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| Number | Title | Issue Date |
| 4554278 | Hydroxybenzenesulfonic acid salts of 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothiene [3,2-c] pyridine useful in inhibiting blood-platelet aggregation The invention relates to new hydroxybenzenesulfonic acid salts of 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno [3,2-c] pyridine, to the preparation method thereof and to the pharmaceutical compositions containing them. The new hydroxybenzenesulfonic acid s... | 11/19/1985 |
| 4550106 | 4-Phenyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridines and salts thereof, compositions and use Compounds of the formula ##STR1## wherein R1 is amino, acetylamino, hydroxymethyl, methoxymethyl or ##STR2## R2 and R3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorin... | 10/29/1985 |
| 4548942 | Anti-acne use of derivatives of (5,4b)-isothiazolo pyridine-3-one An anti-acne composition comprises in a carrier suitable for topical application to the skin an active compound having the formula ##STR1## wherein R1 is linear or branched alkyl having 1-12 carbon atoms, mono- or polyhydroxyalkyl having 2... | 10/22/1985 |
| 4537894 | Methods of using compositions having antithrombotic and anti-blood-platelet-aggregating activity This invention relates to a therapeutic composition comprising, as active ingredient, a combination of a pyridine derivative having an anti-blood-platelet-aggregation activity and of sulfinpyrazone. Said composition has outstanding anti-blood-platelet-aggregat... | 08/27/1985 |
| 4529596 | Thieno [3,2-c] pyridine derivatives and their therapeutic application This invention relates to new thieno [3,2-c] pyridine derivatives having the formula: ##STR1## in which: Y represents the OH group or an OR group in which R is a straight or branched lower alkyl radical, or Y represents a group ##STR2## in ... | 07/16/1985 |
| 4528291 | 2-(4'-Pyridinyl)-thiazole compounds and their use in increasing cardiac contractility The pyridinyl-thiazole derivatives of the present invention exhibit good cardiotonic activity.... | 07/09/1985 |
| 4525357 | Derivatives of bicyclic 2-iminothiazolidine oximes Novel derivatives of bicyclic 2-iminothiazolidine oximes and methods of preparing same. This invention is also directed to an insecticidal composition comprising an acceptable carrier and an insecticidally effective amount of a compound of this invention,... | 06/25/1985 |
| 4512985 | N-carbamoyl derivatives of (5,4b)-isothiazolo pyridine-3-one and anti-acne cosmetic compositions containing the same N-carbamoyl derivatives of (5,4b)-isothiazolo pyridine-3-one have the formula ##STR1## wherein R1 represents hydrogen, linear or branched alkyl having 1-12 carbon atoms, cycloalkyl having 3-6 carbon atoms or ##STR2## wherein n is... | 04/23/1985 |
| 4500534 | Thieno-pyridinone derivatives, process for its preparation, and anti-blood-platelet and anti-thrombotic applications thereof This invention relates to a new thieno-pyridinone derivative of the formula: ##STR1## and its pharmaceutically acceptable inorganic or organic acid addition salts. This invention relates also to a process for the preparation of said compound and... | 02/19/1985 |
| 4499094 | Derivatives of arene and hetero-arene carboxamides and their use as medicaments Compounds with the formula: ##STR1## in which R1 and R2 represent independently, a linear or branched alkyl, cycloalkyl, phenylalkyl or cycloalkylalkyl group. R1 and R2 may also represent an alkenyl or alky... | 02/12/1985 |
| 4496568 | Antiinflammatory thieno [2,3-c]pyridine derivatives This invention relates to a process for the preparation of antiinflammatory thieno [2,3-c]- and [3,2-c]pyridines having respectively the following formulae: ##STR1## in which R1 and R2, which may be the same or different, r... | 01/29/1985 |
| 4490377 | Acid stabilized compositions of thieno-pyridine derived compounds A stable pharmaceutical composition which comprises an acid salt of a thieno-pyridine derived compound, a pharmaceutically acceptable, non-volatile acid and optionally other suitable pharmaceutical excipients.... | 12/25/1984 |
| 4482559 | 4-Phenyl-4,5,6,7-tetrahydro-thieno [2,3-c]pyridines, compositions and use Compounds of the formula ##STR1## wherein R1 is amino, acetylamino, hydroxymethyl, methoxymethyl or ##STR2## R2 and R3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorin... | 11/13/1984 |
| 4464377 | Anti-thrombotic therapeutic compositions This invention relates to therapeutic compositions comprising, as active ingredients, a combination of a pyridine derivative having an anti-blood-platelet-aggregation activity with a derivative having beta-blocking properties, which exhibit synergistic an... | 08/07/1984 |
| 4448779 | Use of MS salt in geriatric medicine Administration of the known drug 5-o-cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine methanesulfonate ("MS salt" or "PCR") is described for the alleviation of the symptoms of senility such as of organic brain syndrome and senile dementia.... | 05/15/1984 |
| 4400384 | 5-o-Cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine methanesulfonate and other novel salts thereof The invention concerns novel 5-o-cyanobenzyl-4, 5, 6, 7-tetrahydrothieno-[3,2-c] pyridine acid addition salts having inhibitory action against blood platelet aggregation without anti-inflammatory activity, and the compositions and methods of use therefor.... | 08/23/1983 |
| 4386092 | Heterocyclic-substituted oxoalkanoic acid derivatives A heterocyclic-substituted oxoalkanoic acid derivative having immunomodulatory activities of the formula: ##STR1## wherein R1 is hydrogen, lower alkyl, phenyl which may be substituted by at least one substituent selected from halogen, lowe... | 05/31/1983 |
| 4367233 | Inhibitors of mammalian collagenase A method of inhibiting mammalian collagenase by using -phenyl-2-(aza)benzothiazolylthioglycolic acids and derivatives thereof, and the pharmaceutically acceptable salts thereof.... | 01/04/1983 |
| 4335128 | Process for the treatment of patients suffering from drepanocytosis This invention relates to a process for the treatment of patients suffering from drepanocytosis, comprising administering to said patients a therapeutically effective dosage of a pyridine derivative having the formula: ##STR1## in which X is oxy... | 06/15/1982 |
| 4322423 | 4-Phenyl-4,5,6,7-tetrahydro-thieno(2,3-C)pyridines and salts thereof Compounds of the formula ##STR1## wherein R1 is chlorine, bromine or alkyl of 1 to 3 carbon atoms; R2 is hydrogen or, when R1 is alkyl, chlorine or bromine; R1 and R2, together with each other, are straigh... | 03/30/1982 |
| 4321266 | 5-o-Cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-C] pyridine The free base, 5-o-cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine, a method for the preparation thereof, therapeutic compositions having blood-platelet aggregation inhibiting activity, therapeutic dosage units of the compositions, and a method for ... | 03/23/1982 |
| 4288438 | Nitrogen-containing heterocyclic ring derivatives and analgesic and anti-inflammatory compositions and methods employing them Novel nitrogen-containing heterocyclic compounds shown by the formula ##STR1## wherein one of R1 and R2 represents a lower alkyl group, a phenyl group, a halophenyl group, or a lower alkoxyphenyl group and the other of them repr... | 09/08/1981 |
| 4282227 | Renal vasodilating 3,4-dihydroxyphenyltetrahydrothienopyridines 3,4-Dihydroxyphenyltetrahydrothieno[2,3-c] or [3,2-c] pyridines are prepared by cyclization of a N-thienylmethyl-2-(3',4'-dimethoxyphenyl)-ethanolamine. These compounds have renal vasodilating activity. A species is 4-(3,4-dihydroxyphenyl)-1,2,3,4-te... | 08/04/1981 |
| 4251533 | Nitrogen-containing heterocyclic compounds Novel nitrogen-containing heterocyclic compounds shown by the formula ##STR1## wherein one of R1 and R2 represents a lower alkyl group, a phenyl group, a halophenyl group, or a lower alkoxyphenyl group and the other of them repr... | 02/17/1981 |
| 4217352 | Anti-inflammatory 4H-1,3-oxathiino(4,5-c) Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.... | 08/12/1980 |
| 4210649 | Process for the treatment of patients suffering from drepanocytosis This invention relates to a process for the treatment of patients suffering from drepanocytosis, comprising administering to said patients a therapeutically effective dosage of a pyridine derivative having the formula: ##STR1## in which X is oxy... | 07/01/1980 |
| 4193997 | Thieno[2,3-c] and [3,2-c]pyridines, process for their preparation and therapeutic applications thereof This invention relates to compounds having the formulae ##STR1## in which: R1 represents hydrogen, a halogen atom or a lower alkyl radical, a lower alkoxy radical or a lower alkylthio radical; R2 represents hydrogen or a lower alkyl,... | 03/18/1980 |
| 4165374 | Thieno[3,2-c]pyridines This invention provides compounds of formula I ##STR1## wherein R1 is (i) hydrogen or alkyl of 1 to 4 carbon atoms, or (ii) chlorine or bromine, in the 2, 3 or 7 position, or (iii) fluorine, cyano or COOB, wherein B is alkyl of 1 to 4 carbon atoms, ... | 08/21/1979 |
| 4147787 | 4,5,6,7-Tetrahydro-thieno[2,3-c]-and [3,2-c]-pyridines, and therapeutic compositions containing the same This invention relates to 4,5,6,7-tetrahydro-thieno[2,3-c]- and [3,2-c]-pyridines having the formulae: ##STR1## in which R1 is selected from hydrogen and halogen; R2 is selected from hydrogen and hydroxy; R3 and R | 04/03/1979 |
| 4136186 | Thieno[3,2-c]pyridine derivatives This invention relates to thieno[3,2-c]pyridine derivatives having the formula: ##STR1## in which: R1 represents an alkyl radical having 1-6 carbon atoms; R2 represents a radical selected from hydrogen and an acyl group; R3 | 01/23/1979 |
| 4124714 | Substituted hydroxy pyridones This disclosure describes novel compounds of the formula: ##STR1## where R3 is hydrogen or halo having an atomic weight of about 19 to 36, which are useful as minor tranquilizers, sleep inducers, muscle relaxants, neuroleptics and anti-ulc... | 11/07/1978 |
| 4104390 | Thieno [2,3-c] and [3,2-c] pyridines This invention relates to pyridine derivatives of the formulae: ##STR1## in which R1 is hydrogen, lower alkyl, aralkyl optionally substituted on the aromatic nucleus with at least a halogen atom or a hydroxy, nitro, amino, cyano, carboxy, ... | 08/01/1978 |
| 4076819 | Thieno-pyridine derivatives and therapeutic composition containing same This invention relates to thieno-pyridine derivatives having the formula: ##STR1## in which R1 is hydrogen or alkyl having 1-6 carbon atoms; R2 is hydrogen or acetyl or lower alkylcarbamoyl and R3 is methyl, nitrobenz... | 02/28/1978 |
| 4075340 | Thieno [2,3-C] pyridine derivatives and therapeutic composition containing same This invention relates to derivatives having the formula: ##STR1## in which R1 is hydrogen or alkyl having 1-6 carbon atoms; X is (CHR2)m in which m is an integer from 2 to 15, or (CHR2)n R3... | 02/21/1978 |
| 4016276 | Treatment of liver dysfunction with 2-amino-6-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridi ne hydrochloride Pharmaceutical compositions containing 2-amino-6-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine hydrochloride and a method of using such compositions in treatment of liver dysfunction in mammals are disclosed.... | 04/05/1977 |
