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| Number | Title | Issue Date |
| 8178568 | Sulfone compounds which modulate the CB2 receptor Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. ... | 05/15/2012 |
| 8058300 | Polycyclic antagonists of lysophosphatidic acid receptors Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination wi... | 11/15/2011 |
| 8048902 | Antagonists of lysophosphatidic acid receptors Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination wi... | 11/01/2011 |
| 8017638 | Isoxazole derivative and isothiazole derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein ... | 09/13/2011 |
| 7863308 | Substituted thiophenes Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. ... | 01/04/2011 |
| 7750030 | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning Methods for treating an individual with a psychiatric order with a pharmacologic agent that enhances learning or conditioning in combination with a session of psychotherapy are provided. These methods of the invention encompass a variety of methods of psychotherapy,... | 07/06/2010 |
| 7557133 | Caspase inhibitors containing isoxazoline ring The present invention relates to an isoxazoline derivative as an inhibitor against various caspases, a process for preparing the same, and a therapeutic composition for preventing inflammation and apoptosis comprising the same. ... | 07/07/2009 |
| 7459473 | N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating... | 12/02/2008 |
| 7368578 | Five-membered heterocyclic compounds The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom... | 05/06/2008 |
| 7361673 | Agents for controlling plant pests The present invention relates to compositions for controlling plant pests containing the compound of the formula (I) in a mixture with specified fungicidally active compounds. ... | 04/22/2008 |
| 7361653 | Pest control agent composition and method of using the same The present invention relates to a composition for noxious organisms-controlling agent having a synergistic effect and a method for using said composition, which comprises, as active ingredients thereof, one or more compounds selected from the phthalamide derivative... | 04/22/2008 |
| 7319111 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use. ... | 01/15/2008 |
| 7304081 | Amido compounds and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases... | 12/04/2007 |
| 7291638 | 3-amido-1,2-benzoisoxazole derivatives, process for preparation, and use thereof The present invention relates to 3-amido-1,2-benzoisoxazole derivatives and their salts represented by formula 1, processes for preparation and usees thereof. More particularly, it relates to a method for improving its bioavailability introducing amino acid residue ... | 11/06/2007 |
| 7288558 | Pharmaceutical composition for treatment for urinary diseases comprising LPA receptor regulator The present invention relates to a pharmaceutical composition for treatment and/or prevention for urinary diseases comprising a lysophosphatidic acid (LPA) receptor regulator. As LPA receptor regulators act on urethra and prostate, compounds acting on this re... | 10/30/2007 |
| 7288538 | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use. ... | 10/30/2007 |
| 7282503 | Fungicidal mixtures based on imidazole derivatives Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X1 and X2 represent halogen and phenyl which can be substituted by halo... | 10/16/2007 |
| 7265093 | Drug therapy for Celiac Sprue Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ... | 09/04/2007 |
| 7265115 | Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals. ... | 09/04/2007 |
| 7241786 | Isoxazole and isothiazole compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula wherein R1, R1a, R1b, R2, R3, R4, R5, R6, R7, R8 | 07/10/2007 |
| 7238689 | Isoxazoline derivative and herbicide comprising the same as active ingredient An isoxazoline derivative represented by the following general formula [I]: wherein R1 and R2 may be the same or different and are each an alkyl group; R | 07/03/2007 |
| 7235589 | Method of treating patients undergoing kidney dialysis This invention relates to a method of treating patients who are receiving dialysis treatments. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in th... | 06/26/2007 |
| 7235664 | Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, | 06/26/2007 |
| 7226940 | Substituted heterocycles for the treatment of diabetes and other diseases The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymph... | 06/05/2007 |
| 7208510 | Fungicidal combinations of active substances The present invention relates to fungicidally active compound combinations of a fluorobenzothiazole derivative of the formula (I) and at least one of the compounds listed in the disclosure. ... | 04/24/2007 |
| 7195876 | Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same Oncokinase fusion polypeptides associated with hyperproliferative disorders and the polynucleotides encoding for such fusion polypeptides are provided. The fusion polypeptides have a C-terminal tyrosine kinase domain fused to an N-terminal domain that is not normall... | 03/27/2007 |
| 7186742 | Benzamide inhibitors of the P2Xreceptor The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1–R3 are as defined herein. The compounds of the invention are useful in the tr... | 03/06/2007 |
| 7179814 | Agents for controlling plant pests The present invention relates to compositions for controlling plant pests containing the compound of the formula (I) in a mixture with specified fungicidally active compounds. ... | 02/20/2007 |
| 7172757 | Method of treating fibroproliferative disorders Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with ... | 02/06/2007 |
| 7166627 | Antibiotic compositions and methods of using the same The present invention relates to a process for the production of substituted 5-isoxazolidinone antibiotics. More specifically the patent relates to the production of compounds that mimic the antibiotic action of β-lactams, are resistant to β-lactamase degradation,... | 01/23/2007 |
| 7161006 | Sulphones for inhibition of gamma secretase The invention provides compounds of formula I: which are inhibitors of γ-secretase and hence useful in the treatment or prevention of Alzheimer's disease. ... | 01/09/2007 |
| 7160913 | Methods and kit for treating Parkinson's disease The efficacy of levodopa therapy in patients being treated for Parkinson's disease is enhanced by administering high doses of a partial glycine agonist. The frequency and severity of levodopa-induced side effects in Parkinson's disease patients are also reduced by a... | 01/09/2007 |
| 7151113 | Pyrazole-amine compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5... | 12/19/2006 |
| 7147852 | Methods for reducing TGF-β production and for promoting repair of liver damage Materials and methods for reducing TGF-β production and promoting repair of liver damage in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of an anti-zvegf3 antibody in combination ... | 12/12/2006 |
| 7125863 | Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t... | 10/24/2006 |
| 7125893 | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I in which R1a, R1b, R2a, R3a, R3b, R4, R... | 10/24/2006 |
| 7119098 | Heteroarylakanoic acids as intergrin receptor antagonists The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the ανβ3 and/or the... | 10/10/2006 |
| 7115593 | Fungicidal combinations of active substances The present invention relates to active compound combinations of a fluorobenzo-thiazole of the formula (I) and at least one of the compounds listed herein. The active compound combinations of the present inventio... | 10/03/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7081538 | Substituted isoxazolines and their use as antibacterial agents Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is O, S or NH; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selecte... | 07/25/2006 |
