Did You Know...
...that the video game, Pong, was invented by a guy who graduated at the bottom of his engineering class? Nolan Bushnell spent more time running the games at a local amusement park than he did on his studies at the University of Utah. His dreams of working for Disney's amusement empire were dashed when the company wouldn't hire him. Taking a boring job, Nolan daydreamed about electronic versions of popular games. He invented Pong, the first video game, and went on to found Atari Co.
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| Number | Title | Issue Date |
| 8158665 | Farnesoid X receptor agonists The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same. ... | 04/17/2012 |
| 8153669 | Quaternary ammonium salts as M3 antagonists Compounds of formula (I), in salt or zwitterionic form, wherein J, L, M, R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the mus... | 04/10/2012 |
| 8138213 | Isoxazoline-substituted benzamide compound and pesticide A 3,5-Bis (substituted aryl) substituted isoxazoline compound of formula (2) or a salt thereof: wherein A1 is a carbon atom or nitrogen atom; X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalky... | 03/20/2012 |
| 8119671 | Isoxazoline-substituted benzamide compound and pest control agent Novel pest control agents, particularly insecticides or miticides are provided. Isoxazoline-substituted benzamide compounds of General Formula (1) or a salt thereof: (where A1, A2 and A3 are... | 02/21/2012 |
| 8088808 | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I). Wherein R, R1, R2, R3 and R4 are as described herein. More s... | 01/03/2012 |
| 8053452 | Substituted isoxazoline or enone oxime compound, and pest control agent There is provided a novel pest control agent (pesticide), particulally insecticide or miticide. A substituted isoxazoline compound or a substituted enone oxime compound represented by Formula (1) or (2), and apest control agent containing them: | 11/08/2011 |
| 8044080 | Isoxazoline derivative and novel process for its preparation The present invention relates to an isoxazoline derivative having the cyclic carboxylic acid hemiketal moiety of formula (1) for use as caspase inhibitor, a process for preparing it, and a pharmaceutical composition comprising it. ... | 10/25/2011 |
| 8022089 | Isoxazoline-substituted benzamide compound and pesticide An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A1, A2 and A3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., ... | 09/20/2011 |
| 7998994 | Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and methods of their use Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and hydrates thereof are disclosed, as well as compositions comprising them and methods of their use. ... | 08/16/2011 |
| 7985762 | Inhibitors of serine proteases The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3—NS4A protease. | 07/26/2011 |
| 7973064 | Method and composition for potentiating an opiate analgesic Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans. ... | 07/05/2011 |
| 7964624 | Inhibitors of serine proteases The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease. ... | 06/21/2011 |
| 7956078 | Crystal structure of human coronavirus 229E main proteinase and uses for developing SARS inhibitors The invention relates to a method of developing a main proteinase SARS inhibitor. Human coronaviruses are major causes of upper respiratory tract illnesses in humans, in particular, the common cold. Recent investigations have shown that a novel coronavirus causes th... | 06/07/2011 |
| 7951828 | Isoxazoline-substituted benzamide compound and pesticide An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A1, A2 and A3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., ... | 05/31/2011 |
| 7951827 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that o... | 05/31/2011 |
| 7947720 | 3,4-di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and ca... | 05/24/2011 |
| 7928130 | Isoxazoline compounds having MIF antagonist activity Methods of use and pharmaceutical compositions for a genus of low molecular weight compounds comprising optionally substituted isoxazoline ring systems that act as inhibitors of MIF (macrophage migration inhibitory factor) are disclosed. Specifically, the compounds ... | 04/19/2011 |
| 7897630 | 5-aryl isoxazolines for controlling invertebrate pests Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof wherein A1, A2 and A3 are independently selected from the group consisting of CR3 and N; B1 B2 | 03/01/2011 |
| 7884117 | Carbonylamino pyrrolopyrazoles, potent kinase inhibitors Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4. | 02/08/2011 |
| 7846956 | Malononitrile compound as pesticides The present invention provides a malononitrile compound represented by the formula (I): wherein any one of X1, X2, X3 and X4 is CR100, wherein R100 is a group represented by the formula: the other thr... | 12/07/2010 |
| 7834040 | Isoxazolic derivative to relieve neuropathic pain The present invention relates to new pharmaceutical uses of an isoxazolic derivative or a pharmaceutically acceptable salt thereof in the preparation of a medicament useful for treating the neuropathic pain. ... | 11/16/2010 |
| 7825147 | Inhibitors of phosphodiesterase type-IV The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructi... | 11/02/2010 |
| 7825146 | Sulfonamide derivative having isoxazole ring A compound represented by the general formula (I-A): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 | 11/02/2010 |
| 7820705 | Compounds and compositions as PPAR modulators The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, part... | 10/26/2010 |
| 7816386 | Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumor agents Cinnamic and phenylpropiolic acid derivatives of formula (I) having antitumour and chemo sensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumours. ... | 10/19/2010 |
| 7790759 | Glycyrrhetinic acid-30-amide derivatives and their use The present invention relates to the field of a medicine for treating diseases associated with inflammation, immunity or infection, and in particular, to glycyrrhetinic acid-30-amide derivatives of general formula I and their preparation, and a pharmaceutical compos... | 09/07/2010 |
| 7790760 | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical composition... | 09/07/2010 |
| 7786155 | Organic compounds The invention relates to compound of the formula I wherein the substituents are as defined in the specification; in free base form or in acid addition salt form; to its preparation, to its use as medicament and to medicamen... | 08/31/2010 |
| 7781469 | Arylacetate derivatives having isoxazole skeleton A compound of the formula (I): pharmaceutically acceptable salt or solvate thereof, wherein Y is a group of the formula: wherein Ring A ... | 08/24/2010 |
| 7759378 | Polyamino acid derivatives and use thereof in compositions for treating keratin fibers The invention concerns the use in a cosmetic composition of at least a poly-aminoacid of general formula (1) in which X is —O—, —S— or —NR3; R1 represents in particular a hydrogen atom or a C1-C40 alkyl radical; ... | 07/20/2010 |
| 7732472 | Mitotic kinesin inhibitors The present invention relates to dihydroisoxazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise th... | 06/08/2010 |
| 7714007 | Method of alleviating chronic pain via peripheral glutaminase regulation A composition having sustained pain-relieving properties such that the composition may be administered to a subject to alleviate chronic pain. The composition includes an effective amount of at least one glutaminase inhibitor. A method for alleviating chronic pain i... | 05/11/2010 |
| 7714008 | Heterocyclic GPR40 modulators The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present... | 05/11/2010 |
| 7705028 | Farnesoid X receptor agonists The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same. ... | 04/27/2010 |
| 7705027 | Isoxazole compounds as inhibitors of heat shock proteins Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: (A), (B) wherein R1, is a group of formula (IA): —Ar1-(Alk1)p-(Z)r-(Alk2)s-Q, whe... | 04/27/2010 |
| 7666888 | Substituted azole aromatic heterocycles as inhibitors of 11β-HSD-1 Compounds of formula I and IV are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorder: wherein the variables A-B, R1, R2, m, a... | 02/23/2010 |
| 7662843 | Isoxazoline compounds having MIF antagonist activity Methods of use and pharmaceutical compositions for a genus of low molecular weight compounds comprising optionally substituted isoxazoline ring systems that act as inhibitors of MIF (macrophage migration inhibitory factor) are disclosed. Specifically, the compounds ... | 02/16/2010 |
| 7652050 | Methods for increasing the survival of aquatic animals infected with an aquatic virus A method of increasing the survival of animals and aquatic species susceptible to birnavirus infection by treating them before, during and/or after birnavirus exposure, with a chemical compound capable of inhibiting viral replication. A method of treating aquatic sp... | 01/26/2010 |
| 7538132 | Isoxazolo derivatives The present invention is concerned with aryl-isoxazole-4-carbonyl-pyrrole-2-carboxylic acid amide derivatives of formula wherein R1, R2, R3, R4, and R5, an... | 05/26/2009 |
| 7521469 | Phosphinic amino acid compounds Compounds of formula (I): wherein: R1 represents hydrogen, alkylcarbonyloxyalkyl or alkylcarbonylthioalkyl, R2 represents hydrogen, alkylcarbonyloxyalkyl, arylcarbonylthioalky... | 04/21/2009 |
