerebrov... | 06/27/2000 |
| 6075031 | Use of creatine analogues and creatine kinase modulators for the prevention and treatment of glucose metabolic disorders The present invention relates to the use of creatine compounds including cyclocreatine and creatine phosphate for treating or preventing a metabolic disorder consisting of hyperglycemia, insulin dependent diabetes mellitus, impaired glucose tolerance, hyp... | 06/13/2000 |
| 6075017 | Compositions for the treatment of dandruff Seborrheic dermatitis of the scalp is treated by a synergistic combination of a cytotoxic agent and an antifungal agent.... | 06/13/2000 |
| 6075023 | Method for combatting fish mycoses and one-celled ectoparasites Fish mycoses and single-cell ectoparasites on fish are controlled using an active compound suitable for inhibiting the mitochondrial respiratory chain at the stage of the b/c1 complex.... | 06/13/2000 |
| 6071942 | Elevation of circulating blood histamine levels Methods for obtaining beneficial stable levels of circulating histamine are disclosed for use in methods for enhancing natural killer cell cytotoxicity and for elevating histamine levels in individuals in need thereof. In such methods, a beneficial level ... | 06/06/2000 |
| 6071541 | Pharmaceutical compositions and methods for managing skin conditions This application relates to a stable pharmaceutical composition and methods for the cleansing of skin to facilitate the prevention, treatment, and management of skin conditions, such as seborrheic dermatitis, psoriasis, folliculitis, rosacea, perioral der... | 06/06/2000 |
| 6066662 | Hydroxylamine derivatives and their use as metalloproteinase inhibiting agents The invention provides hydroxylamine derivatives of formula (I) wherein A, R1, R2 and R3 have the significance given in the description, which are matrix metalloproteinase inhibitors and which also prevent TNF release. The... | 05/23/2000 |
| 6060468 | N-substituted azaheterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R1a, R2, R2a, p, r and s are as defined in the detailed part of the presen... | 05/09/2000 |
| 6057346 | Inhibition of retroviral LTR promoters by calcium response modifiers A class of calcium-response modification compounds is disclosed which inhibits the activation of retroviral LTR promoters, including the HIV-LTR. This class of compounds are used to delay or suppress the transition of a retroviral infection from a latent ... | 05/02/2000 |
| 6048862 | Benzylamidine derivatives with serotonin receptor binding activity This invention relates to compounds having serotonin receptor binding activity and to their medical use, particularly in the treatment of CNS conditions such as migraine. Described herein are compounds which have the general formula: ##STR1## wh... | 04/11/2000 |
| 6042877 | Method for the manufacture of anti-microbial articles A method for making an anti-microbial article is described, the method comprising: providing a substrate; forming a solution comprising a chelating polymer and a metal ion; depositing the solution on the substrate; drying the substrate to form a coated su... | 03/28/2000 |
| 6034081 | Potentiation of biocide activity using an N-alkyl heterocyclic compound A method for increasing the effectiveness of a microbicide is described, wherein a microbicide and an N-alkyl heterocyclic compound are applied to a substrate or aqueous system subject to the growth of microorganisms. The N-alkyl heterocyclic compound is ... | 03/07/2000 |
| 6028094 | Agent for prevention and suppression of dry coughing caused by angiotensin converting enzyme inhibitors The present invention is to provide an agent for the prevention and depression of dry coughing caused by angiotensin converting enzyme inhibitors which comprises a thromboxane synthetase inhibitor or thromboxane receptor antagonist as the active ingredien... | 02/22/2000 |
| 6020368 | Carbamoyloxy derivatives of mutiline and their use as antibacterials Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the... | 02/01/2000 |
| 5994294 | Nitrosated and nitrosylated -adrenergic receptor antagonist compounds, compositions and their uses Disclosed are nitrosated and nitrosylated -adrenergic receptor antagonists, compositions of an -adrenergic receptor antagonist (-antagonist), which can optionally be substituted with at least one NO or NO2 moiety, and a com... | 11/30/1999 |
| 5981556 | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.... | 11/09/1999 |
| 5968966 | Method and compositions for the treatment of renal failure Methods and compositions for treating renal failure patients are provided. Pursuant to the present invention, a renal failure patient is provided with an intravenous or dialysis solution that includes a therapeutically effective amount of L-carnosine. In ... | 10/19/1999 |
| 5968964 | Fungicidal liquid formulation The invention relates to a liquid fungicidal composition comprising (a) a fungicidally acceptable carrier comprising a mixture of 1-pentanol and 2-methylbutanol, wherein the ratio (by weight) of the 1-pentanol to 2-methylbutanol is from 1:1 to 1:10; (b) a... | 10/19/1999 |
| 5965558 | Modulators of proteins with phosphotyrosine recognition units Y--X--C(R').dbd.C(R")COOR"' (A1) The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to th... | 10/12/1999 |
| 5965621 | Methods and compositions for reducing or maintaining body weight in a mammal A method for reducing or maintaining the level of adipose tissue formation in a mammal includes the step of administering a pantethine composition to the mammal in an amount and for a period of time sufficient to achieve a desired body weight. Composition... | 10/12/1999 |
| 5965579 | Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them The invention relates to compounds of the formula: ##STR1## Compounds of the above formula have a great affinity for the neurotensin receptors.... | 10/12/1999 |
| 5962500 | Insulin sensitivity with angiotensin II receptor blocking imidazoles This invention relates to a novel method of using an Angiotensin II antagonist for the improvement of insulin sensitivity alone or in conjunction with the treatment of hypertension. Angiotensin II antagonists such as the class of substituted imidazoles re... | 10/05/1999 |
| 5962508 | Retinoid receptor agonists for promoting hair growth and/or retarding hair loss A regimen for inducing/stimulating hair growth and/or retarding hair loss on an individual in need of such treatment, comprising administering thereto, advantageously topically and for such period of time as required to elicit the desired effect, an effec... | 10/05/1999 |
| 5958958 | 1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors 1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.... | 09/28/1999 |
| 5958884 | Compositions and methods for treating erectile dysfunction Methods and compositions for treating patients having erectile dysfunction are described. The method involves the step of treating a patient with a combination of an AT1 specific Angiotensin II antagonist and Angiotensin II agonist. Preferably ... | 09/28/1999 |
| 5958933 | Neurologically active compounds and compounds with multiple activities A method for treating a mammal having a damaged central nervous system, as the result of trauma or disease, for reestablishing previously destroyed neurological functions in a traumatized or diseased mammal, or for controlling spasticity and for providing... | 09/28/1999 |
| 5952361 | Compositions The present invention involves the novel use of various classes of drugs, such as H2 and H3 agonists, as erectogenic agents in the treatment of male and female sexual dysfunction.... | 09/14/1999 |
| 5952346 | Use of non-peptide bradykinin antagonists for the treatment or prevention of Alzheimer's disease The invention relates to the use of non-peptide bradykinin antagonists for the production of pharmaceuticals for the prevention and treatment of Alzheimer's disease. Suitable Compounds are non-peptide bradykinin antagonists which inhibit the actions of th... | 09/14/1999 |
| 5952354 | Tris carbamic acid esters: inhibitors of cholesterol absorption Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are therefore implicated in the inhibition of absorption of cholester... | 09/14/1999 |
| 5948776 | Compositions and methods for treating bone deficit conditions Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15Å, are effective in treating condit... | 09/07/1999 |
| 5942532 | 2-substituted phenyl-benzimidazole antibacterial agents The invention relates to benzimidazole antibacterial compounds of the Formula I: ##STR1## as described herein, pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhib... | 08/24/1999 |
| 5939449 | Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them The invention relates to compounds of the formula: ##STR1## The compounds have great affinity for the neurotensin receptors.... | 08/17/1999 |
| 5925616 | Treatment of fungal infections using a combination of an anti-fungal compound and an H-alkyl heterocyclic compound A method for increasing the effectiveness of an anti-fungal compound is described. In the method, an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof are administered to a mammal in a combined amount effective to treat a fungal ... | 07/20/1999 |
| 5925374 | Anthelmintic preparation A pour-on anthelmintic composition, including its method of preparation and use, the composition preferably having being prepared by mixing at a common temperature (I) a premix of an anthelmintic compound or compounds (for example a benzimidazole) with a ... | 07/20/1999 |
| 5922721 | Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof A 1,2-ethanediol derivative represented by the general formula I! or its salt: ##STR1## has a NGF activity-potentiating effect and is useful as a remedy for various diseases caused by degeneration of central nervous system or peripheral nervou... | 07/13/1999 |
| 5922709 | Antifungal composition An antifungal composition, containing a synergistic mixture, containing the compound of the formula (I): ##STR1## wherein R is acetyl or lower alkyl; or a pharmaceutically acceptable salt thereof; and an azole antifungal agent selected from the group... | 07/13/1999 |
| 5919464 | Treatment of aberrant cellular states with biomodulators Biomodulators, which regulate cellular differentiation and proliferation, as well as methods of use thereof, e.g., for treating various conditions, e.g., cancer, senescence, immunological disorders and vascular disease; for stimulating normal tissue archi... | 07/06/1999 |
