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| Number | Title | Issue Date |
| 6048854 | 2,3-diaminopropionic acid derivative The present invention relates to a 2,3-diaminopropionic acid derivative of the formula (1): ##STR1## or a pharmaceutically acceptable salt thereof. The compounds of the present invention are useful as a platelet aggregation inhibitor, a cancer m... | 04/11/2000 |
| 6043251 | Use of 1-(2-naphth-2-ylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyr idine for preparing drugs for treating amyotrophic lateral sclerosis The present invention relates to the use of 1-(2-naphth-2-ylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid ine or its addition salts with pharmaceutically acceptable acids for the preparation of drugs intended for the treatment of amyotrophic l... | 03/28/2000 |
| 6037347 | Combination preparation for use in dementia The invention relates to a composition which is a pharmaceutical combination preparation comprising a compound which has an acetylcholinesterase-inhibitory action or exhibits muscarinergic action and a compound which increases the endogenous extracellular... | 03/14/2000 |
| 6037351 | Method of inhibiting hepatitis B virus A method is disclosed for the treatment of hepatitis B virus (HBV) infections which comprises administering to the infected host an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which the alkyl group contains from 3 to 6 carbon atoms.... | 03/14/2000 |
| 6037334 | Phosphonates, process for preparing the same and medicaments Compounds of formula I ##STR1## in which R1, R2 are the same or different and denote a hydrogen atom, an alkyl group, a cycloalkyl group, a hydroxyalkyl group, an alkenyl group, an alkinyl group or an aralkyl group or R1 | 03/14/2000 |
| 6037352 | Muscarinic antagonists Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R1, R2, R3, R4, R21, R... | 03/14/2000 |
| 6034067 | Serine protease inhibitors The invention relates to a compound having formula (I), wherein A, B, X, N, Z and Q are defined as described in the description. The compounds of the invention have anticoagulant activity and can be used in treating or preventing thrombin-related diseases... | 03/07/2000 |
| 6034081 | Potentiation of biocide activity using an N-alkyl heterocyclic compound A method for increasing the effectiveness of a microbicide is described, wherein a microbicide and an N-alkyl heterocyclic compound are applied to a substrate or aqueous system subject to the growth of microorganisms. The N-alkyl heterocyclic compound is ... | 03/07/2000 |
| 6030971 | Methods and compositions for controlling biofouling using amides The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amide to inhibit bacterial adhesion to the submergible surface. The ... | 02/29/2000 |
| 6030952 | Benzofuran-acrylic acid derivatives and their use as modulators of RXRs or RARs receptors The present invention provides novel heteroaryl compounds having the general formula (I): ##STR1## their pharmaceutical compositions to be used as human and veterinary medicine, particularly in the treatment of dermatological, rheumatic, respira... | 02/29/2000 |
| 6028082 | Human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them Compounds of formula (I), a method for obtaining them and pharmaceutical compositions containing them are described. The compounds are useful as human NK3 receptor antagonists.... | 02/22/2000 |
| 6025371 | Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones The invention provides chemistry libraries containing fused 2,4-pyrimidinediones. The invention also provides methods for the construction of fused 2,4-pyrimidinedione containing libraries. The invention further provides methods for the identification of ... | 02/15/2000 |
| 6020344 | Enzyme inhibitors and methods of use Novel enzyme-inhibitory compounds are disclosed. The subject invention further pertains to methods and compositions for the inhibition of bacteria, viruses, parasites, and other pathogens.... | 02/01/2000 |
| 6020368 | Carbamoyloxy derivatives of mutiline and their use as antibacterials Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the... | 02/01/2000 |
| 6017929 | Cholinesterase activator The invention relates to a cholinesterase activator comprising, as an active ingredient, a compound represented by the following general formula (I): ##STR1## wherein A means a group such as a phenyl group or indanyl group, B denotes a group suc... | 01/25/2000 |
| 6015837 | Method for treating scoliosis with 댢-adrenoceptor agonists A method of treating scoliosis by adminstering 댢 adrenergic agonists in amounts sufficient to correct the condition.... | 01/18/2000 |
| 6011035 | Calcium channel blockers Compounds of the formula ##STR1## wherein m is 0, 1 or 2; wherein when m is 0, Z is O, when m is 1, Z is N, and when m is 2, Z is C; Y is H, OH, NH2, or an organic moiety of 1-20C, optionally additionally containing 1-8 heteroatoms selecte... | 01/04/2000 |
| 6008244 | Halopropargyl compounds as marine antifouling agents Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying onto or into the marine structure a halopropargyl quaternary ammonium compound, halopropargyl benzoxazolone compound, or halopropargylhydantoin compound.... | 12/28/1999 |
| 6004933 | Cysteine protease inhibitors The present invention relates to cysteine protease inhibitors of the general formula (I): ##STR1## wherein Z is a cysteine protease binding moiety; X and Y are S, O or optionally substituted N; and R1 is optionally substituted alkyl or ... | 12/21/1999 |
| 6004977 | N-(pyridinylamino) isoindolines and related compounds Novel N-(pyridinylamino)isoindolines and related compounds, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the N-(pyridinylamino)isoindolines and related compounds, th... | 12/21/1999 |
| 6001853 | Hydroxylamine compositions for the prevention or retardation of cataracts A pharmaceutical composition and treatment to inhibit the development of cataracts in the crystalline lens of the eye by administering a hydroxylamine to a subject at risk of developing a cataract. The pharmaceutical composition comprises a hydroxylamine ... | 12/14/1999 |
| 5985926 | Method for inhibiting intracellular viral replication There is disclosed a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans by administering an effective amount of a compound that inhibits cellular signaling... | 11/16/1999 |
| 5977180 | Anandamide analog compositions and method of treating intraocular hypertension using same Anandamide analogues useful for the treatment of intraocular hypertension, as well as ophthalmic compositions comprising the same and a cyclodextrin, and methods of use of these compounds to treat intraocular hypertension.... | 11/02/1999 |
| 5972940 | Arginine analogues having nitric oxide synthase inhibitor activity A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and --NO2, E is --O-- or a covalent bond, n is an integer from 1 to 12, R1... | 10/26/1999 |
| 5972892 | Topical composition containing a substance P antagonist The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating the irritant effect of this product. It also relates to t... | 10/26/1999 |
| 5972952 | Neuroprotective pharmaceutical composition containing stereoisomers of arylcyclohexylamines The invention relates to pharmaceutical compositions for neuroprotection containing the compound (1S,2R) 1-[1-(2-thienyl)-2-alkylcyclohexyl]piperidine or (1S,2R) 1-[1-(2-furanyl)-2-alkylcyclohexyl]piperdine, or their pharmaceutically acceptable salts... | 10/26/1999 |
| 5972962 | Treatment of pruritus The use of certain known 1,3,4 trisubstituted 4-aryl-piperidines for the treatment of pruritus in humans and animals is disclosed.... | 10/26/1999 |
| 5958881 | Composition containing VIP for injection and a method of enhancing visualization of tissues during medical procedures A method of inducing a temporary substantial paralysis of an area of interest in a patient undergoing a medical procedure is provided. The method involves administering a therapeutically effective amount of vasoactive intestinal peptide (VIP) admixed with... | 09/28/1999 |
| 5948912 | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands Disclosed are compounds encompassed by general formula (I), wherein, A represents ethenylene, or A represents --X--CH2 --; where X is carbon or oxygen, provided that when X is oxygen, the oxygen is adjacent the 6-membered ring; R1, R... | 09/07/1999 |
| 5945420 | Immunopotentiating and infection protective agent and production thereof An immunopotentiating and infection protective agent comprising riboflavin and/or a riboflavin derivative, which is safe for the human, animals or the like, an immunopotentiating and infection protective agent comprising riboflavin and/or a riboflavin der... | 08/31/1999 |
| 5942548 | Use of ethynyl alanine amino diol compounds for treatment of hypertension Compounds characterized generally as ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of cardiovascular disorders. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO a... | 08/24/1999 |
| 5935953 | Methods for controlling invertebrate pests using cocaine receptor binding ligands The invention relates to a method of controlling an invertebrate pest, comprising contacting the pest with a pest-controlling amount of an agent having substantial inhibitory activity toward a phenylethanolamine reuptake transporter as determined by radio... | 08/10/1999 |
| 5929088 | Cyclic amino acids as pharmaceutical agents Novel cyclic amino acids of formula (Ia) or (Ib) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropathological d... | 07/27/1999 |
| 5925646 | Heterocyclic aryl-, alkyl- and cycloalkylacetamides The heterocyclic aryl-, alkyl- and cycloalkylacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compou... | 07/20/1999 |
| 5925634 | Use of ibogaine for treating neuropathic pain This invention discloses that ibogaine, a plant derivative, can be used safely to treat neuropathic pain (i.e, pain which does not respond conventionally to opiate drugs such as morphine). Ibogaine functions inside the CNS as an NMDA antagonist which is i... | 07/20/1999 |
| 5925616 | Treatment of fungal infections using a combination of an anti-fungal compound and an H-alkyl heterocyclic compound A method for increasing the effectiveness of an anti-fungal compound is described. In the method, an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof are administered to a mammal in a combined amount effective to treat a fungal ... | 07/20/1999 |
| 5919781 | Use of NK-1 receptor antogonists for treating substance use disorders The present invention provides a method for the treatment or prevention of substance use disorders using an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such a NK-1 receptor antagonist.... | 07/06/1999 |
| 5919829 | Gastrin and cck receptor ligands Compounds of formula (Ia), (Ib), or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R1.sub.(m) represents up to 6 substituents, K represents --O--, --S--, --CH2 --, --N(R2)-- or --N(C... | 07/06/1999 |
| 5914324 | 6-Hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same 6-hydroxy and 6-oxo-androstane derivatives of formula (I), active on the cardiovascular system. ##STR1## wherein: the symbol A represents CH--OR, C.dbd.N--OR, CH--CH.dbd.N--OR and C.dbd.CH--N--OR; and R1, R2 and R3 ar... | 06/22/1999 |
| 5912255 | Topical fluoroquinolone antibiotics combined with benzoyl peroxide A pharmaceutical composition of all fluoroquinolones, including but not limited to, ciprofloxacin, ofloxacin, enoxacin, cinoxacin, pefloxacin, lomefloxacin, norfloxacin, tosufloxacin, fleroxacin, temafloxacin, trovafloxacin, and difloxacin, mixed with ben... | 06/15/1999 |
