Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 5962468 | 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1- cyclopropyl-6-fluoro-4-oxo-1, 4-dihydro-1, 8-naphthyridine-3-carboxylic acid and the process for the preparation thereof The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically, the present invention relates to 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4 -oxo-1,4-dihydro-1,8... | 10/05/1999 |
| 5958947 | DNA-affinic hypoxia selective cytotoxins Hypoxia selective cytotoxins having the structural formula ##STR1## wherein D, E, F and G, independently, are carbon or nitrogen, with the proviso that three or more of D, E, F and G are carbon; R1 and R2, independently, are sel... | 09/28/1999 |
| 5955473 | Fungicidal quinolines Quinolines of the formula I ##STR1## where the substituents are as defined herein, the corresponding N-oxides and acid addition salts, a process for their preparation, fungicidal compositions, and their use for controlling harmful fungi.... | 09/21/1999 |
| 5952354 | Tris carbamic acid esters: inhibitors of cholesterol absorption Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are therefore implicated in the inhibition of absorption of cholester... | 09/14/1999 |
| 5948791 | Quinoline derivatives for treating malaria The invention relates to novel quinoline derivatives and their therapeutic use against malaria.... | 09/07/1999 |
| 5935973 | Heterocyclcarboxamide derivatives and their use as therapeutic agents Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R1 is an optional substituent; U is an alkylene chain optionally substituted by one or more... | 08/10/1999 |
| 5932195 | Arylaminomethylenecamphor derivatives Arylaminomethylenecamphor derivatives of the formula (1) ##STR1## where the C.dbd.C double bond is in the Z or E configuration, and the variables have the following meanings: R1 H, CH3, R2 H, C1 -C6 -... | 08/03/1999 |
| 5925660 | Phosphatase inhibitors and methods of use thereof The present invention is directed to compounds having the formula: ##STR1## The invention further provides a method of making the compounds. The compounds are useful as inhibitors of protein phosphatases, for example PP1, PP2A, PP3, CDC25A and CDC25B... | 07/20/1999 |
| 5922733 | Pyridil carboxamides as 5HT2B/2C receptor antagonists Novel heterocyclic compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders are disclosed.... | 07/13/1999 |
| 5916900 | 7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists This invention involves involves the use of compounds having the following structure: ##STR1## wherein: (a) R is unsubstituted C1 -C3 alkanyl or alkenyl; and (b) R' is selected from hydrogen; unsubstituted C1 -C3 | 06/29/1999 |
| 5908842 | Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase Substituted 2-acylaminopyridine compounds and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders.... | 06/01/1999 |
| 5889021 | Active Compounds The present invention relates to novel quinoline derivatives of the formula ##STR1## which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory dis... | 03/30/1999 |
| 5885967 | Antithrombotic agents This invention relates to peptide derivatives, pharmaceutical formulations containing those compound and methods of their use as thrombin inhibitors.... | 03/23/1999 |
| 5880135 | Substituted 4-phenylaminothiazoles, their process of preparation and the pharmaceutical compositions containing them A compound, as well as its stereoisomers and addition salts, possssing antagonist activity with respect to corticotropin releasing hormone (CRF) has the formula: ##STR1## in which R1, and R21 which are identical or different, ar... | 03/09/1999 |
| 5866562 | Ring-bridged bis-quinolines The present invention relates to ring-bridged bis-quinolines of the general formula (I): ##STR1## in which the indicated substituents are as defined in the description. The invention also provides a process for the preparation of compounds of the ... | 02/02/1999 |
| 5866579 | Imidazole and imidazoline derivatives and uses thereof This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human 댒 adrenergic receptors. This invention is also related to the use of these compounds for the treatment of any disease... | 02/02/1999 |
| 5859025 | Fluoroalkyl- and fluoroalkoxy-substituted heterocyclic bradykinin antagonists, process for their preparation, and their use Fluoroalkyl- and fluoroalkoxy-substituted heterocyclic bradykinin antagonists, process or their preparation, and their use Heterocyclic fluoroalkyl derivatives and fluoroalkoxy derivatives of the formula (I) having bradykinin-antagonistic action ##STR1## ... | 01/12/1999 |
| 5856309 | Amidinopyrroline derivatives, processes for their production and pharmaceutical agents containing these compounds Compound of formula (I) are disclosed ##STR1## as well as optically active isomers or pharmacologically acceptable salts thereof. The compounds are useful active ingredients in pharmaceutical compositions, and methods of treating osteoporosis, inflam... | 01/05/1999 |
| 5856338 | Sulfonamide-substituted compounds, processes for their preparation, their use as a medicament or diagnostic, and pharmaceutical preparation comprising them Compounds of formula I ##STR1## having the meanings indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and therapy of cardiovascular disorders, in particular arrhythmias; for the tre... | 01/05/1999 |
| 5856322 | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in t... | 01/05/1999 |
| 5837714 | Solid pharmaceutical dispersions This invention provides solid pharmaceutical dispersions comprising a poorly soluble drug substance, as SR48692 or naproxen, xylitol and Transcutol, and a method of preparing such dispersions comprising the steps of dissolving the poorly soluble drug subs... | 11/17/1998 |
| 5834485 | Quinoline sulfonamides and their therapeutic use The subject invention pertains to quinolinesulfonamides. The subject compounds can be used to treat disease states, such as those that are associated with proteins that mediate cellular activity, for example, by inhibiting phosphodiesterase IV (PDE IV) or... | 11/10/1998 |
| 5827865 | Heterocyclic compounds as pharmaceutical Compounds of Formula (I) A1 --X--(CH2)n --O--A2 --A3 --Y.R2(I) or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wh... | 10/27/1998 |
| 5798365 | Substituted quinoline derivatives, a process for their preparation, and their use Compounds of the formula I, ##STR1## and also their tautomeric forms of the formula Ia, ##STR2## in which the substituents R1 to R6 and X have said meanings, exhibit antiviral activity.... | 08/25/1998 |
| 5795889 | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from ... | 08/18/1998 |
| 5786365 | Use of nonpeptide bradykinin antagonists for the treatment and prevention of chronic fibrogenetic liver disorders, acute liver disorders and the complications associated therewith The invention relates to the use of nonpeptide bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders (hepatic cirrhosis and hepatic fibrosis), acute liver disorders and for the prevention of... | 07/28/1998 |
| 5783576 | Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositions New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.... | 07/21/1998 |
| 5776947 | Use of quinoline-3-carboxamide compounds for inhibiting the production of tumor necrosis factor (TNF) and/or for the treatment of septic shock The use of a quinoline-3-carboxamide compound comprising structure (I), optionally with substituents for the hydrogen atoms shown (H1-9), and a salt of compound (I) where (a) ---- represents that there are two conjugated double bonds between th... | 07/07/1998 |
| 5767129 | Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof The present invention relates to novel substituted quinolines and isoquinolines and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the preparation and pharmaceutical compo... | 06/16/1998 |
| 5756532 | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino2 3-E!-indol-8-ones and derivatives The compounds of formula I: ##STR1## wherein R1 and R2 are, independently, hydrogen, alkyl, phenyl or benzyl; or R1 and R2, taken together, are benzylidene optionally substituted with R3 as defin... | 05/26/1998 |
| 5747532 | Combinational therapeutic methods employing nitric oxide scavengers and compositions useful therefor In accordance with the present invention, there are provided combinational therapeutic methods for the in vivo inactivation or inhibition of formation (either directly or indirectly) of species which induce the expression of nitric oxide synthase, as well... | 05/05/1998 |
| 5739148 | 6-(2-Imidazolinylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists The subject invention relates to compounds having the structure: ##STR1## wherein: (a) R is unsubstituted C1 -C3 alkanyl or alkenyl; (b) R' is selected from unsubstituted C1 14 C3 alkanyl or alkenyl; unsubstitut... | 04/14/1998 |
| 5736557 | N,N-bis (quinolin-4-yl)-diamine derivatives, their preparation and their use as antimalarials Disclosed are N,N'-bis(quinolin-4-yl)diamine derivatives of general formula I wherein R1 signifies halogen or trifluoromethyl, R2 signifies hydrogen or halogen, A signifies cyclohexane-1,3-diyl, 2-methyl-cyclohexane-1,3-diyl, cyclohe... | 04/07/1998 |
| 5733931 | Cyclohexanediurea derivative and process for its production The present invention provides a cyclohexanediurea derivative, inclusive of its salt, represented by the following formula (I): ##STR1## wherein R1 and R2 are the same or different and they each represent a straight-chain or bra... | 03/31/1998 |
| 5719144 | Fibrinogen receptor antagonists Fibrinogen receptor antagonists having the formula ##STR1## where L is L is (CH2)p, where p is 1 or 2; and Z is --CR1 .dbd.CR2 --; which are useful for inhibiting platelet aggregation for example ##STR... | 02/17/1998 |
| 5716967 | Isoxazoline compounds as antiinflammatory agents This invention relates to isoxazoline compounds which are selective inhibitors of phosphodiesterase type IV (PDEIV). The isoxazoline compounds are useful in inhibiting PDEIV and in the treatment of AIDS, asthma, arthritis, bronchitis... | 02/10/1998 |
| 5716966 | 7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists The subject invention involves methods of treating nasal congestion comprising administration, to a human or lower animal in need of such treatment of a safe and effective amount of a compound having the following structure: ##STR1## wherein: (a... | 02/10/1998 |
| 5712289 | Quinoline-5,8-diones and methods of using them The invention provides quinoline-5,8-diones having the following formula: ##STR1## wherein X, Z and R1 through R3 are defined in the specification, and salts of these quinolinediones. The invention also provides a method of maki... | 01/27/1998 |
| 5700821 | Phosphatase inhibitors and methods of use thereof The present invention is directed to compounds having the formula: ##STR1## The invention further provides a method of making the compounds. The compounds are useful as inhibitors of protein phosphatases, for example PP1, PP2A, PP3, CDC25A and CDC25B... | 12/23/1997 |
| 5698581 | Substituted N-heteroaroylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament containing them The invention relates to heteroaroylguanidines of the formula I ##STR1## in which the substituents HA and R(1) to R(5) have the meanings given in the specification. These compounds exhibit very good antiarrhythmic properties and are outstandingly sui... | 12/16/1997 |
