Class 514/294 - Ring nitrogen is shared by two of the cyclos

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein a ring nitrogen is a member of two
No. of patents: 236
Last issue date: 06/28/2011

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Number	Title	Issue Date
4530926	Perfluorotricyclic amines as oxygen carriers A novel compound of the formula, ##STR1## wherein k, j, l and m are zero or an integer of from 1 to 3, and n is an integer of from 1 to 3, the rings A, B and C being optionally substituted with at least one trifluoromethyl group, prepared by reacting...	07/23/1985
4529583	Composition and method of immobilizing emetics and method of treating human beings with emetics A therapeutic composition is coated with a mixture of an emetic chemical and an inert material. A method for reducing absorption into the body of a being of an emetic chemical while still retaining localized emetic activity comprises combining prior to in...	07/16/1985
4524148	Antimicrobial 8,9-dihalobenzo[ij]quinolizine carboxylic acids The compounds 8-bromo-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quiniolizine-2- carboxylic acid and 8-chloro-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H,-benzo[ij]quinolizine-2 -carboxylic acid are disclosed as potent antimicrobials. Pharma...	06/18/1985
4494547	2H-isoindolediones, their synthesis and use as radiosensitizers Isoindoledione compounds of the formula: ##STR1## wherein: R1 and R3 each separately is phenyl, substituted phenyl, alkyl of 1 to 4 carbons, --CHO, --CH2 OR6, --CO2 R6, --COR6	01/22/1985
4481200	଱₂ -Adrenoceptor antagonistic benzoquinolizines The invention concerns benzoquinolizines of formula ##STR1## and their pharmaceutically acceptable acid addition salts. In the formula R1 and R2 which may be the same or different each represent hydrogen, lower alkyl, lower alko...	11/06/1984
4476131	Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyrido[1,2-a]- q Tricyclic benzo fused compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R1 is H or certain acyl groups; Q is CO2...	10/09/1984
4472405	Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives The compound 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carbo xylic acid is disclosed as a potent antimicrobial agent with a broad spectrum of activity. Esters, acyl chlorides, alkylaminoalkyl ester salts and pharmaceutically...	09/18/1984
4472406	Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives Certain 6,7-dihydro-8-(imidazol-1-yl)-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxyli c acids are disclosed as potent antimicrobial agents with an unusual spectrum of activity. Esters, acyl chlorides, alkylaminoalkyl ester salts, salts of a nitrogen atom...	09/18/1984
4472407	Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]q u The 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo- 1H,5H-benzo[ij]quinolizine-2-carboxylic acids are disclosed as potent antimicrobial agents with a broad spectrum of activity. Esters, acyl chlorides, amides, alkylaminoalkyl ester salts and pharmaceuticall...	09/18/1984
4459278	Composition and method of immobilizing emetics and method of treating human beings with emetics A therapeutic composition is coated with a mixture of an emetic chemical and an inert material. A method for reducing absorption into the body of a being of an emetic chemical while still retaining localized emetic activity comprises combining prior to in...	07/10/1984
4454139	଱₂ -Adrenoceptor antagonistic benzoquinolizines The invention concerns benzoquinolizines of formula ##STR1## and their acid addition salts. In the formula R7 is lower alkyl or a phenyl or naphthyl radical optionally substituted with specified substituents and R8 is methyl or ...	06/12/1984
4443447	Phenyl-substituted tricyclic antibacterial agents Antimicrobial compounds of the following formula are disclosed: ##STR1## wherein X is selected from the group consisting of --O--, --CH2 and ##STR2## m is 0 or 1; R1 is selected from the group consisting of hydrogen, nitro,...	04/17/1984
4404207	Antimicrobial 8-substituted benzo [IJ]quinolizines Antimicrobial compounds of the following formula are disclosed: ##STR1## wherein Het is selected from the goup consisting of pyrryl, pyrrolidyl, tetrazolyl of the formula ##STR2## wherein R1 is lower alkyl or benzyl and oxadiazolyl of...	09/13/1983
4400386	Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine This invention relates to antimicrobial compounds of the formula ##STR1## wherein X is hydrogen or fluorine; Y is selected from the group consisting of ##STR2## and ester, carboxylate salts, and alkylaminoalkyl ester salts thereof....	08/23/1983
4399141	5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof 5-Substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anticonvulsants....	08/16/1983
4380543	Antimicrobial 8-cyano-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxyl ic acids The compounds 8-cyano-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid and 8-cyano-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-c arboxylic acid are disclosed as potent antimicrobial agents. Pharmaceutic...	04/19/1983
4343811	2[3-(4-Chlorophenyl)-1,2-dimethyl-1H-indol-5-yloxy]-2-methyl propanoic acid and hyperlipidemic or atheosclerotic use thereof This invention relates to novel indole derivatives of formula ##STR1## and the non-toxic, pharmacologically acceptable salts thereof. These compounds exhibit desirable pharmacological properties, especially lipid-level lowering and anti-atherosclerot...	08/10/1982
4332810	N-(Substituted)-2,5-ethano-8-hydroxy (or methoxy)-1,2,3,4,5,6-hexahydro-3 (or 4)-benzazocine centrally-acting analgesics Novel N-(substituted) derivatives of 2,5-ethano-8-hydroxy (or methoxy)-1,2,3,4,5,6-hexahydro-3 (or 4)-benzazocine of the formula: ##STR1## are centrally acting analgesics effective in the relief of pain....	06/01/1982
4328232	Benzoquinolizines, anti-secretory compositions containing them, and methods of treating ulcers employing them The invention concerns benzoquinolizines of the general formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein the ##STR2## linkage represents a single bond linkage of formula ##STR3## or a double...	05/04/1982
4235910	Benzoquinolizines having blood pressure lowering activity, and in some instances, anti-secretory activity The invention concerns benzoquinolizines of the general formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R1 and R2 which may be the same or different, each represent hydrogen, lower a...	11/25/1980
4230710	Amide derivatives of 2-substituted anilino-hexahydrobenzo[a]quinolizines, and methods of treating hypertension employing them Disclosed are novel 2-substituted anilino-hexahydrobenzo[a]quinolizines of the formula: ##STR1## wherein R and R' are independently H or --OCH3 and R" is ##STR2## These compounds, and their pharmacologically acceptable, non-toxic acid...	10/28/1980
4218448	Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils Polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils, such as 1,2-dihydro-8-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-6-methy l-4H-pyrrolo-[3,2,1-ij]quinolin-7-one, useful as antihypertensive agents....	08/19/1980
4198414	Compounds and methods for treating diabetic complications Novel4-H-pyrrolo[3,2,1-ij]quinolin-1,2-diones having the formula ##STR1## wherein R1 is hydrogen or methyl and R2 is methyl or phenyl are disclosed. The compounds are useful as inhibitors of aldose reductase....	04/15/1980
4193998	1,2,3,4,6,7-Hexahydro-11B଱H-benzo[a]quinolizine-derivatives There are provided new compounds of the formula I ##STR1## wherein both R1 moieties stand for an alkyl group having 1 to 4 carbon atoms or form together a methylene bridge, R2 is cyano or an alkoxycarbonyl group having 1 to 4 carbon ...	03/18/1980
4183937	Blood pressure lowering benzoquinolizines The invention concerns novel benzoquinolizines of formula (I) ##STR1## and their pharmaceutically acceptable acid addition salts. In formula (I) R1 and R2 which may be the same or different, each represent hydrogen, lower alkyl,...	01/15/1980
4183938	1,8-Ethano-5-oxo-octa- and -decahydroquinolines and mydriatic compositions thereof Compounds of the general formula: ##STR1## wherein X is selected from the group consisting of oxygen, CH2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aralkyl groups and when X desig...	01/15/1980
4175119	Composition and method to prevent accidental and intentional overdosage with psychoactive drugs A composition and method of inducing emesis to preclude death from accidental or intentional overdosage of a therapeutic composition. The surface of the therapeutic composition is coated with an emetic chemical of such quantity that if the therapeutic com...	11/20/1979
4151282	Compositions and methods for treating diabetic complications Methods for using 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-dione and pharmaceutical compositions thereof in preventing diabetic complications are disclosed....	04/24/1979
4083985	6-Oxa-1-aza tricyclo dodecan-5-ones as psychomotor stimulators Compounds of the general formula ##STR1## wherein X is selected from the group consisting of oxygen CH2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aryl groups and when X designates...	04/11/1978
4076820	Benzoquinolizines and hypotensive compositions containing them The invention relates to novel benzoquinolizines of the general formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R1 and R2 which may be the same or different, each represent hydrogen,...	02/28/1978
4051247	Method of using 7-hydroxy-benzo[ij]quinolizine-2-carboxylic acid derivatives Certain substituted 6,7-dihydro-7-hydroxy-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acids and salt and ester derivatives thereof are described. These compounds are useful antibacterial agents. SP This is a division of application Ser. No. 567,510, fil...	09/27/1977
4015005	1,2,5,6-Tetrahydro-4H-pyrrolo(3,2,1-j)quinolin-2-ones The invention discloses 1,2,5,6-tetrahydro-4H-pyrrolo-(3,2,1-ij)quinolin-2-ones having pharmacological activity in animals and useful as CNS depressant agents. The compounds may be prepared by treating a haloacetyl derivative of 1,2,3,4-tetrahydroqui...	03/29/1977
4008325	Control of rice blast disease employing certain pyrido compounds A method of treatment or control of diseases of rice plants comprising contacting the plants, and the seeds thereof with an effective amount of a compound of the formula: ##STR1## or a non-phytotoxic acid addition salt thereof, wherein each of X and ...	02/15/1977
4006218	Potentiated medicaments Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quaternary ammonium compounds, bisdiguanides, anti-fungal agents, phenols, hydroxydiphenyls, carbanilides, salicylani...	02/01/1977
3995041	Derivatives of 2-substituted-hydroxyanilino-hexahydro-2H-benzo[଱]quinolizines 2-Substituted-hydroxyanilino-hexahydro-2H-benzo[଱]quinolizines of the structural formula, ##SPC1## In which R1 is a hydrogen atom or an alkanoyl group of 2 to 4 carbon atoms and each of substituents R2, R3, R4	11/30/1976
3985882	Substituted benzo[ij]quinolinzine-2-carboxylic acids and derivatives thereof as bactericidal agents Certain substituted 6,7-dihydro-1-oxo-1H,5H-benzo[ij]-quinolizine-2-carboxylic acids and hydrazides, esters, amides and salts thereof, intermediates therefor, and a process for their preparation are described; the compounds are active as anti-microbi...	10/12/1976

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Class 514/294 - Ring nitrogen is shared by two of the cyclos