Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 6429197 | Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain It has now been discovered that GLP-1 treatment after acute stroke or hemorrhage, preferably intravenous administration, can be an ideal treatment because it provides a means for optimizing insulin secretion, increasing brain anabolism, enhancing insulin ... | 08/06/2002 |
| 6428780 | Compounds and compositions for delivering active agents Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration are provided, and methods of preparatio... | 08/06/2002 |
| 6426329 | Immunosuppressant activity of insulin-like growth factor I (IGF-I) The invention provides a composition for improving an action of an immunosuppressant, comprising insulin-like growth factor I or its analog as an active ingredient.... | 07/30/2002 |
| 6423344 | Dispersible macromolecule compositions and methods for their preparation and use A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly contr... | 07/23/2002 |
| 6417237 | Macromolecular drug complexes and compositions containing the same Macromolecular drug complexes containing a drug, like human growth hormone, and a polymer having a plurality of acid moieties, like carboxyl moieties or phosphonic acid moieties, and compositions containing the same, are disclosed. Compositions, particula... | 07/09/2002 |
| 6410511 | Formulations for amylin agonist peptides The present invention is concerned with a pharmaceutical formulation in a container, for example, a vial, prefilled cartridge, prefilled syringe or disposable pen, comprising approximately 0.01 to about 0.5% (w/v) amylin agonist, preferably pramlintide, i... | 06/25/2002 |
| 6410508 | Glucose-dependent insulinotropic peptide for use as an osteotropic hormone The examples demonstrate that GIP receptor mRNA and protein are present in normal bone and osteoblastic-like cell lines, and that high-affinity receptors for GIP can be demonstrated by 125 I GIP binding studies. When applied to osteoblast-like ... | 06/25/2002 |
| 6403562 | Materials and methods for treating autoimmune disease The subject invention pertains to novel methods for treating autoimmune-related diseases, such as Multiple Sclerosis (MS). One embodiment of the method of the invention comprises administering interleukin-10 (IL-10) and transforming growth factor-beta (TG... | 06/11/2002 |
| 6399566 | Topical preparation for introducing insulin in living organisms The invention relates to topically applicable pharmaceutical preparations which enable one to introduce insulin in living organisms by transdermal resorption. These preparations comprise (i) insulin (ii) capsaicine, histamine and/or cantharis extract, and... | 06/04/2002 |
| 6399090 | Insulin supplemented infant formula An infant formula in a powder or solution form including nutritional components and an insulin supplement. A method of feeding an infant including the steps of dissolving an infant formula powder containing nutritional components and an insulin supplement... | 06/04/2002 |
| 6379882 | Method for selecting compounds for treating ischemia-related cellular damage A method of screening for and treating subjects with a therapeutically effective amount of a compound that is effective in reducing cellular damage related to an ischemic condition, such as stroke or glaucoma. Test compounds are selected and therapeutical... | 04/30/2002 |
| 6368619 | Hydrophobic preparations of hydrophilic species and process for their preparation Single phase preparations of hydrophilic species, in particular macromolecular compounds such as proteins or glycoproteins in a hydrophobic solvent such as an oil can be obtained by preparing a hydrophile/amphiphile array in which the hydrophilic head gro... | 04/09/2002 |
| 6365177 | Insulin supplemented infant formula An infant formula in a powder or solution form including nutritional components and an insulin supplement. A method of feeding an infant including the steps of dissolving an infant formula powder containing nutritional components and an insulin supplement... | 04/02/2002 |
| 6358504 | Compounds and compositions for delivering active agents Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.... | 03/19/2002 |
| 6350432 | Pressurized container having an aerosolized pharmaceutical composition A pharmaceutical composition solubilized in a propellant that can be administered buccally or to the lungs using a metered dose dispenser is provided. The composition comprises a pharmaceutical agent; glycerin and/or polyglycerin; phenol and/or methyl phe... | 02/26/2002 |
| 6350458 | Mixed micellar drug deliver system and method of preparation Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in micellar form are disclosed. The micelles are formed from an alkali metal alkyl sulfate, and at least one additional micelle-forming compound as described in the specification... | 02/26/2002 |
| 6346242 | Compounds and compositions for delivering active agents The present invention provides a compound having the formula ##STR1## or a salt thereof which facilitates the delivery of active agents. Compositions and dosage unit forms comprising the compound of the present invention and at least one active agent, suc... | 02/12/2002 |
| 6342225 | Pharmaceutical active conjugates The invention provides an analogue of a pharmaceutical active whose molecular weight is less than 25,000 Daltons, the analogue comprising a pharmaceutical active whose molecular weight is less than 25,000 Daltons covalently linked to a pendant molecular g... | 01/29/2002 |
| 6339061 | Process for the stabilization of proteins in complex mixtures during their storage in aqueous solvents The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of hetero... | 01/15/2002 |
| 6335316 | Method for administering acylated insulin The invention relates to a method of administering a fatty acid-acylated insulin or insulin analog by inhalation, a method for treating diabetes by administering a fatty acid-acylated insulin or insulin analog by inhalation, and a method for treating hype... | 01/01/2002 |
| 6331522 | Antibacterial and antifungal peptide The present invention provides a peptide with antibacterial and antifungal properties, and compositions containing the peptide. Methods of making and using the antibacterial and antifungal peptide are also provided.... | 12/18/2001 |
| 6326154 | Ligand-mediated immunofunctional hormone binding protein assay method A ligand=mediated immunofunctional assay (LIFA) method for detecting the presence and the concentration of polypeptide hormone binding proteins which comprises capturing the binding protein with a solid phase bound first antibody, saturating the bound hor... | 12/04/2001 |
| 6322784 | Adipogenic differentiation of human mesenchymal stem cells A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into t... | 11/27/2001 |
| 6316404 | Treating NIDDM with RXR agonists This invention relates to methods and compositions for the treatment of non-insulin-dependent diabetes mellitus using an RXR agonist alone or in combination with a PPARγ agonist such as a thiazolidinedione compound.... | 11/13/2001 |
| 6313088 | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.... | 11/06/2001 |
| 6312665 | Aerosol formulations for buccal and pulmonary application A mixed micellar aerosol pharmaceutical formulation is provided. The formulation comprises a pharmaceutical agent, an alkali metal alkyl sulphate, at least three micelle-forming compounds, a phenol and a propellant. The propellant provides enchanced absor... | 11/06/2001 |
| 6309633 | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same The invention provides a drug-oligomer conjugate having the following general formula: ##STR1## wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently selected from the group consisting of straight or branched P... | 10/30/2001 |
| 6310038 | Pulmonary insulin crystals The present invention relates to zinc free insulin crystals having a diameter below 10 μm and to therapeutic powder formulations suitable for pulmonary administration containing such insulin crystals. The crystals of the present invention exhibit a bette... | 10/30/2001 |
| 6310040 | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs Disclosed is a method for promoting retinal neuronal survival in a mammal, wherein the neuronal cells are at risk of dying. The method comprises administering to the mammal an effective dose of at least one of the following substances: IGF-I; a functional... | 10/30/2001 |
| 6306821 | Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol) Poly(ethylene glycol) (PEG), a highly biocompatible hydrophilic polyether, is tethered to poly(propylene fumarate) (PPF), a biodegradable polyester. To avoid change in molecular weight distribution of PPF, end hydroxyl groups of PPF are reacted with bis-c... | 10/23/2001 |
| 6306432 | High and low load formulations of IGF-I in multivesicular liposomes Disclosed are multivesicular liposomes (MVLs) containing IGF-I with substantially full bioavailability, wherein the loading of the IGF-I into the liposomes is modulated by adjusting the osmolarity of the aqueous component into which the agents are dissolv... | 10/23/2001 |
| 6291495 | Method and composition for the treatment of diabetes This invention is directed to a novel method and composition for the treatment of diabetes mellitus (Type I, Impaired Glucose Tolerance ["IGT"] and Type II). More specifically, this invention pertains to a novel method of treating diabetes mellitus by inc... | 09/18/2001 |
| 6287859 | Identification, functional expression and chromosal localization of a sustained human proton-gated cation channel Non inactivating or slowly inactivating proton-gated cation channels are thought to play an important role in the perception of pain that accompanies tissue acidosis. We have identified a novel human proton-gated cation channel subunit that has biphasic d... | 09/11/2001 |
| 6281015 | Localized delivery of factors enhancing survival of transplanted cells Growth factors and/or angiogenic factors are administered in combination with dissociated cells to be transplanted, preferably in microspheres with the cells on or in a polymeric matrix, to enhance survival and proliferation of the transplanted cells. Exa... | 08/28/2001 |
| 6274549 | Treatment of type 1 diabetes Insulin analogues which are substantially devoid of hypoglycemic effect can be used for treating of delaying the onset of type 1 diabetes or ameliorating of an early stage thereof in a mammal at risk of developing diabetes.... | 08/14/2001 |
| 6271200 | Proteinic drug delivery system using aerosolized membrane-mimetic amphiphiles A mixed liposome pharmaceutical composition with multilamellar vesicles is provided. The vesicles are comprised of a pharmaceutical agent, membrane-mimetic amphiphiles and various phospholipids. A method of making the composition using high speed mixing o... | 08/07/2001 |
| 6267981 | Method of producing sustained-release preparation This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a suppression of initial burst, and a constant long-term release of th... | 07/31/2001 |
| 6268335 | Insoluble insulin compositions The present invention relates to insoluble compositions containing acylated proteins selected from the group consisting of acylated insulin, acylated insulin analog, and acylated proinsulin, and formulations thereof. The formulations are suitable for pare... | 07/31/2001 |
| 6251856 | Insulin derivatives The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the -amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in t... | 06/26/2001 |
| 6231882 | Mixed micellar delivery system and method of preparation A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal C8 to C22 alkyl sulphate, alkali metal salicylate, a pharmaceutically acceptable edetate and at least one absorption enhancing compounds. The a... | 05/15/2001 |
