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| Number | Title | Issue Date |
| 8178567 | Insecticidal substituted amino heterocyclic and heteroaryl derivatives Certain substituted amino heterocyclic and heteroaryl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula (I): wherein R, R1, R2, R3, R4, A, B and Q are ful... | 05/15/2012 |
| 8110591 | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors The present invention relates to novel compounds selected from 2-aminoaryloxazoles that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases ... | 02/07/2012 |
| 8080570 | α2B and α2C agonists Described herein are compounds that can be useful as bioactive agents. More specifically, the compounds described herein can be useful as both α2B and α2C adrenergic agonists. Methods of synthesis and administration of the compounds are also ... | 12/20/2011 |
| 7998993 | TRPV1 antagonists Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV 1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating... | 08/16/2011 |
| 7763641 | Broadspectrum heterocyclic substituted phenyl containing sulfonamide HIV protease inhibitors The present invention concerns the compounds having the formula (I), N-oxides, salt, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein Haryl is an aromatic monocyclic, bicyclic or tricyclic heterocycle having 3 to 14 ring memb... | 07/27/2010 |
| 7498352 | TGF-β superfamily production/secretion promoter The present invention provides a TGF-β superfamily production/secretion promoter comprising a compound represented by the formula wherein R1 is a halogen atom, an optionally substituted heterocyclic group, an op... | 03/03/2009 |
| 7462635 | Thiazole and oxazole VDAC regulator The present invention provides a VDAC regulator comprising a compound represented by the formula (I): wherein R1 is a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxyl... | 12/09/2008 |
| 7429607 | 5-HTreceptor antagonists The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalky... | 09/30/2008 |
| 7368578 | Five-membered heterocyclic compounds The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom... | 05/06/2008 |
| 7329682 | Method for inhibiting 5-lipoxygenase using a benzoxazole derivative A benzoxazole derivative is disclosed for inhibiting 5-lipoxygenase. ... | 02/12/2008 |
| 7317024 | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof The invention relates to a class of novel non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have th... | 01/08/2008 |
| 7317030 | Compounds as inhibitors of cell proliferation and viral infections The present invention relates to novel compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Z is NH, or ... | 01/08/2008 |
| 7265130 | NPY Y5 antagonist The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R1 is lower alkyl, cycloalkyl or the like, ... | 09/04/2007 |
| 7244752 | Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are ... | 07/17/2007 |
| 7202257 | Anti-inflammatory medicaments Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel com... | 04/10/2007 |
| 7189712 | 1,3-Oxazole compounds for the treatment of cancer Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. | 03/13/2007 |
| 7189751 | Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents The present invention provides medicinal compositions characterized by comprising as the active ingredient either a compound represented by a formula [I] or a pharmaceutically acceptable composite thereof; ... | 03/13/2007 |
| 7183276 | Azole compounds The present invention provides a compound represented by the formula (I) wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocycl... | 02/27/2007 |
| 7183300 | Inhibitors of HIV-1 capsid formation: substituted aryl aminomethyl thiazole ureas and analogues thereof Substituted aryl aminomethyl thiazole ureas and analogues thereof that act as inhibitors of viral capsid formation, including HIV capsid formation, are provided here. Generally the virus capsid formation inhibitors described herein are compounds of Formula I ... | 02/27/2007 |
| 7166625 | Method for treating fibrotic diseases and other indications Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: | 01/23/2007 |
| 7163952 | Azole compound and medicinal use thereof The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is —COOR7, —X1-A1-COOR7 (R7 is H, alkyl) or tetr... | 01/16/2007 |
| 7148249 | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, ... | 12/12/2006 |
| 7125893 | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I in which R1a, R1b, R2a, R3a, R3b, R4, R... | 10/24/2006 |
| 7119113 | Oxazoles as mGluR1 enhancers The invention relates to carboxamide derivatives as defined in the specification and claims, to a process for their preparation, to pharmaceutical compositions comprising them and to their use as mGluR1 enhancers in the treatment and prevention of neurological disor... | 10/10/2006 |
| 7112599 | Oxazole compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula wherein R3, R5, R6, R7, and Z, and other variables enumerated under one or more of R3, R5 | 09/26/2006 |
| 7112607 | Allosteric adenosine receptor modulators The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators for uses including p... | 09/26/2006 |
| 7109224 | Acyl guanidine compounds and use thereof Acyl guanidine compounds of the following Formula wherein R1, R2, R3, R4 and L are described herein, and pharmaceutical compositions thereof, are useful in treating leu... | 09/19/2006 |
| 7105551 | Thiazole derivatives for treating PPAR related disorders The present invention provides compounds of formula (I). These compounds are used for the treatment of PPAR related diseases ... | 09/12/2006 |
| 7037931 | CCK-1 receptor modulators There are provided by the present invention certain pyrazole based CCK-1 receptor modulators. ... | 05/02/2006 |
| 6995181 | Modulators of the glucocorticoid receptor and method Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the s... | 02/07/2006 |
| 6992081 | Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases. ... | 01/31/2006 |
| 6992083 | Benzoxazol derivatives The invention relates to compounds of formula wherein R is phenyl, unsubstituted or substituted by halogen or —CH2N(CH3)(CH2)nOCH3 | 01/31/2006 |
| 6972292 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds ... | 12/06/2005 |
| 6951873 | Methods for treating age-related behavioral disorders in companion animals Methods for the treatment of age-related behavioral disorders in companion animals are disclosed. These comprise administering to a companion animal in need of such treatment a therapeutically effective amount of an acetylcholinesterase inhibitor. A preferred acetyl... | 10/04/2005 |
| 6916814 | Methods of treating cytokine mediated diseases Disclosed are methods of treating certain cytokine mediated diseases or conditions using novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. ... | 07/12/2005 |
| 6900202 | Di-substituted imineheterocyclic compounds There is provided di-substituted iminoheterocyclic compounds of the following formula (I): in which, A is optionally substituted alkyl group, optionally substituted aryl group ... | 05/31/2005 |
| 6867226 | Serotonin 5-HT3 receptor partial activator This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. | 03/15/2005 |
| 6846838 | Ureido-substituted aniline compounds useful as serine protease inhibitors Compounds having the formula (I), or pharmaceutically-acceptable salts, hydrates or prodrugs thereof, are effective as inhibitors of Factor VIIa. ... | 01/25/2005 |
| 6770664 | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of the formula: wherein Y is a radical of Formulae II or III: in which the substituents have the meaning indi... | 08/03/2004 |
| 6762200 | Oxa(thia)zolidine derivative and anti-inflammatory drug The present invention provides medicinal compositions characterized by containing as the active ingredient either a compound represented by a general formula (1) or a pharmaceutically acceptable composite thereof, [where... | 07/13/2004 |
