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| Number | Title | Issue Date |
| 8183258 | Heterocyclic compounds and their uses Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psorias... | 05/22/2012 |
| 8183259 | Heterocyclic compounds and their uses Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psorias... | 05/22/2012 |
| 8178558 | Substituted pyridylmethyl bicycliccarboxyamide compounds This invention relates to novel substituted pyridylmethyl bicyclocarboxamide compounds and to their use in therapy. These compounds are particularly useful as modulators of the VR1 (Type I Vanilloid) receptor, and are thus useful for the treatment of pain, neuralgia... | 05/15/2012 |
| 8148399 | Macrocyclic inhibitors of hepatitis C virus Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; ... | 04/03/2012 |
| 8119660 | Small-molecule inhibitors of the androgen receptor The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: or a compound of Formula II: wherein R1, R2 | 02/21/2012 |
| 8114893 | Compounds and methods of use In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are... | 02/14/2012 |
| 8044068 | Aminopyrrolidine compound Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia,... | 10/25/2011 |
| 8026253 | Quinoline inhibitors of HCV polymerase Compounds having the formula I wherein wherein R1, R2, R3, R4, X1, X2, X3 and X4 and as defined herein are Hepatitis C virus NS5b polym... | 09/27/2011 |
| 8008324 | Indole derivatives and their use as medicament The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors. ... | 08/30/2011 |
| 7998980 | Compounds for modulating TRPV3 function The present application relates to compounds and methods for treating pain and other conditions related to TRPV3. ... | 08/16/2011 |
| 7977355 | N-(2-hydroxyethyl)-N-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl N-(2-hydroxyethyl)-N-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, pharmaceutically acceptable salts thereof, and/or mixtures thereof, as well as, pharmaceutical compositions thereof, methods of treatment therewith, and processe... | 07/12/2011 |
| 7960409 | Pharmaceutical phenylquinoline and chromen-2-one triazole compounds The instant invention provides compounds of Formula I which are leukotriene biosynthesis inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotec... | 06/14/2011 |
| 7947713 | Tripeptidyl peptidase inhibitors The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as cholecystokinis (CCKs). The invention further relates to methods for ... | 05/24/2011 |
| 7943641 | 7-((1H-imidazol-4-yl)methyl)-5,6,7,8-tetrahydroquinoline A compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 05/17/2011 |
| 7915292 | Antibacterial quinoline derivatives The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines ther... | 03/29/2011 |
| 7884114 | Compounds The present invention relates to a compound which is N-(4-{4-[(6-butyl-8-quinolinyl)oxy]-1-piperidinyl}butyl)ethanesulfonamide and salts thereof, processes for its preparation, to compositions containing it and to its use i... | 02/08/2011 |
| 7872020 | TGF-β inhibitors The present invention provides crystalline 2-(6-methyl-pyridin-2-yl)-3-[6-amido-quinolin-4-yl)-5,6-dihydro -4H-pyrrolo[1,2-b]pyrazole monohydrate. ... | 01/18/2011 |
| 7858641 | Substituted dihydroisoquinolinone compounds A variety of low molecular weight, guanidino-containing dihydroisoquinolinoines capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure ID where the values of the variable are d... | 12/28/2010 |
| 7858642 | Substituted hydroxyethylamine aspartyl protease inhibitors The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal... | 12/28/2010 |
| 7834030 | Phenyl-[1,2,4]-oxadiazol-5-one derivatives, pharmaceutical compositions and therapeutic use thereof The present invention comprises phenyl-[1,2,4]-oxadiazol-5-one derivatives of the general formula I: wherein the R1-R10 and B, U, V, W, X, Y and Z substituents are defined herein. The claimed invention also comprises the co... | 11/16/2010 |
| 7825131 | Quinoline potassium channel inhibitors The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like. ... | 11/02/2010 |
| 7825132 | Inhibition of FGFR3 and treatment of multiple myeloma Methods of inhibiting fibroblast growth factor receptor 3 and treating various conditions mediated by fibroblast growth factor receptor 3 are provided that include administering to a subject a compound of Structure I, a pharmaceutically acceptable salt thereof, a ta... | 11/02/2010 |
| 7807694 | Chemokine receptor binding heterocyclic compounds Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole. ... | 10/05/2010 |
| 7776883 | Quinolin-4-ones as inhibitors of retroviral integrase for the treatment of HIV, AIDS and AIDS related complex (ARC) Novel quinoline inhibitors of retroviral integrase, particularly HIV-1 integrase. The quinoline inhibitors are oxoquinolines that can be used for preventing or treating AIDS or HIV infection in a subject. ... | 08/17/2010 |
| 7772250 | Compounds This invention relates to cinnamate salts of 5-[(R)-2-(2-{4-[4-(2-amino-2-methyl-propoxy)-phenylamino]-phenyl}-ethylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one. ... | 08/10/2010 |
| 7754735 | Substituted indoles The present invention relates to substituted indoles of formula (I), useful as pharmaceutical compounds for treating respiratory disorders. ... | 07/13/2010 |
| 7745463 | Alkene piperidine derivatives as antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine derivatives that possess unique antiviral activity. More particularly,... | 06/29/2010 |
| 7705018 | Substituted quinolines and their uses in treatment of inflammatory and related conditions Substituted bicyclic heteroaryls having the general formula and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammat... | 04/27/2010 |
| 7700621 | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R1a, R1b, R2a, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G... | 04/20/2010 |
| 7696227 | Small-molecule inhibitors of the androgen receptor The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: or a compound of Formula II: wherein R1, R2 | 04/13/2010 |
| 7696226 | HIV protease inhibiting compounds A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed. ... | 04/13/2010 |
| 7687517 | 3,9-Diazabicyclo [3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors Novel 3,9-diazabicyclo[3.3.1]nonane derivatives of formula (I) useful as monoamine neurotransmitter re-uptake inhibitors are provided: These compounds can also be used in methods for therapy and be included in pharmaceutica... | 03/30/2010 |
| 7687516 | Alcohol free formulation of argatroban An aqueous formulation of argatroban and of related compounds is disclosed along with a reconstitutable formulation, each of which is substantially, if not totally alcohol free. The formulations are also substantially free, if not totally free, of mono-, di-, and ol... | 03/30/2010 |
| 7671070 | Method of treating ophthalmic infections with moxifloxacin compositions Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal cond... | 03/02/2010 |
| 7662834 | Methods of 1H-indol-3-yl-2-oxoacetamide compounds This invention relates to treating cancer or an angiogenesis-related disease using a compound of formula 1: wherein R1, R2, R3, R4, and n are defined herein. ... | 02/16/2010 |
| 7659286 | N-(2-hydroxyethyl)-N-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide N-(2-hydroxyethyl)-N-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, pharmaceutically acceptable salts thereof, and/or mixtures thereof, as well as, pharmaceutical compositions thereof, methods of treatment therewith, and processe... | 02/09/2010 |
| 7648999 | Activator for peroxisome proliferator-activated receptor δ A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having... | 01/19/2010 |
| 7592357 | Compounds Novel Inhibitors of Rho-kinases are disclosed. ... | 09/22/2009 |
| 7592358 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds Alkyne compounds having MCH-receptor antagonistic activity, which are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes. ... | 09/22/2009 |
| 7589106 | Alcohol free formulation of argatroban An aqueous formulation of argatroban and of related compounds is disclosed along with a reconstitutable formulation, each of which is substantially, if not totally alcohol free. The formulations are also substantially free, if not totally free, of mono-, di-, and ol... | 09/15/2009 |
