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| Number | Title | Issue Date |
| 8153601 | Azithromycin-containing aqueous pharmaceutical composition and a method for the preparation of the same The invention provides an azithromycin-containing aqueous pharmaceutical composition, which comprises at least one member selected from the group consisting of azithromycin, and pharmaceutically acceptable salts thereof, and at least one member selected from the gro... | 04/10/2012 |
| 8093219 | Topical application of ivermectin for the treatment of dermatological conditions/afflictions Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected... | 01/10/2012 |
| 8080530 | Topical application of ivermectin for the treatment of dermatological conditions/afflictions Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected... | 12/20/2011 |
| 8067382 | Anthelmintic composition The invention relates to a novel formulation having the advantage of including triclabendazole in solution. In addition a further anthelmintic may be included. The formulation is made by mixing the abamectin and benzyl alcohol and mixing this with triclabendazole an... | 11/29/2011 |
| 8053418 | Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative A novel compound that has antimicrobial activity against penicillin-resistant Streptococcus pneumoniae, and an anti-penicillin resistant pneumococci agent that includes the compound as an active ingredient are provided. Thus, an anti-penicillin resistant pneu... | 11/08/2011 |
| 8017589 | Avermectin B1 and avermectin B1 monosaccharide derivatives having an alkoxymethyl substituent in the 4″-or 4′-position What is described are a compound of the formula wherein n is 0 or 1; A-B is —CH═CH— or —CH2—CH2—; R1 is C1-C12-alkyl, C3 | 09/13/2011 |
| 7781411 | Derivatives of avermectin, avermectin monosaccharide and avermectin aglycone Certain derivatives of avermectin, avermectin monosaccharide and avermectin aglycone, having on the 4″, 4′ or 13 position, respectively, a 6-membered cyclic acetal with a substituent on position 2, that are useful in controlling pests, in particular pests that a... | 08/24/2010 |
| 7754696 | Application of water and organic solvent soluble Ivermectin for topical and oral use A stable, palatable solution of Ivermectin in water is provided for the mass medication of animals. The present formulation does not require the use of benzyl alcohol and is stable indefinitely in the concentrated form and for up to 30 days when mixed with water. | 07/13/2010 |
| 7732416 | Avermectins substituted in the 4″-position having pesticidal properties What is described are a compound of the formula in which R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alk... | 06/08/2010 |
| 7704961 | Avermectins and avermectin monosacharides substituted in the 4′-and 4″ position having pesticidal properties Described is a compound of the formula (I) wherein the bond between carbon atoms 22 and 23 is a single or double bond; m is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; and... | 04/27/2010 |
| 7687470 | Avermectin and avermectin monosaccharide substituted in the 4″- and 4″ position respectively Avermectin and avermectin monosaccharaide compounds, derivatives, and compositions thereof are provided as well as processes for preparing such compounds, derivatives, and compositions. Intermediates in the preparation of avermectin and avermectin monosaccharaide de... | 03/30/2010 |
| 7687471 | Benzimidazole non-aqueous compositions The present invention provides a stable veterinary oral composition which comprises one or more surfactants, a water-miscible solvent, optionally an oil and an effective amount of each of a benzimidazole antihelmintic compound, such as triclabendazole and a macrocyc... | 03/30/2010 |
| 7678773 | Salts of avermectins substituted in the 4″-position and having pesticidal properties A compound of formula wherein X− is an anion; n is 1, 2, 3 or 4; R1 is C1-C12alkyl, C3-C8cycloalkyl; or C2 | 03/16/2010 |
| 7671034 | Stabilized formulation of ivermectin feed premix with an extended shelf life The invention relates to a stabilized premix feed or feed-like formulation that has an extended shelf life due to a decrease of the degradates of the active ingredient by controlling the amount of an already existing stabilizer in the formulation. The feed premix is... | 03/02/2010 |
| 7632820 | Avermectin and avemectin monosaccharide derivatives substituted in the 4″- or 4′-position having pesticidal properties Disclosed are compounds of the formulain which n is 0 or 1; X—Y is —CH═CH— or —CH2—CH2—; Z is —C(═O)—, —C(═S)— or —SO2—; R1 is C1-C12alkyl, C3-C8cyc... | 12/15/2009 |
| 7605134 | 4″-Deoxy-4″-(s)-amino avermectin derivatives A description is given of compounds of the formula which in the 4″-position has the (S)-configuration and wherein R1 is C1-C12alkyl, C3-C8cycloalkyl; or C2-C12alkenyl; R2 is hy... | 10/20/2009 |
| 7582612 | Multi-action anthelmintic formulations The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus tetrahydropyrimidines. An examples of a tetrahydropyrimidine includes pyrantel. A pharmaceutical fo... | 09/01/2009 |
| 7550440 | Topical application of ivermectin for the treatment of dermatological conditions/afflictions Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected... | 06/23/2009 |
| 7521429 | Avermectin B1 monosaccharide derivatives A compound of formula (I) wherein the bond between carbon atoms 22 and 23 may be a single or a double bond; R1 is C1-C12alkyl, C3-C8cycloalkyl, or C2-C12alkenyl; R2 and R3 | 04/21/2009 |
| 7396820 | Anthelmintic formulations The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus hexahydropyrazinoisoquinolines, tetrahydropyrimidines and benzimidazoles or febantel. Examples of h... | 07/08/2008 |
| 7396819 | Anthelmintic formulations The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus hexahydropyrazinoisoquinolines and tetrahydropyrimidines. Examples of these include praziquantel an... | 07/08/2008 |
| 7378399 | Avermectins substituted in the 4″ and 4′-positions having pesticidal properties What is described are a compound of the formula (I) Wherein A-B is —CH═CH— or —CH2—CH2—; n is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl;... | 05/27/2008 |
| 7368435 | Topical endoparasiticide and ectoparasiticide formulations A topical formulation having significant parasiticidal activity effective against endoparasites and/or ectoparasites such as heartworms, mites, fleas, ticks, flies is provided, which can be safe to use and avoids the many common deleterious side effects of conventio... | 05/06/2008 |
| 7358367 | Present invention relates to the new 3-decladinosyl derivatives of 9-deoxo-9a-aza9a-homoerythromycin a 9a, 11-cyclic carbamates The present invention relates to the new 3-decladinosyl derivatives of 9-de-oxo-9a-aza9a-homoerythromycin A 9a,11-cyclic carbamate of the general formula (I), their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, wherei... | 04/15/2008 |
| 7358053 | Methods for detecting and reversing resistance to macrocyclic lactone compounds This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The in... | 04/15/2008 |
| 7335753 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using... | 02/26/2008 |
| 7282487 | Method for treating bacterial infections in horses or pigs with tilmicosin The invention relates to methods of treating a bacterial infection in a horse or a pig. The method involves administering to the horse or pig a composition comprising (i) a salt made from tilmicosin and a lipophilic acid and (ii) a pharmaceutically acceptable solven... | 10/16/2007 |
| 7250402 | Avermectin derivatives A compound represented by the general formula (I) or a salt thereof: wherein represents —CH═CH—, —CH2—CH2— or the like, | 07/31/2007 |
| 7247617 | Sixteen-member macrolide antiinfective agents Sixteen membered macrolide anti-infective agents having a structure according to formula I where R1, R2, R3, R4, R5, and R6 are as defined herein,... | 07/24/2007 |
| 7241755 | Epothilone derivatives The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are as defined herein,... | 07/10/2007 |
| 7195773 | Pesticidal composition A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a haloalkyl group, m is 0 or 1, and Q is or a substituted or unsubstituted hete... | 03/27/2007 |
| 7144866 | Avermectin derivatives Provided is a compound represented by the general formula (I) or a salt thereof: wherein, —XY— represents —CH═CH— and the like, between R2 and the carbon atom at 5-posi... | 12/05/2006 |
| 7125899 | Epothilone derivatives The present invention relates to epothilone derivatives, having the following formula: in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7... | 10/24/2006 |
| 7119076 | Preventives or remedies for endometriosis or uterine myoma A drug effective for prevention and therapy of endometriosis and hysteromyoma is disclosed. The drug for prevention and/or therapy of endometriosis and/or hysteromyoma according to the present invention comprises as an effective ingredient a macrolide antibiotic. | 10/10/2006 |
| 7097848 | Synergistic insecticidal mixtures The invention relates to insecticidal mixtures comprising the compound of the formula (I) and at least one further known active compound selected from the group consisting of abamectin, emamectin or emamectin ben... | 08/29/2006 |
| 7091226 | Cancer treatment with epothilones The invention relates to the treatment of a proliferative disease, especially according to certain treatment regimens, with an epothilone, especially with epothilone A and more preferably epothilone B; as well as to the treatment of certain cancers with such an epot... | 08/15/2006 |
| 7087237 | Ocular solutions Containing at least one macrolide antibiotic and/or mycophenolic acid provide anti-inflammatory, anti-cell proliferation, anti-cell migration, anti-angiogenesis, antimicrobial, and antifungal effects. In one embodiment, the solution is administered intraocularly aft... | 08/08/2006 |
| 7083803 | Ocular solutions Ocular solutions containing at least one macrolide antibiotic and/or mycophenolic acid provide anti-inflammatory, anti-cell proliferation, anti-cell migration, anti-angiogenesis, antimicrobial and antifungal effects. In one embodiment, the solution is administered i... | 08/01/2006 |
| 7083802 | Treatment of ocular disease A formulation to treat ocular conditions such as dry eye disease, as well as other conditions, is disclosed. Rapamycin and/or ascomycin is administered intraocularly, such as by topical application, injection into the eye, or implantation in or on the eye. For examp... | 08/01/2006 |
| 7064108 | Topical ivermectin composition A topical gel composition comprising between about 0.005 and 1.0% ivermectin, between about 30 and 40% of a pharmaceutically acceptable alcohol, between about 30 and 40% of a pharmaceutically acceptable glycol, and a pharmaceutically acceptable carrier, useful for t... | 06/20/2006 |
