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| Number | Title | Issue Date |
| 8420674 | Method of providing pirfenidone therapy to a patient The invention relates to methods for decreasing adverse events associated with pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) therapy. The invention discloses an optimized dose escalation scheme that results in the patient having increased tolerance to adverse even... | 04/16/2013 |
| 8410139 | Prodrugs of a piperidinyl derivative as modulators of chemokine receptor activity The present application describes prodrugs of the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma ... | 04/02/2013 |
| 8362040 | 4-phenylpiperidine derivatives as renin inhibitors Compounds of the present invention having the formula exhibit inhibitory activity on the natural enzyme renin. Thus, compounds of formula (I) may be employed for the treatment of hypertension, atherosclerosis, unstable coro... | 01/29/2013 |
| 8334306 | Nitroxide free radical synergized antineoplastic agents Nitroxide free radicals attached to antineoplastic agents can synergize their potencies to cancer cells. This invention relates to any antineoplastic agents and their derivatives chemically attached with nitroxide free radicals, such as TEMPO and its radical derivat... | 12/18/2012 |
| 8299098 | Piperidinyl derivative as a modulator of chemokine receptor activity The present application describes the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic... | 10/30/2012 |
| 8258159 | Inhibitors of the α2β1/GPIa-IIa integrin Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of int... | 09/04/2012 |
| 8247434 | Fexofenadine polymorphs and processes of preparing the same Anhydrous crystalline fexofenadine hydrochloride Form C, crystalline fexofenadine acetate monohydrate Form D, crystalline fexofenadine acetate dihydrate Form E and crystalline fexofenadine free base monohydrate Form F, processes of preparing the same, pharmaceutical... | 08/21/2012 |
| 8222277 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of non... | 07/17/2012 |
| 8211916 | N- and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl] piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred compounds exhibit highly differential behavior as between the DAT and S... | 07/03/2012 |
| 8129414 | Non-competitive NMDA receptor antagonists Disclosed herein are non-competitive NMDA receptor antagonists having chemical structures similar to that of phencyclidine (PCP). These antagonists contain a polycyclic ring structure in place of the cycloalkyl ring of PCP. The antagonists also differ from PCP in th... | 03/06/2012 |
| 7994198 | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase Compounds of formula (I); wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase. ... | 08/09/2011 |
| 7910609 | Inhibitors of integrin alpha2beta1 with modified urea moiety Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of int... | 03/22/2011 |
| 7910608 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as define... | 03/22/2011 |
| 7910607 | Nitroxide free radical synergized antineoplastic agents Nitroxide free radicals attached to antineoplastic agents can synergize their potencies to cancer cells. This invention relates to any antineoplastic agents and their derivatives chemically attached with nitroxide free radicals, such as TEMPO and its radical derivat... | 03/22/2011 |
| 7812035 | 4-substituted piperidines, and methods of use thereof One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine tra... | 10/12/2010 |
| 7700628 | Aromatic ether derivatives useful as thrombin inhibitors This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process fo... | 04/20/2010 |
| 7662838 | Use of a deoxynojirimycin derivative or a pharmaceutically salt thereof The invention relates to the use of a deoxynojirimycin derivative, or pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of insulin resistance, hyperpigmentation and/or inflammatory processes in the skin, a fungal disease... | 02/16/2010 |
| 7635707 | Pirfenidone treatment for patients with atypical liver function Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include administering to a patient pirfenidone at doses lower than the full target dosage ... | 12/22/2009 |
| 7625928 | Nitroxide radioprotector formulations and methods of use Pharmaceutical compositions useful in preventing and treating negative side effects accompanying radiotherapy are disclosed. More particularly, new formulations that can be applied to the skin and mucous membranes of patients undergoing radiotherapy and methods of u... | 12/01/2009 |
| 7595331 | N-and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred compounds exhibit highly differential behavior as between the DAT and SE... | 09/29/2009 |
| 7582655 | Antineoplastic compounds The present invention relates to 4-piperidone derivatives represented by the following formula (I) and the acid addition salts thereof. The method of preparation and antineoplastic activity of the said compounds are disclos... | 09/01/2009 |
| 7569588 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, m, p, r, R1, R2, R3, R4, R5, R6, W and X1 are as defined in the specification. Th... | 08/04/2009 |
| 7566729 | Modifying pirfenidone treatment for patients with atypical liver function Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include administering to a patient pirfenidone at doses lower than the full target dosage ... | 07/28/2009 |
| 7531555 | Compositions and methods for selective inhibition of nicotine acetylcholine receptors The present invention concerns methods for treating or preventing neurological disorders characterized by dysfunction of nicotinic acetylcholine receptors by administering 2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH), or a pharmaceutically acceptable salt the... | 05/12/2009 |
| 7501442 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, m, p, r, R1, R2, R3, R4, R5, R6, W and X1 are as defined in the specification. Th... | 03/10/2009 |
| 7456199 | Biphenyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, m, p, s, t, W, Ar1, X1, R1, R2, R3, R4, R6, and R7 are as defined in t... | 11/25/2008 |
| 7442711 | Amelioration of the development of cataracts and other ophthalmic diseases Ophthalmically acceptable compositions used in arresting the development of cataracts or macular degeneration comprising a pharmaceutically acceptable carrier or diluent and a compound having the formula: where R1 | 10/28/2008 |
| 7439257 | Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics. | 10/21/2008 |
| 7435746 | 5-thiopiperdinyl prostaglandin E analogs A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. Y and R are described in detail herein A compound having an ω chain comprising ... | 10/14/2008 |
| 7411093 | Aminocycloalkanes as DPP-IV inhibitors The present invention relates to compounds of formula (I) wherein R1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or p... | 08/12/2008 |
| 7407973 | Use of pirfenidone in therapeutic regimens The present invention provides methods for treating a disorder, and methods for inhibiting a stress-activated protein kinase (SAPK) in a cell in an individual, the methods generally involving administering to an individual in need thereof an effective amount of pirf... | 08/05/2008 |
| 7393873 | Arylsulfonamide derivatives N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 07/01/2008 |
| 7378446 | Compound having anti-HCV activity and process for producing the same The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV,... | 05/27/2008 |
| 7375230 | Fermentation and purification of migrastatin and analog Migrastatin and a migrastatin analog can be produced by fermentation of Streptomyces platensis NRRL 18993 and used in pharmaceutical formulations to treat cancer and/or inhibit metastasis of cancer cells. ... | 05/20/2008 |
| 7368443 | 2,6-disubstituted piperidines and piperazine compounds The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula: which are used to treat diseases of the central nervous system, drug abuse, and withdrawal there... | 05/06/2008 |
| 7361666 | Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-couple... | 04/22/2008 |
| 7348341 | Chemical compounds The invention concerns compounds of formula (I), and their use in therapy, particularly in the modulation of CCR3 activity. ... | 03/25/2008 |
| 7338965 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precu... | 03/04/2008 |
| 7338962 | Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us... | 03/04/2008 |
| 7326716 | Treatment of inflammatory bowel disease The present invention provides a method of treating inflammatory bowel disease which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a piperidinyl prostaglandin E analog. ... | 02/05/2008 |
