Famous Patents
William F. Semple, a dentist, was awarded the first US Patent on chewing gum in 1869. His recipe contained powdered chalk.
PatentStorm News
Make the Most of PatentStorm
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest patents by subscribing to an RSS feed.
Got questions? Ask a Patent Expert!
Registered users: Manage your profile, comments and alerts.
| Number | Title | Issue Date |
| 7601748 | Anti-androgenic pyrrolidines with tumor-inhibiting action This invention relates to anti-androgenic N-[ω-[3-[4-cyano-3-(trifluoromethyl)-phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]alkyl]-substituted pyrrolidines of general formula I, with a strongly pronounced antiproli... | 10/13/2009 |
| 7429570 | Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes ... | 09/30/2008 |
| 7425546 | Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes ... | 09/16/2008 |
| 7354933 | Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors The present invention relates to a cyclic urea compound of formula I: as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use... | 04/08/2008 |
| 7326694 | Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes ... | 02/05/2008 |
| 7271188 | Imidazolidine derivatives The present invention provides a compound represented by formula (I): [Formula 1] wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, eac... | 09/18/2007 |
| 7164027 | Aralkyl ester soft drugs The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is administered. The parent drug comp... | 01/16/2007 |
| 7144908 | Agonists of beta-adrenoceptors The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. | 12/05/2006 |
| 7138421 | Anti-androgenic pyrrolidines with tumor-inhibiting action This invention relates to anti-androgenic N-[ω-[3-[4-cyano-3-(trifluoromethyl)-phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]alkyl]-substituted pyrrolidines of general formula I, with a strongly pronounce... | 11/21/2006 |
| 7105497 | Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes ... | 09/12/2006 |
| 7081469 | Benzimidazole vascular damaging agents Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid t... | 07/25/2006 |
| 7019004 | Hydantoin derivatives with affinity for somatostatin receptors The invention provides compounds of formula (I) wherein X, Y, R1, R2, R3 and R4 are as defined in the description, and the preparation thereof. The compounds of the formula bind to somatostatin receptors and are useful as ... | 03/28/2006 |
| 6987097 | Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes ... | 01/17/2006 |
| RE38934 | Method and reagents for N-alkylating ureides A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I with an alkylating agent of structure III in the presence of a basic catalyst in an... | 01/10/2006 |
| 6982097 | Biocidal compositions and methods of using same This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using the biocidal compositions for the disinfection of water that may conta... | 01/03/2006 |
| 6977267 | Spiro-hydantoin compounds useful as anti-inflammatory agents Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L... | 12/20/2005 |
| 6960474 | Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator Selective androgen receptor modulators (SARMs) having antagonist activity in hormone-dependent tumors while exhibiting no activity or agonist activity against other nontumor tissues containing the androgen receptor as well as methods for identifying, designing and u... | 11/01/2005 |
| 6875438 | Preparations for topical administration of substances having antiandrogenic activity A preparation comprising at least one form of lipid nanoparticles or a nanoemulsion comprising at least one compound of the formula I and/or one stereoisomeric form of the compound of the formula I and/or one physiolog... | 04/05/2005 |
| 6864273 | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein —Z1—Z2 | 03/08/2005 |
| 6812237 | N-substituted peptidyl nitriles as cysteine cathepsin inhibitors Compounds of the formula (I), wherein R1 is aryl or biaryl; R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7-alkyl in ... | 11/02/2004 |
| 6794406 | Indole derivatives The invention relates to new indole derivatives, processes for their preparation, and their use in medicaments. ... | 09/21/2004 |
| 6753339 | Fungicide compositions The invention concerns fungicide compositions comprising a compound (I) which is (4-S)-4-mehtyl-2-methylthio-4-phenyl-1-phenylamino-2-imidazoline-5-one and a compound (II) which is N1-[(R)-1-(6-fluoro-2-benzothiazolyl)ethyl]-N2-isopropoxycarbon... | 06/22/2004 |
| 6680302 | Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the inventio... | 01/20/2004 |
| 6667334 | Imidazolidine derivatives, the production thereof, their use and pharmaceutical preparations containing the same The present invention relates to imidazolidine derivatives of the formula I, ##STR1## in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable... | 12/23/2003 |
| 6548487 | Agent for treatment of bladder troubles A method for promoting vesical mucosa epithelium dilatation and/or healing vesical mucosa of a patient's bladder, comprising: administering to the inside of the patient's bladder a solution comprising hyaluronic acid and/or a pharmaceutically acceptable s... | 04/15/2003 |
| 6531499 | Matrix metalloproteinase inhibitors and method of using same Peptoid compounds of Formula I and Formula II are disclosed ##STR1## The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.... | 03/11/2003 |
| 6525086 | Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X, T, Q, Z, U, Y, Ar, p and n are as defined in the speci... | 02/25/2003 |
| 6521654 | Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations including them Substituted imidazolidine derivatives of the formula I, ##STR1## in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active com... | 02/18/2003 |
| 6469059 | Fungicidal composition and method for disease control of paddy-rice plants A fungicidal composition for paddy-rice plants has as active ingredients N-(1-cyano-1,2-dimethylpropyl)-2-(2,4-dichlorophenoxy)propanamide in combination with one or more compounds selected from fungicidally active compounds. The combination is useful in ... | 10/22/2002 |
| 6462063 | C-proteinase inhibitors The present invention relates to a novel class of N,N'-di substituted hydantoin hydroxamates capable of inhibiting C-proteinase, and to their use to regulate, modulate and/or inhibit abnormal collagen formation as a therapeutic approach towards the treatm... | 10/08/2002 |
| 6451824 | Sulfonylaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 09/17/2002 |
| 6420410 | Method for treating neoplasia by exposure to N,N'-substituted benzimidazol-2-ones A method for inhibiting neoplastic cells and related conditions by exposing them to N,N'-substituted benzimidazol-2-ones.... | 07/16/2002 |
| 6380200 | Combination of aldose reductase inhibitors and selective serotonin reuptake inhibitors for the treatment of diabetic complications This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or said prodrug and selective serotonin reuptake inhibitor (SSR... | 04/30/2002 |
| 6365608 | Fungicide mixtures based on pyridine carboxamides Fungicidal mixtures comprise as active components a) an amide compound of the formula I A--CO--NR1 R2 I in which A is an aryl group or an aromatic or non-aromatic, 5- or 6-membered heterocycle which has from 1 to 3 hetero atoms selected from... | 04/02/2002 |
| 6355623 | Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the inventio... | 03/12/2002 |
| 6319949 | Pesticidal sprays A method for preventing fungal diseases in crops which comprises the steps of: (a) applying to a crop an aqueous or a non-aqueous spray composition which includes a pesticide and a spray adjuvant including a solvent and an emulsifier, wherein the solvent ... | 11/20/2001 |
| 6313102 | Method for stabilization of biological substances during drying and subsequent storage and compositions thereof The present invention encompasses methods of increasing stability of biological substances during drying and the dried compositions derived therefrom. The compositions have improved storage stability.... | 11/06/2001 |
| 6294562 | Salts of ethyl 3-(2-(4-(4-amino-imino-methyl)phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl )acetylamino)-3-phenylpropionate The present invention relates to ethyl 3-(2-(4-(4-(amino-imino-methyl)-phenyl)-4-methyl-2,5-dioxoimidazolidin-1-y l)acetylamino)-3-phenylpropionate salts of the formula I, ##STR1## in which HM is maleic acid, and to their physiologically tolerated salts, ... | 09/25/2001 |
| 6284784 | Substituted 2-pyrrolidinone activators of PKC Compounds of formula I: ##STR1## wherein R1 and R2 have any of the values defined in the specification, and their pharmaceutically acceptable salts, are PKC activators and are useful for treating diseases, such as, for example, ... | 09/04/2001 |
| 6255331 | Stable biocidal compositions Disclosed are biocidal compositions comprising mixtures of formaldehyde-releasing imidazolidines, such as 1,3-dimethylol-5,3-dimethylhydantoin, and 3-isothiazolones stabilized with low levels of copper salts.... | 07/03/2001 |