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| Number | Title | Issue Date |
| 6262101 | Immunotherapeutic agents Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor , nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovis replication, asthma, and inflammatory condi... | 07/17/2001 |
| 6262093 | Methods of treating cancer with benzimidazoles This invention is a method of treating cancer, both carcinomas and sarcomas, and viral infections, in particular HIV through the administration of a pharmaceutical composition containing a benzimidazole derivative. The composition is also claimed. The ben... | 07/17/2001 |
| 6258823 | Materials and method for treating or preventing pathogenic fungal infection This invention concerns derivatives of rapamycin and their antifungal uses. Also disclosed are materials and methods relevant to the identification of non-immunosuppressive antifungal rapamycin derivatives.... | 07/10/2001 |
| 6258851 | Metalloproteinase inhibitors Compounds of formula (I), wherein A, B, X, R1, R2, R3, R4, R5, R6 are as defined in the specification, are matrix metalloproteinase inhibitors. ##STR1##... | 07/10/2001 |
| 6255331 | Stable biocidal compositions Disclosed are biocidal compositions comprising mixtures of formaldehyde-releasing imidazolidines, such as 1,3-dimethylol-5,3-dimethylhydantoin, and 3-isothiazolones stabilized with low levels of copper salts.... | 07/03/2001 |
| 6242472 | Methods for the pulmonary delivery of biological agents Methods of delivering a therapeutic or diagnostic agent in a perfluorochemical liquid carrier are provided. In preferred embodiments, the disclosed methods use compositions in the form of an emulsion or a dispersion for delivery of a biological agent to t... | 06/05/2001 |
| 6239175 | Carbamoyloxy derivatives of mutiline and their use as antibacterials Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the... | 05/29/2001 |
| 6239151 | Compounds as inhibitor of tumor necrosis factor alpha release The invention provides hydrazine derivatives of the formula ##STR1## wherein R1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R2 is an acyl group derived from an -, &#... | 05/29/2001 |
| 6225329 | Modulators of protein tyrosine phosphatases (PTPases) The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PT... | 05/01/2001 |
| 6221893 | Administration of histamine for therapeutic purposes Methods for obtaining beneficial stable levels of circulating histamine are disclosed for use in methods for enhancing natural killer cell cytotoxicity. In such methods, a beneficial level of circulating histamine is attained and an agent whose ability to... | 04/24/2001 |
| 6211186 | Enzyme Inhibitors The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in heal... | 04/03/2001 |
| 6207703 | Methods and materials for treating and preventing inflammation of mucosal tissue The invention involves methods and materials for treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves administrating an antifungal agent such that it contact mucus in an amount, at a frequency, and for a dura... | 03/27/2001 |
| 6207694 | Pharmaceutical compositions and methods for managing scalp conditions This application relates to a pharmaceutical composition for the prevention, treatment, and management of scalp conditions, such as dandruff, seborrheic dermatitis, psoriasis, folliculitis, and hair thinning including a therapeutically effective amount of... | 03/27/2001 |
| 6201002 | Method for reducing mortality with an angiotensin II antagonist Angiotensin II receptor antagonists are useful in reducing and preventing mortality and sudden cardiac death in symptomatic heart failure patients. Losartan potassium has been shown to reduce mortality and sudden cardiac death in this patient population. ... | 03/13/2001 |
| 6201001 | Imidazole antiproliferative agents Compounds of formula I ##STR1## inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.... | 03/13/2001 |
| 6200977 | Pyrimidine derivatives Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.... | 03/13/2001 |
| 6191159 | Disubstituted pyrazolines and triazolines as factor Xa inhibitors The present application describes disubstituted pyrazolines and triazolines of formulae I and II: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of M1 and M2 maybe N and D may be a variety of N-containing gro... | 02/20/2001 |
| 6191157 | Hetero-linked phenylglycinolamides The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are suitable as active compounds in medicaments.... | 02/20/2001 |
| 6177427 | Treatment of glaucoma and ocular hypertension Compositions of non-steroidal glucocorticoid antagonists for treating glaucoma or ocular hypertension and methods for their use are disclosed.... | 01/23/2001 |
| 6174910 | AT1 receptor antagonist for the stimulation of apoptosis The invention provides the use of an AT1 receptor antagonist, or a pharmaceutical salt thereof, for producing a pharmaceutical preparation for the stimulation of apoptosis and for the treatment of pathological symptoms which are substantially r... | 01/16/2001 |
| 6174883 | 3-substituted-2-oxindoles derivatives This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the phamaceutically-accepted salts thereof which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. T... | 01/16/2001 |
| 6172097 | Spiro imidazoline compounds The invention relates to a compound of formula (I): ##STR1## wherein: A represents an optionally substituted benzene ring, B represents an imidazoline ring of formula (Ia) or (Ib): ##STR2## and medicinal products containing the same/are useful in treating or i... | 01/09/2001 |
| 6166060 | 1H-4(5)-substituted imidazole derivatives The present invention provides, in its principal aspect, compounds of the general formula: ##STR1## when A is --NHCO--, --N(CH3)--CO--, --NHCH2 --, --N(CH3)--CH2 --, --CH.dbd.CH--, --COCH2 --, CH... | 12/26/2000 |
| 6166088 | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and... | 12/26/2000 |
| 6166017 | Method of using ketoconazole and related substances in medicaments for treatment of type II diabetes and methods of treating same A method for the medical treatment of diabetes mellitus type II and for counteracting the risk factors forming part of the Metabolic syndrome (also known as the "deadly quartet" or "syndrome X" or the Insulin Resistance Syndrome) in a patient having incre... | 12/26/2000 |
| 6165980 | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents A distamycin derivative of formula (I): ##STR1## wherein: n is 2, 3 or 4; R0 is C1 -C4 alkyl or --CH2 CH2 --X2, wherein X2 is a halogen atom; R1 and R2 are ... | 12/26/2000 |
| 6159977 | Therapeutic anti-fungal nail preparation A therapeutic solution and application procedure for curing Nail fungus infections or Onychomycosis comprising a combination of an anti-fungal agent with DMSO in a anhydrous solution of Polyglycol, and including a secondary anti-inflammatory agent. The DM... | 12/12/2000 |
| 6150379 | Compounds and compositions as anticoagulants The present invention relates to novel biheterocyclic derivatives which are factor Xa inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.... | 11/21/2000 |
| 6150382 | Thio acid derived monocyclic n-heterocyclics as anticoagulants This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invent... | 11/21/2000 |
| 6147097 | Imidazole derivatives as anti-HIV agents An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R1 represents hydrogen, C1 | 11/14/2000 |
| 6140354 | N-substituted aminotetralins as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders ଲ-Aminotetralin derivatives of the formula: ##STR1## which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing a ଲ-aminotetralin derivative as the active ingredient are ... | 10/31/2000 |
| 6127396 | Imidazoline compounds The invention relates to a compound of formula (I): ##STR1## wherein: A represents an optionally substituted benzene ring, B represents an imidazoline ring of formula (Ia) or (Ib): ##STR2## X represents CR6, CR6 R7, N... | 10/03/2000 |
| 6124333 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6124332 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6124299 | Calcitonin mimetics Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The c... | 09/26/2000 |
| 6121260 | Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. Many of the compounds are nove... | 09/19/2000 |
| 6121299 | Modulating inflammation with cytochrome P-450 activators and inhibitors This invention relates to methods of modulating inflammation in mammals. Inflammation is modulated by regulating the cytochrome P-450 pathway. Inflammation is reduced by treating the subject with substances, such as bezafibrate and clofibrate, which induc... | 09/19/2000 |
| 6121273 | N-linked sulfonamides of heterocyclic thioesters This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin pr... | 09/19/2000 |
| 6117869 | Compounds for and methods of inhibiting matrix metalloproteinases The present invention relates to compounds of Formula I that inhibit matrix metalloproteinases and to a method of inhibiting matrix metalloproteinases using the compounds ##STR1## More particularly, the present invention relates to a method of treati... | 09/12/2000 |
| 6114393 | Use of inhibitors of the sodium-hydrogen exchanger for the production of a pharmaceutical for the treatment of disorders which are caused by protozoa Inhibitors of the sodium-hydrogen exchanger are suitable on their own or in combination with other classes of active compound for the production of a medicament for the treament of diseases which are caused by protozoa; thus of diseases which are caused b... | 09/05/2000 |
