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Class 514/282 - One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein one of the pentacyclo ring system
No. of patents: 497
Last issue date: 05/29/2012


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NumberTitleIssue Date
5187177Method and a pharmaceutical preparation for treating pain
A method of relieving pain comprises administering, to the subject suffering from the pain, a pharmaceutically effective amount of glucagon and a spasmogenic analgesic. A ratio of 0.1-10 parts of glucagon per 10 parts of analgesic is administered. Further...
02/16/1993
5183807Use of monosialoganglioside GM, to prevent the development of tolerance to the analgesic effect of morphine and related drugs
The use of monosialoganglioside GM1, of its pharmacologically acceptable salts and of its internal ester derivative for the preparation of pharmaceutical compositions for preventing the development in man of tolerance to the analgesic effect of...
02/02/1993
5180736Polycyclic amines useful as cerebrovascular agents
A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed....
01/19/1993
5175144Method of retarding the progression of chronic renal failure
Progression of chronic renal failure can be retarded (slowed or arrested) by administering to humans suffering from such disorder an agent which suppresses the production of glucocorticoids in the human. The agents may be administered alone or in combinat...
12/29/1992
5164398Ibuprofen-antitussive combinations
This invention relates to pharmaceutical compositions for use in the treatment of pain and inflammation and the relief of cough and cold symptoms in a mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatory effective amount ...
11/17/1992
5130412Electrochemical drug release and article
An electrically conducting self-doped carbazole polymer of the formula: ##STR1## wherein A is a bifunctional molecule capable of bonding to a positively charged molecule at one end and is capable of bonding to a flexible spacer group Z at another end...
07/14/1992
5116840Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune respo...
05/26/1992
5114947Method for alleviating anxiety using benzobicyclic carboxamides
Benzofuran--7--carboxamides with anxiolytic activity....
05/19/1992
5104875Combination preparations containing rifampicin and thioacetazon
Pharmaceutical combination preparations containing rifampicin and thioacetazon and optionally isonicotinic acid hydrazide or ethambutol and the use of same for the treatment of mycobacterial infections....
04/14/1992
5102887Method for reducing emesis and nausea induced by the administration of an emesis causing agent
A method for preventing or relieving nausea and emesis associated with the use of an emesis-causing agent in warm-blooded animals comprises administering to the animal both a narcotic analgesic and a quaternary derivative of noroxymorphone prior to, simul...
04/07/1992
5086058Method for treating alcoholism with nalmefene
A method for treating alcoholism. The alcohol-drinking response of alcoholics is extinguished by having them drink alcoholic beverages while nalmefene, an opiate antagonist, blocks the positive reinforcement effect of ethanol in the brain....
02/04/1992
5084460Methods of therapeutic treatment with N-(3-ouinuclidinyl)-2-hydroxybenzamides and thiobenzamides
This invention provides 3-quinuclidinyl benzamides which in the form of pharmaceutical compositions have utility as therapeutic agents which exhibit anxiolytic antipsychotic and cognitive improving effects in warm blooded animals. Illustrative of an inven...
01/28/1992
5075341Treatment for cocaine abuse
Mixed opiate agonist/antagonists, particularly buprenorphine, is provided for the treatment of cocaine dependence and concurrent cocaine and opiate abuse and dependence....
12/24/1991
5073380Oral sustained release pharmaceutical formulation and process
A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a pharmaceutical active, hydroxyethyl cellulose, a wicking agent e...
12/17/1991
5071853Polycyclic amines useful as cerebrovascular agents
A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed....
12/10/1991
5057322Method of treating mast cell disease
A method of treating a patient suffering from mast cell disease comprising daily administration to such patient of from about 1 to about 150 mg of a pure narcotic antagonist, e.g., nalmefene or naltrexone. The antagonist may be administered in divided dos...
10/15/1991
50575195-HT3 antagonists: use in reducing opiate tolerance
The use of 5-HT3 antagonists and their pharmaceutically acceptable salts in reducing tolerance to opiates in particular morphine....
10/15/1991
5053228Polymeric temperature sensitive drug carrier
The drug carrier of this invention provides a temperature-sensitive polymer chemically bonded to a drug. The drug carrier is capable of releasing a drug continuously in the body. The drug carrier is a liquid when administered and becomes solid in the body...
10/01/1991
5028612Method for treating emotional numbness
An opiate antagonist or a pharmaceutically acceptable salt thereof is used to treat emotional numbness associated with Post Traumatic Stress Disorder and other psychopathologic conditions....
07/02/1991
5013739Method of treating chronic fatigue syndrome using an opiate receptor antagonist
Chronic herpes viral infections, including chronic genital herpes caused by the herpes simplex virus, Type 2, and chronic infections due to the Epstein-Barr virus, chronic fatigue syndrome, chronic inflammatory connective tissue disease, including rheumat...
05/07/1991
5013740Method for treating emotional numbness and coma
An opiate antagonist or a pharmaceutically acceptable salt thereof is used to treat emotional numbness associated with Post Traumatic Stress Disorder and other psychopathologic conditions. Opiate antagonist or a pharmaceutically acceptable salt thereof is...
05/07/1991
5004613Oral sustained release pharmaceutical formulation and process
A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a pharmaceutical active, hydroxyethyl cellulose, a wicking agent e...
04/02/1991
5002936Lipophilic complexes of pharmacologically active inorganic mineral acid esters of organic compounds
The present invention provides a composition with the structure (L)m (E)n wherein (L)m and (E)n are bound as a complex, wherein L is a lipophilic compound; wherein E is a nonlipophilic, ionic, inorganic ester of an o...
03/26/1991
4994466Method of treatment for multiple sclerosis
A method of treating a patient suffering from multiple sclerosis comprising daily administration to such patient of from about 1 to about 100 mg of a pure narcotic antagonist, e.g., nalmefene or naltrexone. The antagonist may be administered in divided do...
02/19/1991
4988705Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune respo...
01/29/1991
4987136Method for controlling gastrointestinal dysmotility
Method for controlling gastrointestinal dysmotility in humans by administration of opioid antagonists....
01/22/1991
4971960Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-infla...
11/20/1990
4970212Method of treating human illnesses which compromise the ability to mount an effective immunological response
A method is disclosed for treating human patients suffering from illnesses, including AIDS, which compromise their ability to mount an effective immunological response. This method comprises administering to the patient a pharmaceutically acceptable cytos...
11/13/1990
4946848Method of treating pruritus with nalmefene and clonidine
A method of treating a mammal suffering from pruritus, whether antigen-induced or disease-induced, comprising orally administering to the subject from about 1 to about 25 mg of the narcotic antagonist nalmefene for an initial period of 1 to 7 days, and gr...
08/07/1990
4940586Skin permeation enhancer compositions using sucrose esters
A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predomi...
07/10/1990
4935428Treating opiate dependence
A pharmaceutical composition in sublingual unit dosage form for maintenance treatment of opiate addicts comprising from 2 to 8 mg buprenorphine and an amount of naltrexone sufficient to substantially attenuate the euphorigenic effect of the buprenorphine ...
06/19/1990
4925848Derivative of codeine useful as an agonist and process for the preparation of it
A compound of the formula: ##STR1## A process for its preparation and pharmaceutical compositions comprising the compound or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable diluent or carrier. The compound exhibits ...
05/15/1990
4923875Method for treatment of mast cell-mediated dermatologic disorders
A method of treating human or animal patients suffering from mast cell-mediated dermatological disorders comprising the administration to the affected skin areas of a topical composition comprising from about 0.01 to about 10% by weight of the narcotic an...
05/08/1990
4912114Morphinan derivatives
Compounds of formula I ##STR1## wherein X and Y each denotes hydrogen or together denote -0-, R1 denotes allyl optionally substituted by 1 to 3 alkyl groups, the substituent or substituents having in total a maximum of 3 carbon atoms, cycl...
03/27/1990
4910152Method for binding opioid receptors
A method of controlling weight in a mammal and diagnosing, treating, and preventing disorders associated with delta-type opioid receptors comprising administering to the mammal a receptor probe or a weight control agent for inhibiting weight gain. The rec...
03/20/1990
4908389Penetration enhancement system
The penetration of various drugs through living membranes, eg., skin, is improved by their use in topical compositions containing certain penetration-enhancer systems....
03/13/1990
4906638Dextromethorphan potentiator for anticonvulsant composition and method
A pharmaceutical composition comprises an anti-epileptic drug that does not inhibit, enhance or otherwise modify dextromethorphan binding to the central nervous system dextromethorphan receptor and an effective amount of dextromethorphan to potentiate the...
03/06/1990
4906637Traumatic and ischemic brain injury treatment with opiate-receptor antagonists
The present invention involves methods of inducing opiate-receptor antagonistic activity in a patient suffering from ischemic or traumatic brain injury by administering to said patient an effective amount of an opiate-receptor antagonist having enhanced a...
03/06/1990
4891377Transdermal delivery of the narcotic analgesics etorphine and analogs
A process for relieving pain and novel topical compositions for transdermal delivery of a narcotic analgesic comprising the application to mammalian skin of an effective amount of a compound of the formula: ##STR1## or a pharmacologically acceptable ...
01/02/1990
4889860Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists
A potent, selective opioid receptor agonist or antagonist exhibiting properties useful for a longacting analgesic or opiate abuse treatment agent or appetite suppressant having the general formula: ##STR1## wherein R is methyl, cyclopropylmethyl or a...
12/26/1989
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