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| Number | Title | Issue Date |
| 6900197 | Cobalt-porphyrin complexes and use thereof as an anti-obesity agent Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleter... | 05/31/2005 |
| 6900161 | Azole or triazole derivatives, method for preparing same and use thereof as fungicides The invention concerns novel azole or triazole derivatives of formula (Ia) or (Ib), wherein: X, Ar1, Ar2, Ar3, A, B and R1 are such as defined in the description, the method for preparing same and their use as fungicides. ... | 05/31/2005 |
| 6897208 | Benzimidazoles The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compo... | 05/24/2005 |
| 6890915 | Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R | 05/10/2005 |
| 6884815 | High affinity small molecule C5a receptor modulators This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as anta... | 04/26/2005 |
| 6881748 | Drug targeting A bioreductive conjugate comprises a bioreductive moiety with at least one therapeutic agent linked thereto and physiologically acceptable derivatives thereof. The bioreductive moiety incorporates an aromatic ring substituted with a nitro group and the conjugate is ... | 04/19/2005 |
| 6878731 | Imidazole alkaloids from Lepidium meyenii and methods of usage The present invention relates to novel imidazole alkaloid compounds that have been isolated as a form of chloride salt from a root extract of Lepidium meyenii Walp, with the common name Maca, and identified below as 1,3-bis(phenylmethyl)-4,5-dimethyl-1H-imida... | 04/12/2005 |
| 6875775 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2, which are the same or different are a) H, halogen, OCH3 | 04/05/2005 |
| 6872741 | Sodium channel modulators The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the pr... | 03/29/2005 |
| 6867229 | Antiparasitic composition for the treatment and protection of pets Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions comprising, in the form of a ready-to-use solution: ... | 03/15/2005 |
| 6855727 | Muscular fatigue-controlling composition and method for providing muscular fatigue-controlling effect An antifatigue composition for reducing muscular fatigue or the like during or after exercise, which includes an imidazole compound obtained from extracts of fishes, shelifishes, fowl, flesh or the like, as an active ingredient. The imidazole compound in the antifat... | 02/15/2005 |
| 6846833 | Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same Compounds of formula (1): wherein: G represents an optionally substituted phenyl or optionally substituted heterocycle, G1 and G2 being N or C, ... | 01/25/2005 |
| 6846837 | Topical administration of basic antifungal compositions to treat fungal infections of the nails Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a pharmaceutically acceptable base in a formulation having a pH of 7.5 to about 13... | 01/25/2005 |
| 6838475 | Imidazolidinones as NS3-serine protease inhibitors of hepatitis C virus The present invention discloses novel imidazolidinones which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazolidinones as well as... | 01/04/2005 |
| 6835725 | Optical data carrier comprising a cyanine dye as light-absorbent compound in the information layer Optical data carrier comprising a preferably transparent substrate which may, if desired, have previously been coated with one or more reflection layers and to whose surface a light-writeable information layer, if desired one or more reflection layers and if desired... | 12/28/2004 |
| 6835726 | Pyrimidine derivatives Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives. ... | 12/28/2004 |
| 6821997 | Therapeutic and prophylactic treatment of aging and disorders of aging in humans A method for the treatment and prophylaxis of conditions of aging in humans, such conditions of aging associated with a decreased presence of cell-specific carbonic anhydrase enzymes in the brain, such as conditions associated with chronic neurodegenerative conditio... | 11/23/2004 |
| 6815440 | Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Compounds of the formula I are suitable for preparing pharmaceuticals for the treatment of disorders in the course of which is invol... | 11/09/2004 |
| 6806291 | Analgesic compounds, their synthesis and pharmaceutical compositions containing them New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These compounds surprisingly possess high analgesic activity with little hepa... | 10/19/2004 |
| 6794405 | Alicyclic imidazoles as H3 agents Alicyclic imidazole compounds; pharmaceutically active compositions containing such compounds; and the use of such compounds in formulations for the control or prevention of disease states in which histamine H3 receptors are involved, such as allergy, inf... | 09/21/2004 |
| 6794518 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer ... | 09/21/2004 |
| 6774116 | Prodrugs via acylation with cinnamate A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have substituents of various electronically donating or electronically with... | 08/10/2004 |
| 6770306 | Drugs for reducing vaginal acidity and treatment of vaginitis, and the use thereof The present invention relates to a pharmaceutical composition for reducing vaginal acidity, treating abnormal enhancement of vaginal acidity, and high acidity vaginitis associated with abnormal enhancement of vaginal acidity, especially for the treatment of fungal v... | 08/03/2004 |
| 6762198 | Dihetero-substituted metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): | 07/13/2004 |
| 6747047 | Insecticidal anthranilamides This invention provides compounds of Formula (1), their N-oxides and agriculturally suitable salts wherein A, B, J, R1, R2, R3 and R4 and n are as defined in the disclosure. Also disclosed are methods for controlling arthr... | 06/08/2004 |
| 6743919 | 2-aroylimidazole compounds for treating cancer Disclosed is a compound represented by Structural Formula (I): R1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl group. Z1 | 06/01/2004 |
| 6743816 | Imidazole derivatives with anti-inflammatory activity Novel imidazole derivatives of formula I and their salts, solvates and prodrugs, wherein the meanings of the different radicals are as shown in the description. Said compounds are useful as anti-inflammatory agents. ... | 06/01/2004 |
| 6737418 | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also i... | 05/18/2004 |
| 6727238 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated fi... | 04/27/2004 |
| 6723743 | High affinity small molecule C5a receptor modulators This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as anta... | 04/20/2004 |
| 6723738 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2 , which are the same or different are a) H, halogen, OCH3, OH; or | 04/20/2004 |
| 6716867 | Use of dexmedetomidine for ICU sedation The present invention relates to a method of sedating a patient while in the intensive care unit comprising administering dexmedetomidine of a pharmaceutically acceptable salt thereof to the patient, wherein the patient remains arousable and orientated. ... | 04/06/2004 |
| 6713500 | Agent for controlling animal diseases caused by parasites The present invention provides an agent for controlling animal diseases caused by parasites, which contains, as an active ingredient, an imidazole compound represented by the formula (I): wherein R1 is a cyano... | 03/30/2004 |
| 6706764 | Use of creatine or creatine analogs for the treatment of diseases of the nervous system The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents again... | 03/16/2004 |
| 6699893 | Glucocorticoid receptor modulators The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compos... | 03/02/2004 |
| 6699898 | Substituted N,N-disubstituted non-fused heterocyclo amino compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 03/02/2004 |
| 6673807 | Immunosuppressive imidazole derivatives and their combination preparations with tacrolimus or cyclosporins Methods for increasing graft survival time comprising administering the combination of a compound that inhibits the production of nitric oxide and a compound that is a tricyclic macrolide, such as tacrolimus.... | 01/06/2004 |
| 6667342 | Benzenesulfonamide-derivatives and their use as medicaments Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens where said nitrogens are optionally oxidised to form the N... | 12/23/2003 |
| 6664283 | Pharmaceuticals for neurogenic pain This invention relates to pharmaceuticals for neuropathic pains comprising an mGluR1 receptor antagonist for systemic administration. Drugs efficacious in treating various neuropathic pain can be provided by the invention.... | 12/16/2003 |
| 6660761 | Method of treatment for fungal infections with a synergistic formulation of antifungal agents The present invention relates to a method of treatment of fungal infections consisting essentially of a synergistic combination of plant compounds that are useful for enhancing the activity of antifungal compounds. The plant compounds, menthol and menthyl... | 12/09/2003 |
