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| Number | Title | Issue Date |
| 5728711 | Treatment of H. pylori infections An infection with Helicobacter may successfully be treated with a compound of the formula ##STR1## wherein R1 is hydrogen or methyl and R2 is hydrogen or L-alanine-L-alanyl, and the pharmaceutically acceptable acid additive ... | 03/17/1998 |
| 5723470 | Fluoroalkenyl compounds and their use as pest control agents Novel 3,4,4-trifluorobutenoic acid derivatives of the formula ##STR1## wherein Q is --(C.dbd.W)--R2 wherein W is O or S, and R2 is an aliphatic or aromatic group when W.dbd.O; --OR50 ; --SR50 ; or --NR... | 03/03/1998 |
| 5721265 | Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells Agents useful for detecting hypoxic tumor cells are provided. The compounds have the structural formula (I) ##STR1## Methods of using the compounds to detect hypoxic tumor cells are also provided, as are pharmaceutical compositions formulated with th... | 02/24/1998 |
| 5712301 | Use of dexmedetomidine for treating ethanol-induced neurodegeneration The present invention involves the prevention of ethanol-induced neurodegeneration through the administration to a subject before, during and/or after ethanol consumption an effective amount of dexmedetomidine of a pharmaceutically acceptable salt thereof... | 01/27/1998 |
| 5710160 | Diphenyl pyridyl ethane derivatives as PDE IV inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## ... | 01/20/1998 |
| 5710171 | Bisphenyl inhibitors of farnesyl-protein transferase The present invention comprises peptidomimetic compounds which comprise a suitably substituted aminoalkylbenzene and analine analogs, further substituted with a second phenyl ring attached via a bond, a heteroatom linker or an aliphatic linker. The instan... | 01/20/1998 |
| 5705514 | Signal transduction inhibitor compounds A method of inhibiting the invasion and metastasis of malignant solid tumors in mammals, said method comprising administering to said mammal an anti-proliferative, anti-invasive and anti-metastasis effective amount of a compound selected from the group of... | 01/06/1998 |
| 5703110 | Benzimidazole derivatives, their production and use Benzimidazole derivatives of the formula (I): ##STR1## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R1 is hydrogen or an optionally substituted hydrocarbon residue; R2 | 12/30/1997 |
| 5703073 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that d... | 12/30/1997 |
| 5693619 | Method of using renin inhibiting N-(2-amino-2-oxoethyl) butanediamide derivatives Disclosed herein is a method of using compounds of the formula: A-N(R1)C(O)CH2 CHR2 C(O)-B wherein A is R3 R4 NC(O)CH2 when, for example, R3 is hydrogen or alkyl and R4 is hydro... | 12/02/1997 |
| 5693633 | Angiotensin II antagonists This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.... | 12/02/1997 |
| 5677326 | Indoline compound and 5-HT3 receptor antagonist containing the same as active ingredient Indoline compounds represented by the general formula: ##STR1## wherein R1 represents the group ##STR2## R2 represents a phenyl group which may be substituted or an aromatic heterocyclic group, and R3 represents ... | 10/14/1997 |
| 5672615 | Arylsulfonamido-substituted hydrodxamic acids Disclosed are the compounds of formula I ##STR1## wherein R and R1 together with the chain to which they are attached or R1 and R2 together with the carbon atom to which they are attached form a ring; pharmaceutically... | 09/30/1997 |
| 5665756 | Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders Novel aminoalkyloximes of the formula ##STR1## wherein: a. X is hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, or a group of the formula ##STR2## wherein Y is hydrogen or loweralkyl, and p is 1 or 2; b. A is a group of the for... | 09/09/1997 |
| 5665753 | Cytokine inhibiting imidazole substituted hydroxamic acid derivatives The present invention relates to a series of novel imidazole substituted hydroxamic acid derivatives, and compositions useful thereof as inhibitors of matrix degrading metalloproteinases, in particular collagenase.... | 09/09/1997 |
| 5658938 | Substituted 1H-imidazoles Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazoles and 4-(2,3-dihydro-1H-inden-1-yl)-1H-imidazoles, their optical isomers and their racemic mixtures, their salts, methods for preparing them and therapeutic compositions containing them. These ... | 08/19/1997 |
| 5656650 | Angiotensin II receptor blocking compositions This invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier, an angiotensin II receptor antagonist and a second agent selected from a diuretic, a calcium channel blocker, a ଲ-adrenoceptor blocker, a renin i... | 08/12/1997 |
| 5656651 | Androgenic directed compositions Substituted phenylthiohydantoins are provided for use in detecting the presence of tumor cells having androgenic receptors and providing for cytostatic and cytotoxic activity toward such cells. The subject compounds provide for vehicles for specific targe... | 08/12/1997 |
| 5643936 | Treatments for diseases characterized by neovascularization The applicant has identified a particular class of imidazoles that inhibit angiogenesis. These imidazoles can be used to beneficially treat a variety of angiogenic conditions.... | 07/01/1997 |
| 5641755 | Regulation of x-ray mediated gene expression Treatment of cells with ionizing radiation is associated with the production of arachidonic acid. Inhibition of phospholipase A2 abolishes radiation-mediated arachidonate production, protein kinase C induction and tumor necrosis factor gene expression. Th... | 06/24/1997 |
| 5633274 | Cancer treatments The Applicant has identified a particular class of imidazoles that inhibit nonprostate cancer cell proliferation. These imidazoles can be used to beneficially treat a variety of cancers. The imidazoles can be administered in a variety of formulations, inc... | 05/27/1997 |
| 5633237 | Imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds for treatment of neurotoxic injury A class of imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes admini... | 05/27/1997 |
| 5622973 | Treatment of osteoporosis with substituted piperidines, pyrrolidines and hexahydro-1H-azepines in combination with bisphosphonates The present invention is directed to certain novel compounds identified as di- and tri-substituted piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R1, R4, R5, A... | 04/22/1997 |
| 5620999 | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II ##STR1## wherein R1 is selected from lower alkyl, lower haloalkyl,... | 04/15/1997 |
| 5616601 | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R1 -R6 are as described in the specifi... | 04/01/1997 |
| 5616599 | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use Compounds of the following formula (I) or the formula (I)p : ##STR1## wherein R1 is alkyl or alkenyl; R2 and R3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R4 | 04/01/1997 |
| 5614544 | Oxazolidinedione derivatives and their use [Object] To provide a new 2,4-oxazolidinedione derivative possessing excellent hypoglycemic and hypolipidemic activities. [Constituent] A 2,4-oxazolidinedione derivative represented by the general formula: ##STR1## wherein X represents --CH2 --... | 03/25/1997 |
| 5610174 | Use of 1A -selective adrenoceptor agonists for the treatment of urinary incontinence The present invention provides a method of treating urinary incontinence in a subject which comprises administering to the subject a therapeutically effective amount of a compound having the following structure: ##STR1## wherein each of the substiute... | 03/11/1997 |
| 5607956 | 1-heteroazolyl-1-heterocyclyl alkane derivatives and their use and their use as neuroprotective agents The present invention relates to novel heterocyclic compounds having the general formula (1) ##STR1## geometric and optical isomers and racemates thereof where such isomers exist, as well as pharmaceutically acceptable acid addition salts thereof ... | 03/04/1997 |
| 5604251 | Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their use Compounds of the formula (I) ##STR1## in which R1 is, for example, ethyl, R2 is, for example, ... | 02/18/1997 |
| 5602122 | Method for lowering total serum cholesterol and treating hypercholesterolemia with aminoacetylmercapto derivatives The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypercholesterolemia.... | 02/11/1997 |
| 5602156 | Method for inhibiting metalloproteinase expression Calcium homeostasis is an important regulator of MMP-2 transcription, activation and activity. Disclosed herein are compounds which inhibit the expression of matrix metalloproteinases in cells. Pharmaceutical application of these compounds to inhibit the ... | 02/11/1997 |
| 5591763 | treatments for diseases characterized by neovascularization The applicant has identified a particular class of imidazoles that inhibit anglogenesis. These imidazoles can be used to beneficially treat a variety of angiogenic conditions.... | 01/07/1997 |
| 5589184 | Pharmaceutical compositions and methods of treatment of the cornea following laser treatment Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treat... | 12/31/1996 |
| 5587390 | Imidazole derivatives having a II antagonist activity Imidazole derivatives having A II antagonist activity, of Formula I, the processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof as therapeutic agents. The described compounds having A II antagonist activity ... | 12/24/1996 |
| 5583136 | Retinoid containing skin care compositions containing imidazoles Skin care compositions comprising a water-in-oil emulsion base containing retinoids and at least one imidazole in a free base form and possessing good physical and chemical stability.... | 12/10/1996 |
| 5583128 | Contraception in female primates without affecting the menstrual cycle The invention relates to the use of aromatase inhibitors for contraception in female primates and to a method for contraception in female primates using such substances and to the use of those substances for the preparation of pharmaceutical compositions ... | 12/10/1996 |
| 5575993 | Ionene polymers containing biologically-active anions Ionene polymers having biologically-active organic and/or inorganic anions are described. Methods to prepare the ionene polymers, compositions containing them and their methods of use are also described.... | 11/19/1996 |
| 5576316 | Method for inhibiting tumor growth rate using creatine or creatine analogs A method for inhibiting tumor growth rate using creatine or creatine analogs is described. The creatine or creatine analogs are administered to subjects such that tumor growth rate is inhibited. Pharmaceutical compositions containing the creatine or creat... | 11/19/1996 |
| 5573765 | Composition and method for treatment of vaginal yeast infections A composition for the treatment of vaginal yeast which promotes normal vaginal bacterial growth during treatment, comprising a yeast-inhibitory agent selected from one or more of the group consisting of ethylene glycol, propylene glycol, and glycerol, an ... | 11/12/1996 |
