Class 514/287 - Three or more hetero atoms in the tetracyclo ring system

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the tetracyclo ring system contains
No. of patents: 153
Last issue date: 04/03/2012

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Number	Title	Issue Date
8148392	2-indolyl imidazo [4,5-d] phenanthroline derivatives and their use in the treatment of cancer 2-indolyl imidazo[4,5-d]phenanthroline compounds of Formula (I) and methods of using same in the treatment of cancer, in particular, solid cancers and leukemia are provided. Pharmaceutical compositions comprising the compounds are also provided. ...	04/03/2012
8097635	Insulin resistance improving agent An object of the present invention is to provide a safe and highly effective insulin resistance improving agent or therapeutic agent for type II diabetes. According to the present invention, an insulin resistance improving agent or a therapeutic agent for type II di...	01/17/2012
8088788	Substituted fused[1,2] imidazo[4,5-] ring compounds and methods [1,2]Imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) substituted with a fused ring containing an oxygen and/or nitrogen atom attached at the 1- and/or 2-position, pharmaceutical compositions c...	01/03/2012
8044065	Benzothienopyridines for use as inhibitors of Eg5 kinesin Compounds of a certain formula I, in which R1, R2, R3, R4 and X have the meanings indicated in the description, are novel effective compounds with Eg5 inhibitory, anti-proliferative and/or apoptosis inducing activity. ...	10/25/2011
7994187	HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones HIV inhibitory compounds of formula: salts, hydrates, solvates, N-oxides, or stereoisomers thereof, wherein A forms pyridine, pyrimidine, pyrazine, pyridazine, triazine, imidazole, pyrazole, triazole, tetrazole...	08/09/2011
7875624	Modulating and measuring cellular adhesion Methods of using compounds having Structure I or the salts or tautomers of the compounds in the treatment of disorders relating to cell adhesion and metastatic processes are presented herein. ...	01/25/2011
7763634	Inhibitors of janus kinases The instant invention provides for tetracyclic compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity ...	07/27/2010
7718665	Benzothienopyridines for use as inhibitors of Eg5 kinesin Compounds of the formula (1) in which R1, R2, R3, R4 and X have the meanings indicated in the description, are novel effective compounds with Eg5 inhibitory, anti-proliferative and/or apoptosis inducing activity. ...	05/18/2010
7652029	Therapeutic compound and treatments Compositions and uses associated with the MT477 family of compounds are disclosed. Particular structural features and properties of the compounds are described in detail. Uses include administering an MT477 family member to a patient for therapeutic purposes. Compos...	01/26/2010
7550477	Inhibitors of checkpoint kinases The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patie...	06/23/2009
7501435	Inhibitors of checkpoint kinases The instant invention provides for compounds which comprise substituted triazoloquinazolinones that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the ...	03/10/2009
7485649	Inhibitors of checkpoint kinases The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patie...	02/03/2009
7329676	2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors The compounds of formula I in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as indicated in the description, are novel effective PDE4 inhibitors. ...	02/12/2008
7291627	Dihydroimidazo[5.1-a]-beta-carboline derivatives, method for their preparation, and their application as a drug The invention concerns dihydroimidazo[5,1-a]-β-carboline compounds of general formula (I) wherein in particular, R1, R2, R3, R4, R6 and R7...	11/06/2007
7238706	4-oxo-1-(3-substituted phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors Compounds represented by Formula (I): or a pharmaceutically acceptable salt thereof, are phosphodiesterrase 4 inhibitors useful in the treatment of asthma and inflammation and useful for the enhancement of cognit...	07/03/2007
RE39679	Substituted heterocycle fused gamma-carbolines The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7	06/05/2007
7144843	Pest controllers An objective of the present invention is to provide a harmful organism control agent that possesses excellent control effect against harmful organisms and can be safely used. The present invention provides a compound of formula (1) or a salt thereof. The present inv...	12/05/2006
7138408	HIV integrase inhibitors, pharmaceutical compositions and methods for their use Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the a...	11/21/2006
7122534	Aryl fused azapolycyclic compounds The present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts, wherein R1, R2, R3 and Z are as defined herein, intermediates in the synthesis of ...	10/17/2006
7001912	HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity...	02/21/2006
6967215	Tetrahydrocarbazoles, a process for the preparation of those compounds, and the use thereof Tetrahydrocarbazoles of formula where Q is —SO2—; —O—; or —(CO)—; X is —(CH)—; or —N—; m is from 1 to 3; t is 0 or 1 and the remaining substituents are as defined herein, are useful as an...	11/22/2005
6960585	Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y1, Y2, and R	11/01/2005
6949646	Imidazonaphthyridines Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful...	09/27/2005
6936622	6-phenylbenzonaphthyridines Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in the description, are novel effective PDE3/4 Inhibitors. ...	08/30/2005
6930114	Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a and can be used for combating cancer. ...	08/16/2005
6858620	Condensed pyridoindole derivatives Compounds of general structural formula (I), and use of the compounds or salts or solvates thereof as therapeutic agents, are disclosed ...	02/22/2005
6852727	Benzimisazo[4,5-f]isoquinolinone derivatives Benzimidazo[4,5-f]isoquinolinone derivatives are inhibitors of Janus protein tyrosine kinases (Jak), and as such are useful as immunosuppressants, and in the treatment of diseases including asthma, allergies, autoimmune diseases. ...	02/08/2005
6838456	Condensed pyridoindole derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ...	01/04/2005
6809096	Phenanthroline-7-one derivatives and their therapeutic uses A pharmaceutical composition including an efficient amount of a compound selected among the compounds of formulae (I) and (Ia). The compounds have interesting cytotoxic properties leading to a therapeutic use as antitumoral medicines.	10/26/2004
6803366	Agent for improving learning or memory Disclosed is an agent for improving learning and/or memory, which is useful for therapy of dementia accompanying disorder of memory due to a cerebrovascular disease, neurodegenerative disease such as Alzheimer's disease, endocrine disease, nutritional or metabolic d...	10/12/2004
6747039	Aza-benzothiopyranoindazoles with antitumor activity The present invention relates to a group of aza-anthrapyrazole compounds having antitumor activity, and processes for their preparation. Compositions containing the aza-anthrapyrazole compounds and methods of treating tumors and cancer in mammals with the compounds ...	06/08/2004
6720348	Combination of gaba agonists and aldose reductase Inhibitors This invention relates to pharmaceutical compositions comprising combinations of a GABA agonist, a prodrug thereof or a pharmaceutically acceptable salt of said GABA agonist or said prodrug and an ARI, a prodrug thereof or a pharmaceutically acceptable salt of said ...	04/13/2004
6713471	Substituted heterocycle fused gamma-carbolines The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, ...	03/30/2004
6706702	Aryl fused azapolycyclic compounds The present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts, wherein R1, R2, R3 and Z are as defined herein, intermediates in the synthesis of su...	03/16/2004
6699899	Substituted acylhydroxamic acids and method of reducing TNF଱ levels Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF଱ and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)p ropanoate....	03/02/2004
6630483	Phenanthridine-N-oxides N-oxides of the compounds of formula (I) in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy ...	10/07/2003
6559160	Compounds and methods for modulating cxcr3 function The invention provides compounds and compositions of the formula: ##STR1## wherein the subscript n is an integer of from 0 to 4; Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;...	05/06/2003
6548515	Dihydrofuro[3,4-b]quinolin-1-one compounds The invention relates to compound of formula (I): ##STR1## wherein: {character pullout} represents a single or double bond, R0 represents hydrogen or hydroxy or alkoxy, R1 and R2, which are identical or different, each represents ...	04/15/2003
6541484	Pyrazolo-pyridine derivatives as ligands for GABA receptors A class of substituted and/or ring-fused pyrazolo[3,4-b]pyridine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent on the pyrazole nitrogen atom adjacent the pyridine nucleus, and an optionally substituted cycl...	04/01/2003
6538005	Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, arm novel active bronchial therapeutics. ##STR1##...	03/25/2003

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Class 514/287 - Three or more hetero atoms in the tetracyclo ring system