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| Number | Title | Issue Date |
| 8188129 | (−)-enantiomer of the 2-[2-(1-chloro-cyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione A novel (−)-enantiomer of 2-[2-(1-chloro-cyclopropyl)-3-(2-chloro-phenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione of the formula a process for preparing this novel active compound and its use as microbicide... | 05/29/2012 |
| 8173690 | Compounds, compositions and methods of using same for modulating uric acid levels Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to ... | 05/08/2012 |
| 8163788 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors The invention relates to a pharmaceutical composition and the use thereof, wherein the pharmaceutical composition contains compounds selected from a group of general formulas (5), (6), (7) and (8) and/or enantiomers, diastereomers or the pharmaceutically acceptable ... | 04/24/2012 |
| 8084483 | Compounds and compositions and methods of use Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant le... | 12/27/2011 |
| 8053456 | Triazole compounds that modulate Hsp90 activity The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treati... | 11/08/2011 |
| 8022091 | Triazole derivative An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P1), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which comp... | 09/20/2011 |
| 8003681 | 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid and methyl ester A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and... | 08/23/2011 |
| 7947721 | S-triazolyl α-mercaptoacetanilides as inhibitors of HIV reverse transcriptase A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and... | 05/24/2011 |
| 7906540 | Non-nucleoside reverse transcriptase inhibitors Compounds of formula I, wherein R1, R2, R3, R4, R5, X, Y, and Ar are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and tre... | 03/15/2011 |
| 7683086 | Fungicidal mixtures The invention relates to a fungicidal mixture that comprises (1) 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazolo-3-thion (prothioconazole) or the salts or adducts thereof and at least one further fungicidal composition, se... | 03/23/2010 |
| 7683087 | N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl] --amino benzoic acids as HIV reverse transcriptase inhibitors A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compoun... | 03/23/2010 |
| 7666891 | Heterocyclic antiviral compounds The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficiency virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human... | 02/23/2010 |
| 7446120 | Peptidomimetic modulators of cell adhesion Peptidomimetics of cyclic peptides, and compositions comprising such peptidomimetics are provided. The peptidomimetics have a three-dimensional structure that is substantially similar to a three-dimensional structure of a cyclic peptide that comprises a cadherin cel... | 11/04/2008 |
| 7435752 | N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl]--amino benozioc acids as HIV reverse transcriptase inhibitors A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O)N-linked amino acid. The compound... | 10/14/2008 |
| 7407963 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof A compound of general formula (I) wherein R and R1 are as defined herein, or a tautomer, diastereomer, enantiomer, or salt thereof, particularly the physiologically acceptable salts thereof, which have valuable p... | 08/05/2008 |
| 7361673 | Agents for controlling plant pests The present invention relates to compositions for controlling plant pests containing the compound of the formula (I) in a mixture with specified fungicidally active compounds. ... | 04/22/2008 |
| 7348345 | Nonnucleoside reverse transcriptase inhibitors This invention relates to methods of treating an HIV infection with novel heterocyclic compounds of formula I wherein R1—R4, X1 and X2 are as defined in the summary and pharmaceutically acceptable salts, and methods to i... | 03/25/2008 |
| 7342037 | Anti-inflammatory medicaments Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel com... | 03/11/2008 |
| 7329683 | 11-β-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia Compounds having Formula (I), including pharmaceutically acceptable salts and prodrugs thereof: are selective inhibitors of the 11β-HSD1 enzyme. They inhibit the 11β-HSD1-mediated conversion of cortisone and other 11-keto-glucocorticoids to cortisol and other 11β... | 02/12/2008 |
| 7317031 | Substituted triazole diamine derivatives as kinase inhibitors The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder. ... | 01/08/2008 |
| 7309721 | Aminoalkylphosphonates and related compounds as Edg receptor agonists The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejecti... | 12/18/2007 |
| 7304082 | 1,2,4-triazole derivatives, compositions, process of making and methods of use Compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinopathy, rheumatoid arthritis, atherosclerotic neovasculari... | 12/04/2007 |
| 7288676 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulph... | 10/30/2007 |
| 7262318 | Substituted heteroaryl- and phenylsulfamoyl compounds The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists. PPAR alpha activators, phar... | 08/28/2007 |
| 7232822 | Reverse-turn mimetics and method relating thereto Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic a... | 06/19/2007 |
| 7208510 | Fungicidal combinations of active substances The present invention relates to fungicidally active compound combinations of a fluorobenzothiazole derivative of the formula (I) and at least one of the compounds listed in the disclosure. ... | 04/24/2007 |
| 7208509 | Non-nucleoside reverse transcriptase inhibitors This invention relates to novel heterocyclic compounds of formula I wherein R1—R4, X1 and X2 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human ... | 04/24/2007 |
| 7176226 | Crystal modification II of 2-[2-(1-chloro-cyclopropyl)-3-(2-chlorophenyl)-2-hydroxy-propyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione This invention relates to crystal form II of 2-[2-(1-chlorocyclopropyl)-3-(2-chloropenyl)-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione of the formula to a process for its preparation and to its use for... | 02/13/2007 |
| 7166607 | Substituted indoles The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders ... | 01/23/2007 |
| 7160684 | Methods of selecting compounds for modulation of bladder function The present invention involves an assay system and method of selecting compounds useful in the treatment of bladder instability and related bladder conditions through the activation of KCNQ potassium channels in the bladder smooth muscle. ... | 01/09/2007 |
| 7157470 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycl... | 01/02/2007 |
| 7144908 | Agonists of beta-adrenoceptors The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. | 12/05/2006 |
| 7144911 | Anti-inflammatory medicaments Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel com... | 12/05/2006 |
| 7115658 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus ... | 10/03/2006 |
| 7115593 | Fungicidal combinations of active substances The present invention relates to active compound combinations of a fluorobenzo-thiazole of the formula (I) and at least one of the compounds listed herein. The active compound combinations of the present inventio... | 10/03/2006 |
| 7105471 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulph... | 09/12/2006 |
| 7078424 | N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating... | 07/18/2006 |
| 7071223 | Benzamide inhibitors of the P2Xreceptor The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1–R3 are as defined herein. The compounds of the invention are useful in the trea... | 07/04/2006 |
| 7067656 | Sulfamoyl compounds and agricultural and horticultural fungicides A sulfamoyl compound of the general formulae (1): wherein R1 and R2 are each independently C1-4 alkyl, or R1 and R2 togeth... | 06/27/2006 |
| 7056941 | 2-[pyrazolyl and triazolyl-3′-oxymethylene]-phenyl-isoxazolones, triazolones and tetrazolones as pesticides and fungicides 2-[Pyrazolyl- and triazolyl-3′-oxymethylene]phenylisoxazolones, -triazolones and -tetrazolones of formula I where: X is a group A, B or C, | 06/06/2006 |
