Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 8158639 | Non-sedating barbiturate compounds as neuroprotective agents Methods of providing neuroprotection are disclosed comprising administering a non-sedative barbiturate compound in an amount sufficient to achieve neuroprotection in a mammalian subject. Preferred compounds are in the family of diphenylbarbituric acid and analogs. P... | 04/17/2012 |
| 8138197 | Spirochromanon derivatives The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of benzene, pyrazole, isoxazole, pyridine, indole, 1H-indazole, 1H-furo[2,3-c]pyrazole, 1H-thieno[2,3-c]pyrazol... | 03/20/2012 |
| 8076346 | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid The present invention relates to a composition and a method of delivering a barbituric acid derivative to the central nervous system of a mammal in need of treatment for neurological conditions. In particular, the present invention relates to a method of administeri... | 12/13/2011 |
| 7776871 | Method of treating movement disorders using barbituric acid derivatives A method of treating movement disorders comprises administering to a human or animal subject in need of treatment a therapeutically effective amount of at least one compound according to the following formula: wherein R | 08/17/2010 |
| 7723346 | Non-sedating barbiturate compounds as neuroprotective agents Methods of providing neuroprotection are disclosed comprising administering a non-sedative barbiturate compound in an amount sufficient to achieve neuroprotection in a mammalian subject. Preferred compounds are in the family of diphenylbarbituric acid and analogs. P... | 05/25/2010 |
| RE41289 | Ultrashort acting hypnotic barbiturates The subject invention concerns novel compounds that are useful as ultrashort acting hypnotic barbiturates. Specifically exemplified are derivatives of barbituric and thiobarbituric acids. They are rapidly metabolized by blood and tissue enzymes to form polar metabol... | 04/27/2010 |
| 7683071 | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid The present invention relates to a composition and a method of delivering a barbituric acid derivative to the central nervous system of a mammal in need of treatment for neurological conditions. In particular, the present invention relates to a method of administeri... | 03/23/2010 |
| 7655667 | Method of treating movement disorders using barbituric acid derivatives A method of treating movement disorders comprises administering to a human or animal subject in need of treatment a therapeutically effective amount of at least one compound according to the following formula: wherein R | 02/02/2010 |
| 7358264 | Statine derivatives for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ... | 04/15/2008 |
| 7354943 | Statine derivatives for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ... | 04/08/2008 |
| 7294624 | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R... | 11/13/2007 |
| 7288546 | Method and compound for inhibition of cell death This invention relates to a chemical compound that inhibits the apoptotic activity of the protease Omi/HtrA2 and homologous proteins. This protease Omi/HtrA2 is present in all mammalian cells so that inhibition of apoptosis in this fashion results enhanced cellular ... | 10/30/2007 |
| 7166610 | Method of treating movement disorders using barbituric acid derivatives A method of treating movement disorders comprises administering to a human or animal subject in need of treatment a therapeutically effective amount of at least one compound according to the following formula: wh... | 01/23/2007 |
| 7119201 | Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, W, and R1 are as defined in the specification, and to pharmace... | 10/10/2006 |
| 7087619 | Method for the treatment of urinary incontinence Urinary incontinence is alleviated in a mammal by administering to the mammal a urinary incontinence alleviating amount of dextromethorphan, dextrorphan, their mixtures and/or pharmaceutically acceptable salts, alone or in combination with a pharmacologically active... | 08/08/2006 |
| 7078048 | Method and compositions for treating rosacea Rosacea is treated with a composition comprising an antimicrobial and at least one of an anti-inflammatory and a non-retinoid inhibitor of at least one of NF-κβ, AP-1, MMPs, adhesion molecules, TLRs, and CD14. The composition may further comprise a retinoid. ... | 07/18/2006 |
| 7074832 | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide or metronidazole, are described. Sulfacetamide compositions further including sulfur are also described. Methods for treating dermatological disorders using the compositio... | 07/11/2006 |
| 7057027 | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The o... | 06/06/2006 |
| 7041673 | Ultrashort acting hypnotic barbiturates The subject invention concerns novel compounds that are useful as ultrashort acting hypnotic barbiturates. Specifically exemplified are derivatives of barbituric and thiobarbituric acids. They are rapidly metabolized by blood and tissue enzymes to form polar metabol... | 05/09/2006 |
| 7041640 | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents A method of increasing the bioavailability upon oral administration of a pharmacologically active target agent, particularly an antitumor or antineoplastic agent which exhibits poor or inconsistent oral bioavailability (e.g., paclitaxel, docetaxel or etoposide), com... | 05/09/2006 |
| 7037962 | Composition and process for enhancing bio-mass production in greenhouses The instant invention relates to a thermoplastic polymer composition useful in greenhouse films to enhance plant growth or in general bio-mass production. Further aspects of the invention are a process for enhancing plant growth in greenhouses by incorporating a pho... | 05/02/2006 |
| RE38934 | Method and reagents for N-alkylating ureides A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I with an alkylating agent of structure III in the presence of a basic catalyst in an... | 01/10/2006 |
| 6939873 | Non-sedating barbituric acid derivatives The present invention relates to novel non-sedating barbituric acid derivatives, pharmaceutical compositions containing them and methods of neuroprotection in cases of cerebral ischemia, head trauma and other acute neurologic injuries, and prevention of resulting ne... | 09/06/2005 |
| 6936620 | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, W, Z, Ua, Xa, Y... | 08/30/2005 |
| 6919332 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, and R1 are as defined in the specification, and to pharmac... | 07/19/2005 |
| 6906079 | Method and reagents for N-alkylating ureides A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I: with an alkylating agent of structure III: in the presence o... | 06/14/2005 |
| 6833372 | Non-peptide GnRH agents, Pharmaceutical compositions, and methods for their use Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonad... | 12/21/2004 |
| 6756379 | Non-sedating barbiturate compounds as neuroprotective agents Methods of providing neuroprotection are disclosed comprising administering a non-sedative barbiturate compound in an amount sufficient to achieve neuroprotection in a mammalian subject. Preferred compounds are in the family of diphenylbarbituric acid and analogs. P... | 06/29/2004 |
| 6716845 | Barbituric acid derivatives The present invention pertains to derivatives of 5,5-disubstituted pyrimidine-2,4,6,-trianones having the formula: wherein R1, R2, R3, and R4 are described herein. These compou... | 04/06/2004 |
| 6706723 | Pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, Y, A, B and R1 are as defined in the specification, and to pharmaceutical compositions and method... | 03/16/2004 |
| 6686350 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 02/03/2004 |
| 6683086 | Ultrashort acting hypnotic barbiturates The subject invention concerns novel compounds that are useful as ultrashort acting hypnotic barbiturates. Specifically exemplified are derivatives of barbituric and thiobarbituric acids. They are rapidly metabolized by blood and tissue enzymes to form po... | 01/27/2004 |
| 6664262 | N-methoxymethyl-5,5-diphenylbarbituric acid A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I: ##STR1## with an alkylating agent of structure III: ##STR2## in the presence of a basic catalyst in aprotic reaction medium. The ureide may ... | 12/16/2003 |
| 6649614 | Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent for treatment of depression or anxiety The present invention relates to the treatment of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or anti-anxiety agent.... | 11/18/2003 |
| 6573269 | Pyrimidine-2,4,6-trione light screening compositions The present invention provides compounds of formula I, which are effective in absorbing ultraviolet radiation and can be used as sunscreen agents: ##STR1## wherein R1 and R2 are each independently C2 -C18 alkyl, C | 06/03/2003 |
| 6559136 | Fungicidal active substance combinations Novel active compound combinations of compounds of the formula (I) ##STR1## in which Z, X and A are each as defined in the description with known active compounds and their use for controlling phytopathogenic fungi are described.... | 05/06/2003 |
| 6545006 | Process for obtaining L-dihydroorotic acid and use thereof The invention relates to a process for obtaining L-dihydroorotic acid by chromatography on an anionic exchange material in a base water mixture under a pressure from about 1.1 MPa to about 40 MPa. The process can be used to investigate the in vitro and in... | 04/08/2003 |
| 6541523 | Methods for treating or preventing fibromyalgia using very low doses of cyclobenzaprine The present invention relates to methods and compositions comprising a very low dose of cyclobenzaprine or metabolite thereof for preventing and treating sleep disturbances and illnesses manifested with sleep dysfunction including fibromyalgia syndrome, c... | 04/01/2003 |
| 6509343 | Fungicidal active substance combinations Active compound combinations comprising a compound of the formula (I) ##STR1## and known fungicidally active compounds, and their use for controlling phytopathogenic fungi, are described.... | 01/21/2003 |
| 6498164 | Barbituric acid derivative and preventive and therapeutic agent for bone and cartilage containing the same A compound of the formula ##STR1## wherein the substituents are as defined in the specification and solvates and salts thereof useful for treating bone and cartilage diseases.... | 12/24/2002 |
