Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 8101630 | Extended release opioid abuse deterrent compositions and methods of making same This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix. ... | 01/24/2012 |
| 8088787 | Methods related to the treatment of neurodegenerative and inflammatory conditions The invention includes methods of neuroprotection, inducing release of neurotrophic factors, inhibiting the over-activation of innate immune cells, attenuating the toxin-induced death and/or damage of tissues, reducing inflammation, treating an inflammation-related ... | 01/03/2012 |
| 8084460 | 6,7-unsaturated-7-carbamoyl substituted morphinan derivative A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): wherein R1 and R2 are each independen... | 12/27/2011 |
| 8067430 | Anti-HIV activity of the opioid antagonist naloxone A method of treating HIV infection by using the novel anti-HIV activity of the opioid antagonist naloxone. ... | 11/29/2011 |
| 8067431 | Chemically modified small molecules Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than ab... | 11/29/2011 |
| 8063059 | Use of compositions containing kappa-opioid receptor antagonists for the treatment of dissociative disorders The invention relates to the use of a composition comprising kappa opioid receptor antagonists for producing a drug for the treatment of dissociative disorders in humans. ... | 11/22/2011 |
| 8058230 | Neurotensin receptor agonists and opioid receptor agonists This document provides methods and materials for treating pain. For example, this document provides methods that involve administering a neurotensin receptor (NTR) agonist and an opioid receptor agonist to a mammal (e.g., a human). Compositions containing an NTR ago... | 11/15/2011 |
| 8058286 | Method for therapy of diarrhea-predominant irritable bowel disorders A method for therapy of diarrhea-predominant irritable bowel disorders comprising as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic group or a pharmaceutically acceptable acid addition salt thereof is disclosed. The method for the... | 11/15/2011 |
| 8034825 | Chemically modified small molecules The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number... | 10/11/2011 |
| 8017622 | Opioid and opioid-like compounds and uses thereof The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ damage. ... | 09/13/2011 |
| 8012990 | Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method m... | 09/06/2011 |
| 7973048 | Pharmaceutical composition A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone, oxymorphone, oxycodone, hydrocodone, methadone, propoxyphene, pentazocine, ... | 07/05/2011 |
| 7943631 | Method of treating drug addiction using dextro-morphine The present invention relates a method of treating drug addiction in an individual by administering to the addicted individual a therapeutically effective amount of dextro-morphine capable of activating an opioid receptor. It is disclosed here that dextro-morphine i... | 05/17/2011 |
| 7939543 | Method of reducing α, β unsaturated ketones in opioid compositions The present invention is directed to a process for reducing the level of α, β-unsaturated ketone in an opioid analgesic composition by hydrogenation the opioid analgesic composition with diimide or a diimide progenitor. ... | 05/10/2011 |
| 7923453 | Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method m... | 04/12/2011 |
| 7919499 | Naltrexone long acting formulations and methods of use The inventions described herein arose from unexpected discoveries made during clinical trials with a long acting formulation of naltrexone. As such, the invention includes a method for treating an individual in need of naltrexone comprising the step of parenterally ... | 04/05/2011 |
| 7910599 | Method for treating eating disorders by selective extinction with transdermal naloxone A method for treating eating disorders by repeatedly administering naloxone in a dosage sufficient to block the effects of opiate agonists to a subject suffering from an eating disorder caused by one or more related problem responses; while the amount of naloxone in... | 03/22/2011 |
| 7902207 | Process for production of amines A process for producing an amine which is characterized by reacting an imine with a nucleophilic compound (except a trialkylsilyl vinyl ether) in the presence of a phosphoric acid derivative represented by the formula (1): ... | 03/08/2011 |
| 7879870 | Treatment of inflammatory and ulcerative diseases of the bowel with opioid antagonists Methods for the treatment of inflammatory and ulcerative diseases of the bowel (e.g., Crohn's disease and ulcerative colitis) with a therapeutically effective dose less than 50 mg. of opioid antagonists (e.g., naltrexone, nalmefene or naloxone) are disclosed. An emb... | 02/01/2011 |
| 7875623 | Process for reducing contaminating Michael acceptor levels in oxycodone and other compositions The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts.... | 01/25/2011 |
| 7872013 | Preparation and utility of opioid analgesics The present disclosure is directed to modulators of opiate- and/or NMDA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the use of such compounds for the treatment and/or management of pain, anxiety, neurodeg... | 01/18/2011 |
| 7851482 | Method for making analgesics Improved analgesic oxymorphone hydrochloride contains less than 10 ppm of alpha, beta unsaturated ketones and pharmaceutical preparations comprising such oxymorphone hydrochloride. The oxymorphone hydrochloride is produced by reducing a starting material oxymorphone... | 12/14/2010 |
| 7820689 | Methods and compositions for preventing or treating cardiovascular disease The present invention relates to a method for preventing or treating a cardiovascular disease. ... | 10/26/2010 |
| 7820688 | Topical anesthetic/opioid formulations and uses thereof Many chemical and pharmaceutical compositions are known to produce antinociceptive effects that are helpful in relieving pain and inflammation. Both opioids and local anesthetics serve an important function in providing peripheral pain relief. Topical administration... | 10/26/2010 |
| 7786133 | Chemically modified small molecules The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number... | 08/31/2010 |
| 7781444 | Pharmaceutical composition for treating fecal incontinence and anal itch Fecal incontinence and anal itch can be treated by administration, more particularly by local application to the anus, of an α adrenergic blocker, nitric oxide synthase inhibitor, prostaglandin F2α, dopamine, morphine, β-blockers, and 5-Hydroxytryptami... | 08/24/2010 |
| 7759358 | Oral bioavailable prodrugs The invention is directed to forming duplex prodrugs that provide significant increase in the transdermal flux of drugs across human skin. The prodrugs are prepared by reacting a drug that can form an ester moiety with phosgene to form a carbonate. The drug can be a... | 07/20/2010 |
| 7718664 | Anti-itching agent A method of inhibiting or reducing occurrence or intensity of pruritus including administering to a patient an effective amount of one or more of the morphinan derivative having a nitrogen-containing cyclic group of the Formula (Ia): ... | 05/18/2010 |
| 7696220 | Methods for the treatment or inhibition of ileus Methods for the treatment of ileus are disclosed wherein the peripheral mu opioid antagonist methylnaltrexone is administered. ... | 04/13/2010 |
| 7691873 | Preparation of pharmaceutical formulations A process for the production of a composition comprising a water-insoluble opioid which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble opioid, ii) a water soluble carrier, and iii) a solvent for each of the opioid and the carrier, an... | 04/06/2010 |
| 7683072 | Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/23/2010 |
| 7674799 | Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/09/2010 |
| 7674800 | Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/09/2010 |
| 7674798 | Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/09/2010 |
| 7666876 | Buprenorphine formulations for intranasal delivery Aqueous formulations suitable for intranasal administration comprise buprenorphine or a physiologically acceptable salt or ester thereof and (a) a pectin having a degree of esterification of less than 50%, (b) chitosan and a polyoxyethylene-polyoxypropylene copolyme... | 02/23/2010 |
| 7655671 | Morphinan derivatives, the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof The present invention relates to a class of morphinan compounds and quaternary ammonium salts thereof, substituted in Position 14, which may be used as highly active analgesics or also as opioid antagonists. The present invention also relates to the pharmaceutically... | 02/02/2010 |
| 7652026 | Pharmaceutical composition A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone, oxymorphone, oxycodone, hydrocodone, methadone, propoxyphene, pentazocine, ... | 01/26/2010 |
| 7645767 | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy Chronic pain is alleviated in a mammal suffering there from by administering to the mammal a chronic pain alleviating amount of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, dextrorphan, ketamine or pharmaceutically acceptable salt th... | 01/12/2010 |
| 7629355 | Treatment of chemical dependency with substantially nonaddicting normorphine and norcodeine derivatives A method is provided for treating a drug-dependent individual so as to effect withdrawal from a drug of abuse, e.g., an opiate such as heroin or oxycodone, a stimulant such as cocaine, or alcohol. The method involves substitution therapy wherein a substantially nona... | 12/08/2009 |
| 7625918 | Hydrocodone polymorphs Hydrocodone bitartrate forms are disclosed which are useful as analgesic agents either in combination with or as replacements for hydrocodone bitartrate. ... | 12/01/2009 |
