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| Number | Title | Issue Date |
| 8173677 | Compositions and methods for effecting NADlevels using a nicotinamide phosphoribosyl transferase inhibitor The present invention relates to methods for decreasing cellular DNA repair in a patient diagnosed with or suspected to have chronic lymphocytic leukemia (CLL); decreasing cellular NAD+ biosynthesis in a patient diagnosed with or suspected to have CLL; or... | 05/08/2012 |
| 8158652 | Substituted pyridone derivative Compounds of a formula (I) [wherein, A represents formula (III-1) R3 is a hydrogen, lower alkyl et al; m is 0 or 1; R1 is a hydrogen atom, halogen atom et al, R2 is a hydrogen et ... | 04/17/2012 |
| 8148400 | Thiazolyl compounds useful as kinase inhibitors The invention provides compounds of formula II: and pharmaceutically acceptable salts thereof. The formula II thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the ... | 04/03/2012 |
| 8124626 | Methods of treating inflammations and infections with pyridinium salts Compounds of pyridinium salts and methods of their use in medicine, particularly in the prophylaxis and treatment of inflammatory conditions, infectious conditions, as well as immune disorders are disclosed. The present invention also relates to methods of controlli... | 02/28/2012 |
| 8124625 | Method of enhancing the expression of apolipoprotein AI using olefin derivatives Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic het... | 02/28/2012 |
| 8106074 | Pyridin-2-yl-methylamine derivatives for treating opiate dependence The invention concerns the use pf compounds of general formula (I) for treating opioid drug dependence, hyperalgesia induced by opiate drug withdrawal and psychological craving induced by opiate drug withdrawal. ... | 01/31/2012 |
| 8088796 | Triamine derivative An object of the present invention is to provide a novel compound which has a potent inhibitory effect on FXa and exhibits an excellent antithrombotic effect when orally administered. The present invention provides a compound represented by the following general for... | 01/03/2012 |
| 8076359 | Renin inhibitors The present invention relates to disubstituted piperidinyl renin inhibitor compounds having the structure (Formula I) and their use in treating cardiovascular events and renal insufficiency. ... | 12/13/2011 |
| 8063068 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or trea... | 11/22/2011 |
| 8044070 | Heteroaryloxy nitrogenous saturated heterocyclic derivative Provided are compounds of a formula (I) and their pharmaceutically-acceptable salts: wherein X1, X2 and X3 each independently represent N or CH; W represents the following formula (II): | 10/25/2011 |
| 8039487 | Piperidine-amide derivatives The invention is concerned with novel piperidine-amide derivatives of formula (I) wherein R1, R2, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salt... | 10/18/2011 |
| 8012993 | Stable S-nitrosothiols, method of synthesis and use The present invention relates to stable S-nitrosothiols derivatives of formula (I) having vasodilating effect and which inhibit the aggregation of the platelets and which therefore are useful for the preparation of medicame... | 09/06/2011 |
| 7973056 | Triazole derivative or salt thereof A triazole derivative or pharmaceutically acceptable salt thereof is provided, the triazole derivative being represented by formula (I): wherein * represents an asymmetric carbon and takes R configuration or S configuration... | 07/05/2011 |
| 7964618 | Chemical compounds Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described. ... | 06/21/2011 |
| 7960411 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4 I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycl... | 06/14/2011 |
| 7928124 | N-aroyl cyclic amine derivatives as orexin receptor antagonists Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 04/19/2011 |
| 7919507 | N-aroyl cyclic amines Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals. ... | 04/05/2011 |
| 7919506 | Dibenzyl amine compounds and derivatives Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such ... | 04/05/2011 |
| 7915294 | Method of treating colorectal carcinoma A method is disclosed for detecting colorectal carcinoma having at least one HERG potassium ion channel, where at least one HERG potassium channel is detected in a tissue biopsy of the human color or rectum. In addition, a method is disclosed for treating colorectal... | 03/29/2011 |
| 7879880 | Substituted aniline derivatives useful as histamine H3 antagonists Disclosed are compounds of the formula or a pharmaceutically acceptable salt thereof, wherein M1 is M | 02/01/2011 |
| 7858643 | Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal ce... | 12/28/2010 |
| 7846946 | Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine Hantagonists Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF o... | 12/07/2010 |
| 7834031 | Radiolabeled glycine transporter inhibitors The present invention is directed to radiolabeled glycine transporter inhibitors which are useful for the labeling and diagnostic imaging of glycine transporters in mammals. ... | 11/16/2010 |
| 7825135 | Heteroaryl piperidine glycine transporter inhibitors The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutam... | 11/02/2010 |
| 7825136 | Potentiators of antibacterial activity The present invention relates to compounds that potentiate the activity of antibacterials. The present invention also relates to compositions useful in treating bacterial infection in mammals, and methods therewith. The present invention also relates to a method of ... | 11/02/2010 |
| 7825137 | Method of treating abnormal cell growth The present invention relates to the use of (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, a novel c-Met/HGFR inhibitor, for treating abnormal cell growth in mammals. In particular, the invention provides meth... | 11/02/2010 |
| 7820696 | Compounds and methods for controlling fungi, bacteria and insects The present invention includes compounds of pyridinium salts and methods of their use for industrial uses. The present invention also relates to methods of controlling fungi and/or bacteria. The present invention may also be used to control insects. ... | 10/26/2010 |
| 7803813 | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-HT1F agonists The present invention relates to compounds of formula I: or a pharmaceutically acceptable acid addition salt thereof, wherein X is C(R3c)═ or N═; R1 is C2-C6 alkyl, substitute... | 09/28/2010 |
| 7799805 | Piperidine carboxylic acid amide derivatives The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel comp... | 09/21/2010 |
| 7790748 | N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones Compounds of Formula (I): are effective in the treatment of a microbial infection. ... | 09/07/2010 |
| 7790747 | Chemokine receptor binding compounds The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrat... | 09/07/2010 |
| 7767694 | Pharmaceutical composition having prokinetic effect The present invention is directed to a method of treating gastrointestinal motility disorders in a subject in need thereof which includes: administering a therapeutically effective amount of O-(3-piperidino-2-hydroxypropyl) nicotinic amidoxime or a pharmaceutically ... | 08/03/2010 |
| 7745465 | Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular cha... | 06/29/2010 |
| 7741341 | Benzimidazole-derivatives as factor Xa inhibitors The present invention relates to compounds of the formula I, wherein R0, R1, R2, Q, V, G and M are as defined herein. The compounds of the formula I are valuable pharmacologically active com... | 06/22/2010 |
| 7723359 | Benzoimidazole compounds Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions. ... | 05/25/2010 |
| 7713998 | Nitrogenous heterocyclic compound and pharmaceutical use thereof The present invention relates to a compound that has p38 MAP kinase inhibitory activity useful as drug medicine, represented by the general formula (I): wherein all the symbols are as defined in the... | 05/11/2010 |
| 7709500 | Chemical compounds The invention provides compounds of formula (I): wherein: X is CH2, O, S(O)2 or NR10; Y is a bond, CH2, NR35, CH2NH, CH2NHC(O), CH(OH), CH(NHCOR | 05/04/2010 |
| 7700624 | 3-aminocyclopentanecrboxamides as modulators of chemokine receptors The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokin... | 04/20/2010 |
| 7691881 | 1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-HTreceptor agonistic activity This invention provides a compound of formula (I): wherein R1 represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom, R2 represents an alkyl group having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or... | 04/06/2010 |
| 7645775 | Triazoles useful as inhibitors of protein kinases The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. ... | 01/12/2010 |
