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| Number | Title | Issue Date |
| 8188054 | Non-peptide macrocyclic histone deacetylase (HDAC) inhibitors and methods of making and using thereof Compounds of Formula I or II, and methods of making and using thereof, are described herein. M represents a macrolide subunit, n is a C1-6 group, optionally containing on... | 05/29/2012 |
| 8173609 | Macrolides useful against inflammatory and allergic diseases New macrolide general compounds of formula I with improved activity making them useful for inhibiting human phosphodiesterase 4 and treating chronic obstructive pulmonary disease (COPD). ... | 05/08/2012 |
| 8148337 | Vaginal compositions for treating pelvic tissue infections and traumas A method of treatment for a pelvic tissue infection by vaginally administering an antibiotic and a prostaglandin to a patient is disclosed. A method of reducing surgical trauma resulting from a gynaecological operation by administering vaginally a composition compri... | 04/03/2012 |
| 8143227 | Azithromycin for treatment of skin disorders Azithromycin has increased efficacy in treating acne and other skin conditions when administered systemically at low doses, below those previously known to produce a clinical antibiotic effect. ... | 03/27/2012 |
| 8097594 | Macrolides and ketolides having antimicrobial activity The present invention provides compounds having antimicrobial activity for preventing and treating diseases caused by microbial infections. Thus, the present invention relates to novel semi-synthetic 11,12-γ lactone macrolides and ketolides having antimicrobial act... | 01/17/2012 |
| 8080529 | Macrolides with anti-inflammatory activity The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4″ position, to their pharmaceutically acceptable derivatives, to proc... | 12/20/2011 |
| 8080528 | Compositions and methods for treatment of cachexia Compositions and methods for preventing and treating wasting disorders, such as cachexia and anorexia, are provided. In one aspect, the present invention provides a method for preventing and treating a wasting disorder in a mammal. In one embodiment, the method of t... | 12/20/2011 |
| 8076301 | 10-substituted macrolide antibiotics Disclosed herein are 10-desmethyl, 10 substituted-macrolides, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using them. The 10-desmethyl macrolides are particularly useful as antibiotics. ... | 12/13/2011 |
| 8063021 | Ketolide anti-infective compounds Compounds according to formula I wherein m is 0 or 1; X is and R1, R2, R3 R4, and R5 are as defined herein, are us... | 11/22/2011 |
| 8030282 | Motilide polymorphs The invention provides polymorphs of a motilide having a structure represented by formula Ia ... | 10/04/2011 |
| 8017588 | Clarithromycin or salt thereof for use in the treatment or prevention of pulmonary disease induced by destruction of pulmonary alveoli For the purpose of treatment and/or prevention of pulmonary disorders caused by the destruction of pulmonary alveoli resulting from smoking, air pollution, noxious gas, etc., there are provided, among others, a method of administering clarithromycin or a salt thereo... | 09/13/2011 |
| 8012943 | Antibacterial agents Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents. ... | 09/06/2011 |
| 7956042 | Crystalline forms of macrolide compounds endowed with antiinflammatory activity The present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with antiinflammatory activity, processes for the preparation of such forms, pharmaceu... | 06/07/2011 |
| 7928078 | Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals. ... | 04/19/2011 |
| 7910559 | Decladinosyl-macrolides with anti-inflammatory activity The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptab... | 03/22/2011 |
| 7803779 | Drugs for the treatment and/or prophylaxis of gastroparesis symptom The present invention provides a therapeutic and/or preventive agent against gastroparesis symptom which is appropriate for continuous medication and which comprises a compound represented by formula (1): (wherein R1 | 09/28/2010 |
| 7749970 | Topical treatment of prevention of ocular infections The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regime... | 07/06/2010 |
| 7732415 | Topical treatment or prevention of ocular infections The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regime... | 06/08/2010 |
| 7718621 | Macrolones—amino substituted quinolones A compound of formula (I) or a pharmaceutically acceptable derivative thereof, having antimicrobial activity, processes for their preparation, compositions containing them and to their use in medici... | 05/18/2010 |
| 7704959 | Azithromycin for the treatment of nodular acne Azithromycin, administered systemically, is an effective treatment for nodules associated with acne vulgaris. ... | 04/27/2010 |
| 7704960 | Macrolide compounds endowed with antiinflammatory activity Macrolide compounds endowed with antiinflammatory activity are described, and more particularly macrolide derivatives lacking cladinose in position 3, with antiinflammatory activity, pharmaceutically acceptable salts thereof and pharmaceutical compositions containin... | 04/27/2010 |
| 7622452 | C-9 alkenylidine bridged macrolides The present invention discloses compounds of formulae (I), (II) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceuti... | 11/24/2009 |
| 7608596 | 10-substituted macrolide antibiotics Disclosed herein are 10-desmethyl, 10 substituted-macrolides, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using them. The 10-desmethyl macrolides are particularly useful as antibiotics. ... | 10/27/2009 |
| 7601695 | Antibacterial agents Described herein are novel macrolides, the preparation of novel macrolides, to the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents. ... | 10/13/2009 |
| 7595300 | 7-quinolyl ketolide antibacterial agents 15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections. ... | 09/29/2009 |
| 7589067 | 6, 11-bridged tricyclic macrolides The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical comp... | 09/15/2009 |
| 7582611 | Motilide compounds Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents. ... | 09/01/2009 |
| 7579324 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or... | 08/25/2009 |
| 7572773 | Single dose fast dissolving azithromycin The present disclosure related to a method of treating an infection by oral administration of a single dose of a fast dissolving form of azithromycin. The disclosure also relates to a method of reducing the adverse effects arising from treatment of a subject having ... | 08/11/2009 |
| 7569550 | 14 and 15 membered ring compounds The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy... | 08/04/2009 |
| 7569549 | Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible with water, x is 1, 1.25, 1.5 or... | 08/04/2009 |
| 7563773 | Anthelmintic oral homogeneous veterinary pastes This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such as horses and household pets. This invention further provides for a p... | 07/21/2009 |
| 7547679 | Ether linked macrolides useful for the treatment of microbial infections The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy... | 06/16/2009 |
| 7524823 | Macrolides The present invention relates to new antibiotic macrolide compounds of the general formula I: with improved activity, to medicaments comprising such antibiotics, and to the use of such antibiotics for the treatment of infec... | 04/28/2009 |
| 7521428 | Macrolide derivatives having effect of potentiating antifungal activity Macrolide derivatives having enhancing effect for activities of azole antifungal agents, acting at low concentration and within a short time against fungal infection and reducing the frequency of appearance of resistant microorganisms. One such substance is a compou... | 04/21/2009 |
| 7517859 | Spirocyclic bicyclolides The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical comp... | 04/14/2009 |
| 7507721 | Macrolides with antiinflammatory activity Macrolide compounds of formula (I) wherein X, R, R1, R2, R3 and R4, have the meanings as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingred... | 03/24/2009 |
| 7462600 | Macrolides Macrolide compounds per se, as shown below and defined herein, and their use, e.g., as antibacterial and antiprotozoal agents in animals, including humans: Also disclosed are methods of preparing the compounds, intermediate... | 12/09/2008 |
| 7446097 | Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals. ... | 11/04/2008 |
| 7438924 | Dry granulated formulations of azithromycin This invention relates to a pharmaceutical formulation, in the form of a tablet, sachet or powder for suspension dosage form, which comprises dry granulated particles of a non-dihydrate form of azithromycin and, optionally, one or more pharmaceutically acceptable ex... | 10/21/2008 |
