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| Number | Title | Issue Date |
| 8188110 | Morphinan compounds This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in met... | 05/29/2012 |
| 8178551 | Orally bioavailable prodrugs of (+)-3-hydroxymorphinan for Parkinson'S disease prevention or treatment The present invention is directed to a novel prodrug of (+)-3-hydroxymorphinan compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the same, and its use for preventing or treating Parkinson's disease. ... | 05/15/2012 |
| 8106065 | Antitussive agent An antitussive, which can be used for therapy or prophylaxis of coughing, is disclosed. The antitussive comprises as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic substituent or a pharmaceutically acceptable acid addition salt th... | 01/31/2012 |
| 8093261 | Rapid release mini-tablets provide analgesia in laboratory animals Pellets containing an analgesic uniformly dispersed in a lipid carrier such as cholesterol mixed with fatty acid esters, can be used to provide long term pain relief. 5 mg cholesterol-tryglyceride-buprenorphine pellets released the majority of drug in 24-48 hours af... | 01/10/2012 |
| 7973049 | Morphinan compounds This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in met... | 07/05/2011 |
| 7943633 | Alkaloid compounds and their use as anti-malarial drugs Anti-malarial alkyloid compounds have the formula: wherein R1-R11 have various disclosed values or their pharmaceutically acceptable salts, and pharmaceutical compositions containing the same. ... | 05/17/2011 |
| 7932264 | Sinomenine derivatives and preparation and uses thereof The present invention relates to the preparation and pharmacological use of sinomenine derivatives of formula I. The approach disclosed herein is the modification of D ring by-substituting for R. Additional substitutions in the other rings are also provided herein. ... | 04/26/2011 |
| 7923454 | Opioid and opioid-like compounds and uses thereof The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations containing the same and methods of use thereof. Uses of the present invention include, but are not limited to, use for the prevention and treatment of septic shock and... | 04/12/2011 |
| 7691874 | Neuroprotective properties of dextrorotatory morphinans The present application discloses a pharmaceutical composition for treating Parkinson's disease and psychotropic intoxication/abusive potential, which contains a morphinan compound. ... | 04/06/2010 |
| 7659282 | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine. ... | 02/09/2010 |
| 7625921 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure ... | 12/01/2009 |
| 7326730 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and composi... | 02/05/2008 |
| 7326690 | Modulation of cell fates and activities by phthalazinediones Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survi... | 02/05/2008 |
| 7320984 | Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group The invention provides a morphinan derivative of the Formula (I): wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y ... | 01/22/2008 |
| 7291628 | Treatment of cocaine abuse using N-substituted derivatives of morphinan The invention is based in part on the discovery that nonselective κ agonists that possess μ receptor-mediated effects in addition to their κ agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can... | 11/06/2007 |
| 7285686 | Process for the preparation of 1,3-substituted indenes An improved process for the preparation of 1,3 substituted indenes which are useful intermediates in the synthesis of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders. ... | 10/23/2007 |
| 7262298 | 4-hydroxybenzomorphans 4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. ... | 08/28/2007 |
| 7256200 | Method and composition for potentiating an oplate analgesic Composition and methods of treating pain and reducing, reversing, or preventing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and a calcium calmodulin kinase (CaMKII) inhibitor as active agents to treat pain in ... | 08/14/2007 |
| 7230000 | Methods and compositions utilizing quinazolinones Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity ... | 06/12/2007 |
| 7205300 | Aryl fused azapolycyclic compounds This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthe... | 04/17/2007 |
| 7199129 | Derivatives of morphine-like opioid compounds The present disclosure concerns compounds of formula (I) and pharmaceutically acceptable salts, hydrates, solvates, pharmaceutically acceptable derivatives, pro-drugs, tautomers and/or isomers thereof. The disclosure also relates to processes for the preparation of ... | 04/03/2007 |
| 7186870 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of the formulae (Ia), (Ib) and (Ic) or a mixture thereof: wherein R1, R2, R | 03/06/2007 |
| 7179803 | Method of modulating ion channel functional activity The present invention relates generally to a method of retarding, reducing or otherwise inhibiting viral functional activity and, more particularly, to a method of reducing, retarding or otherwise inhibiting viral functional activity by down-regulating Vpu ion chann... | 02/20/2007 |
| 7172767 | Opioid agonist / antagonist combinations The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide ... | 02/06/2007 |
| 7144882 | Aryl fused azapolycyclic compounds This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthe... | 12/05/2006 |
| 7109333 | Heterocyclic compounds A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) ... | 09/19/2006 |
| 7101890 | Benzazepine derivatives, drugs containing these and use of the same for producing drugs New derivatives of benzazepine, particularly of benzofuro[3a,3,2,ef][2]benzazepin of the general formula (I) and new compounds of the general formula (III) Dru... | 09/05/2006 |
| 7091372 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of the formulae (Ia), (Ib) and (Ic) or a mixture thereof: wherein R1, R2, R | 08/15/2006 |
| 7087619 | Method for the treatment of urinary incontinence Urinary incontinence is alleviated in a mammal by administering to the mammal a urinary incontinence alleviating amount of dextromethorphan, dextrorphan, their mixtures and/or pharmaceutically acceptable salts, alone or in combination with a pharmacologically active... | 08/08/2006 |
| 7062312 | Combination and method including a visual marker for determining compliance with a medication regimen A method and combination including a visual marker for monitoring a patient to determine compliance with a medication regimen. An orally administrable medication composition is provided in combination with a visual marker. When the combination is orally ingested, th... | 06/13/2006 |
| 7026329 | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists This invention relates to a method for selectively enhancing the analgesic potency of a bimodally-acting opioid agonist such as morphine and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects asso... | 04/11/2006 |
| 7009073 | Method for preparing indan-1,3-dicarboxylic acid A method for preparing indan-1,3-dicarboxylic acid compounds which are useful intermediates in the syntheses of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders. ... | 03/07/2006 |
| 6959708 | Method for co-application of gases and drugs to potentiate their action in relieving headaches, angina and other ailments Apparatus, methods and kits for treating symptoms associated with common ailments such as headaches, rhinitis, asthma, epilepsy, nervous disorders and the like, are provided. The apparatus includes dispensers for carbon dioxide and other therapeutic gases. The metho... | 11/01/2005 |
| 6921775 | Methods for modulating brain damage Methods are disclosed for modulating brain damage mediated by non-NMDA ionotropic glutamate receptor antagonists, as topiramate, in conditions such as periventricular leukomalacia, cerebral palsy, mental retardation and neonatal stroke. ... | 07/26/2005 |
| 6919423 | Hepatitis C inhibitor compound Compounds of formula (I): wherein B, X, R3, R21, R22, R1 and Rc are defined herein. The compounds are useful as inhibitors of HCV NS3 protease. ... | 07/19/2005 |
| 6908901 | Hepatitis C inhibitor peptide analogs Compounds of formula (I): wherein B, Y, R3, R24, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease. ... | 06/21/2005 |
| 6897241 | Preparation of topical regional compositions for the relief of pain A method is presented for the preparation of topically applied compositions used for the treatment of regional pain, especially sympathetically mediated pain. NMDA receptor antagonists, such as ketamine or dextromethorphan, and one or more tricyclic antidepressants,... | 05/24/2005 |
| 6855735 | Ketamine treatment of restless legs syndrome The present invention is directed to a method for treating symptoms associated with Restless Legs Syndrome (RLS). The method includes administering to a warm-blooded animal in need of such treatment a dose of ketamine sufficient to alleviate symptoms associated with... | 02/15/2005 |
| 6844438 | N-substituted derivatives of morphinan and uses thereof The invention is based in part on the discovery that nonselective κ agonists that possess μ receptor-mediated effects in addition to their κ agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can... | 01/18/2005 |
| 6806291 | Analgesic compounds, their synthesis and pharmaceutical compositions containing them New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These compounds surprisingly possess high analgesic activity with little hepa... | 10/19/2004 |
