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| Number | Title | Issue Date |
| 8188131 | Compounds that enhance Atoh1 expression This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatm... | 05/29/2012 |
| 8188132 | Linked dibenzimidazole derivatives The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the co... | 05/29/2012 |
| 8168668 | Compounds The present invention relates to new compounds or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing s... | 05/01/2012 |
| 8119675 | Benzimidazole derivatives Novel compounds of the formula I (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R, Q, W, X and Z hav... | 02/21/2012 |
| 8106084 | Synthesis and anti-proliferative effect of benzimidazole derivatives This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrazine compounds having selected substituti... | 01/31/2012 |
| 8101643 | Benzimidazole derivatives The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the co... | 01/24/2012 |
| 8084484 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds for treating or inhibiting p... | 12/27/2011 |
| 8076367 | Benzimidazolylidene propane-1,3-dione derivative or salt thereof Compounds useful as GnRH receptor antagonists are provided. The present inventors have further examined propane-1,3-dione derivatives and confirmed as a result that a propane-1,3-dione having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene), or a compound which has benzene... | 12/13/2011 |
| 8076366 | Forms of bendamustine free base Novel polymorphic forms of bendamustine free base are described, including amorphous bendamustine free base, six anhydrous crystalline forms, four hydrate forms, and five solvate forms, with methods of their preparation and use also being described. ... | 12/13/2011 |
| 8076365 | Viral polymerase inhibitors The present invention relates to compounds represented by formula (I) wherein A, B, D, E, R2, R3, R4, R5, R6, R9, a, b, d and e are as defined herein, their salt or ester and pharmaceutical compositio... | 12/13/2011 |
| 8063089 | Inhibitors of nucleophosmin (NPM) and methods for inducing apoptosis Nucleophosmin inhibitors are disclosed which inhibit the multimerization of nucleophosmin and the biological activity of nucleophosmin, such as the ability of nucleophosmin to inhibit apoptosis and inhibit cellular differentiation. These small molecule inhibitors ar... | 11/22/2011 |
| 8034835 | 1-[[2-amino-3-(substituted alkyl)-3H-benzimidazolyl[methyl]-3-substituted-1,3-dihydro-benzoimidazol-2-ones and structural analogs Inhibitors of RSV replication of formula (I) which can be represented by formula (I) the salts and stereochemically isomeric forms thereof, wherein R is a radical of formula | 10/11/2011 |
| 8017641 | P38 inhibitors and methods of use thereof This invention relates to inhibitors of p38 and methods of utilizing the inhibitors and pharmaceutical compositions thereof in the treatment and prevention of various disorders mediated by p38. ... | 09/13/2011 |
| 8017640 | Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment Compounds of the general formula (I) or (IA) in which X is H, Y is a leaving group, R1 preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which C is jo... | 09/13/2011 |
| 8008335 | Indole and benzimidazole derivatives The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compou... | 08/30/2011 |
| 7977365 | Antiviral drugs for treatment of arenavirus infection Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical c... | 07/12/2011 |
| 7951829 | Benzimidazole modulators of VR1 The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them. ... | 05/31/2011 |
| 7947723 | Synthesis and anti-proliferative effect of benzimidazole derivatives This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrizine compounds having selected substituti... | 05/24/2011 |
| 7935719 | N-substituted-azacyclylamines as histamine-3 antagonists The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor: wherein the variables are described in th... | 05/03/2011 |
| 7923464 | Benzimidazole derivatives and their use for modulating the GABAreceptor complex This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders,... | 04/12/2011 |
| 7915299 | 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith. ... | 03/29/2011 |
| 7879895 | Benzimidazole derivatives useful as selective androgen receptor modulators (SARMS) The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. ... | 02/01/2011 |
| 7875644 | 1-acyldihydropyrazole derivatives Compounds of the formula (I), in which R1, R2, R3a, R3b, R3c and R3d have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter al... | 01/25/2011 |
| 7872037 | Antiviral drugs for treatment of arenavirus infection Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical c... | 01/18/2011 |
| 7863310 | Kinase inhibitors The present invention provides kinase inhibitors of Formula I: ... | 01/04/2011 |
| 7776900 | Benzimidazole derivatives and their use for modulating the GABAreceptor complex This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders,... | 08/17/2010 |
| 7763644 | Imidazole derivatives, processes for preparing them and their uses The present invention relates to imidazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals. ... | 07/27/2010 |
| 7732474 | Pharmaceutical preparation containing a benzimidazole compound mixed with microcrystalline cellulose and a method for its preparation The present invention relates to oral pharmaceutical preparations in the form of pellets in which a benzimidazole compound is stabilized by combining it with microcrystalline cellulose. ... | 06/08/2010 |
| 7728026 | 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatm... | 06/01/2010 |
| 7728025 | 2-heteroaryl-substituted benzimidazole derivative A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity ... | 06/01/2010 |
| 7714010 | Pyrrolobenzimidazolones and their use as anti-proliferative agents The invention relates to pyrrolobenzimidazolone compounds of formula (I), wherein A, T and R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessiv... | 05/11/2010 |
| 7709519 | Benzimidazolylidene propane-1,3 dione derivative or salt thereof Compounds useful as GnRH receptor antagonists are provided. The present inventors have further examined propane-1,3-dione derivatives and confirmed as a result that a propane-1,3-dione having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene), or a compound which has benzene... | 05/04/2010 |
| 7705031 | Benzimidazoles useful as modulators of ion channels The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also pro... | 04/27/2010 |
| 7700638 | 1,5,7-trisubstituted benzimidazole derivatives and their use for modulating the GABAreceptor complex This invention relates to novel 1,5,7-trisubstituted benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system di... | 04/20/2010 |
| 7687529 | Substituted propylamine derivatives and methods of their use The present invention is directed to substituted propylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention an... | 03/30/2010 |
| 7683090 | Treating agent for irritable bowel syndrome Pharmaceutical compositions for treatment of irritable bowel syndrome including non-constipated irritable bowel syndrome such as diarrhea-predominant irritable bowel syndrome and alternating constipation/diarrhea irritable bowel syndrome in male and female patients,... | 03/23/2010 |
| 7652052 | Process for producing ramosetron or its salt To provide a novel process for producing ramosetron or its salt that is useful as a pharmaceutical, especially as a therapeutic and/or preventive agent for digestive symptoms caused by administration of an anti-malignant tumor agent, diarrheal-type irritable bowel s... | 01/26/2010 |
| 7652053 | Diaminocycloalkane MCH receptor antagonists Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 01/26/2010 |
| 7645784 | Benzimidazole derivatives Compounds of formula I, wherein R1, m, R2, R3, p, n, R5 and R9 are as defined as in the specification, salts, solvates or solvated salts thereof, processes for their pr... | 01/12/2010 |
| 7645785 | Benzimidazole derivatives The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and este... | 01/12/2010 |
