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| Number | Title | Issue Date |
| 8153671 | Heterotetracyclic compounds as TPO mimetics The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or diso... | 04/10/2012 |
| 8080571 | Tricyclic angiotensin II agonists There is provided compounds of formula I, wherein A, X1, X2, X3, X4, Y1, Y2, Y3, Y4, Z1, Z2, R4 and R | 12/20/2011 |
| 8048905 | Tetrazole-substituted arylamides as P2Xand P2Xantagonists Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or opt... | 11/01/2011 |
| 8048904 | Process for the preparation of olmesartan medoxomil The present invention provides a process for the preparation of Olmesartan medoxomil by condensing the ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate with 4-[2-(trityl tetrazol-5-yl)phenyl]benzyl bromide to obtain ethyl 4-(1-hydroxy-1-methyl ethyl... | 11/01/2011 |
| 8039496 | Therapeutic compounds Disclosed herein is a compound of the formula. Therapeutic methods, compositions, and medicaments for the treatment of glaucoma or ocular hypertension related thereto are also disclosed. ... | 10/18/2011 |
| 7776896 | 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection This invention is directed to compounds of formula (I): where A, B, D, E, m, and R1-R5 are as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable s... | 08/17/2010 |
| 7414071 | Methods of treatment with selective EP4 receptor agonists The present invention provides a method of treating hypertension, liver failure, loss of patency of ductus arteriosus, glaucoma or ocular hypertension in a patient, comprising administering to the patient a therapeutically effective amount of a selective EP4 | 08/19/2008 |
| 7361672 | Heteroarylacetamide inhibitors of factor Xa The invention is concerned with novel heteroarylacetamides of formula (I) Rd—C(O)—N(Re)—Rc—CH2—C(O)—N(Ra)(Rb) (I) wherein Ra to Re are as def... | 04/22/2008 |
| 7314885 | Pyrrole compounds useful as kinase inhibitors The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for making the compounds and methods of using the compositions in the treatm... | 01/01/2008 |
| 7309721 | Aminoalkylphosphonates and related compounds as Edg receptor agonists The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejecti... | 12/18/2007 |
| 7307096 | Combined agents for treatment of glaucoma A pharmaceutical composition for the prophylaxis or treatment of glaucoma which comprises an angiotensin II antagonist and at least one compound selected from an adrenaline receptor blocker, a prostaglandin and a carbonic anhydrase inhibitor; and a method for the pr... | 12/11/2007 |
| 7291623 | Compounds that interact with kinases A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereo... | 11/06/2007 |
| 7291639 | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) This invention provides methods of inhibiting plasminogen activator inhibitor-1 (PAI-1) in a mammal, utilizing compounds of the formula: wherein: A is C or N; B is O, S, N, or CH═CH; | 11/06/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7214696 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective... | 05/08/2007 |
| 7196089 | EPreceptor antagonists Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O... | 03/27/2007 |
| 7192497 | Thermally stable booster explosive and process for manufacture A thermally stable booster explosive and process for the manufacture of the explosive. The product explosive is 2,4,7,9-tetranitro-10H-benzo[4,5]furo[3,2-b]indole (TNBFI). A reactant/solvent such as n-methylpyrrolidone (NMP) or dimethyl formamide (DMF) is made sligh... | 03/20/2007 |
| 7163954 | Substituted naphthyl benzothiophene acids The present invention relates generally to substituted naphthyl benzothiophene acids and methods of using them. ... | 01/16/2007 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7148248 | Method of treating or inhibiting the development of brain inflammation and sepsis A leukotriene C4 and D4 antagonist is used to treat or inhibit brain inflammation and sepsis by acting to inhibit increased capillary permeability and white blood cell extravasation. Potential candidate compounds can be screened in a non-human mammal before or after... | 12/12/2006 |
| 7115658 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus ... | 10/03/2006 |
| 7109223 | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EPreceptor agonists in the treatment of glaucoma This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a p... | 09/19/2006 |
| 7087553 | Soil fumigant, herbicide, larvacide, ovacide and fungicide A treatment for eliminating unwanted organisms in agriculture, the treatment comprising a first component comprising allyl isothiocyanate emulsified in water, and a second component comprising a solution of phosphorus and water. ... | 08/08/2006 |
| 7078424 | N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating... | 07/18/2006 |
| 7045663 | Chiral integrin modulators and methods of use thereof The invention provides enantiomers of ajoene and derivtives of Z(−)-ajoene. The derivative of Z(−)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tissu... | 05/16/2006 |
| 7019149 | Thromboxane ligands without blood clotting side effects A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering to a mammal suffe... | 03/28/2006 |
| 7001723 | Catalytic RNAs with aminoacylation activity The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylation activity comprise a catalytic domain and an aminoacylation domain. The catalytic RNA molecules having trans amin... | 02/21/2006 |
| 6972298 | Method of treating or inhibiting neutrophil chemotaxis by administering a MEK inhibitor The present invention provides a method of treating or preventing neutrophil chemotaxis. Specifically, the present invention provides a method of treating or preventing neutrophil migration by administering to a patient a MEK inhibitor. ... | 12/06/2005 |
| 6972292 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds ... | 12/06/2005 |
| 6967015 | Diagnostic method for detecting dysplastic epithelial tissue In diagnostic testing for cancer and precancer of the epithelium, the undesired binding of cancer-selective dyes to proteins in the extracellular matrix, which may lead to false positives, is reduced by applying to the epithelium being tested, before application of ... | 11/22/2005 |
| 6953798 | β-alanine derivates Alkanoic acid derivatives of formula (1) are described: Ar1(Alka)rL1Ar2CH(R1)C(Ra)(Ra′)R (1) Ar1 is an optionally substituted aromatic or... | 10/11/2005 |
| 6951869 | Use of leukotriene receptor antagonist for treatment of scarring A method of preventing or treating either scarring or capsular contractures in subjects in need of such treatment comprising the administration of leukotriene receptor antagonists to said subject in need of treatment. ... | 10/04/2005 |
| 6916831 | Flavone acetic acid analogs and methods of use thereof Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and S; m is from 1 to 3; n... | 07/12/2005 |
| 6906085 | Tetrahydropyran derivatives as neurokinin receptor antagonists The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7 and R8 represent a variety of subst... | 06/14/2005 |
| 6900234 | Synergistic therapeutic compositions and methods Compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, synergistic compositions comprising amounts of at least two therapeutic agents selected from the group c... | 05/31/2005 |
| 6890928 | Aromatic sulfone hydroxamic acids and their use as protease inhibitors This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This inventi... | 05/10/2005 |
| 6867299 | Oxamide IMPDH inhibitors Disclosed are compounds of the general formula which are oxamide derivatives and inhibitors of the enzyme inosine monophosphate dehydrogenase (IMPDH). ... | 03/15/2005 |
| 6864272 | Method and composition for treating cancer using cellular organelle crystallizing agents This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular organelle and/or cytoskeleton crystallizing agents (e.g. tetrazolium... | 03/08/2005 |
| 6756378 | VLA-4 inhibitor compounds Compounds that selectively inhibit the binding of ligands to α4β1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by Formula I: As selecti... | 06/29/2004 |
| 6723742 | Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I in which R1-R5 are as defined in the description. The compounds have useful pharmaceutical properties and are particularly activ... | 04/20/2004 |
