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| Number | Title | Issue Date |
| 7528152 | Hemiasterlin derivatives and uses thereof in the treatment of cancer The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1 | 05/05/2009 |
| 7514453 | Method for enhancing mutant protein activity Provided is a method for enhancing the activity of a protein, which protein when mutated, folds in an incorrect conformation in the endoplasmic reticulum, by contacting the protein with an effective amount of a compound which specifically binds to the protein and in... | 04/07/2009 |
| 7501439 | Tartrate salt of isofagomine and methods of use A novel tartaric acid salt of Isofagomine (Isofagomine tartrate) that can be used for the treatment of Gaucher disease is provided. The invention also provides a crystalline form of isofagomine tartrate, method for preparing the salt, a pharmaceutical composition co... | 03/10/2009 |
| 7495012 | Arylsulfonamides and uses related thereto Arylsulfonamide compounds of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: ... | 02/24/2009 |
| 7473697 | 2-Oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders This invention relates to new 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives of formula (1) having anticonvulsant activity which are useful as therapeutic agents for the treatment or prevention of epilepsy and other neurological disorders. The inven... | 01/06/2009 |
| 7442711 | Amelioration of the development of cataracts and other ophthalmic diseases Ophthalmically acceptable compositions used in arresting the development of cataracts or macular degeneration comprising a pharmaceutically acceptable carrier or diluent and a compound having the formula: where R1 | 10/28/2008 |
| 7432283 | Heterocyclic GABAsubtype selective receptor modulators This invention relates to a method for modulating α2 subtype GABAA receptors with heterocyclic compounds of formula I, and salts, solvates and prodrugs thereof. The invention further relates to novel heteocyclic compounds and pharmaceutical co... | 10/07/2008 |
| 7432284 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 10/07/2008 |
| 7423170 | Anticancer agents based on regulation of protein prenylation Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g.... | 09/09/2008 |
| 7417042 | Compounds for enzyme inhibition Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited b... | 08/26/2008 |
| 7393862 | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias Methods of treating, preventing or managing leukemias are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as Revlimid® or lenalidomide. The invention further relates to methods of treatment using this compo... | 07/01/2008 |
| 7390821 | Methods of reducing angiogenesis The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a nicotinic acetyl choline receptor antagonist. The methods are useful to treat conditions associat... | 06/24/2008 |
| 7387271 | Immunostimulatory combinations The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen. ... | 06/17/2008 |
| 7388112 | Immunomodulation with novel pharmaceutical compositions The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. Examples are those having the structures: wherein a, b and c are integers from 0 to 12, X equals NH or CH... | 06/17/2008 |
| 7384959 | Treatment of convulsive states Single enantiomer-threo-methylphenidate is useful in the therapy of a convulsant state, e.g. epilepsy, a bipolar disorder or narcolepsy. It may be administered topically. ... | 06/10/2008 |
| 7381727 | Pyrrole derivatives, their preparation and their therapeutic use The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The in... | 06/03/2008 |
| 7371746 | 1,2,4-Thiadiazole compounds and pests controlling composition containing the same The present invention relates to a 1,2,4-thiadiazole compound of the formula (I) represented by the formula (1): wherein R1? represents C3-C7 alkynyl and X represents C4-C7 straight alkylene optionally substituted with one to four of R2?, C4-C7 straight alkenylene o... | 05/13/2008 |
| 7361669 | Compositions and method for inhibiting TGF-β This invention provides compounds that are inhibitors of the TGF-β signaling pathway. The compounds are represented by formula I: where A′ is N or CH; Ring B is preferably an triazolyl, imidazolyl, or thiazolyl ring; —... | 04/22/2008 |
| 7361215 | Material and method for treatment of timber A material and method for treating timber. The material comprises a preservative and a carrier. The carrier is selected such that it remains mobile within the wood and provides for migration of the preservative within the treated wood. By providing a carrier which i... | 04/22/2008 |
| 7355042 | Treatment of CNS disorders using CNS target modulators The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositio... | 04/08/2008 |
| 7351717 | Substituted pyrrolidine and related compounds This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer ... | 04/01/2008 |
| 7351718 | Substituted pyrrolidine and related compounds This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer ... | 04/01/2008 |
| 7345059 | Diphenylpyridine derivatives, preparation and therapeutic application thereof The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I): where: R1 represents hydrogen or a (C1-C4)alkyl; ... | 03/18/2008 |
| 7342043 | Medicinal compositions improving brain function and method for improving brain function An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-... | 03/11/2008 |
| 7338976 | Heterocyclic esters or amides for vision and memory disorders This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic esters and amides. ... | 03/04/2008 |
| 7338952 | Acetylenic compounds useful in treating inflammatory disorders This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorder. ... | 03/04/2008 |
| 7335681 | Amino ceramide-like compounds and therapeutic methods of use Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer sy... | 02/26/2008 |
| 7332176 | viruses Unique Solenopsis invicta viruses (SINV) have been identified and their genome sequenced. Oligonucleotide primers have been developed using the isolated nucleic acid sequences of the SINV. The viruses are used as a biocontrol agent for control of fire ants. | 02/19/2008 |
| 7320978 | Oxazole derivatives, preparation and therapeutic use thereof This invention relates to compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as described herein. The i... | 01/22/2008 |
| 7317025 | Non-peptidic NPY Y2 receptor inhibitors The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurologica... | 01/08/2008 |
| 7317026 | CNS target modulators The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. More specifically, the invention is directed to derivatized, e.g., ester or carboxylic acid derivatized, doxepins, and analogs thereof, useful for the treatment of sl... | 01/08/2008 |
| 7312218 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or hetero... | 12/25/2007 |
| 7312219 | Heteroaromatic inhibitors of fructose 1,6-bisphosphatase Novel FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 12/25/2007 |
| 7309709 | Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula: wherein R1 to R6, X, Z and A are as defined. These compounds have activity inhibiting production of Aβ-peptide. The invention also... | 12/18/2007 |
| 7304050 | Antibacterial agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I a... | 12/04/2007 |
| 7291679 | Recyclable polymer and process for production thereof A novel resin is provided which is renewable with less energy. A process for renewing the resin is also provided. The present invention includes a polymer having the repeating unit represented by Structural Formula (1) below, and a process for producing the polymer:... | 11/06/2007 |
| 7291633 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands Compounds of the formula I in which R1, R2, R3 and R4 are as defined in claim 1, are ligands of the nicotinic acetylcholine receptor and/or serotonergic ligands and are suitable for the prophylaxis or treatment of psychose... | 11/06/2007 |
| 7285544 | Use of nitroxides in treating skin disease Methods of treating inflammatory skin diseases such as rosacea, atopic dermatitis, contact dermatitis, drug eruptions, psoriasis, seborrheic dermatitis, connective tissue diseases, autoimmune disorders, urticaria or hives, and inflammation associated with skin infec... | 10/23/2007 |
| 7283151 | Pixel clock generation device causing state transition of pixel clock according to detected state transition and phase data indicating phase shift amount A transition detection circuit detects a transition of a state of a pixel clock, and outputs a detection signal according to a timing of the detected state transition. A control signal generation circuit generates a control signal according to the detection signal a... | 10/16/2007 |
| 7282499 | Sigma receptor inhibitors The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to some pyrazole derivatives, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy... | 10/16/2007 |
