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| Number | Title | Issue Date |
| 8188106 | Ligand activators of the RAR receptors and pharmaceutical/cosmetic applications thereof Novel ligand compounds having the structural formula (I): in which: Ar is a radical selected from among the radicals of formulae (a)-(c) below: | 05/29/2012 |
| 8153646 | Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation The present invention provides methods of improving cognitive and motor deficits associated with central nervous system (CNS) disorder or condition in an animal. The methods comprise a general administration of phosphodiesterase 4 inhibitors and optionally training ... | 04/10/2012 |
| 8153645 | Treating pain using selective antagonists of persistent sodium current The present invention provides methods of treating chronic pain in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transie... | 04/10/2012 |
| 8124612 | Treating neurological disorders using selective antagonists of persistent sodium current The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative ... | 02/28/2012 |
| 8114886 | Pyridylmethylsulfone derivative The present invention relates to a novel compound having an effect of inhibiting production/secretion of β-amyloid protein. The present invention provides a compound represented by the general formula (1): ... | 02/14/2012 |
| 8076348 | Acylguanidine derivative or salt thereof [Problem] To provide a compound which can be used in the prevention and/or treatment of diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly in the treatment of irritable bowel syndrome (IBS) and/or prevention of mig... | 12/13/2011 |
| 8071610 | Compositions and methods for enhancing brain function Compositions and methods are provided that enhance cognition in a human to which the composition is orally administered. Remarkably, clinical studies have proven that contemplated compositions achieve the desired effects using a minimal number of active ingredients ... | 12/06/2011 |
| 8030323 | Pyrazole carboxamide derivatives, pharmaceutical compositions and its preparation A compound of formula (I) or pharmaceutically acceptable salts and/or solvates or hydrates thereof. A process for preparing the compound, a pharmaceutical composition comprising the compound and an application for resisting cannabinoid CB1 receptor are provided.... | 10/04/2011 |
| 8008314 | Method of recovering cyanopyridines Hydrolysis of cyanopyridine may be reduced by use of picoline as a predominately non-aqueous quench fluid. The picoline quench fluid may also be a reactant in the manufacture of cyanopyridine. ... | 08/30/2011 |
| 8008315 | Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceu... | 08/30/2011 |
| 7964609 | Use of mGluR5 antagonists for the treatment of gerd The present invention relates to the use of metabotropic glutamate receptor 5 antagonists for the inhibition of transient lower esophageal sphincter relaxations. A further aspect of the invention is directed to the use of metabotropic glutamate receptor 5 antagonist... | 06/21/2011 |
| 7947700 | Carboxylic acid amides, the preparation thereof and their use as medicaments The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers,... | 05/24/2011 |
| 7939542 | Cinnamaldehyde derivatives having improved solubility in water, a method for preparing the same and a pharmaceutical composition comprising the same Disclosed herein are a novel cinnamaldehyde compound represented by Chemical Formula 1 or pharmaceutically acceptable salts thereof. The cinnamaldehyde compound has improved solubility in water and has inhibitory effects on the growth of cancer cells because it indu... | 05/10/2011 |
| 7915274 | Nitrogen containing heterocyclic compounds and medicines containing the same Compounds represented by the following general formula: [wherein X1, X2, X3 and X4 each independently represent a single bond, C1-6 alkylene, etc.; A2 repres... | 03/29/2011 |
| 7868015 | Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors. ... | 01/11/2011 |
| 7863287 | Compositions of non-steroidal anti-inflammatory drugs, decongestants and anti-histamines The present invention is directed to a pharmaceutical composition and method for the treatment of rhinitis and cold-like symptoms which includes a non-steroidal anti-inflammatory drug (NSAID), a decongestant, and an antihistamine. It has been found that an NSAID enh... | 01/04/2011 |
| 7858634 | Amorphous 3-pyridil-1-hydroxyethyliden-1,1-biphosphonic acid monosodium salt and process for the preparation thereof A process for the preparation of 3-pyridil-1-hydroxyethyliden-1,1-biphosphonic acid monosodium salt of formula in an amorphous form, preferably lyophilized, and its pharmaceutical compositions are described. Said amorphous ... | 12/28/2010 |
| 7816367 | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1 | 10/19/2010 |
| 7790738 | Methods of treating and preventing AIDS using of COX-2 inhibitors The present invention provides a method of treating or preventing a disorder typified by an immunodificiency (e.g. HIV), wherein the patient is administered a COX-2 inhibitor or derivative or pharmaceutically acceptable salt thereof, preferably diisopropylfluorophas... | 09/07/2010 |
| 7745456 | Synthesis and antimicrobial activity of novel dicationic “reversed amidines” The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently s... | 06/29/2010 |
| 7727997 | N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors o... | 06/01/2010 |
| 7705011 | Agent for treatment and prevention of endometriosos and uterine adenomyosis An object of the present invention is to provide an agent for use in the effective treatment and prevention of endometriosis and uterine adenomyosis. The present invention relates to an agent for use in the treatment and prevention of endometriosis or uterine adenom... | 04/27/2010 |
| 7687513 | Aminopyridinium ionic liquids Disclosed herein are aminopyridinium cations and compositions containing these cations. Piperidino pyridinium cations and compositions containing these cations are also described. Ionic compositions, particularly liquid ionic compositions that contain the aminopyrid... | 03/30/2010 |
| 7671065 | Pyridine derivatives as potassium ion channel openers The present invention is directed to novel pyridine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels. ... | 03/02/2010 |
| 7671066 | Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridynyl alkylene alcohols, methods of preparing such compounds, compositions containing them and ... | 03/02/2010 |
| 7648993 | Methods of treating disorders with Group I mGluR antagonists mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be used to treat epilepsy and anxiety in a human having Fragile X syndrome... | 01/19/2010 |
| 7645765 | Use of moxaverin for treating erectile dysfunction, forms of dementia or diseases associated to an arteriosclerotic occlusion The invention relates to a drug containing an aqueous formulation of Moxaverin and at least one water-miscible solubilizer. ... | 01/12/2010 |
| 7638524 | Combination therapy for treating hypercholesterolemia The invention relates to methods for treating hypercholesterolemia and atherosclerosis, and reducing serum cholesterol in a mammal. The methods of the invention comprise administering to a mammal a first amount of a bile acid sequestrant compound which is an unsubst... | 12/29/2009 |
| 7625917 | Thiolesters and uses thereof This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and t... | 12/01/2009 |
| 7622475 | EP2 agonists The invention provides EP2 agonists, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for lowering intraocular pressure and thereby treating glaucoma. ... | 11/24/2009 |
| 7550476 | Condensed polycyclic compounds The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: or a pharmaceutically acceptable salt thereof and a pharmaceutical composi... | 06/23/2009 |
| 7550474 | Substituted phenyl acetamides and their use as protease inhibitors Phenyl acetamide compounds are described, including compounds of Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3-R6, R11, B, Y and W are set forth in... | 06/23/2009 |
| 7550475 | Condensed polycyclic compounds The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: or a pharmaceutically acceptable salt thereof and a pharmaceutical composi... | 06/23/2009 |
| 7498337 | Acid secretion inhibitor The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R... | 03/03/2009 |
| 7482357 | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorat... | 01/27/2009 |
| 7482358 | Imidazoline compounds Compounds represented by the general formula (I): wherein Ar1 and Ar2 are each aryl or heteroaryl; R1 is lower cycloalkyl, —Ar3, or a group of the general formula (a), (b) or (c... | 01/27/2009 |
| 7470702 | Benzimidazoles Novel compounds of the formula I in which R1, R1′, L, E, G, M, Q, U, R2, m, p and q have the meanings indicated. Further, the compounds of formula I can be used as, for example, inhibitors of tyrosine kinases, for example TIE-2 , a... | 12/30/2008 |
| 7459461 | Phosphonic acid compounds as inhibitors of serine proteases The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders. ... | 12/02/2008 |
| 7435729 | Compounds and methods for modulation of estrogen receptors Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for ER-β over ER-α. Methods are disclosed for modulating ER-β in cell an... | 10/14/2008 |
| 7423012 | Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the preventio... | 09/09/2008 |
