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| Number | Title | Issue Date |
| 5739135 | Inhibitors of microsomal triglyceride transfer protein and method Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R1 to R7 | 04/14/1998 |
| 5731313 | Use of anthracyclinone derivatives in amyloidosis The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and p... | 03/24/1998 |
| 5728715 | Dihydropyridazinones, pyridazinones and related compounds as fungicides This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula ##STR1## wherein A, Q, D and R1 are as defined within, compositions containing these compounds and methods of controlling agricultural and... | 03/17/1998 |
| 5714485 | Piperidine and hexahydropyridazine thrombin inhibitors Compounds of the invention have the following structure: ##STR1##... | 02/03/1998 |
| 5709867 | Polyaromatic amide compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic amides have the structural formula (I): ##STR1## wherein Z is a radical --CO--NH-- or --NH--CO--, and are useful for the treatment of a wide variety of disease states, whether human or vete... | 01/20/1998 |
| 5705509 | Tricyclic heterocyclic compounds as 5-HT4 receptor antagonists Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X1 --(CH2)x --X2 and the aromatic carbon atoms to which they are attached form 5-7 membered ring wherein X1 is O or S; X... | 01/06/1998 |
| 5691353 | Method of inhibiting aortal smooth muscle cell proliferation using naphthyl compounds The present invention provides a compound of formula I ##STR1## wherein R1 is H, OH, halo, OCO(C1 -C6 alkyl), OCO(aryl), OSO2 (C4 -C6 alkyl), OCOO(C1 -C6 alkyl), ... | 11/25/1997 |
| 5686468 | Methods of inhibiting hirsutism and alopecia in women A method of inhibiting hirsutism or alopecia in women comprising administering to a female human in need of treatment an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydrogen, --... | 11/11/1997 |
| 5686435 | Vitamin D amide derivatives The invention pertains to vitamin D amide derivatives of formula (I). These novel 1-hydroxy vitamin D derivatives and their 20-epi analogues comprise compounds of formula (I) and corresponding 5,6-trans isomers, where Y represents an alkylene or al... | 11/11/1997 |
| 5686465 | Sex steroid activity inhibitors Inhibitors of sex steroid activity, for example those having the general structure ##STR1## may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress estrogen synthesis. Such pharmaceutical composit... | 11/11/1997 |
| 5686467 | Methods of inhibiting imperfect tissue repair A method of inhibiting imperfect tissue repair or a physiological condition due at least in part thereto comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R | 11/11/1997 |
| 5686469 | Aminomethylene derivaties as immunosuppressants Compounds which suppress human T-lymphocyte proliferation are disclosed. The active compounds essentially contain at least the following structure: ##STR1##... | 11/11/1997 |
| 5686476 | Methods of inhibiting Alzheimer's Disease This invention encompasses methods for the inhibition of Alzheimer's Disease comprising administering to a human in need thereof an effective amount of a compound of Formula I ##STR1## wherein R1 and R3 are independently hydroge... | 11/11/1997 |
| 5672611 | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the Formula 1.0 to a biological system. I... | 09/30/1997 |
| 5670511 | Indolepiperidine derivatives Indolepiperidine derivatives of the formula I ##STR1## and their physiologically acceptable salts exhibit action on the central nervous system, in particular dopamine-agonistic or dopamine-antagonistic action.... | 09/23/1997 |
| 5668153 | Piperidine derivatives and their use as therapeutic agents Compounds of formula (I) ##STR1## exemplified by formulae (Ia) and (Ib) ##STR2## are tachykinin receptor antagonists useful in the treatment of disorders associated with the presence of an excess of tachykinins such as pain, inflammation, m... | 09/16/1997 |
| 5658931 | Method for inhibiting mammalian breast carcinoma with tamoxifen, and analogs thereof, and certain naphthyl compounds The present invention provides a method of inhibiting hormone-dependent breast carcinoma in a mammal comprising administering to said mammal in need of treatment an effective amount of a first component which is a compound of formula I ##STR1## ... | 08/19/1997 |
| 5656606 | Camphor compounds promote release of growth hormone The present invention is directed to certain novel compounds identified as camphor derivatives of the general structural formula: ##STR1## wherein A, X, Y, R2a, R4, and R5 are as defined herein. These compounds promot... | 08/12/1997 |
| 5654306 | Piperidine derivative and pharmaceutical composition A piperdine derivative having the formula (I) or a pharmacologically acceptable salt thereof: R1 --X--A--R2 (I) wherein R1 is selected from the group consisting of substituted or unsubstituted... | 08/05/1997 |
| 5654299 | Aryl substituted heterocycles The present invention concerns the novel use of aryl substituted heterocycles of formula I, set out below, which antagonize the pharmacological actions of one of ent endogenous neuropeptide tachykinins an the neurokinin 2 (NK2) receptor making them useful... | 08/05/1997 |
| 5652259 | Methods of inhibiting Alzheimer's disease This invention encompasses methods for the inhibition of Alzheimer's Disease comprising administering to a human in need thereof an effective amount of a compound of Formula I ##STR1## wherein R1 and R3 are independently hydroge... | 07/29/1997 |
| 5650442 | Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric ox... | 07/22/1997 |
| 5646144 | 1-acylpiperidine compounds 1-Acylpiperidine compound of the formula I ##STR1## in which R1 is an optionally substituted aralkyl, aryloxyalkyl, heteroaralkyl, aroyl, heteroaroyl, cycloalkylcarbonyl, aralkanoyl, heteroarylalkanoyl, aralkoxycarbonyl or arylcarbamoyl ra... | 07/08/1997 |
| 5639763 | Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines Compounds of the following structure, the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: ##STR1## in which U is selected from --(CH2)n -- and ethylidene; Q is selected from h... | 06/17/1997 |
| 5639766 | N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to therapeutically active azaheterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment rela... | 06/17/1997 |
| 5637598 | Methods of inhibiting bone loss The instant invention provides methods for inhibiting bone loss comprising adminstering to a mammal in need of treatment a compound as provided in formula I.... | 06/10/1997 |
| 5637310 | Method of treating prostatic adenocarcinoma Invented is a Method of Treating Prostatic Adenocarcinoma by employing asteroid 5--reductase inhibiting compound or a combination of steroid 5--reductase inhibiting compounds.... | 06/10/1997 |
| 5635537 | 8-substituted-2-aminotetralins A compound of the formula ##STR1## Z is hydrogen or halogen, Q is COR1 or 5-or 6-membered aryl which may contain 1 or 2 heteroatoms selected from N, 0 or S and may be substituted or fused wherein R is hydrogen or C1 -methyl (cis... | 06/03/1997 |
| 5635518 | N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to therapeutically active azaheterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment rela... | 06/03/1997 |
| 5622975 | Methods for inhibiting vascular smooth muscle cell migration Methods of inhibiting vascular smooth muscle cell migration comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independent... | 04/22/1997 |
| 5622971 | Endothelin antagonists A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.... | 04/22/1997 |
| 5622973 | Treatment of osteoporosis with substituted piperidines, pyrrolidines and hexahydro-1H-azepines in combination with bisphosphonates The present invention is directed to certain novel compounds identified as di- and tri-substituted piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R1, R4, R5, A... | 04/22/1997 |
| 5620991 | Aromatic amidine derivatives and salts thereof An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: ##STR1## wherein the group represented by ##STR2## is a group selected from ... | 04/15/1997 |
| 5610157 | N-(3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzo-dioxin) carboxamide derivatives N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives, their N-oxide forms and pharmaceutically acceptable salts having gastrointestinal motility stimulating properties, compositions containing ... | 03/11/1997 |
| 5607949 | [(Benzodioxan, benzofuran or benzopyran) alkylamino] alkyl substituted guanidines The present invention is concerned with vasoconstricive [(benzodioxan, benzofuran or benzopyran)alkylamino]alkyl substituted guanidines having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, and the stereochemic... | 03/04/1997 |
| 5605926 | Trifluoromethyl-containing pseudopeptides active against retroviruses The present invention relates to new trifluoromethyl-containing pseudopeptides of the general formula (I) ##STR1## in which W, A, B, D, E, R1, R2 and R3 have the meaning as outlined of their making and use as pharmace... | 02/25/1997 |
| 5604242 | Heterocyclic chemistry The present invention relates to therapeutically active azaheterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment rela... | 02/18/1997 |
| 5597826 | Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist The present invention relates to novel compositions containing the serotonin selective re-uptake inhibitor (SSRI), preferably (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenam ine, and an agonist or antagonist of the serotonin 1 (5... | 01/28/1997 |
| 5596004 | Methods of inhibiting male infertility A method of inhibiting male infertility comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R1 and R3 are independently hydrogen, --CH3, ##STR2## ... | 01/21/1997 |
| 5589486 | N-hydroxyalkyl-substituted 1,2,3,6-tetrahydro-pyridine and piperidine derivatives The invention relates to novel N-hydroxy-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives of the formula ##STR1## wherein A, B, D, E, G, I and R are as defined in the specification, m is 0, 1 or 2, with the proviso that: m is 0 or 2,... | 12/31/1996 |
