Did You Know...
...that the Eveready Battery began as an invention called the "electric flowerpot," which was a tube with a battery and light bulb inside? The idea was to fasten this gizmo to the side of a flowerpot so it would illuminate the flowers from the bottom. The idea died on the vine and the businessman who licensed the flower pot, Conrad Huber, was left with a pile of useless tubes -- until he found a way to market them as batteries to light the world!
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| Number | Title | Issue Date |
| 4452775 | Cholesterol matrix delivery system for sustained release of macromolecules Delivery systems for releasing macromolecular active agents to a body site at a controlled rate for a prolonged period of time, comprising a cholesteric matrix permeable to passage of the macromolecular active agent by diffusion, are disclosed. The choles... | 06/05/1984 |
| 4448765 | Liposomes and their use in treating human or other mammalian patients Microvesicles are stabilized by the incorporation of a polymer having aliphatic lipophilic groups with a chain of at least six atoms attached to the backbone thereof. Such microvesicles may incorporate a physiologically active substance such as an antigen... | 05/15/1984 |
| 4439181 | Polyol-hormone mixture for use in chronic parenteral hormone administration A method of preventing the precipitation of proteins, such as hormone preparations, within drug delivery systems that depend on the fluidity of the infusate for proper function. A polyol, such as glycerol, is mixed with the protein solution prior to the i... | 03/27/1984 |
| 4434159 | Pharmaceutical composition for intrarectal administration, and suppository prepared therefrom A pharmaceutical composition for intrarectal administration comprising a pharmaceutically effective amount of an active ingredient which when administered alone to the rectum, is substantially unabsorbable into the living body through the mucous membrane ... | 02/28/1984 |
| 4423039 | Disaggregated solutions of polypeptides, their preparation and use The present invention is directed to a solution of a polypeptide, such as, for example, insulin, the solution being prepared and maintained at pH 6.8 to 8.0 and in which the polypeptide remains in solution in disaggregated form. This is accomplished by th... | 12/27/1983 |
| 4394372 | Process for making lipid membrane structures A process for producing lipid membrane structures (vesicles or liposomes) is disclosed, wherein a solution of bilayer forming compounds in a narrowly-defined two component solvent system is dispersed in an aqueous solution and, subsequently, at least a po... | 07/19/1983 |
| 4377512 | Oxygen carrier for blood substitute A hemoglobin modified by covalently bound inulin.... | 03/22/1983 |
| 4371523 | Reducing the aggregation of insulin in solution A method for reducing aggregation of insulin within aqueous insulin solutions comprising including in said insulin solutions an anti-aggregation agent selected from pharmaceutically acceptable organic compounds having at least two carboxylic acid moieties... | 02/01/1983 |
| 4356167 | Liposome drug delivery systems A liposome medicament delivery system wherein the medicament is encapsulated in a liposome comprising an aliphatic liquid-sterol-water lamellae. The lipid may be a sodium or potassium salt of a C4 to C18 fatty acid, and the sterol ma... | 10/26/1982 |
| 4320197 | Semi-synthesis of human insulin A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on a lysine carbonyl in peptide bondings and produced by Achromobact... | 03/16/1982 |
| 4320196 | Semi-synthesis of human insulin A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.... | 03/16/1982 |
| 4269821 | Biological materials There are described processes for the preparation of submicroscopic particles of physiologically acceptable polymer associated with a biologically active material, by polymerizing a monomer in the presence of the biologically active material or by adsorbi... | 05/26/1981 |
| 4224179 | Process for the preparation of liposomes in aqueous solution A process for the preparation of a solution or suspension of liposomes in an aqueous medium comprising the steps of dispersing a first aqueous liquid in an essentially water-insoluble solvent in the presence of a compound of the formula XY wherein X is a ... | 09/23/1980 |
| 4179337 | Non-immunogenic polypeptides Polypeptides such as enzymes and insulin are coupled to polyethylene glycol or polypropropylene glycol having a molecular weight of 500 to 20,000 daltons to provide a physiologically active non-immunogenic water soluble polypeptide composition. The polyet... | 12/18/1979 |
| 4164573 | Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal A method and composition for a rectally administered hypoglycemic agent into the bloodstream for the treatment of diabetes in mammals. The hypoglycemic agent is mixed with a physiological surface active agent which results in a suspension. This suspension... | 08/14/1979 |
| 4153689 | Stable insulin preparation for nasal administration Nasal administration of insulin is achieved by the use of an aqueous solution whose pH value is not higher than 4.7.... | 05/08/1979 |
| 4139611 | Organic peptide containing substance recovered from blood having insulin-like activity Organic peptide containing substances with insulin-like activity derived from blood or a blood component of a warm-blooded animal, which comprises the steps of pre-treating the blood or blood component by adjusting the pH thereof to a value of from 2 to 4... | 02/13/1979 |
| 4085204 | Process for obtaining insulin like active substances The invention concerns a novel process for obtaining insulin-like active substances from blood or a blood component of a warm-blooded animal, which comprises the steps of pre-treating the blood or blood component by adjusting the pH thereof to a value of ... | 04/18/1978 |
| 3989821 | Polypeptides The modification of porcine or bovine insulin by treatment with a lysine specific amino-endopeptidase, which has the effect of removing L-lysyl-L-alanine from the B chain of the insulin. The products obtained have full insulin-like activity but are less a... | 11/02/1976 |
| 3950517 | Insulin derivatives A physiologically acceptable insulin derivative has the terminal amino group of the B chain (B1, phenylalanine) protected by an acyl group or other blocking group containing up to 7 carbon atoms and the amino group of the A chain (A1... | 04/13/1976 |
| 3937820 | Insulin composition providing alternatives to immunological resistance A novel insulin composition of improved stability and compatibility comprising in an aqueous suspension crystallized insulin and amorphous des-phenyl-alanineB1 insulin of the same species, and a method for its manufacture.... | 02/10/1976 |
| 3937668 | Method for incorporating substances into protein microspheres The subject matter of this invention is a process for solid albumin particles so that such spheric particles may act as a carrier for radioactivity, drugs, insecticides, dyes, metal salts, etc. In order to prepare such spheric particles, the substance to ... | 02/10/1976 |
