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| Number | Title | Issue Date |
| 8183272 | Indanyl compounds Compounds exhibiting calcium receptor antagonist activity that are safe and orally administrable having Formula (I) or pharmaceutically acceptable salts thereof: ... | 05/22/2012 |
| 8183271 | Tetrazole derivatives and their use for the treatment of cardiovascular diseases The present application relates to novel tetrazole derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the ... | 05/22/2012 |
| 8178569 | Crystalline imidazole-5-carboxylic acid derivative The invention provides the crystalline imidazole-5-carboxylic acid derivative (I, the chemical name: 2-butyl-4-chloro-1-[2′-(1H-tetrazol-5-yl) 1,1′-biphenyl-methyl]-imidazole-5-carboxylic acid, 1-[(isopropoxy)-carbonyloxy]methyl ester), its preparation method an... | 05/15/2012 |
| 8163786 | Preparation of a lead-free primary explosive Embodiments of the present subject matter provide a compound and material that may be used as a lead-free primary explosive. An embodiment of the present subject matter provides the compound copper(I) nitrotetrazolate. Certain embodiments of the present subject matt... | 04/24/2012 |
| 8153670 | Factor Xa inhibitors The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such... | 04/10/2012 |
| 8143298 | Dual-acting antihypertensive agents The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have A... | 03/27/2012 |
| 8138214 | Pharmaceutical composition The invention provides a new pharmaceutical compositions for treating cardiovascular disease, which contains the active component 2-butyl-4-chloro-1-[2′-(1H-tetrazol-5-yl)1,1′-biphenyl-methyl]imidazole-5-carboxylic acid, 1-[(isopropoxy)carbonyloxy]methyl ester d... | 03/20/2012 |
| 8124634 | CB1 receptor modulators Compounds of formula (I) suppress the normal signalling activity CB1 receptors, and are thus useful in the treatment of diseases or conditions which are mediated by CB1 receptor signalling activity, such as treatment of obesity and overweight, prevention of weigh ga... | 02/28/2012 |
| 8119672 | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections. ... | 02/21/2012 |
| 8119673 | Compounds 148 This invention relates to novel pharmaceutically useful compounds of formula (I), in particular compounds that are competitive inhibitors of trypsin-like serine proteases, especially thrombin, their use as medicaments, pharmaceutical compositions containing them and... | 02/21/2012 |
| 8106082 | Dual-acting antihypertensive agents The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT | 01/31/2012 |
| 8106081 | Combination of organic compounds useful for treating diabetes The present invention relates to a combination, especially a pharmaceutical composition, comprising as active ingredients (i) an AT1-receptor antagonist or a pharmaceutically acceptable salt thereof; (ii) (a) an insulin secretion... | 01/31/2012 |
| 8101642 | 3-substituted propanamine compounds Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containi... | 01/24/2012 |
| 8097639 | Light sensitive PDMS for complex pattern formation Disclosed herein is a surface functionalized poly(dimethylsiloxane) (PDMS) and methods for making the same. The surface functionalized PDMS disclosed herein is applicable in the general field of microfluidics, bioMEMS (bio-microelectromechanical systems), soft litho... | 01/17/2012 |
| 8088809 | Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, and/or cardiometabolic disorders. ... | 01/03/2012 |
| 8063082 | Certain chemical entities, compositions, and methods Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described. ... | 11/22/2011 |
| 8058301 | Salt hydrates The invention relates to new forms of salts of valsartan or crystalline, also partly crystalline and amorphous salts of valsartan, the respective production and usage, and pharmaceutical preparations containing such a salt. ... | 11/15/2011 |
| 8053454 | Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3 Compounds of formula (I), useful for inhibiting PIM-I and/or PIM-3: and pharmaceutically acceptable salts thereof, wherein Y, Z, R1, R3, Q, X and R4 are as defined above. Pharmaceutical compositions and methods of treating diseases a... | 11/08/2011 |
| 8053455 | Angiotensin II receptor antagonists A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is selected from the group consisting of ... | 11/08/2011 |
| 8053453 | Pyrazolone compounds and thrombopoietin receptor activator A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective or a platelet increasing agent, which contains a thrombopoietin receptor activator represented by the formula (1): wherein A is a C?2-14#19... | 11/08/2011 |
| 8048903 | 5-iodotetrazoles The compounds of the formula (I) in which R1 represents hydrogen or in each case optionally substituted alkyl, alkenyl, alkynyl or phenyl are highly suitable as microbicides for protecting plants and... | 11/01/2011 |
| 8003679 | Use of inhibitors of the renin-angiotensin system Inhibitors of the rennin-angiotensin system are useful for the treatment or prevention of conditions associated with hypoxia, such as stroke. ... | 08/23/2011 |
| 8003680 | Therapeutic compounds Disclosed herein are compounds of the formula therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 08/23/2011 |
| 7981914 | Tetrazole-substituted aryl amide derivatives and uses thereof Compounds of the formula: wherein R1, R2, Ar1, Ar2, and n are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subj... | 07/19/2011 |
| 7964625 | Antibiotics comprising bis(1-aryl-5-tetrazoly1)methane derivatives The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds, the bis(1-aryl-5-tetrazolyl)methanes, which are especially useful for combating infections with gram-positive ... | 06/21/2011 |
| 7960422 | Pharmaceutically active compounds containing tetrazolyl and triazolyl rings Compounds of formula (I) wherein R1 is as well as pharmaceutically acceptable salts, hydrates and/or enantiomers thereof are useful as compounds that exhibit activity a... | 06/14/2011 |
| 7943648 | Salts of imidazole-5-carboxylic acid derivatives, a method for preparing same and pharmaceutical compositions comprising same The present invention provides pharmaceutically acceptable salts of imidazole-5-carboxylic acid derivatives, methods for preparing same and pharmaceutical compositions comprising same. The salts obtained by the present invention can be easily dissolved in common sol... | 05/17/2011 |
| 7943647 | Process for the preparation of tetrazole derivatives from organo aluminium azides The present invention relates to a method for preparing substituted tetrazoles of the formula or a tautomer or salt thereof, wherein R represents an organic residue. Also provided are compounds obtained according to this me... | 05/17/2011 |
| 7932279 | Substituted tetrazole compounds and uses thereof The present invention provides tetrazole compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the tetrazole compounds. The present invention provides methods of treating a cell prolife... | 04/26/2011 |
| 7888380 | 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives 1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triaz... | 02/15/2011 |
| 7884118 | 1-cycloalkyl-5-iodotetrazoles The compounds of the formula (I) in which R1 represents cycloalkyl, and its stereoisomers and any mixtures thereof are highly suitable as microbicides for protecting plants and materials. ... | 02/08/2011 |
| 7879893 | Ligands for the HisB10 Znsites of the R-state insulin hexamer The present invention relates to novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer having the formula A-B-C-D-X (III), wherein: A is a chemical group which reversibly binds to a HisB10 Zn2+ sites of an... | 02/01/2011 |
| 7875641 | Sesquihydrate hydrochloride salt of irbesartan The present invention relates to sesquihydrate hydrochloride salt of irbesartan and pharmaceutical compositions comprising the same. ... | 01/25/2011 |
| 7872035 | Angiotensin II antagonists The present invention relates to the use of an angiotensin II type 1 receptor antagonist of the general formula (I) in the manufacture of a medicament for the prophylactic and/or therapeutic treatment of a vascular headache condition such as migraine, in a subject s... | 01/18/2011 |
| 7858651 | Imidazole-5-carboxylic acid derivatives, the preparation method therefor and the uses thereof The invention discloses imidazole-5-carboxylic acid derivatives, and their preparation methods. The derivatives of the invention are Angiotensin II receptor antagonists with angiotensin II antagonistic activity and antihypertensive activity, and thereby can be used ... | 12/28/2010 |
| 7851494 | Method for the treatment of metabolic disorders Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed. ... | 12/14/2010 |
| 7834041 | Dual-acting antihypertensive agents The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT | 11/16/2010 |
| 7834042 | Angiotensin II receptor antagonists A compound having the structure (Formula I), wherein Y is —Y1—Y2—Y3—Y4—Y5—; Y1 is C(O) or C(R1R2); Y2 is O, C(O), P(O)(OH) or CH2, provided that... | 11/16/2010 |
| 7812044 | Anticancer agents Remedies/preventives for hormone-independent cancer, hormone-independent cancer cell proliferation inhibitors, apoptosis inducers for cancer cells, etc. each containing a compound having an angiotensin II antagonism, its prodrug or a salt thereof. Thus, excellent an... | 10/12/2010 |
| 7807702 | Substituted thiophene carboxylic amide glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention d... | 10/05/2010 |
