Class 514/306 - Quinolizines (including hydrogenated)

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the bicyclo ring system has the following
No. of patents: 135
Last issue date: 05/08/2012

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Number	Title	Issue Date
8173672	Quinolizidinone M1 receptor positive allosteric modulators The present invention is directed to compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disord...	05/08/2012
8143273	Quinolizidine and indolizidine derivatives The present invention relates to a compound of formula I-A or I-B wherein X, R1, R2 and R3 are defined herein; or to a pharmaceutically acceptable acid add...	03/27/2012
7915287	Substituted heterocycles and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophyl...	03/29/2011
7879875	P38 kinase inhibiting agents Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty ar...	02/01/2011
7842702	Treatment for irritable bowel syndrome N-(1H-tetrazol-5-yl)-1-phenoxy-4H-quinolizin-4-one-3-carboxamide is effective for treating IBS. In addition, IBS may be effectively treated with N-(1H-tetrazol-5-yl)-1-phenoxy-4H-quinolizin-4-one-3-carboxamide when used concomitantly with at least one of various ser...	11/30/2010
7776880	Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof The disclosure relates to a compound of formula (I): wherein m, n, Ar, and R are as defined in the disclosure, to compositions containing them and to their therapeutic use. The disclosure also relates to processes for prepa...	08/17/2010
7745459	Quinolizinone compound and use thereof as HIV integrase inhibitor A pharmaceutical agent having an anti-HIV action, particularly, a pharmaceutical agent having an integrase inhibitory action, is provided. The present invention relates to a quinolizinone compound represented by the following formula [I]	06/29/2010
7595327	Beta-sulfonamide hydroxamic acid inhibitors of tace/matrix metalloproteinase This invention provides compounds of Formula I, having the structure: that are useful in treating diseases or disorders mediated by TNF-α, such as arthritis (rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, ost...	09/29/2009
7569583	Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and ...	08/04/2009
7417055	Kinase inhibitory phosphonate analogs The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such com...	08/26/2008
7329657	Indazolyl-substituted pyrroline compounds as kinase inhibitors The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or am...	02/12/2008
7304060	Indazolyl-substituted pyrroline compounds as kinase inhibitors The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or am...	12/04/2007
7282221	Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag...	10/16/2007
7253182	Enantiomerically pure basic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments Disclosed are enantiomerically pure cyclic aminoalcohol esters of arylcycloalkylhydroxycarboxylic acids with at least 90% enantiomeric excess of the (3R,2′R), (3S,2′R), (3R,2′S), or (3S,2′S) configured enantiomer. ...	08/07/2007
7229996	Rifamycin derivatives Novel rifamycin derivatives of formula I (both hydroquinone and corresponding quinone (C1-C4) forms): or their salts, hydrates or prodrugs thereof, wherein: a preferred R comprises...	06/12/2007
7226931	(R/S) rifamycin derivatives, their preparations and pharmaceutical compositions Rifamycin derivatives having the following structure of general formula I (both hydroquinone and corresponding quinone (C1-C4) forms): or its salts, hydrates or prodrugs thereof; wherein a p...	06/05/2007
7223773	4-oxoquinolizine antibacterial agent having 2-pyridone skeleton as partial structure The present invention provides a 4-oxoquinolizine antibacterial agent having a 2-pyridone skeleton as a partial structure and also having a strong antibacterial effect on gram-positive bacteria, gram-negative bacteria or anaerobic bacteria. The compound having the f...	05/29/2007
7160898	Pharmacological treatment for sleep apnea The present invention relates to pharmacological methods for the amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity. ...	01/09/2007
7125863	Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t...	10/24/2006
RE39300	Inhibiting the development of tolerance to and/or dependence on an addictive substance Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor activation, e.g., a ganglioside such as GM1 or GT1b	09/19/2006
7105701	β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor....	09/12/2006
7041677	Use of monochloroflosequinan in the treatment of sexual dysfunction The present invention described the administration of halogenated flosequinan derivatives and the enantiomers of halogenated flosequinan derivatives for the treatment of sexual dysfunction (in males and females) and for the treatment of cardiovascular disease. ...	05/09/2006
7041693	Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein L, Z0, R1, R4, R5, a...	05/09/2006
6962917	Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ...	11/08/2005
6900224	Antimicrobial quinolones, their compositions and uses Compounds of the following formula: are effective antimicrobial agents. ...	05/31/2005
6884806	Bicyclic lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel bicyclic lactam derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein A, B, C, D, R1, and R2 are defined in the present speci...	04/26/2005
6878706	Cyanamides useful as reversible inhibitors of cysteine proteases Compounds according to the following formula (I): wherein the variables Q and R1 to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B...	04/12/2005
6878713	Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydr...	04/12/2005
6870056	Substitituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of...	03/22/2005
6841559	Pyridinones to treat and prevent bacterial infections Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods by which these derivatizations occur is described. Two regioselectiv...	01/11/2005
6762200	Oxa(thia)zolidine derivative and anti-inflammatory drug The present invention provides medicinal compositions characterized by containing as the active ingredient either a compound represented by a general formula (1) or a pharmaceutically acceptable composite thereof, [where...	07/13/2004
6762181	Aminomethylpyrrolidine derivatives having aromatic substituents This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of th...	07/13/2004
6743817	Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists...	06/01/2004
6740654	Squaric acid derivatives Squaric acid derivatives of formula (1) are described: wherein Het is an optionally substituted bicyclic fused ring heteroaromatic group; L2 is a covalent bond or an atom or group —O—, —S�...	05/25/2004
6667315	Cardioprotective phosphonates and malonates The present invention provides for pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to pyridoxine malo...	12/23/2003
6653309	Inhibitors of IMPDH enzyme technical field of the invention The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for inhibit...	11/25/2003
6632825	Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis Compounds of the formula: ##STR1## where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containi...	10/14/2003
6630488	Quinolizinones as integrin inhibitors The present invention is directed towards novel compounds that are effective inhibitors of integrins, particularly ଱IIbଲ.sub.3 or ଱v integrins such as ଱vଲ.sub.3 and ଱vଲ.sub.5....	10/07/2003
6608079	Indole derivatives and their use as 5-HT1F agonists The present invention relates to a compound of formula (I), or a pharmaceutical acid addition salt thereof, which are useful for activating 5-HT1F receptors and inhibiting neuronal protein extravasation in a mammal. ##STR1##...	08/19/2003
6602882	Quinoline derivatives and their use as antibacterial agents Piperidine derivatives and pharmaceutical derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man....	08/05/2003

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Class 514/306 - Quinolizines (including hydrogenated)