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| Number | Title | Issue Date |
| 8173689 | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one addi... | 05/08/2012 |
| 8168663 | Pharmaceutically acceptable salt of 6-carboxy-2-(3,5 dichlorophenyl)-benzoxazole, and a pharmaceutical composition comprising the salt thereof Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective... | 05/01/2012 |
| 8163785 | Pyrazolo[5,1b]oxazole derivatives as CRF-receptor antagonists There are described 4-difluoromethoxyphenyl pyrazolo[5.1-b]oxazole derivatives of Formula I: which are useful as corticotropin releasing factor (CRF) receptor antagonists and as pharmaceuticals. ... | 04/24/2012 |
| 8158664 | Antimicrobial and radioprotective compounds The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroato... | 04/17/2012 |
| 8106080 | Compositions and methods for enhancing nitric oxide delivery The present invention is directed to compounds, combinations, compositions and methods for enhancing nitric oxide (NO) delivery to target sites, and in particular to muscle, both normal and dystrophic. Enhanced NO delivery according to the present invention may be a... | 01/31/2012 |
| 8034833 | Phosphorus binder for treatment of renal disease The present invention relates to oral compositions which are useful for binding phosphorus in ingesta, and inhibiting absorption of phosphorus from the gastrointestinal tract of subjects. A method for binding phosphorus in ingesta and inhibiting its absorption from ... | 10/11/2011 |
| 8030337 | Tricyclic compound and pharmaceutical use thereof The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like. ... | 10/04/2011 |
| 7998991 | Neurotherapeutic treatment for sexual dysfunction A method for improving sexual function is described. A mammal suffering from sexual dysfunction or otherwise in need of enhanced sexual function is administered a compound selected from those that are capable of inhibiting the activity of β-lactams, penicillin-bind... | 08/16/2011 |
| 7994203 | Organic compounds There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists. ... | 08/09/2011 |
| 7989482 | Indoline anti-cancer agents Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided. ... | 08/02/2011 |
| 7960420 | Diazonamide analogs with improved solubility Diazonamide A analogs, and the salts, esters and conjugates thereof, having improved aqueous solubility are provided. Also provided are pharmaceutical compositions, and methods for preparing and using such compounds and compositions for the treatment of proliferativ... | 06/14/2011 |
| 7919515 | 3-phenylpropionic acid derivatives The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C1-C4-alkyl group; Y represents NH, N—C1-C10-alkyl, O, or S; Z... | 04/05/2011 |
| 7879891 | Caspase inhibitor prodrugs This invention relates to prodrugs of caspase inhibitors comprising of a furo[3,2-d]oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds, particularly caspase inhibitors. This invention also relates to the pro... | 02/01/2011 |
| 7868033 | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding Compounds, compositions and methods are provided for stabilizing transthyretin and for treating, preventing, or ameliorating one or more symptoms of transthyretin mediated diseases. In one embodiment, the compounds are benzoxazoles and related compounds. ... | 01/11/2011 |
| 7863306 | Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optional... | 01/04/2011 |
| 7825145 | Antimicrobial and radioprotective compounds The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroato... | 11/02/2010 |
| 7737166 | Antifungal bicyclic hetero ring compounds A 1,6-β-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechan... | 06/15/2010 |
| 7709513 | Benzooxazol-2-one derivatives as lipase and phospholipase inhibitors The invention relates to benzooxazol-2-one derivatives of general formula (I) with the meanings indicated in the description, the pharmaceutically usable salts thereof, and the use thereof as medicinal substances. ... | 05/04/2010 |
| 7659296 | Vitamin D receptor modulators The present invention relates to novel, non-secosteroidal, phenyl-benzoxazole compounds of Formula (I) wherein the variables R, R′, RP, RP3, LP1, LP2, ZP, RB, RB′, LXB and ZXB are as hereinafter defined, the... | 02/09/2010 |
| 7622490 | Broadspecturm 2-amino-benzoxazole sulfonamide HIV protease inhibitors The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optional... | 11/24/2009 |
| 7598282 | Neuroprotective agents Novel stereoisomers of GS-164 are provided. The compounds, such as (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol (TH-237A) and (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol (TH-242A) exh... | 10/06/2009 |
| 7534804 | Benzoxazole inhibitors of 15-lipoxygenase The present application provides benzoxazole inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions. ... | 05/19/2009 |
| 7531564 | Substituted benzoxazoles as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in t... | 05/12/2009 |
| 7521467 | Compounds for use in weight loss and appetite suppression in humans Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, obtainable from monocotyledonous plants, or by chemicals synthesis, ... | 04/21/2009 |
| RE40558 | Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P... | 10/28/2008 |
| 7427637 | Mitotic kinesin inhibitors The present invention relates to bicyclic dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions w... | 09/23/2008 |
| 7419974 | Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z... | 09/02/2008 |
| 7414138 | Benzoxazole and benzodiazole UV-A sunscreens The present invention relates to 1,3-benzoxazole or benzodiazole UV-A sunscreens and to compositions, in particular topical compositions, containing the above UV-A sunscreens. ... | 08/19/2008 |
| 7414046 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also re... | 08/19/2008 |
| 7384964 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (... | 06/10/2008 |
| 7384965 | Fused heterocyclic derivatives as PPAR modulators The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U ia an aliphatic linker; (c) Y is selected from the gr... | 06/10/2008 |
| 7378433 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-... | 05/27/2008 |
| 7368846 | Microactuator with displacement sensing function and deformable mirror including the microactuator According to the present invention, a moving element Ai such as an electrostatically driven actuator is displaced by supplying a drive signal thereto. Meanwhile, a displacement sensing section 6 senses its displacement and a calibrating section 15 auto... | 05/06/2008 |
| 7365087 | Oxazole derivatives of tetracyclines This invention provides compounds of the formula: wherein A″, X and Y are defined in the specification. These compounds are useful as antibacterial agents. ... | 04/29/2008 |
| 7361647 | Analogs of benzoquinone-containing ansamycins and methods of use thereof The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where... | 04/22/2008 |
| RE40245 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates ... | 04/15/2008 |
| 7355050 | (Meth)acrylate amide acetals The present invention, in one aspect, is a composition comprising (meth)acrylate amide acetals. Acetals of the present invention are useful as components in coatings for automotive and architectural structures. Coatings comprising components of the present invention... | 04/08/2008 |
| 7354946 | Biarylurea derivatives The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a c... | 04/08/2008 |
| 7354949 | Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound represented by formula (I): [wherein ... | 04/08/2008 |
| 7348322 | Glucocorticoid receptor modulators as antiinflammatory agents The present invention relates to compounds of formula I: wherein A, X, R1, R2 and R3 are as defined herein and pharmaceutically acceptable salts thereof. The invention also relates to method... | 03/25/2008 |
