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| Number | Title | Issue Date |
| 8188128 | Opioid receptor subtype-selective agents Opioid receptor compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a condition mediated by an opioid receptor by administering an effective amount of the opioid receptor compound to a patient in need thereof.... | 05/29/2012 |
| 8183273 | Bicyclic compound, production and use thereof The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein... | 05/22/2012 |
| 8178570 | Tie-2 modulators and methods of use The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/... | 05/15/2012 |
| 8163787 | Triazolone derivatives A compound represented by the following general formula (1) or salts thereof or hydrates of the foregoing: wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc... | 04/24/2012 |
| 8153672 | Polymorphic forms of deferasirox (ICL670A) The invention relates to crystalline forms of 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid and to its amorphous form, to processes for the preparation thereof, to compositions containing the same and their uses for the manufacture of a medicament for... | 04/10/2012 |
| 8148415 | Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity The present invention relates to steroid sulphatase and/or aromatase inhibitors of Formula III or Formula IV, wherein A is selected from H, OH, halogen and hydrocarbyl; D, E and F are each independently of each other an optional linker group; P, Q and R are independ... | 04/03/2012 |
| 8143299 | Anti-mitotic anti-proliferative compounds Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof. ... | 03/27/2012 |
| 8129421 | Method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-benzoic acid A method for preparing 4-[3,5-bis(2-hydroxyphenyl )-[1,2,4]triazol-1-yl]benzoic acid of formula (I) by reaction of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one of formula (II) with 4-hydrazinobenzoic acid of formula (III) in an organic acid or in a mixture of an orga... | 03/06/2012 |
| 8124635 | Antimicrobial composition useful for preserving wood Antimicrobial compositions useful for preserving wood, and comprising a variety of antimicrobial compounds. ... | 02/28/2012 |
| 8110592 | Agrochemical formulations that can be dispersed in water containing polyalkoxytriglycerides as penetration enhances The present invention relates to novel water-dispersible agrochemical formulations such as, for example, water-based suspension concentrates and water-dispersible granules of agrochemically active compounds comprising a penetrant from the class of the polyalkoxytrig... | 02/07/2012 |
| 8110593 | Phenoxymethyl imidazoline derivatives and their use as pesticides The present invention relates to imidazoline derivatives and their use as insecticidal, acaricidal, molluscicidal and nematocidal agents. The invention also extends to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising such imidazoline d... | 02/07/2012 |
| 8106083 | Triazole compounds that modulate HSP90 activity The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperprolif... | 01/31/2012 |
| 8093279 | Compound There is provided a compound of Formula I wherein R3, R4, R5, R6 and R7 are independently selected from H and —Y—R8; wherein each R8 is indepe... | 01/10/2012 |
| 8084482 | Compositions and kits comprising a fungicidal triazole and an alkoxylated alcohol, and their uses The present invention relates to compositions comprising (a1) a fungicidal triazole; and (b1) ethoxylated 2-propylheptanol having a mole average degree of ethoxylation from 7.5 to 8.5, to kits comprising the triazole and alcohol alkoxylate in separate containers, as... | 12/27/2011 |
| 8084481 | Substituted arylimidazolone and triazolone as inhibitors of vasopressin receptors The present application relates to novel, substituted 4-arylimidazol-2-ones and 5-aryl-1,2,4-triazolones, processes for the production thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases and the use thereof for the produ... | 12/27/2011 |
| 8080572 | Dual-acting antihypertensive agents In one aspect, the invention relates to compounds having the formula: wherein: Ar, r, Z, X, R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compou... | 12/20/2011 |
| 8063083 | Method for treating non-Hodgkin's lymphoma The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating non-Hodgkin's lymphoma, in a subject in need thereof. ... | 11/22/2011 |
| 8058302 | Process for preparing pure anastrozole The present invention discloses two new related substances (6) and (7) of Anastrozole synthesis from Q.A. Salt (5) as in Scheme—1 and purification procedures to get Anastrozole (1) free from (6) and (7). ... | 11/15/2011 |
| 8039497 | 1,2,4-triazole derivatives as sigma receptor inhibitors The invention relates to the use of compounds having pharmacological activity towards the sigma receptor, and more particularly to 1,2,4-triazole derivatives of formula (I) to processes of preparation of such compounds and to pharmaceutical compositions comprising t... | 10/18/2011 |
| 8034834 | Method for treating proliferative disorders with HSP90 inhibitors The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating Bcr-Abl, FLT-3, EGFR, c-Kit, B-raf, and NPM-ALK associated cancers, in a subject in need thereof. ... | 10/11/2011 |
| 8026264 | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dysli... | 09/27/2011 |
| 8022090 | Vitamin C composition stabilized with cationic material, anionic material and caffeic acid derivative The present invention relates to a composition containing vitamin C. The composition according to the present invention includes cationic material and anionic material as a primary stabilizing agent of the vitamin C; and a caffeic acid derivative as a secondary stab... | 09/20/2011 |
| 8013005 | Dual-acting antihypertensive agents The invention is directed to compounds having the formula: wherein: Ar, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1... | 09/06/2011 |
| 8008333 | Single dose aromatase inhibitor for treating infertility The use of an aromatase inhibitor (AI) in the preparation of a medicament for use in inducing ovulation in a female suffering from anovulatory infertility which comprises administering to said female a single dose of the at least one aromatase inhibitor. The use of ... | 08/30/2011 |
| 7968579 | Antifungal triazole derivatives Disclosed herein are antifungal triazole derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same. The triazole derivatives of Chemical Formula 1 or pharmaceutically acceptable salts... | 06/28/2011 |
| 7932280 | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dysli... | 04/26/2011 |
| 7910614 | Azolylmethyloxiranes, use thereof for controlling plant pathogenic fungi, and agents containing the same The present invention relates to azolylmethyloxiranes of the general formula I in which A or B is benzodioxolyl which is optionally substituted by one to five of the following substituents: halogen, CN, NO... | 03/22/2011 |
| 7902240 | Substituted pyrazole and triazole compounds as KSP inhibitors Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof: ... | 03/08/2011 |
| 7902239 | Diaminotriazoles useful as inhibitors of protein kinases The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. ... | 03/08/2011 |
| 7884119 | Triazole derivatives useful as Axl inhibitors Triazole derivatives and pharmaceutical compositions containing the derivatives are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the derivatives in treating diseases or conditions associated with ... | 02/08/2011 |
| 7875643 | Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein G is selected from a group consisting of: phenyl, pyridyl, benzothiaz... | 01/25/2011 |
| 7875642 | Crystalline forms of an inhibitor of 11-β-hydroxysteroid dehydrogenase type 1 Novel crystalline salts of 3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]-4,5-dicyclopropyl-r-4H-1,2,4-triazole are potent inhibitors of 11β-hydroxysteroid dehydrogenase Type 1 and are useful for the treatment of conditions associated with Metabolic Syndrome as we... | 01/25/2011 |
| 7872036 | 3-triazolylphenyl sulfide derivative and insecticide, miticide and nematicide containing it as an active ingredient To provide novel 3-triazolylphenyl sulfide derivatives having excellent soil treatment activity as insecticides, miticides or nematicides for agricultural and horticultural plants. 3-Triazolylphenyl sulfide derivatives represented by the formula [1]: | 01/18/2011 |
| 7863309 | Dual-acting antihypertensive agents In one aspect, the invention relates to compounds having the formula: wherein: Ar, r, Z, X, R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compou... | 01/04/2011 |
| 7851495 | Thiophene-carboxamides useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseas... | 12/14/2010 |
| 7846958 | Fungicidal use The use of benzophenones of the formula I in which R is hydrogen or C1-C4-alkyl and Hal is fluorine, chlorine or bromine for controlling Pseudocercosporella herpo... | 12/07/2010 |
| 7846957 | Aromatase inhibition to enhance assisted reproduction The use of at least one aromatase inhibitor in the production of a medicament for improving the implantation and pregnancy rates for a female undergoing assisted reproduction treatment, which comprises one or more daily doses of an aromatase inhibitor (AI) for admin... | 12/07/2010 |
| 7838544 | Heterocyclic inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and methods of using the same The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydr... | 11/23/2010 |
| 7829589 | Sulfonamide compounds and uses thereof Compounds that modulate GHS-R are described, for examples compounds formula (I) ... | 11/09/2010 |
| 7829588 | Modulators of the PPAR-type receptors and pharmaceutical/cosmetic applications thereof Novel compounds that are modulators of PPAR-type receptors having the structural formula (I): are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and in... | 11/09/2010 |
