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| Number | Title | Issue Date |
| 4537779 | Pharmacologically active compounds Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.... | 08/27/1985 |
| 4530931 | 8-Quinoline carbanilates for the inhibition of lipolysis X is in the 8 position and is O(CH2)n, N(CH2)n ; Y is O(CH2)n, N(CH2)n ; R2 is monosubstituted or independently disubstituted H, carboxyl, or alkylcarboxy; Z is 0; an... | 07/23/1985 |
| 4507307 | N1 -Acyl-3-amino-1,2,3,4-tetrahydroquinoline compounds active on the cardiocirculatory system N1 -acyl-3-amino-1,2,3,4-tetrahydroquinoline compounds active on the cardiocirculatory system, pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the new compounds and some intermediates useful in the preparation ... | 03/26/1985 |
| 4507308 | Analgesically or anti-inflammatory effective 4-quinolyl anthranilic acid derivatives The novel anthranilic acid derivatives having the structural formula (I): ##STR1## wherein n is 0, 1 or 2, one of R1 and R2 is chloro or trifluoromethyl and the other is hydrogen, and R is 2-oxo-3-oxolanyl or 2-oxo-3-oxazolidiny... | 03/26/1985 |
| 4482561 | Therapeutically effective piperidyl N-(4-quinolyl)-anthraniloyloxyalkanoates The N-substituted-4-(optionally substituted)-2-, 3- or 4-piperidyl N-(7- or 8-substituted-4-quinolyl)-anthraniloyloxyalkanoates having the structural formula (I): ##STR1## in which R is a straight or branched chain alkyl radical having from 1 to ... | 11/13/1984 |
| 4479950 | Aroylaminoacid disulfides Compounds of the structure ##STR1## wherein: P and Q are independently hydrogen, halo, CF3, OR1, SR1, sulfamoyl, alkyl and NR1 R2 ; R1, and R2 are independently hydrogen, alkyl, ... | 10/30/1984 |
| 4478822 | Drug delivery system utilizing thermosetting gels This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a liquid at room temperature but forms a semi-solid or gel a... | 10/23/1984 |
| 4465685 | Antiinflammatory pyrazole thioureas Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and anti-asthmatic agents. The compounds may be administered as the ra... | 08/14/1984 |
| 4440770 | Diuretic, hypotensive and antiedemic quinoline oximes A pharmaceutical composition having diuretic, hypotensive and antiedemic effects which contains a 6-halo-4-oximino-1,2,3,4-tetrahydroquinoline derivative or a salt thereof, and a method to use the above-described derivative or a salt thereof as a diuretic... | 04/03/1984 |
| 4438128 | Cardioactive aryloxypropanolamines The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R1, R2, R3 and R4, which may be the same or different, are hydrogen or halogen atoms or lower alkyl, cyano, ... | 03/20/1984 |
| 4430341 | Water soluble pesticidal quaternary ammonium salt compounds Water soluble quaternary ammonium salt compounds exhibit outstanding insecticidal and miticidal activity coupled with reduced mammalian toxicity and acceptable phytotoxicity.... | 02/07/1984 |
| 4407803 | Antiinflammatory 1-(quinolinyl)-2-pyrazoline derivatives Described are compounds of the formula ##STR1## wherein R2 -R8 independently of one another denote hydrogen, loweralkyl, phenyl, alkoxy, halo, hydroxy, nitro, trifluoromethyl, ##STR2## with the proviso that at least one but... | 10/04/1983 |
| 4405644 | Medicaments for the treatment of disorders of lipometabolism and their use The invention relates primarily to pharmaceutical compositions and medicaments containing a compound of Formula (I), infra as the active ingredient. Also included in the invention are methods for combatting lipometabolic illnesses by administration of an ... | 09/20/1983 |
| 4399142 | Pharmacologically active compounds Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolymethylthio)ethylamino]-4-pyrimidone.... | 08/16/1983 |
| 4357333 | N-Substituted 2-(8-halo and trifluoromethyl 4-quinolylamino)benzamides and analgesic use thereof The disclosure describes new 4-aminoquinoline derivatives of general formula ##STR1## and their pharmaceutically acceptable acid addition salts, where X is trifluoromethyl or halogen, Z is hydrogen or a defined substituent and R is a group havin... | 11/02/1982 |
| 4343804 | 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds A method of reducing gastric acidity and treating peptic ulcers and pharmaceutical compositions therefor with certain 4-amino-3-quinolinecarboxylic acids and esters are disclosed. Illustrative of compounds useful in the method which relies on activity as ... | 08/10/1982 |
| 4321257 | Potentiated medicaments Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quarternary ammonium compounds, bisdiguanides, anti-fungal agents, phenols, hydroxydiphenyls, carbanilides, salicylan... | 03/23/1982 |
| 4302459 | Liposome carriers in leishmaniasis chemotherapy with 8-aminoquinoline derivatives An improved method is provided for the chemotherapy of leishmanial infects. An 8-aminoquinoline anti-leishmanial agent is encapsulated within liposomes and the liposome-encapsulated drug is injected into the body. Subject use of a liposome carrier has pr... | 11/24/1981 |
| 4299835 | 4-[(3-(4-Quinolyl)propyl])piperidines, their preparation and their use as medicines Pharmaceutical preparations containing as active ingredient a compound having the formula: ##STR1## wherein R represents hydrogen, alkyl having 1 to 4 carbon atoms or alkenyl having 2 to 4 carbon atoms; and X represents hydrogen, alkyl, alkoxy or alk... | 11/10/1981 |
| 4293549 | Quinolinyl guanidines having antiinflammatory, analgesic or antipyretic activity This invention relates to new compounds, salts, complexes and acylated derivatives thereof, methods of producing said compounds, intermediates used in the method, pharmaceutical compositions containing the present compounds and methods of producing same, ... | 10/06/1981 |
| 4293551 | N-Amino-3,4,5-trihydroxypiperidines, their production and their medicinal use The invention relates to N-amino-3,4,5-trihydroxypiperidines, methods for their production, compositions containing said compounds. Also included are methods for the use of said compounds and compositions.... | 10/06/1981 |
| 4282230 | Imidazolylethoxy derivatives of quinoline-2- or 4-methanols, antimicrobial compositions containing them and method for treating bacterial or fungal infections with them Imidazolylethoxy derivatives of quinoline-2- or 4-methanols having the general formula ##STR1## and their acid addition salts are useful as antifungal and antibacterial agents.... | 08/04/1981 |
| 4282223 | Isoquinoline derivatives, processes for their manufacture and their use for the manufacture of medicaments Isoquinolines of the formula ##STR1## of which representative compounds are such as 3-N-methylpiperazino-1-phenyl-isoquinoline-4-aldehyde, 3-N-methylpiperazino-1-(2-fluorophenyl)-isoquinoline-4-aldehyde, or 3-N-[3-(4-fluoro-benzoyl)-propyl]-pipe... | 08/04/1981 |
| 4259335 | 1-Methyl-4-piperidinol esters of 4-quinolinylamino benzoates and antiinflammatory and analgesic compositions and methods employing them 1-methyl-4-piperidinol esters of the formula: ##STR1## in which R is 7-chloro-4-quinolyl, 7-trifluoromethyl-4-quinolyl or 8-trifluoromethyl-4-quinolyl. These compounds and physiologically tolerable acid addition salts thereof may be used as medicines... | 03/31/1981 |
| 4241058 | Heterocyclics useful as fungicides and fungicidal compositions thereof Heterocyclic compounds characterized by the formula ##STR1## wherein R1, R3, R4, R5, R6, X and z are as hereinafter set forth, prepared, inter alia, by reacting a compound characterized by the fo... | 12/23/1980 |
| 4235908 | 4-Aminoquinoline derivatives, useful as anti-inflammatory agents New 4-aminoquinoline derivatives having the formula ##STR1## wherein X is halogen or trifluoromethyl at the designated 7- or 8-position; Z is hydrogen, halogen, lower alkyl, lower alkoxy, nitro, di(lower alkyl)amino or trifluoromethyl, n is from 1 to... | 11/25/1980 |
| 4233305 | Novel derivatives of 2-(4-quinolinylamino)-5-fluoro-benzoic acids Derivatives of 2-(4-quinolinylamino)-5-fluorobenzoic acid compounds of the formula ##STR1## wherein X is selected from the group consisting of chlorine and --CF3 in the 7- or 8-position and R is selected from the group consisting of h... | 11/11/1980 |
| 4226848 | Method and preparation for administration to the mucosa of the oral or nasal cavity A method for administering a medicament which comprises adhering to the mucosa of the oral or nasal cavity a pharmaceutical preparation comprising (a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellul... | 10/07/1980 |
| 4202892 | Biocidal methyladamantyl hydrazines and pharmaceutical compositions containing them The invention provides novel 1- or 2-adamantylmethyl hydrazines of the general formula A ##STR1## In this formula Ad is 1- or 2-adamantyl, R1 and R2 are the same or different and are each hydrogen or a lower unsubstituted or sub... | 05/13/1980 |
| 4181725 | Method for alleviating psoriasis Pharmaceutical compositions administered to humans and animals topically for treatment of proliferative skin diseases, primarily psoriasis. The composition comprises a pharmaceutical carrier with at least one active ingredient selected from the group cons... | 01/01/1980 |
| 4173636 | Decahydroquinolines, pharmaceutical compositions and methods of use The invention relates to decahydroquinoline derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R1 represents an alkyl or alkoxy group, a lower dialkylamino grou... | 11/06/1979 |
| 4166853 | Antihypertensive 7-trifluoromethyl-4-aminoquinolones Antihypertensive compounds of the formula II ##STR1## wherein D is a piperidino or 1,2,5,6-tetrahydropyridino ring; wherein X is chloro or trifluoromethyl; wherein R1 is hydrogen or hydroxy when the D ring is piperidino, or nothing when th... | 09/04/1979 |
| 4122181 | Analgesic (3-micotinamido-N(quinolyl) anthranilates and method of use The invention concerns new chemical compounds which can be used as medicaments, their preparation, and pharmaceutical compositions, and method of treating therewith. The new chemical compounds have the general formula ##STR1## in which X, which is in... | 10/24/1978 |
| 4025519 | Benzenesulfonyl-ureas Sulfonyl-ureas of the formula ##STR1## wherein X represents a heteroaromatic 5- or 6-ring substituted, if desired, by one or two methyl groups and/or annellated with benzene, which ring may contain in addition to a nitrogen atom a further nitrogen, o... | 05/24/1977 |
| 4007275 | N-(quinolyl)-anthranilates, their compositions, and use N-(7- or 8-substituted-quinolyl-4)-anthranilates of the formula ##STR1## wherein X in the 7 or 8 position is trihalomethylthio, Z is --(CH2)n -- or --(CH2)m --O--(CH2)p --, n is a whol... | 02/08/1977 |
| 4002762 | 2-Amino-3,4-dihydropyridines used to effect coronary vessel dilation and treat hypertension 3-Substituted 2-amino-3,4-dihydropyridine-3-carboxylic acid esters are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid esters with an alkylating agent in the presence of an inert organic solvent at a temperature of from 20° C to 200° ... | 01/11/1977 |
| 3988459 | Novel analgesic compositions Novel analgesic compositions comprising an effective amount of (A) a member of the group consisting of 4-[o-(2',3'-dihydroxypropyloxycarbonyl)-phenyl]-amino-8-trifluoromethyl-qu inoline and its non-toxic, pharmaceutically acceptable acid addition salts ... | 10/26/1976 |
| 3974279 | N,N'-bis-(6-amino)-4,4-hexamethylenediamino quinaldine dihydrochloride as an anti-L-1210 lymphoid and P388 lymphocytic leukemia agent A method of prolonging survival time of mammalian cancer hosts and/or ameliorating tumor growth comprising administering a therapeutically effective amount of N,N'-bis-(6-amino)-4,4-hexamethylenediamino quinaldine dihydrochloride.... | 08/10/1976 |
