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| Number | Title | Issue Date |
| 8188113 | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, k... | 05/29/2012 |
| 8188114 | Pyrrolo[2,3-C]pyridine derivatives and processes for the preparation thereof The present invention provides novel pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable s... | 05/29/2012 |
| 8178554 | Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds as well as their use as medica... | 05/15/2012 |
| 8178553 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by ... | 05/15/2012 |
| 8178552 | 7-Azaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in med... | 05/15/2012 |
| 8168651 | Protein kinase modulators The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim ki... | 05/01/2012 |
| 8168652 | Inhibitors of AKT activity The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compo... | 05/01/2012 |
| 8163769 | Antibacterial compounds Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophyl... | 04/24/2012 |
| 8158647 | Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators Provided herein are substituted pyrrolopyridine heterocycles and substituted pyrazolopyridine heterocycles, pharmaceutical compositions comprising said heterocycles and methods of using said heterocycles in the treatment of disease. The heterocycles disclosed herein... | 04/17/2012 |
| 8153652 | Fab I inhibitors Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections. ... | 04/10/2012 |
| 8148393 | Zolpidem tablets A zolpidem tablet having modified release is designed as a tablet-in-tablet dosage form. ... | 04/03/2012 |
| 8148395 | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases The present invention relates to azolopyridin-3-one derivatives of the general formula I with the meanings indicated in the description, their pharmaceutically usable salts and their use as medicinal substances. ... | 04/03/2012 |
| 8148394 | Azaindoles having serotonin receptor affinity Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula I: wherein A, B, D, E, R1 to R3 and n are described herein. Also ... | 04/03/2012 |
| 8143271 | Compounds and methods for kinase modulation, and indications therefor Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. ... | 03/27/2012 |
| 8138202 | Stable SNS-595 compositions and methods of preparation Methods of preparing substantially pure SNS-595 substance are disclosed. Also provided are compositions comprising SNS-595 substance that are substantially pure and essentially free of visible particles. ... | 03/20/2012 |
| 8138201 | Treatment of progressive neurodegenerative disease with ibudilast Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine). ... | 03/20/2012 |
| 8129403 | Chemical compounds This invention relates to novel compounds having the formula (I); and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer. ... | 03/06/2012 |
| 8129404 | Compounds and uses thereof N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-4-trifluoromethyl-benzenesulfonamide, N-[3-(4-ethynyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-4-trifluoromethyl-benzenesulfonamide, and salts thereof, formulations thereof, c... | 03/06/2012 |
| 8124615 | Diketo substituted pyrrolo[2,3-C]pyridines Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, diketo fused azolopiperidine and azolopiperazine derivatives of Formula I: that possess ... | 02/28/2012 |
| 8119657 | Enantiomeric compositions of 2-amino-1-(2-isopropylpyrazolo[1,5-α]pyridin-3-yl)propan-1-one and related methods Enantiomerically pure (S)-2-amino-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one, (S)-AV1013, is a candidate therapeutic for treating neuropathic pain, addiction behavior and drug withdrawal symptoms. Also described are methods for preparing and using (S)-AV... | 02/21/2012 |
| 8114889 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are amide compounds which can be prepared from certain heteoraryl carboxylic acids and certain diazabicycloalkanes. The compounds ... | 02/14/2012 |
| 8114890 | Anti-constipation composition An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in ratio of bi-cyclic/mono-cyclic structure of at least 1:1. The halogenated-bi-cyclic compound is represented by Fo... | 02/14/2012 |
| 8110585 | Bicyclic compound and pharmaceutical use thereof The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substit... | 02/07/2012 |
| 8106068 | Compositions and methods for modulating c-kit and PDGFR receptors The invention provides compounds of Formula (2), and pharmaceutical compositions thereof, wherein R1, R2, R3, R4 and L are as described herein; as well as methods for using such c... | 01/31/2012 |
| 8106069 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or ass... | 01/31/2012 |
| 8080561 | Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors The present invention provides a compound of Formula I or a pharmaceutically acceptable salt form thereof, wherein A, L1, R1, R2, R3, R4, R5, R6, ... | 12/20/2011 |
| 8076354 | Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions compri... | 12/13/2011 |
| 8071613 | Anti-constipation composition An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio of bi-cyclic/mono-cyclic structure of at least 1:1. The halogenated-bi-cyclic compound is represented by ... | 12/06/2011 |
| 8071614 | Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, q, A, B, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions ... | 12/06/2011 |
| 8067433 | Methods, compositions, and kits for the treatment of ophthalmic disorders The invention features methods, kits, and compositions for the treatment of ophthalmic disorders. The compositions include a corticosteroid in combination with a non-steroidal immunophilin-dependent immunosuppressant. ... | 11/29/2011 |
| 8067434 | Compounds and methods for development of Ret modulators Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for ex... | 11/29/2011 |
| 8067435 | Nitrogen-containing heterocyclic compounds, their preparation and their use as antibacterial drugs The invention relates to nitrogen-containing heterocyclic compounds of general formula (I) wherein: R1 represents a (CH2)n—NH2 radical, n being equal to 1 or 2; | 11/29/2011 |
| 8048892 | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof are useful as inhibitors of HIF prolyl hydroxylases where the definitions of the variables are provided herein. ... | 11/01/2011 |
| 8044066 | Derivatives of pyrrolopyridine-2-carboxamides, preparation thereof and therapeutic application thereof The invention relates to compounds of formula (I): Wherein n, the pyrrolopyridine core, X, Y and W are as described herein. The invention also relates to a preparation method and to a therapeutic application. ... | 10/25/2011 |
| 8030327 | Fused imidazole derivative The present invention relates to a compound represented by the Formula [I]: Wherein: the A ring is a 5-membered aromatic heterocyclic group containing at least one hetero atom selected fro... | 10/04/2011 |
| 8022083 | Antiviral phosphonate analogs The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing su... | 09/20/2011 |
| 8012992 | Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity The present invention provides compounds are disclosed herein having the formula: Wherein n is 1 or 2; m is 0 or 1; p is 0, 1 or 2; R1 is aryl, heteroaryl or alkyl; R | 09/06/2011 |
| 8008321 | Imidazo[1,5-a] pyridine derivatives, method for preparing same and pharmaceutical compositions containing same The invention concerns compounds of formula I, a method for preparing said compounds, pharmaceutical compositions containing same and the therapeutic uses thereof. ... | 08/30/2011 |
| 8008320 | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors The present invention relates to a compound of formula (I) wherein R1 is H, C1-C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C6... | 08/30/2011 |
| 7998974 | Fused heterocyclic compounds and their use as sirtuin modulators Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, dis... | 08/16/2011 |
