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Class 514/282 - One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein one of the pentacyclo ring system
No. of patents: 520
Last issue date: 05/14/2013


1                      
NumberTitleIssue Date
8440686Nalmefene prodrugs
The present invention relates to ester prodrugs of nalmefene of formula (I), pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of substance abuse disorders such as alcohol abuse an...
05/14/2013
8440687Oligomer-opioid agonist conjugates
The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of th...
05/14/2013
8420663Peripheral opioid receptor antagonists and uses thereof
The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof. ...
04/16/2013
8420662Stable solid preparation containing 4,5-epoxymorphinan derivative
It is an object of the present invention to provide a stable solid preparation comprising a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof as an effective ingredient. That is, the present invention provides the stab...
04/16/2013
8410129Treatment for paresis/paralysis
The present invention relates to a novel use of opioid compounds for treatment of a neurologic or neurogenic disorder. Such neurologic or neurogenic disorders include lingual, pharyngeal, laryngeal, esophageal, urinary bladder sphincter, lumbar and lumbo-sacral spin...
04/02/2013
8399475Crystalline and amorphous forms of naltrexone hydrochloride
The present invention relates to novel crystalline forms of naltrexone hydrochloride including hydrated and solvated forms and a novel amorphous form. The invention also describes methods of preparing the various crystalline forms. The present invention also relates...
03/19/2013
8394813Active agent delivery systems and methods for protecting and administering active agents
The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions...
03/12/2013
8394814Method of purifying crude noscapine
The invention provides a method for separating noscapine from an opium source without substantially changing the color of the noscapine. ...
03/12/2013
8389540Polymorphic forms of naltrexone
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorpora...
03/05/2013
8367693Opioid salts and formulations exhibiting anti-abuse anti-dose dumping properties
A drug substance with a pharmaceutically acceptable organic acid addition salt of an opioid wherein said organic acid is selected from Structure A: wherein R1-R4 are independently selected from H, a...
02/05/2013
8362029Opioid-containing oral pharmaceutical compositions and methods
The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an opioid (including salts thereof) and a salt of a non-steroidal anti-inflammatory drug (NSAID)....
01/29/2013
8343992Synthesis of -methylnaltrexone
This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use. ...
01/01/2013
8338444Opioid salts and formulations exhibiting anti-abuse and anti-dose dumping properties
A drug substance with a pharmaceutically acceptable organic acid addition salt of an opioid wherein said organic acid is selected from Structure A: wherein R1-R4 are independently selected from H, a...
12/25/2012
8329720Opioid salts and formulations exhibiting abuse deterrent and anti-dose dumping properties
A drug substance with a pharmaceutically acceptable organic acid addition salt of an opioid wherein said organic acid is selected from Structure A: wherein R1-R4 are independently selected from H, a...
12/11/2012
8324236Crystalline forms of a 3-carboxypropyl-aminotetralin compound
The invention provides crystalline solid forms of (S)-4-((2S,3S)-7-carbamoyl-1,1-diethyl-3-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamino)-2-cyclohexylmethyl-butyric acid. The invention also provides pharmaceutical compositions comprising such crystalline solid form...
12/04/2012
83187653-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a phar...
11/27/2012
8314118Methods and compositions for treating dry eye
This invention relates to treatment of dry eye. In particular, the invention relates to methods and formulations for treating dry eye based on topical application of opioid antagonists such as naltrexone. ...
11/20/2012
8247425Peripheral opioid receptor antagonists and uses thereof
The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof. ...
08/21/2012
8227483Polymorphs of 6-beta-naltrexol
The present invention provides polymorphs of 6-beta-naltrexol and process for their preparation. In particular, the present invention provides crystalline forms of the free base of 6-beta-naltrexol and processes for their preparation. The present invention also prov...
07/24/2012
8222267Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia
A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method m...
07/17/2012
8211905Opioid salts and formulations exhibiting anti-abuse and anti-dose dumping properties
A drug substance with a pharmaceutically acceptable organic acid addition salt of an opioid wherein said organic acid is selected from Structure A: wherein R1-R4 are independently selected from H, alky...
07/03/2012
8198291Intranasal opioid compositions
The present invention relates to pharmaceutical compositions for intranasal administration to a mammal that contain an effective amount of an opioid, a liquid nasal carrier for the opioid, and optionally a sweetener, flavoring agent or masking agent. In some embodim...
06/12/2012
8193209Analgesic combination of oxycodone and meloxicam
Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of meloxicam and/or at least one a pharmaceutically acceptable salt thereof and a dose oxycodone and/or at least one a pharmaceu...
06/05/2012
8188108Pharmaceutical composition
A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone, oxymorphone, oxycodone, hydrocodone, methadone, propoxyphene, pentazocine, ...
05/29/2012
8188107Analgesic combination of oxycodone and N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl] methanesulfonamide
Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of N-[3 -(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl] methanesulfonamide and/or at least one a pharmaceutically acceptabl...
05/29/2012
8183256Remedy or preventive for integration dysfunction syndrome
A method of treating schizophrenia, which method can treat especially positive symptoms of schizophrenia and does not cause impaired information processing related to cognitive deficiencies or the like which is a symptom of schizophrenia. The method of treating schi...
05/22/2012
8173666Oligomer-opioid agonist conjugates
The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of th...
05/08/2012
8143268Bicyclic pyrimidinones and uses thereof
The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effect...
03/27/2012
8143267Analgesic combination of oxycodone and nimesulide
Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of nimesulide and/or at least one pharmaceutically acceptable salt thereof and oxycodone and/or at least one pharmaceutically ac...
03/27/2012
8101630Extended release opioid abuse deterrent compositions and methods of making same
This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix. ...
01/24/2012
8088787Methods related to the treatment of neurodegenerative and inflammatory conditions
The invention includes methods of neuroprotection, inducing release of neurotrophic factors, inhibiting the over-activation of innate immune cells, attenuating the toxin-induced death and/or damage of tissues, reducing inflammation, treating an inflammation-related ...
01/03/2012
80844606,7-unsaturated-7-carbamoyl substituted morphinan derivative
A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): wherein R1 and R2 are each independen...
12/27/2011
8067430Anti-HIV activity of the opioid antagonist naloxone
A method of treating HIV infection by using the novel anti-HIV activity of the opioid antagonist naloxone. ...
11/29/2011
8067431Chemically modified small molecules
Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than ab...
11/29/2011
8063059Use of compositions containing kappa-opioid receptor antagonists for the treatment of dissociative disorders
The invention relates to the use of a composition comprising kappa opioid receptor antagonists for producing a drug for the treatment of dissociative disorders in humans. ...
11/22/2011
8058230Neurotensin receptor agonists and opioid receptor agonists
This document provides methods and materials for treating pain. For example, this document provides methods that involve administering a neurotensin receptor (NTR) agonist and an opioid receptor agonist to a mammal (e.g., a human). Compositions containing an NTR ago...
11/15/2011
8058286Method for therapy of diarrhea-predominant irritable bowel disorders
A method for therapy of diarrhea-predominant irritable bowel disorders comprising as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic group or a pharmaceutically acceptable acid addition salt thereof is disclosed. The method for the...
11/15/2011
8034825Chemically modified small molecules
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number...
10/11/2011
8017622Opioid and opioid-like compounds and uses thereof
The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ damage. ...
09/13/2011
8012990Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia
A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method m...
09/06/2011
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