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| Number | Title | Issue Date |
| 8067428 | Platelet ADP receptor inhibitors Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives whi... | 11/29/2011 |
| 8058284 | [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in v... | 11/15/2011 |
| 7829574 | Substituted quinazoline compounds and their use in treating angiogenesis-related diseases Substituted quinazoline compounds of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and ... | 11/09/2010 |
| 7691867 | Chemical compounds Quinazoline derivatives of formula (I); for use in the treatment of proliferative diseases such as cancer and in the preparation of medicaments for use in the treatment of proliferative diseases, and to process for their preparation, as well as pharmaceutical compos... | 04/06/2010 |
| 7622474 | Platelet ADP receptor inhibitors Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives whi... | 11/24/2009 |
| 7507741 | Heterocyclic compounds Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein... | 03/24/2009 |
| 7504408 | Quinzoline derivatives for use in the treatment of cancer The invention concerns quinazoline derivatives of Formula (I) wherein each of Z, m, R1, n, R3, Z2 and R14 have any of the meanings defined hereinbefore in the description; process... | 03/17/2009 |
| 7348332 | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines The present invention relates to compounds of formula wherein R1, R2, and n are as defined herein and to pharmaceutically acceptable acid addition salts thereof. | 03/25/2008 |
| 7326712 | Substituted tricyclic compounds as protein kinase inhibitors Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including ... | 02/05/2008 |
| 7304059 | Substituted quinazolin-4-ylamine analogues Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activati... | 12/04/2007 |
| 7268142 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to in... | 09/11/2007 |
| 7223756 | Quinazoline compounds with therapeutic use The invention concerns the use of the quinazoline derivatives of Formula (I) wherein each of m, R1, Z, n and R3 have any of the meanings defined in the description in the manufacture of a medicament for use in the prevention or treatment of T c... | 05/29/2007 |
| 7189734 | Anilinoquinazaolines as protein tyrosine kianse inhibitors Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein... | 03/13/2007 |
| 7173136 | 3-Cyano-quinoline derivatives The invention concerns quinoline derivatives of Formula (I) wherein each of Z1, m, R1, n, R3, Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmac... | 02/06/2007 |
| 7157466 | Quinazoline ditosylate salt compounds Ditosylate salts of 4-quinazolineamines are described as well as methods of using the same in the treatment of disorde4rs characterized by aberrant erbB family PTK activity. ... | 01/02/2007 |
| 7157467 | Therapeutic use The invention concerns the use of the quinazoline derivatives of Formula (I) Wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description in the manufacture of a medicament for use in the prevention or trea... | 01/02/2007 |
| 7148230 | Quinazoline derivatives The invention concerns quinazoline derivatives of Formula I wherein R1 and R2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical composition... | 12/12/2006 |
| 7141576 | Cancer treatment method A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as pharmaceutical combinations and compositions containing the same. ... | 11/28/2006 |
| 7141577 | Quinazoline derivatives The invention concerns quinazoline derivatives of Formula I (A Chemical Formula should be inserted here—please see paper copy enclosed) wherein each of Z, m, R1, n and R3 have any of the meanings defined hereinbefore in the description; proce... | 11/28/2006 |
| 7115615 | Quinazoline derivatives The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; processes for their preparat... | 10/03/2006 |
| 7109333 | Heterocyclic compounds A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) ... | 09/19/2006 |
| 7109332 | 2,4-dioxo-3-quinazolinylaryl sulfonylureas 2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds having the formula: wherein R is a member selected from the group consisting of H and C1-6 alkyl; | 09/19/2006 |
| 7105669 | Quinazoline derivatives A compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2 or NR10 where R10 is hydrogen or C1-6 alkyl, and R1, R2, R3, R4, R5, R | 09/12/2006 |
| 7084147 | Anilinoquinazaolines as protein tyrosine kinase inhibitors Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein... | 08/01/2006 |
| 7022849 | Quinazoline and pyrido[2,3-d]pyrimidine inhibitors of phosphodiesterase (PDE) 7 Quinazoline and pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula wherein R1, R2, L, Y1, Y2, Y3 and Z are as described herein,... | 04/04/2006 |
| 7019012 | Quinazoline derivatives and pharmaceutical compositions containing them A compound of general formula I wherein: Ra is a benzyl, 1-phenylethyl, or 3-chloro-4-fluorophenyl group; Rb is a dimethylamino, N-methyl-N-ethy... | 03/28/2006 |
| 7001904 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases The invention concerns quinazoline and quinoline derivatives of Formula (I) wherein Q1 includes a quinazoline or quinoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X | 02/21/2006 |
| 6982264 | Substituted alcohols useful in treatment of Alzheimer's disease The invention relates to substituted alcohol compounds of the formula (I): wherein X, R1, R2, R3, RN, R20 and RC are defined herein. The compounds are u... | 01/03/2006 |
| 6962922 | Alkynylated quinazoline compounds A compound selected from those of formula (I): wherein W1 represents O, S, or —NR3 in which R3 represents hydrogen, alkyl, OH or CN; W2 represe... | 11/08/2005 |
| 6933300 | JAK-3 inhibitors for treating allergic disorders Inhibitors of JAK3 kinase for the treatment of allergy, and others are described. ... | 08/23/2005 |
| 6919338 | Substituted quinazoline derivatives and their use as inhibitors of aurora-2 kinase The use of a compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6alkyl; R | 07/19/2005 |
| 6911446 | Methods of modulating serine/threonine protein kinase function with quinazoline-based compounds The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with quinazoline-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the inv... | 06/28/2005 |
| 6897214 | Quinazoline derivatives The invention concerns quinazoline derivatives of the formula I wherein X1 is a direct link or a group such as CO, C(R2)2 and CH(OR2); | 05/24/2005 |
| 6894041 | Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: | 05/17/2005 |
| 6849625 | Quinazoline derivatives with anti-tumour activity The invention concerns quinazoline derivatives of Formula I wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; processes for their preparation, pha... | 02/01/2005 |
| 6713485 | Heterocyclic compounds The present invention relates to substituted heteroaromatic compounds, methods for their preparation, pharmaceutical compositions containing them and their use in medicine. Specifically, the invention relates to quinazoline derivatives useful in treating disorders m... | 03/30/2004 |
| 6645971 | Quinazolinone derivatives A compound given by general formula (1): ##STR1## [wherein T represents oxygen or sulfur atom, Y represents alkyl, cycloalkyl group, etc., ring W represents benzene ring, etc., R1 and R2 represent independently hydrogen atom, lower a... | 11/11/2003 |
| 6525086 | Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X, T, Q, Z, U, Y, Ar, p and n are as defined in the speci... | 02/25/2003 |
| 6498172 | Prostaglandin agonists and their use to treat bone disorders This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 12/24/2002 |
| 6498154 | Cyclic regimens using quinazolinone and benzoxazine derivatives This invention relates to cyclic combination therapies utilizing, in combination with progestins, estrogens, or both, compounds which are progesterone receptor antagonists of the general structure: ##STR1## wherein: R1 and R2 are H, ... | 12/24/2002 |
