Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 6432935 | Pharmaceutical compositions, mainly vaginal suppository, containing many different active ingredients Compositions comprising an antibiotic, sulphonamide, at least one an antiquagul agent, e.g., clotrimazol (bis-phenyl-(2-chlorophenyl)-1-imidazolyl-methane), natamycin, or nystatin,and 5-nitro-metronidazol (5-nitro-inidazoles) e.g., (metronidazol or t... | 08/13/2002 |
| 6426360 | 4,5-substituted imidazolyl compounds for the treatment of inflammation A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula ##STR1## wherein R1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, ... | 07/30/2002 |
| 6420407 | Ophthalmic formulation which modulates dilation An ophthalmic formulation is disclosed which reduces dilation in dim light and reduces redness.... | 07/16/2002 |
| 6420375 | Fused ring compounds, process for producing the same and use thereof To provide a novel compound of the formula: ##STR1## [wherein A1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A2 is an aromatic ring which may be substituted, X is a divalent group, Y i... | 07/16/2002 |
| 6413947 | Anilide derivative, production and use thereof This invention is to provide a compound of the formula: ##STR1## wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: ##STR2## wherein the ring A is an optionally substituted 5- to 6-membered arom... | 07/02/2002 |
| 6410574 | Fungicidal composition and method for using the same The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide selected from the compounds having a fungicidal activity ag... | 06/25/2002 |
| 6410562 | Hypoglycemic imidazoline compounds This invention relates to certain novel imidazoline compounds and analogues thereof, to their use for the treatment of diabetes, diabetic complications, metabolic disorders, or related diseases where impaired glucose disposal is present, to pharmaceutical... | 06/25/2002 |
| 6399612 | Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases Heteroaryl butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stro... | 06/04/2002 |
| 6395765 | Antiparasitic composition for the treatment and protection of pets Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions comprising, in the form of a ready-to-use solution: a) an insectici... | 05/28/2002 |
| 6395740 | Calcitonin mimetics Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The c... | 05/28/2002 |
| 6395724 | Multibinding inhibitors of cyclooxygenase-2 Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently ... | 05/28/2002 |
| 6391879 | Therapeutic anti-fungal nail preparation A therapeutic solution and application procedure for curing and preventing nail fungus and athlete's foot infections or Onychomycosis comprising a combination of an anti-fungal agent with DMSO in a anhydrous solution of Polyglycol. The DMSO acts as a solv... | 05/21/2002 |
| 6391327 | Pesticidal composition A pesticidal composition comprising prallethrin and a neonicotinoid compound given in the following formula (1), (2) or (3), as an active ingredient ##STR1## wherein, A represents a 6-chloro-3-pyridyl, 2-chloro-5-thiazolyl, tetrahydrofuran-2-yl, tetr... | 05/21/2002 |
| 6383523 | Pharmaceutical compositions and methods for managing skin conditions This application relates to a stable pharmaceutical composition and methods for the cleansing of skin to facilitate the prevention, treatment, and management of skin conditions, such as seborrheic dermatitis, psoriasis, folliculitis, rosacea, perioral der... | 05/07/2002 |
| 6380254 | Method and composition for treating and preventing pathogenic effects caused by intracellular calcium overload The present invention provides a method and composition for treating or preventing pathogenic effects in a mammal caused by intracellular calcium overload, comprising administering to a mammal a mixture of sodium co-transport dependent amino carboxylic ac... | 04/30/2002 |
| 6380236 | Method of treating onychomycosis A method of treating onychomycosis is described which includes administration to an infected area around a nail of a patient a tissue softening composition containing urea and an antifungal composition in one or separate compositions, concurrently or non-... | 04/30/2002 |
| 6380224 | Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders Amine and amide derivatives of the formula: ##STR1## which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing amines and amides of formula A as the active ingredient are described. The ... | 04/30/2002 |
| 6380165 | Immunological advanced glycation endproduct crosslink There is disclosed a means for standardizing a kit that provides a means for measuring the formation of advanced glycosylation endproducts (AGEs). The present invention further provides a novel isolate AGE that is antigenic and useful for forming antibodi... | 04/30/2002 |
| 6375965 | Composition for controlling harmful bio-organisms and method for controlling harmful bio-organisms using the same A composition for controlling harmful bio-organisms comprising (a) at least one imidazole compound represented by formula (I): ##STR1## wherein R represents a lower alkyl group or a lower alkoxy group; and n represents an integer of 1 to 5, as an active i... | 04/23/2002 |
| 6372772 | Inhibitors of redox signaling and methods of using same The present invention is directed to a composition or formulation which inhibits or interferes with cellular redox function, and method of using same to restore normal cellular function. More specifically, the composition of the present invention interfer... | 04/16/2002 |
| 6365616 | Methimazole derivatives and tautomeric cyclic thiones to treat autoimmune diseases The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. These methods utilize specifically-defined methimazole derivatives and tautomeric cyclic... | 04/02/2002 |
| 6362211 | Polycyclic indanylimidazoles with alpha2 adrenergic activity A compound of formula I ##STR1## wherein R1 to R3, --A--, m and t are as defined in claim 1, or a pharmaceutically acceptable salt or ester thereof, useful as an alpha2 adrenergic agent.... | 03/26/2002 |
| 6362210 | Carboxylic acid amides, pharmaceutical compositions containing these compounds and their use Carboxylic acid amides of general formula ##STR1## which inhibit telomerase and are useful for treating tumour diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are: (1) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-phenyl)-amide,... | 03/26/2002 |
| 6358980 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors Compounds of the formula: ##STR1## useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.... | 03/19/2002 |
| 6348464 | Pyrrolecarbonylimino derivatives as naaladase inhibitors The present invention relates to pharmaceutical compositions and methods of using pyrrolecarbonylimino derivatives to inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, thereby effecting neuronal activities, inhibiting ang... | 02/19/2002 |
| 6346518 | Itraconazole and saperconazole stereoisomers The present invention is concerned with the stereoisomeric forms of itraconazole (X=Cl) and saperconazole (X=F), which may be represented by the formula ##STR1## and the pharmaceutically acceptable acid addition salt forms thereof, processes for prep... | 02/12/2002 |
| 6329373 | Metalloproteinase inhibitors A compound of formula (I) ##STR1## wherein X is a --CONHOH group and the R groups are defined in the claims. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation and inhibitors of the release of tumour necrosis factor ... | 12/11/2001 |
| 6319949 | Pesticidal sprays A method for preventing fungal diseases in crops which comprises the steps of: (a) applying to a crop an aqueous or a non-aqueous spray composition which includes a pesticide and a spray adjuvant including a solvent and an emulsifier, wherein the solvent ... | 11/20/2001 |
| 6313132 | Therapeutically active diarylpropylamines; their pharmaceutically acceptable salts; a method for their preparation and method for their use The invention relates to novel compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, whe... | 11/06/2001 |
| 6310084 | Metalloproteinase inhibitors The present invention relates to therapeutically active hydroxamic acid, N-formyl-N-hydroxyamino and carboxylic acid derivatives, their preparation, and pharmaceutical compositions containing them. These compounds are useful in the inhibition of metallopr... | 10/30/2001 |
| 6310083 | Caged amino acid derivatives bearing photolabile protective groups Derivatives of o-nitromandelyoxycarbonyl (Nmoc) which are capable of releasing an amino acid (or derivative thereof), upon irradiation with ultraviolet (UV) light are disclosed, as well as a method for producing a free amino acid (or derivative thereof) e... | 10/30/2001 |
| 6306891 | HIV integrase inhibitors Nitrogen-containing heteroaryl dioxo-butyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either a... | 10/23/2001 |
| 6306887 | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases Compounds of Formula (1.0.0): ##STR1## are described wherein A is for example aryl, heteroaryl or heterocyclyl, Y is preferably --C(.dbd.O)--; B is independently selected from a group of moieties, the most preferred of which are those of partial Formulas ... | 10/23/2001 |
| 6300356 | Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in die risk of experiencing an adverse cardiac event, such as... | 10/09/2001 |
| 6297268 | Imidazoles as cholesterol lowering agents In one embodiment, the present invention discloses a method and pharmaceutical composition for lowering serum cholesterol in a patient. The method comprises administering to the patient a pharmaceutical composition comprising a therapeutically effective c... | 10/02/2001 |
| 6288101 | Imidazoles with serotonin receptor binding activity This invention relates compounds having serotonin receptor binding activity, to pharmaceutical compositions containing them and to their medical use, particularly in the treatment of CNS conditions. Described herein are compounds which have the general fo... | 09/11/2001 |
| 6281238 | 4-aryl-1-oxa-9-thia-cylopenta[B]fluorenes This invention provides compounds of Formula I having the structure ##STR1## wherein B and D are each, independently, hydrogen, halogen, --CN, alkyl of 1-6 carbon atoms, aryl, or aralkyl of 6-12 carbon atoms; R1 is hydrogen, alkyl of 1-6 carbon atom... | 08/28/2001 |
| 6265412 | Minoxidil compositions for external use There is provided a composition for external use with a reduced skin irritation comprising minoxidil and 0.01 to 2 parts by weight of at least one antihistaminic agent selected from the group consisting of chlorphenylamine maleate, diphenylimidazole, diph... | 07/24/2001 |
| 6265428 | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (1): ##STR1## where X and Y are selected from groups that include O, S, and NH; and ... | 07/24/2001 |
| 6265425 | Combination of a RAMBA and a tocopherol The present invention is concerned with the use of a tocopherol for the manufacture of a medicament for avoiding, alleviating, suppressing or overcoming the adverse side-effects of therapy with a retinoic acid metabolism blocking agent. The present invent... | 07/24/2001 |
