Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 8183251 | Hydantoin compounds and pharmaceutical compositions thereof The invention provides compounds of formula (I): wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing ... | 05/22/2012 |
| 8178547 | Heterocyclic antiviral compounds Compounds having the formula I wherein A, R1, R2, R3, R4a, R4b, R4c, R5, R6, R7a, R7b, Ar1, Rc, Rd, Re, Rf | 05/15/2012 |
| 8138196 | Antifungal wallboards and building materials and methods for the production thereof The present invention relates to, inter alia, methods for the treatment of wallboards and the treated wallboards. In particular, the invention relates to the treatment of wallboards with a fungicidally effective amount of a strobilurin or strobilurin-type fungicide.... | 03/20/2012 |
| 8106062 | Calcium channel blockers The present invention is directed in part towards methods of modulating the function of calcium channels with dihydropyrimidine, dihydropyrimidone, dihydropyrimidinethione, and dihydropyridine compounds. In addition, the invention describes methods of preventing and... | 01/31/2012 |
| 8106063 | Pyrimidyl sulphone amide derivatives as chemokine receptor modulators A compound of formula (I), pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof for the treatment of asthma, allergic rhinitis, COPD, inflammatory bowel disease, irritable bowel syndrome, osteoarthritis, osteoporosis, rheumatoid arthritis,... | 01/31/2012 |
| RE43029 | Process for preparing a creatine heterocyclic acid salt and method of use This invention relates to a process for the synthesis and method of use of an effective amount of a creatine heterocyclic acid salt for the regulation athletic function in humans. ... | 12/13/2011 |
| 8026247 | Bicyclic amides as kinase inhibitors The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositio... | 09/27/2011 |
| 8017620 | Dutpase inhibitors Deoxyuridine derivatives of the formula where R1 is H or various substituents; D is —NHCO—, —CONH—, —O—, —C(═O)—, —CH═CH, —C≡C—, —NR5—; ... | 09/13/2011 |
| 7998968 | Substituted pyrimidines and [1,2, 4] triazoles and the use thereof for treating prophylaxis, cardiovascular diseases, metabolic diseases and/or central nervous system diseases A compound represented by the formula (I): wherein R1 is an oxo group, ═N—R or the like; a group represented by the formula: is a group represented by the formula: | 08/16/2011 |
| 7989465 | 4,6-disubstituted pyrimidines useful as kinase inhibitors The present invention provides 4,6-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable salts and compositions thereof, and methods of using the same. The present invention also provides probe compounds, such as compounds of fo... | 08/02/2011 |
| 7968559 | Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders: ... | 06/28/2011 |
| 7893072 | Trp-p8 active compounds and therapeutic treatment methods Compounds of the disclosure provide compositions, which are effective for prophylaxis and treatment of diseases or disorders, such as cell-proliferation, angiogenesis, or apoptosis mediated diseases. The disclosure encompasses compounds, analogs, prodrugs, metabolit... | 02/22/2011 |
| 7875622 | Methods and compositions for treating pulmonary hypertension and related diseases and disorders Methods of treating pulmonary hypertension are disclosed. Particular methods comprise the administration of a tryptophan hydroxylase inhibitor and at least one other active pharmaceutical ingredient to patient in need thereof. Pharmaceutical formulations are also di... | 01/25/2011 |
| 7868012 | Sulfamides as endothelin receptor antagonists for the treatment of cardiovascular diseases The invention relates to novel sulfamic acid amides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and... | 01/11/2011 |
| 7858632 | Diaminopyrimidines as P2Xand P2Xantagonists Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): | 12/28/2010 |
| 7825128 | Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs The invention relates to sulfoximine-substituted pyrimidines of the general formula I processes for the preparation thereof and their use as drugs. ... | 11/02/2010 |
| 7795271 | Substituted pyrimidinones Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R4, and R5 are defined herein. These compounds are useful for treating diseases and ... | 09/14/2010 |
| 7795270 | DUTPase inhibitors Deoxyuridine derivatives of the formula (I) where R1 is H or various substituents; D is —NHCO—, —CONH—, -0-, —C(═O)—, —CH═CH, —C≡C—, —NR5—; R4 is hydrogen or various substituents; R5 is H, C | 09/14/2010 |
| 7790734 | Dipeptidyl peptidase inhibitors Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein. ... | 09/07/2010 |
| 7790735 | Methanocarba cycloalkyl nucleoside analogues The present invention provides novel nucleoside and nucleotide derivatives that are useful agonist or antagonists of P1 and P2 receptors. For example, the present invention provides a compound of formula A-M, wherein A is modified adenine or uracil and M is a constr... | 09/07/2010 |
| 7786132 | Aminopyrimidine compounds and methods of use The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated ... | 08/31/2010 |
| 7781442 | Compounds and uses thereof in modulating amyloid beta Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. ... | 08/24/2010 |
| 7776870 | Methods for modulating Lyn kinase activity and treating related disorders The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising the compounds or a pharmaceutically acceptable salts thereof that are useful in modulating lyn kinase activity. In particular, the compounds or a pha... | 08/17/2010 |
| 7776869 | Heteroaryl-substituted alkyne compounds and method of use The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I ... | 08/17/2010 |
| 7763630 | HIV integrase inhibitors The invention encompasses a series pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical... | 07/27/2010 |
| 7754731 | Potassium salt of an HIV integrase inhibitor Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula: Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the... | 07/13/2010 |
| 7745454 | Alpha amino acid derivatives-inhibitors of leukocyte adhesion mediated by VLA-4 Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian... | 06/29/2010 |
| 7745453 | Hydroxypyrimidinone derivatives having inhibitory activity against HIV integrase Compounds of Formula (1), pharmaceuticals containing the same, especially anti-HIV agents having anti viral activity, especially inhibitory activity against HIV integrase, wherein X represents either one of the following gr... | 06/29/2010 |
| 7741334 | Low dose therapy for treating viral infections A method of treating viral infections, particularly Hepatitis B (HBV) and Human Immunodeficiency Virus (HIV), by administering a low dose of Elvucitabine to a patient suffering viral infection is provided herein. The Elvucitabine dosages provided herein for effectiv... | 06/22/2010 |
| 7737157 | Pyrimidine compounds Pyrimidine compounds of the following formula: wherein R1, R2, R3, R4, R5, X, Q1, Q2, and Q3 are defined herein. Also disclosed is a me... | 06/15/2010 |
| 7732457 | Amino-pyridines as inhibitors of β-secretase The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles. | 06/08/2010 |
| 7732456 | Pyridone derivative The invention provides pyridone derivatives represented by a general formula (I) [in the formula, R1 and R2 may be same or different and stands for H, etc., or R1 an... | 06/08/2010 |
| 7723345 | Multicyclic amino acid derivatives and methods of their use Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders: ... | 05/25/2010 |
| 7723344 | Dipeptidyl peptidase inhibitors Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein. ... | 05/25/2010 |
| 7713986 | Compounds and methods for treatment of chemotherapy-induced anemia The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein. ... | 05/11/2010 |
| 7709493 | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders: ... | 05/04/2010 |
| 7705008 | Prostaglandin analogs Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. A, X, J, E, and Z are as described herein. These compounds are useful for treating diseases. ... | 04/27/2010 |
| 7705007 | Cis-imidazolines There are provided compounds of the formula I wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity. ... | 04/27/2010 |
| 7687509 | Pyrimidinecarboxamide derivatives This disclosure relates to novel HIV integrase inhibitors their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in me... | 03/30/2010 |
| 7678804 | Pyrimidine derivatives for treatment of hyperproliferative disorders Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a lin... | 03/16/2010 |
