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| Number | Title | Issue Date |
| 8188112 | Naphthalamide derivatives having antiproliferative activity The invention relates to compounds for use in medicine. The compounds are of general formula (I) as disclosed herein and the pharmaceutically acceptable salts, individual isomers and mixtures of isomers thereof, wherein X, X′ and X″ are independently O or S; Z i... | 05/29/2012 |
| 8133902 | Ammosamides as anticancer agents A compound having the general the general structure I is provided: (Formula I), wherein Z is a substituent selected from a group consisting of S and O; X is a substituent selected from a group consisting of Cl, Br, I, OH and NH2; each of R1 and R2 | 03/13/2012 |
| 8119656 | Inhibitors of the influenza virus non-structural 1 protein The present invention generally relates to compounds to treat viral infections and methods of their use. In particular, compounds of the present invention inhibit the activity of NS1 protein, thereby mitigating viral infection and, in particular, influenza virus inf... | 02/21/2012 |
| 7557120 | Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity The present invention is directed to compounds of formulae (I and II)(wherein A, D, E, X, l, m, n and R1 through R18 are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as... | 07/07/2009 |
| 7342028 | Medical use for tachykinin antagonists The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharm... | 03/11/2008 |
| 7291629 | Neurotrophin antagonist compositions A pharmaceutical composition comprising a compound of Formula I wherein R1 is selected from, inter alia, alkyl, aryl-loweralkyl, heterocycle-loweralkyl, loweralkyl-carbonate; optionally substituted ami... | 11/06/2007 |
| 7186741 | Neurotensin active 2,3,diaryl-pyrazolidine derivatives The invention relates to a group of novel 2,3 diaryl-pyparazolidine derivatives having formula (1). The symbols used in formula (1) have the meanings given in the specification. The compounds have inhibiting activity on enzymes which degrade the neuropeptide neurote... | 03/06/2007 |
| 7148352 | Method of inhibiting neurotrophin-receptor binding The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTR common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75... | 12/12/2006 |
| 7135481 | Naphthalimide compositions and uses thereof Methods of treating a solid tumor are disclosed comprising administering amonafide in combination with an antiproliferative agent. ... | 11/14/2006 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 6989390 | Amonafide salts Disclosed is a salt of amonafide or amonafide analogs represented Structural Formula (I): R1 is —(CH2)nN+HR3R4 X− or R1 is —(CH2) | 01/24/2006 |
| 6921771 | Method of treating sexual disturbances The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually therapeutic amount is from ab... | 07/26/2005 |
| 6903127 | Method of treating sexual disturbances The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually therapeutic amount is from ab... | 06/07/2005 |
| 6890945 | Method of treating sexual disturbances The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually therapeutic amount is from ab... | 05/10/2005 |
| 6809112 | Method of treating sexual disturbances The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually therapeutic amount is from ab... | 10/26/2004 |
| 6670369 | Use of phanquinone for the treatment of alzheimer's disease The use of phanquinone for the manufacture of a pharmaceutical composition for the prevention or the treatment of Alzheimer's disease is disclosed. Also methods of treatment or prevention of Alzheimer's disease are disclosed.... | 12/30/2003 |
| 6630173 | Naphthalimide compositions and uses thereof A method of treatment of a host with a cellular proliferative disease, comprising contacting the host with a naphthalimide and an antiproliferative agent, each in an amount sufficient to modulate said cellular proliferative disease, is described. In some ... | 10/07/2003 |
| 6492380 | Method of inhibiting neurotrophin-receptor binding The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTR common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor ... | 12/10/2002 |
| 6451808 | Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists Metformin is formulated as a pharmaceutical composition that also includes a 5-hydroxytryptamine-3 receptor antagonist to suppress the gastrointestinal side effects that are associated with metformin administration in many patients.... | 09/17/2002 |
| 6410505 | Dimeric non-azo naphthalimides and uses for the same A class of predominantly hydrophilic 1,8-naphthalimide dyes. The dye contains at least two 1,8-naphthalimide ring systems, joined by a spacer moiety. Each of the 1,8-naphthalimide ring system has a ring nitrogen atom and bears, at the 4 position, an amino... | 06/25/2002 |
| 6380193 | Fused tricyclic compounds, methods and compositions for inhibiting PARP activity A compound of formula I: ##STR1## or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof.... | 04/30/2002 |
| 6303569 | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric compounds comprise the formula: ##STR1## wherein: B is H, OH, OSiR13, a residue of an amine-containing target moiety or a resi... | 10/16/2001 |
| 6300331 | Naphthalimidobenzamide derivatives The present invention relates to a naphthalimidobenzamide derivative represented by the following formula (1): ##STR1## (wherein, R1 represents a hydrogen atom, etc., Y represents a hydrogen atom or --CON(R4)--A2 --X2... | 10/09/2001 |
| 6300340 | Bisimide compounds A compound of formula (I) ##STR1## in which: m, and n, which may be identical or different, represent 0 or 1, X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino,... | 10/09/2001 |
| 6133259 | Alkyl, alkenyl and alkynyl chrysamine G derivatives for inhibition of cell degeneration and toxicity associated with amyloid deposition Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloido... | 10/17/2000 |
| 6066632 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to me... | 05/23/2000 |
| 5998405 | Fused tropane-derivatives as neurotransmitter reuptake inhibitors The present invention discloses compounds of the formula, or any of its enantiomers or any mixture thereof, a pharmaceutically acceptable addition salt thereof or the N-oxide thereof wherein X and Y together forms .dbd.O, .dbd.S, .dbd.NOR2, .dbd.CR | 12/07/1999 |
| 5990106 | Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof This invention relates to bicyclic amino group-substituted pyridonecarboxylic acid derivatives of the general formula A--Pri esters thereof and salts thereof, wherein: Pri is a pyridonecarboxylic acid residue, and A is a bicyclic amino group represented by the... | 11/23/1999 |
| 5948776 | Compositions and methods for treating bone deficit conditions Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15Å, are effective in treating condit... | 09/07/1999 |
| 5869479 | Treatment of upper airway allergic responses Relief from the symptoms of rhinitis is obtained by treatment with: (a) an antihistaminic effective amount of a histamine H1 receptor antagonist; together with (b) a sufficient amount of a histamine H3 receptor antagonist to provide ... | 02/09/1999 |
| 5863912 | Method of treatment of hormone-unresponsive metastiatic prostate cancer Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity and amelioration of cyclophosphamide-associated toxicity ... | 01/26/1999 |
| 5854263 | 1-(1,4-benzodioxanyl)alkyl!-3-(heteroaryl) pyrrolidines and related compounds and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 12/29/1998 |
| 5854273 | Bisimide compounds A compound of formula (I) ##STR1## in which: X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino, Z represent a linear or branched C | 12/29/1998 |
| 5854277 | Thiophenebutanoic acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T... | 12/29/1998 |
| 5789418 | Bis-naphthalimides for the treatment of cancer Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula ##STR1## wherein X, X', X" and X'", A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical... | 08/04/1998 |
| 5776963 | 3-(heteroaryl)-1-(2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1-(2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 07/07/1998 |
| 5766600 | Non-azo naphtalimide dyes and uses for same A class of predominantly hydrophobic non-azo N-substituted 1,8-naphthalimide compounds, each bearing, at its 3-position, a nucleofuge and, at its 4-position, a heteroatomic electron-releasing group. The heteroatomic electron-releasing group is being chara... | 06/16/1998 |
| 5670514 | Compositions for inhibiting bone loss The present invention provides methods of inhibiting bone loss in mammals via the administration to a mammal in need of such treatment an effective amount of a compound from a series of benzoquinolin-3-ones. Such compounds also are sequentially or concurr... | 09/23/1997 |
| 5658911 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. T... | 08/19/1997 |
| 5654319 | N-[(4-heteroaryl-1-piperidinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 08/05/1997 |
