Class 514/320 - Hetero ring in the polycyclo ring system

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the polycyclo ring system contains
No. of patents: 715
Last issue date: 03/27/2012

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Number	Title	Issue Date
8143281	Indoles The present invention is concerned with novel indol-3-yl-carbonyl-piperidine-benzopyrrolone, -benzoxazolone and -benzotriazole derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of ...	03/27/2012
8093267	Methods of treating rheumatoid arthritis Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:	01/10/2012
8063070	Bicyclic benzamides of 3-or 4-substituted 4-(aminomethyl)-piperidine derivatives The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof. Processes for preparing said products, formula...	11/22/2011
8063069	Prucalopride-N-oxide The present invention is concerned with a novel benzamide derivative and the pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions comprising said novel compound, processes for preparing said compounds and compositions, and the use the...	11/22/2011
7951822	1,3-dihydroisobenzofuran derivatives The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases th...	05/31/2011
7928125	N-aroyl cyclic amine derivatives as orexin receptor antagonists Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists. ...	04/19/2011
7919509	2-oxochromene derivatives To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused ...	04/05/2011
7919508	3-piperidinylisochroman-5-ols as dopamine agonists The present invention provides compounds of formula I: a stereoisomer or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, X and n are defined as d...	04/05/2011
7893090	N-aroyl cyclic amine derivatives as orexin receptor antagonists Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists. ...	02/22/2011
7812034	Method of using protease inhibitors for the treatment of liposarcomas Liposarcomas are treated using HIV protease inhibitors, particularly nelfinavir. The protease inhibitors may be used alone or in combination with traditional cancer treatments, such as chemotherapy, radiotherapy, or surgery. ...	10/12/2010
7803814	Tricyclic steroid hormone nuclear receptor modulators The present invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and me...	09/28/2010
7790750	Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1 and R2 taken together...	09/07/2010
7732464	Heterocyclic substituted 4-(aminomethyl)-piperidine benzamides as 5HT-antagonists The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as...	06/08/2010
7652040	Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT-antagonists The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as...	01/26/2010
7649001	Fused benzene derivative and use The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ...	01/19/2010
7638535	4-(aminomethyl)-piperidine benzamides as 5HT-antagonists The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as...	12/29/2009
7635706	5HT-antagonistic 4-(aminomethyl)-piperidine benzamides The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as...	12/22/2009
7534801	Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor. ...	05/19/2009
7524864	Methods of treating sleep disorders The invention relates to novel antihistamines and methods of modulating sleep by administering a doxepin analog or a pharmaceutically effective salt thereof. ...	04/28/2009
7470710	N-aroyl cyclic amine derivatives as orexin receptor antagonists This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen, NR3 or a group (CH2), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an op...	12/30/2008
7425565	Use of benzothiopenes to treat and prevent prostate cancer Disclosed herein is a method for treating and preventing prostate cancer, and particularly androgen-independent prostate cancer, the method including administering to a mammal a benzothiopene having the formula or pharmaceu...	09/16/2008
7423052	Piperidine compounds for use as orexin receptor antagoinst A invention relates to N aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists. ...	09/09/2008
7396828	PI-3 kinase inhibitor prodrugs The invention provides prodrugs of inhibitors of PI-3 kinase. The compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine. ...	07/08/2008
7393862	Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias Methods of treating, preventing or managing leukemias are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as Revlimid® or lenalidomide. The invention further relates to methods of treatment using this compo...	07/01/2008
7393861	Derivatives of 4-aminopiperidine and their use as a medicament A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic method...	07/01/2008
7390798	Carboxamide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in...	06/24/2008
7378421	Chromenone derivatives Novel compounds of the formula I in which R1, R2, R3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for...	05/27/2008
7378399	Avermectins substituted in the 4″ and 4′-positions having pesticidal properties What is described are a compound of the formula (I) Wherein A-B is —CH═CH— or —CH2—CH2—; n is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl;...	05/27/2008
7371764	Quinolin-isoquinolin-and quinazolin-oxyalkylamides and their use as fungicides The present invention discloses fungicidal compounds and compositions of the formula (1): wherein the substituents R1, R2, R3, R4, R5, X, Y and Z are as defined in the ...	05/13/2008
7368476	Hydroxamates as therapeutic agents The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparin...	05/06/2008
7361657	Respiratory syncytial virus replication inhibitors This invention concerns the use of compounds of formula (I) wherein −a1=a2−a3=a4—is a radical of formula —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH—, —CH═CH—C...	04/22/2008
7355042	Treatment of CNS disorders using CNS target modulators The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositio...	04/08/2008
7345060	Compounds having βadrenergic receptor agonist and muscarinic receptor antagonist activity The invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7a, R7b, W, G1	03/18/2008
7342027	1-phenylpiperidin-3-one derivatives and processes for the preparation thereof Provided are 1-phenylpiperidin-3-one derivatives and pharmaceutically acceptable salts thereof, having cysteine protease inhibitory activity, pharmaceutical compositions containing the same as an active ingredient, and processes for the preparation thereof. ...	03/11/2008
7338953	Method of treating chronic fatigue syndrome Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual. ...	03/04/2008
7332508	Substituted homopiperidine, piperidine or pyrrolidine derivatives A novel class of substituted homopiperidine, piperidine and pyrrolidine derivatives, methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the histamine H3 receptor. More particularly, the...	02/19/2008
7329654	Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their prepar...	02/12/2008
7326721	Doxepin analogs and methods of use thereof The invention relates to novel doxepin analog compounds and methods of modulating sleep by administering such compounds, or a pharmaceutically effective salt thereof. ...	02/05/2008
7326720	Phenyl- and pyridylpiperidines with TNF activity The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independent...	02/05/2008
7317025	Non-peptidic NPY Y2 receptor inhibitors The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurologica...	01/08/2008

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Class 514/320 - Hetero ring in the polycyclo ring system