Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7674799 | Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/09/2010 |
| 7674800 | Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/09/2010 |
| 7674798 | Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 03/09/2010 |
| 7666876 | Buprenorphine formulations for intranasal delivery Aqueous formulations suitable for intranasal administration comprise buprenorphine or a physiologically acceptable salt or ester thereof and (a) a pectin having a degree of esterification of less than 50%, (b) chitosan and a polyoxyethylene-polyoxypropylene copolyme... | 02/23/2010 |
| 7655671 | Morphinan derivatives, the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof The present invention relates to a class of morphinan compounds and quaternary ammonium salts thereof, substituted in Position 14, which may be used as highly active analgesics or also as opioid antagonists. The present invention also relates to the pharmaceutically... | 02/02/2010 |
| 7652026 | Pharmaceutical composition A pharmaceutical composition comprising an analgesic or analgesic combination and a stool softener is disclosed. The analgesic is selected from morphine, meperidine, fentanyl, hydromorphone, oxymorphone, oxycodone, hydrocodone, methadone, propoxyphene, pentazocine, ... | 01/26/2010 |
| 7645767 | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy Chronic pain is alleviated in a mammal suffering there from by administering to the mammal a chronic pain alleviating amount of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, dextrorphan, ketamine or pharmaceutically acceptable salt th... | 01/12/2010 |
| 7629355 | Treatment of chemical dependency with substantially nonaddicting normorphine and norcodeine derivatives A method is provided for treating a drug-dependent individual so as to effect withdrawal from a drug of abuse, e.g., an opiate such as heroin or oxycodone, a stimulant such as cocaine, or alcohol. The method involves substitution therapy wherein a substantially nona... | 12/08/2009 |
| 7625918 | Hydrocodone polymorphs Hydrocodone bitartrate forms are disclosed which are useful as analgesic agents either in combination with or as replacements for hydrocodone bitartrate. ... | 12/01/2009 |
| 7538118 | 6-aminomorphinane derivatives, method for production and use thereof This invention relates to compounds of the formula (I). ... | 05/26/2009 |
| 7501433 | Opioid and opioid-like compounds and uses thereof The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ damage. ... | 03/10/2009 |
| 7501434 | 6-carboxy-normorphinan derivatives, synthesis and uses thereof The present invention relates to compounds of formula I, synthesis thereof, and methods of using the same. ... | 03/10/2009 |
| 7462626 | Compositions for affecting weight loss Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) or a melanocortin 4 recepto... | 12/09/2008 |
| 7402591 | Analgesic compositions containing buprenorphine An analgesic composition in parenteral unit dosage form or in a unit dosage form suitable for delivery via the mucosa comprising an amount of buprenorphine which is less than the clinical dose required to achieve pain relief and an amount of naloxone such that the r... | 07/22/2008 |
| 7375111 | Compositions for affecting weight loss Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) or a melanocortin 4 recepto... | 05/20/2008 |
| 7354955 | (2S)-amino(phenyl)acetic acid and derivatives as αδ voltage-gated calcium channel ligands The present invention relates to a method for treating pain, reflex sympathetic dystrophy, spasticity, and bipolar disorder using ligands of the α2δ voltage-gated calcium channel, wherein the ligand comprises (2s)-aminophenyl acetic acid and derivatives... | 04/08/2008 |
| 7342017 | 1,2,5-Thiadiazol-3-yl-piperazine therapeutic agents useful for treating pain, depression and anxiety A compound of formula: (wherein X, R1, R3, R4, and R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Thiadiazolylpiperazine Compound”), pharmaceutical... | 03/11/2008 |
| 7338971 | Treatment of inflammatory, cancer, and thrombosis disorders This invention provides for the treatment of inflammatory, cancer and thrombotic disorders through the administration, in combination, of a COX2 inhibitor, low dose aspirin, and antioxidant flavanoids, flavonoids or isoflavones and at least one of these combinations... | 03/04/2008 |
| 7329664 | Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with ... | 02/12/2008 |
| 7320984 | Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group The invention provides a morphinan derivative of the Formula (I): wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y ... | 01/22/2008 |
| 7314880 | Cardioprotective delta opioid receptor agonists and methods of using same The present invention relates to compositions and methods of treatment for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective effects of ischemic preconditioning. The compounds are used to reduce ... | 01/01/2008 |
| 7291628 | Treatment of cocaine abuse using N-substituted derivatives of morphinan The invention is based in part on the discovery that nonselective κ agonists that possess μ receptor-mediated effects in addition to their κ agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can... | 11/06/2007 |
| 7285544 | Use of nitroxides in treating skin disease Methods of treating inflammatory skin diseases such as rosacea, atopic dermatitis, contact dermatitis, drug eruptions, psoriasis, seborrheic dermatitis, connective tissue diseases, autoimmune disorders, urticaria or hives, and inflammation associated with skin infec... | 10/23/2007 |
| 7279493 | Therapeutic agents useful for treating pain A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an ef... | 10/09/2007 |
| 7279579 | Polymorphic forms of naltrexone This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorpora... | 10/09/2007 |
| 7276250 | Sustained release formulations of oxymorphone Sustained release formulations of oxymorphone or pharmaceutically acceptable salts thereof; methods for making the sustained release formulations of oxymorphone or pharmaceutically acceptable salts thereof; and methods for using the sustained release formulations of... | 10/02/2007 |
| 7271173 | Mixed opioids and uses thereof This invention features opioid compounds having activity at kappa and mu receptors, methods for preparing the mu/kappa opioids, and methods for the treatment of pain or a dopamine dysregulation disease, such as schizophrenia, attention deficit hyperactivity disorder... | 09/18/2007 |
| 7262298 | 4-hydroxybenzomorphans 4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. ... | 08/28/2007 |
| 7262194 | Therapeutic agents useful for treating pain A compound of formula: wherein X is S or O and A, R1-R4, n, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Pyridazinylpiperazine Compound”), compositions c... | 08/28/2007 |
| 7256200 | Method and composition for potentiating an oplate analgesic Composition and methods of treating pain and reducing, reversing, or preventing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and a calcium calmodulin kinase (CaMKII) inhibitor as active agents to treat pain in ... | 08/14/2007 |
| 7241741 | Methods and compositions for the treatment of asthma and related disorders The present invention provides methods for the treatment of respiratory tract mucositis in individuals in need of such treatment, the method comprising the systemic administration to the individual of therapeutically effective amounts of at least one anti-fungal age... | 07/10/2007 |
| 7238775 | Receptor(SSTR4)-selective somatostatin analogs Analogs of SRIF which are selective for SSTR4 in contrast to the other cloned SRIF receptors are useful in determining tissue and cellular expression of the receptor SSTR4 and its biological role in regulating tumor growth. SRIF analog peptides, such as des-AA1... | 07/03/2007 |
| 7230005 | Compounds and methods for lowering the abuse potential and extending the duration of action of a drug The abuse potential of a bioavailable drug such as an opiate analgesic agent is reduced and its duration of action is extended by converting it to a poorly absorbed ester prodrug or other prodrug derivative prior to formulation. Unlike many existing sustained releas... | 06/12/2007 |
| 7226619 | Material for controlling diversion of medications A combination of a pro-agonist first medication in timed release form, and a sequestered second non-antagonist medication allows the first medication to be effective if taken according to medical directions. If the combination is tampered with or otherwise taken in ... | 06/05/2007 |
| 7226768 | Cytochrome P450 oxygenases Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P45... | 06/05/2007 |
| 7220737 | Noribogaine in the treatment of pain and drug addiction The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal from drug dependency. In the latter case, the noribogaine treatment sh... | 05/22/2007 |
| 7209588 | Unified system and method for animal behavior characterization in home cages using video analysis In general, the present invention is directed to systems and methods for finding the position and shape of an animal using video. The invention includes a system with a video camera coupled to a computer in which the computer is configured to automatically provide a... | 04/24/2007 |
| 7201920 | Methods and compositions for deterring abuse of opioid containing dosage forms This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix. ... | 04/10/2007 |
| 7199129 | Derivatives of morphine-like opioid compounds The present disclosure concerns compounds of formula (I) and pharmaceutically acceptable salts, hydrates, solvates, pharmaceutically acceptable derivatives, pro-drugs, tautomers and/or isomers thereof. The disclosure also relates to processes for the preparation of ... | 04/03/2007 |
| 7199159 | Use of biguanide derivatives for making a medicine having a wound healing effect The present invention relates to the use of biguanide derivatives of general formula I below: in which: the groups R1 and R2 represent, independently of each other, a hydrogen a... | 04/03/2007 |